Cited by 3,185COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Dermatological and COVID-19 studies

The DOI matches its Crossref record; 258 of the 261 references it cites were found in a registry or an index.

Extrapulmonary manifestations of COVID-19

Open access

Gupta, Aakriti, Madhavan, Mahesh V., Sehgal, Kartik, Nair, Nandini, Mahajan, Shiwani, Sehrawat, Tejasav S., Bikdeli, Behnood, Ahluwalia, Neha, Ausiello, John C., Wan, Elaine Y., Freedberg, Daniel E., Kirtane, Ajay J., Parikh, Sahil A., Maurer, Mathew S., Nordvig, Anna S., Accili, Domenico, Bathon, Joan M., Mohan, Sumit, Bauer, Kenneth A., Leon, Martin B., Krumholz, Harlan M., Uriel, Nir, Mehra, Mandeep R., Elkind, Mitchell S. V., Stone, Gregg W., Schwartz, Allan, Ho, David D., Bilezikian, John P., Landry, Donald W.·2020·Nature Medicine

DOI 10.1038/s41591-020-0968-3PMC PMC11972613

Open this paper in CoChat — free account

Abstract

Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Here we review the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s41591-020-0968-3

Cites

258 of 258 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969
Epidemiological and clinical characteristics of 99 cases of 2019 novel Coronavirus pneumonia in Wuhan, China: a descriptive study.
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286
Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus-Infected pneumonia in Wuhan, China
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148
La certeza de lo impredecible
Martínez–González, M. B. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,292
Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention
Wu, Z., & McGoogan, J. M. (2020) · JAMA · doi:10.1001/jama.2020.2648 · Cited by 17,016
An interactive web-based dashboard to track COVID-19 in real time
Dong, E., Du, H., & Gardner, L. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30120-1 · Cited by 10,048

Show all 261 references

Research works printed but not linked: 1

Pilotto, A. et al. Steroid-responsive encephalitis in Covid-19 disease. Ann. Neurol. (2020). · DOI

Sorted by citations

Items 601–700 of 1,002

Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study
Wendel‐Garcia, P. D., Mas, A., González-Isern, C., Ferrer, R., Máñez, R., Masclans, J.-R., Sandoval, E., Vera, P., Trenado, J., Fernández, R., et al. (2022) · Critical Care · doi:10.1186/s13054-022-03905-5 · Cited by 31
A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and Antibody
Scheim, D. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052558 · Cited by 32
12-Month Post-Discharge Liver Function Test Abnormalities Among Patients With COVID-19: A Single-Center Prospective Cohort Study
Liao, X., Li, D., Ma, Z., Zhang, L., Zheng, B., Li, Z., Li, G., Liu, L., & Zhang, Z. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.864933 · Cited by 31
Body composition and risk factors associated with sarcopenia in post-COVID patients after moderate or severe COVID-19 infections
González‐Islas, D., Sánchez-Moreno, C., Orea‐Tejeda, A., Hernández-López, S., Salgado-Fernández, F., Keirns‐Davis, C., Galicia-Amor, S., Trejo-Mellado, E., Gochicoa‐Rangel, L., & Castorena-Maldonado, A. R. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-02014-x · Cited by 31
Smoking is associated with increased risk of cardiovascular events, disease severity, and mortality among patients hospitalized for SARS-CoV-2 infections
Poudel, R., Daniels, L. B., DeFilippis, A. P., Hamburg, N. M., Khan, Y. M., Keith, R. J., Sampath-Kumar, R., Strokes, A. C., Robertson, R. M., & Bhatnagar, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0270763 · Cited by 31
SARS-CoV-2-Associated ssRNAs Activate Human Neutrophils in a TLR8-Dependent Fashion
Gardiman, E., Bianchetto-Aguilera, F. M., Gasperini, S., Tiberio, L., Scandola, M., Lotti, V., Gibellini, D., Salvi, V., Bosisio, D., Cassatella, M. A., et al. (2022) · Cells · doi:10.3390/cells11233785 · Cited by 31
Microglial Inflammatory Responses to SARS‐CoV‐2 Infection: A Comprehensive Review
Dey, R., & Bishayi, B. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01444-3 · Cited by 33
In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19
López‐Cortés, A., Guevara‐Ramírez, P., Kyriakidis, N. C., Barba‐Ostria, C., Cáceres, Á. L., Guerrero, S. X., Ortiz‐Prado, E., Munteanu, C. R., Tejera, E., Cevallos-Robalino, D., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.598925 · Cited by 30
Critical neurological features of COVID-19: Role of imaging methods and biosensors for effective diagnosis
Singh, V., Allawadhi, P., Khurana, A., Banothu, A. K., & Bharani, K. K. (2021) · Sensors International · doi:10.1016/j.sintl.2021.100098 · Cited by 30
Endocrine Dysfunction among Patients with COVID-19
Kumar, B., Gopalakrishnan, M., Garg, M. K., Purohit, P., Banerjee, M., Sharma, P., Khichar, S., Kothari, N., Bhatia, P. K., Nag, V., et al. (2021) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_577_20 · Cited by 30
Post-COVID-19 Arthritis and Sacroiliitis: Natural History with Longitudinal Magnetic Resonance Imaging Study in Two Cases and Review of the Literature
Colatutto, D., Sonaglia, A., Zabotti, A., Cereser, L., Girometti, R., & Quartuccio, L. (2021) · Viruses · doi:10.3390/v13081558 · Cited by 30
Coronavirus Disease 2019: Clinics, Treatment, and Prevention
Burkert, F. R., Lanser, L., Bellmann‐Weiler, R., & Weiß, G. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.761887 · Cited by 30
Post-COVID syndrome: prevalence, organ pathogenesis and routes of correction. A systematic review
Канорский, С. Г. (2021) · Кубанский научный медицинский вестник · doi:10.25207/1608-6228-2021-28-6-90-116 · Cited by 30
Immune-Guided Therapy of COVID-19
Ferraccioli, G., Gremese, E., Goletti, D., Petrone, L., Cantini, F., Ugel, S., Canè, S., & Bronte, V. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0675 · Cited by 30
VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells
Temerozo, J. R., Sacramento, C. Q., Rodrigues, N. F., Pão, C. R. R., de Freitas, C. S., Dias, S. D. S. G., Ferreira, A. C., Mattos, M., Soares, V. C., Teixeira, L., et al. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.5cova1121-626r · Cited by 30
SARS-CoV-2 Infection and Taste Alteration: An Overview
Scotto, G., Fazio, V., Muzio, E. L., Muzio, L. L., & Spirito, F. (2022) · Life · doi:10.3390/life12050690 · Cited by 30
Sufficient Sleep, Time of Vaccination, and Vaccine Efficacy: A Systematic Review of the Current Evidence and a Proposal for COVID-19 Vaccination.
Rayatdoost, E., Rahmanian, M., Sanie, M. S., Rahmanian, J., Matin, S., Kalani, N., Kenarkoohi, A., Falahi, S., & Abdoli, A. (2022) · PubMed Central · Cited by 30
Thrombosis-related circulating miR-16-5p is associated with disease severity in patients hospitalised for COVID-19
Eyileten, C., Wicik, Z., Simões, S. N., Martins, D., Klos, K., Wlodarczyk, W., Assinger, A., Sołdacki, D., Chciałowski, A., Siller-Matula, J. M., et al. (2022) · RNA Biology · doi:10.1080/15476286.2022.2100629 · Cited by 30
Our early experience with mesenteric ischemia in COVID-19 positive patients
Al Mahruqi, G., Stephen, E., Abdelhedy, I., & Al Wahaibi, K. (2021) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2021.01.064 · Cited by 29
COVID-19 myocarditis and postinfection Bell’s palsy
Dahl, E. H., Mosevoll, K. A., Cramariuc, D., Vedeler, C. A., & Blomberg, B. (2021) · BMJ Case Reports · doi:10.1136/bcr-2020-240095 · Cited by 29
Infection, inflammation and intervention: mechanistic modelling of epithelial cells in COVID-19
Fadai, N. T., Sachak-Patwa, R., Byrne, H. M., Maini, P. K., Bafadhel, M., & Nicolau, D. V. (2021) · Journal of The Royal Society Interface · doi:10.1098/rsif.2020.0950 · Cited by 29
Protecting providers and patients: results of an Internet survey of health care workers’ risk perceptions and ethical concerns during the COVID-19 pandemic
O’Neal, L., Heisler, M., Mishori, R., & Haar, R. J. (2021) · International Journal of Emergency Medicine · doi:10.1186/s12245-021-00341-0 · Cited by 29
Late Phase of COVID-19 Pandemic in General Cardiology. A Position Paper of the ESC Council for Cardiology Practice
Richter, D. J., Guasti, L., Koehler, F., Squizzato, A., Nistri, S., Christodorescu, R., Diévart, F., Gaudio, G. V., Asteggiano, R., & Ferrini, M. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13466 · Cited by 31
The Use of CytoSorb Therapy in Critically Ill COVID-19 Patients: Review of the Rationale and Current Clinical Experiences
Ruiz‐Rodríguez, J. C., Molnár, Z., Deliargyris, E., & Ferrer, R. (2021) · Critical Care Research and Practice · doi:10.1155/2021/7769516 · Cited by 29
Basic mechanisms of SARS-CoV-2 infection. What endocrine systems could be implicated?
Soldevila, B., Puig‐Domingo, M., & Marazuela, M. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09678-6 · Cited by 29
Platelet Phenotype Analysis of COVID-19 Patients Reveals Progressive Changes in the Activation of Integrin αIIbβ3, F13A1, the SARS-CoV-2 Target EIF4A1 and Annexin A5
Ercan, H., Schrottmaier, W. C., Pirabe, A., Schmuckenschlager, A., Pereyra, D., Santol, J., Pawelka, E., Traugott, M. T., Schoergenhofer, C., Seitz, T., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.779073 · Cited by 29
Immuno-Endocrinology of COVID-19: The Key Role of Sex Hormones
Tramontana, F., Battisti, S., Napoli, N., & Strollo, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.726696 · Cited by 29
Adverse Outcome in COVID-19 Is Associated With an Aggravating Hypo-Responsive Platelet Phenotype
Schrottmaier, W. C., Pirabe, A., Pereyra, D., Heber, S., Hackl, H., Schmuckenschlager, A., Brunnthaler, L., Santol, J., Kammerer, K., Oosterlee, J., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.795624 · Cited by 29
Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients
Song, Z., Bao, L., Deng, W., Liu, J., ErJun, R., Lv, Q., Liu, M., Qi, F., Chen, T., Deng, R., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00891-6 · Cited by 29
After the virus has cleared—Can preclinical models be employed for Long COVID research?
Jansen, E. B., Orvold, S. N., Swan, C. L., Yourkowski, A., Thivierge, B. M., Francis, M. E., Ge, A., Rioux, M. L., Darbellay, J., Howland, J. G., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010741 · Cited by 29
Presence of symptoms 6 weeks after COVID-19 among vaccinated and unvaccinated US healthcare personnel: a prospective cohort study
Mohr, N. M., Plumb, I. D., Harland, K. K., Pilishvili, T., Fleming-Dutra, K. E., Krishnadasan, A., Hoth, K. F., Saydah, S., Mankoff, Z., Haran, J. P., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-063141 · Cited by 29
Viruses and amyloids - a vicious liaison
Hammarström, P., & Nyström, S. (2023) · Prion · doi:10.1080/19336896.2023.2194212 · Cited by 29
Understanding the Impact of Sociocultural Gender on Post-acute Sequelae of COVID-19: a Bayesian ApproachPreprint
Gebhard, C. E., Sütsch, C., Bengs, S., Todorov, A., Deforth, M. E., Buehler, K. P., Meisel, A., Schuepbach, R. A., Zinkernagel, A. S., Brugger, S. D., et al. (2021) · medRxiv · doi:10.1101/2021.06.30.21259757 · Cited by 29
Rapid generation of circulating and mucosal decoy ACE2 using mRNA nanotherapeutics for the potential treatment of SARS-CoV-2
Kim, J., Mukherjee, A., Nelson, D., Jozic, A., & Sahay, G. (2020) · doi:10.1101/2020.07.24.205583 · Cited by 28
Viral infections and pathogenesis of glaucoma: a comprehensive review
Ahmad, F., Deshmukh, N., Webel, A. D., Johnson, S., Suleiman, A., Mohan, R. R., Fraunfelder, F. “. W., & Singh, P. K. (2023) · Clinical Microbiology Reviews · doi:10.1128/cmr.00057-23 · Cited by 28
Impact of COVID-19 pandemic on the incidence and prevalence of postural orthostatic tachycardia syndrome
Dulal, D., Maraey, A. M., Elsharnoby, H. R., Chacko, P., & Grubb, B. P. (2025) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcae111 · Cited by 28
No Small Matter: A Perspective on Nanotechnology-Enabled Solutions to Fight COVID-19
Jones, G. W., Monopoli, M. P., Campagnolo, L., Pietroiusti, A., Tran, L., & Fadeel, B. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0286 · Cited by 28
Urinary Peptides Significantly Associate with COVID‐19 Severity: Pilot Proof‐of‐Principle Data and Design of a Multicentric Diagnostic Study
Wendt, R. T., Kalbitz, S., Lübbert, C., Kellner, N., Macholz, M., Schroth, S., Ermisch, J., Latosisnka, A., Arnold, B. F., Mischak, H., et al. (2020) · PROTEOMICS · doi:10.1002/pmic.202000202 · Cited by 28
Current targets and drug candidates for prevention and treatment of SARS-CoV-2 (COVID-19) infection
Goyal, R. K., Majeed, J., Tonk, R. K., Dhobi, M., Patel, B. M., Sharma, K., & Apparsundaram, S. (2020) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm.2020.03.118 · Cited by 28
Understanding Viral Infection Mechanisms and Patient Symptoms for the Development of COVID-19 Therapeutics
Choi, H. M., Moon, S. Y., Yang, H.-I., & Kim, K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041737 · Cited by 28
Spiking dependence of SARS‐CoV‐2 pathogenicity on TMPRSS2
Abbasi, A. Z., Kiyani, D. A., Hamid, S. M., Saalim, M., Fahim, A., & Jalal, N. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26911 · Cited by 29
A novel multi-omics-based highly accurate prediction of symptoms, comorbid conditions, and possible long-term complications of COVID-19
Barh, D., Tiwari, S., Andrade, B. S., Weener, M. E., Goés‐Neto, A., Azevedo, V., Ghosh, P., Blum, K., & Ganguly, N. K. (2021) · Molecular Omics · doi:10.1039/d0mo00189a · Cited by 28
Oral and cutaneous manifestations of covid-19 in pediatric patients
de Moraes, M. F., Natalino, Y. D. R., HOLANDA, A. F., Sobrinho, H. F. D. S., Sarmento, L. C., Gomes, A. P. M., & Sanglard, L. F. (2021) · RGO - Revista Gaúcha de Odontologia · doi:10.1590/1981-86372021000520200136 · Cited by 28
Ocular Manifestations of Hospitalized COVID-19 Patients in a Tertiary Care Academic Medical Center in the United States: A Cross-Sectional Study
Feng, Y., Park, J., Zhou, Y., Armenti, S. T., Musch, D. C., & Mian, S. I. (2021) · Clinical ophthalmology · doi:10.2147/opth.s301040 · Cited by 28
Microvascular Dysfunction in Patients with Critical Covid-19, a Pilot Study
Tehrani, S., & Gille-Johnson, P. (2021) · Shock · doi:10.1097/shk.0000000000001803 · Cited by 28
Specific Treatment Exists for SARS-CoV-2 ARDS
Kanwar, B. A., Khattak, A., Lee, J., Balentine, J., Kast, R. E., Oh, S.-S., Sergi, C., & Lee, J. (2021) · Vaccines · doi:10.3390/vaccines9060635 · Cited by 28
Sleep Disruption and Depression, Stress and Anxiety Levels in Women With Polycystic Ovary Syndrome (PCOS) During the Lockdown Measures for COVID-19 in the UK
Kite, C., Atkinson, L., McGregor, G., Clark, C. C. T., Brown, J. E. P., Kyrou, I., & Randeva, H. S. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.649104 · Cited by 28
Animal models of SARS-CoV-2 and COVID-19 for the development of prophylactic and therapeutic interventions
Renn, M., Bartok, E., Zillinger, T., Hartmann, G., & Behrendt, R. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107931 · Cited by 28
Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19
Sun, C., Jan, J., Wang, I.-H., Ma, H., Ko, H., Wu, P., Kuo, T.-J., Liao, H.-N., Lan, Y.-H., Sie, Z., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009758 · Cited by 28
The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis
Zou, M., Su, X., Wang, L., Yi, X., Qiu, Y., Yin, X., Zhou, X., Niu, X., Wang, L., & Su, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729776 · Cited by 28
The role of exercise in rehabilitation of discharged COVID-19 patients
Bo, W., Xi, Y., & Tian, Z. (2021) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2021.09.001 · Cited by 28
Increased serum catalytic iron may mediate tissue injury and death in patients with COVID-19
Chakurkar, V., Rajapurkar, M. M., Lele, S. S., Mukhopadhyay, B. N., Lobo, V., Injarapu, R., Sheikh, M., Dholu, B., Ghosh, A., & Jha, V. (2021) · Scientific Reports · doi:10.1038/s41598-021-99142-x · Cited by 28
Post-COVID-19 conditions in Ecuadorian patients: an observational study
González‐Andrade, F. (2021) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2021.100088 · Cited by 28
Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges
Terrier, O., Si‐Tahar, M., Ducatez, M., Chevalier, C., Pizzorno, A., Goffic, R. L., Crépin, T., Simon, G., & Naffakh, N. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010106 · Cited by 28
Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1
Kolarič, A., Jukič, M., & Bren, U. (2022) · Pharmaceuticals · doi:10.3390/ph15020165 · Cited by 28
Toxin-like peptides in plasma, urine and faecal samples from COVID-19 patients
Brogna, C., Cristoni, S., Petrillo, M., Querci, M., Piazza, O., & den Eede, G. V. (2021) · F1000Research · doi:10.12688/f1000research.54306.1 · Cited by 28
Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed Therapies
Premeaux, T. A., Yeung, S. T., Bukhari, Z., Bowler, S. A., Alpan, O., Gupta, R., & Ndhlovu, L. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.842740 · Cited by 28
Vestibular Cochlear Manifestations in COVID-19 Cases
Kaliyappan, K., Chen, Y., & Muthaiah, V. P. K. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.850337 · Cited by 28
Global Trends and Research Hotspots in Long COVID: A Bibliometric Analysis
Jin, H., Lu, L., & Fan, H. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063742 · Cited by 28
Risk Factors for Coronavirus Disease 2019 (COVID-19)-Associated Pulmonary Aspergillosis in Critically Ill Patients: A Nationwide, Multicenter, Retrospective Cohort Study
Kim, S., Hong, J. Y., Bae, S., Lee, H., Wi, Y. M., Ko, J., Kim, B., Joo, E., Seok, H., Shi, H. J., et al. (2022) · Journal of Korean Medical Science · doi:10.3346/jkms.2022.37.e134 · Cited by 28
Persistent Symptoms After Acute COVID-19 Infection in Omicron Era
Jung, Y. H., Ha, E.-H., Choe, K. W., Lee, S., Jo, D. H., & Lee, W. J. (2022) · Journal of Korean Medical Science · doi:10.3346/jkms.2022.37.e213 · Cited by 28
Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial
Fish, M., Rynne, J., Jennings, A. R., Lam, C., Lamikanra, A., Ratcliff, J., Trevelin, S. C., Timms, E. M., Jiriha, J., Tosi, I., et al. (2022) · Intensive Care Medicine · doi:10.1007/s00134-022-06869-w · Cited by 28
The Prognostic Value of Pentraxin-3 in COVID-19 Patients: A Systematic Review and Meta-Analysis of Mortality Incidence
Capra, A. P., Ardizzone, A., Pantò, G., Paterniti, I., Campolo, M., Crupi, L., Squeri, R., & Esposito, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043537 · Cited by 28
Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study
Reyes, L. F., Rodríguez, A. H., Fuentes, Y. V., Duque, S., García-Gallo, E., Bastidas, A. R., Serrano-Mayorga, C. C., Ibañez-Prada, E. D., Moreno, G., Ramirez-Valbuena, P. C., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-32265-5 · Cited by 28
Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19
Robertson, S. J., Bedard, O., McNally, K. L., Shaia, C., Clancy, C. S., Lewis, M. C., Broeckel, R. M., Chiramel, A. I., Shannon, J. G., Sturdevant, G. L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40076-5 · Cited by 28
Viral infections in lung transplantation
Munting, A., & Manuel, O. (2021) · Journal of Thoracic Disease · doi:10.21037/jtd-2021-24 · Cited by 27
Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases
Abd‐Elaziz, K., Jeseňák, M., Vašáková, M., & Diamant, Z. (2020) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000743 · Cited by 27
Pituitary Apoplexy Attributed to COVID-19 Infection in the Absence of an Underlying Macroadenoma or Other Identifiable Cause
Bordes, S. J., Phang-Lyn, S., Nájera, E., Borghei-Razavi, H., & Adada, B. (2021) · Cureus · doi:10.7759/cureus.13315 · Cited by 27
Cutaneous Manifestations Related to COVID-19 Immune Dysregulation in the Pediatric Age Group
Larenas‐Linnemann, D. E., Luna-Pech, J. A., Navarrete-Rodriguez, E. M., Rodríguez‐Pérez, N., Arias‐Cruz, A., Blandón-Vijil, M. V., Del-Rio-Navarro, B. E., Estrada-Cardona, A., Onuma‐Takane, E., Pozo-Beltrán, C. F., et al. (2021) · Current Allergy and Asthma Reports · doi:10.1007/s11882-020-00986-6 · Cited by 27
The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19
Geurts, M. H., van der Vaart, J., Beumer, J., & Clevers, H. C. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.11.009 · Cited by 27
Liver transplantation for acute liver failure in a SARS-CoV-2 PCR-positive patient
Yohanathan, L., Campioli, C. C., Mousa, O. Y. S., Watt, K. D. S., Friedman, D. Z. P., Shah, V. H., Ramkissoon, R. A., Hines, A. S., Kamath, P. S., Razonable, R. R., et al. (2021) · American Journal of Transplantation · doi:10.1111/ajt.16582 · Cited by 27
Light Sheet Microscopy-Assisted 3D Analysis of SARS-CoV-2 Infection in the Respiratory Tract of the Ferret Model
Zaeck, L. M., Scheibner, D., Sehl‐Ewert, J., Müller, M., Hoffmann, D., Beer, M., Abdelwhab, E. M., Mettenleiter, T. C., Breithaupt, A., & Finke, S. (2021) · Viruses · doi:10.3390/v13030529 · Cited by 27
Impact of presymptomatic COVID-19 on vascular and skeletal muscle function: a case study
Trinity, J. D., Craig, J. C., Fermoyle, C. C., McKenzie, A. I., Lewis, M. T., Park, S. H., Rondina, M. T., & Richardson, R. S. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00236.2021 · Cited by 27
A case report of monoarthritis in a COVID-19 patient and literature review
Cincinelli, G., Taranto, R. D., Orsini, F., Rindone, A., Murgo, A., & Caporali, R. F. (2021) · Medicine · doi:10.1097/md.0000000000026089 · Cited by 27
Reducing the global burden of sepsis: a positive legacy for the COVID-19 pandemic?
The European Society of Intensive Care Medicine (ESICM), The Global Sepsis Alliance (GSA), Reinhart, K., The Society of Critical Care Medicine (SCCM), Levy, M. M., Finfer, S. R., Machado, F. R., Kaplan, L., Kesecioğlu, J., Rhodes, A., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06409-y · Cited by 27
Cardiac pathology in COVID-19: a single center autopsy experience
Sang, C. J., Burkett, A. E., Heindl, B. F., Litovsky, S. H., Prabhu, S. D., Benson, P. V., & Rajapreyar, I. N. (2021) · Cardiovascular Pathology · doi:10.1016/j.carpath.2021.107370 · Cited by 27
Propiedades psicométricas de la escala Post-COVID-19 Functional Status para adultos sobrevivientes de COVID-19
Lorca, L. A., Ribeiro, I. L., Torres‐Castro, R., Sacomori, C., & Rivera, C. (2021) · Rehabilitación · doi:10.1016/j.rh.2021.07.002 · Cited by 27
Venous Thrombosis within 30 Days after Vaccination against SARS-CoV-2 in a Multinational Venous Thromboembolism Registry
Bikdeli, B., Jiménez, D., Rodríguez, P. D., Valle, F. G., Porras, J. A., Barba, R., Ay, C., Malý, R., Braester, A., Imbalzano, E., et al. (2022) · Viruses · doi:10.3390/v14020178 · Cited by 27
Self-citation
Multiphysics and multiscale modeling of microthrombosis in COVID-19
Li, H., Deng, Y., Li, Z., Dorken‐Gallastegi, A., Mantzoros, C. S., Frydman, G. H., & Karniadakis, G. E. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009892 · Cited by 27
Clinical status of patients 1 year after hospital discharge following recovery from COVID-19: a prospective cohort study
Li, D., Liao, X., Ma, Z., Zhang, L., Dong, J., Zheng, G., Zi, M., Peng, W., Wei, L., Li, Z., et al. (2022) · Annals of Intensive Care · doi:10.1186/s13613-022-01034-4 · Cited by 27
The osteo-metabolic phenotype of COVID-19: an update
di Filippo, L., Frara, S., Doga, M., & Giustina, A. (2022) · Endocrine · doi:10.1007/s12020-022-03135-3 · Cited by 27
Brain neuronal and glial damage during acute COVID-19 infection in absence of clinical neurological manifestations
Plantone, D., Locci, S., Bergantini, L., Manco, C., Cortese, R., Meocci, M., Cavallaro, D., d’Alessandro, M., Bargagli, E., & Stefano, N. D. (2022) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2022-329933 · Cited by 27
Rapid rEcognition of COrticosteRoiD resistant or sensitive Sepsis (RECORDS): study protocol for a multicentre, placebo-controlled, biomarker-guided, adaptive Bayesian design basket trial
Fleuriet, J., Heming, N., Meziani, F., Reignier, J., Declercq, P.-L., Mercier, E., Müller, G., Colin, G., Monnet, X., Robine, A., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2022-066496 · Cited by 28
Hyper‐inflammation and complement in COVID ‐19
Pires, B. G., & Calado, R. T. (2023) · American Journal of Hematology · doi:10.1002/ajh.26746 · Cited by 27
SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature
Lebrun, L., Absil, L., Remmelink, M., Mendonça, R. D., D’Haene, N., Gaspard, N., Rusu, Ș., Racu, M.-L., Collin, A. M., Allard, J., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01566-1 · Cited by 27
Rates of ICD-10 Code U09.9 Documentation and Clinical Characteristics of VA Patients With Post–COVID-19 Condition
Wander, P. L., Baraff, A. J., Fox, A., Cho, K., Maripuri, M., Honerlaw, J. P., Ho, Y.-L. A., Dey, A., O’Hare, A. M., Bohnert, A. S. B., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.46783 · Cited by 27
Long COVID Definition, Symptoms, Risk Factors, Epidemiology and Autoimmunity: A Narrative Review
Kozłowski, P., Leszczyńska, A., & Ciepiela, O. (2024) · American Journal of Medicine Open · doi:10.1016/j.ajmo.2024.100068 · Cited by 27
Ventricular systolic dysfunction with and without altered myocardial contractility: Clinical value of echocardiography for diagnosis and therapeutic decision-making
Dandel, M., & Hetzer, R. (2020) · International Journal of Cardiology · doi:10.1016/j.ijcard.2020.11.068 · Cited by 27
Drawing Comparisons between SARS-CoV-2 and the Animal Coronaviruses
Ghosh, S., & Malik, Y. S. (2020) · Microorganisms · doi:10.3390/microorganisms8111840 · Cited by 28
Seroprevalence Study and Cross-Sectional Survey on COVID-19 for a Plan to Reopen the University of Alicante (Spain)
Tuells, J., Egoavil, C. M., Pena, M. Á., Montagud, A. C., Penadés, E. M., Caballero, P., Zapater, P., Puig‐Barberà, J., & Sánchez, J. A. H. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18041908 · Cited by 26
Adverse cardiovascular magnetic resonance phenotypes are associated with greater likelihood of incident coronavirus disease 2019: findings from the UK Biobank
Raisi‐Estabragh, Z., McCracken, C., Cooper, J. A., Fung, K., Paiva, J. M., Khanji, M. Y., Rauseo, E., Biasiolli, L., Raman, B., Piechnik, S. K., et al. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01808-z · Cited by 26
Seguimiento de los pacientes con secuelas no respiratorias de la COVID-19
Hernando, J. E. C. (2021) · FMC - Formación Médica Continuada en Atención Primaria · doi:10.1016/j.fmc.2020.11.004 · Cited by 26
Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies
Deng, H., Tang, T.-X., Chen, D., Tang, L., Yang, X., & Tang, Z. (2021) · Pathogens · doi:10.3390/pathogens10050582 · Cited by 26
Activation of Vasopressin System During COVID-19 is Associated With Adverse Clinical Outcomes: An Observational Study
Gregoriano, C., Molitor, A., Haag, E., Kutz, A., Koch, D., Haubitz, S., Conen, A., Bernasconi, L., Hammerer‐Lercher, A., Fux, C. A., et al. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab045 · Cited by 26
The Emergence of SARS-CoV-2 within the Dog Population in Croatia: Host Factors and Clinical Outcome
Stevanović, V., Tabain, I., Vilibić‐Čavlek, T., Maurić, M., Benvin, I., Hruškar, Ž., Kovač, S., Šmit, I., Miletić, G., Hađina, S., et al. (2021) · Viruses · doi:10.3390/v13081430 · Cited by 26
Comorbidities, sequelae, blood biomarkers and their associated clinical outcomes in the Mount Sinai Health System COVID-19 patients
Brojakowska, A., Eskandari, A., Bisserier, M., Bander, J. A., Garikipati, V. N. S., Hadri, L., Goukassian, D. A., & Fish, K. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253660 · Cited by 26
ACE2 in the Gut: The Center of the 2019-nCoV Infected Pathology
Guo, Y., Wang, B., Gao, H., Gao, L., Hua, R., & Xu, J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.708336 · Cited by 26
SARS-CoV-2 Infection and Pancreatic β Cell Failure
Mine, K., Nagafuchi, S., Mori, H., Takahashi, H., & Anzai, K. (2021) · Biology · doi:10.3390/biology11010022 · Cited by 26
The Prevalence and Associated Death of Ventricular Arrhythmia and Sudden Cardiac Death in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis
Tan, Z., Huang, S., Mei, K., Liu, M., Ma, J., Jiang, Y., Zhu, W., Yu, P., & Liu, X. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.795750 · Cited by 26
AI-powered drug repurposing for developing COVID-19 treatments
Liu, Z., Chen, X., Carter, W., Moruf, A., Komatsu, T. E., Pahwa, S., Chan‐Tack, K. M., Snyder, K., Petrick, N., Cha, K., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824010-6.00005-8 · Cited by 26

Authors: Gupta, A., Madhavan, M. V., Sehgal, K., Nair, N., Mahajan, S., Sehrawat, T. S., Bikdeli, B., Ahluwalia, N., Ausiello, J. C., Wan, E. Y., Freedberg, D. E., Kirtane, A. J., Parikh, S. A., Maurer, M. S., Nordvig, A. S., Accili, D., Bathon, J. M., Mohan, S., Bauer, K. A., Leon, M. B., Krumholz, H. M., Uriel, N., Mehra, M. R., Elkind, M. S. V., Stone, G. W., Schwartz, A., Ho, D. D., Bilezikian, J. P., & Landry, D. W.
Affiliations: Yale New Haven Hospital (US)
Columbia University Irving Medical Center (US)
Beth Israel Deaconess Medical Center (US)
Mayo Clinic (US)
Icahn School of Medicine at Mount Sinai (US)
Cardiovascular Research Foundation (US)
NewYork–Presbyterian Hospital (US)
Brigham and Women's Hospital (US)
Aaron Diamond AIDS Research Center (US)
Corresponding author: Landry, Donald W.
ORCID: Gupta, Aakriti
Madhavan, Mahesh V.
Sehgal, Kartik
Mahajan, Shiwani
Sehrawat, Tejasav S.
Bikdeli, Behnood
Ahluwalia, Neha
Ausiello, John C.
Wan, Elaine Y.
Freedberg, Daniel E.
Kirtane, Ajay J.
Parikh, Sahil A.
Maurer, Mathew S.
Nordvig, Anna S.
Accili, Domenico
Bathon, Joan M.
Mohan, Sumit
Bauer, Kenneth A.
Leon, Martin B.
Krumholz, Harlan M.
Uriel, Nir
Mehra, Mandeep R.
Elkind, Mitchell S. V.
Stone, Gregg W.
Schwartz, Allan
Ho, David D.
Bilezikian, John P.
Landry, Donald W.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2020-07
Volume: 26
Issue: 7
Pages: 1017-1032
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/s41591-020-0968-3
PMC: PMC11972613
OpenAlex: W3040801404
Cited by: 3,185
References: 261
Citations by year: 2026: 125 · 2025: 182 · 2024: 333 · 2023: 558 · 2022: 751 · 2021: 965 · 2020: 261
FWCI: 29.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Health & Human Services | National Institutes of Health (T32 - HL007854, K23- DK111847)
U.S. Department of Defense (PR-181960)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (5T32 - NS007153)
U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 - AR050026, U01- AR068043)
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R01 - MD014161, U01- DK116066)
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (K08-HL122526, R01 - HL152236, R03 - HL146881)
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Health Sciences › Medicine › Dermatology › Dermatological and COVID-19 studies
Keywords: COVID-19 pandemic, SARS-CoV-2, extrapulmonary manifestations, thrombotic complications, cardiac dysfunction, cardiac arrhythmias, acute coronary syndrome, acute kidney injury, gastrointestinal symptoms, hepatocyte injury, hyperglycemia, ketosis, neurological complications, ocular symptoms, skin complications, ACE2 receptor, thromboinflammation, endothelial injury, immune dysregulation
MeSH terms: Betacoronavirus, COVID-19, SARS-CoV-2, Endothelium, Vascular, Humans, Inflammation, Organ Specificity, Pneumonia, Viral, Renin-Angiotensin System, Thrombosis, Coronavirus Infections, Disease Progression, Virus Internalization, Adaptive Immunity, Pandemics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Extrapulmonary manifestations of COVID-19

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks