The DOI matches its Crossref record; 258 of the 261 references it cites were found in a registry or an index.
Extrapulmonary manifestations of COVID-19
Open accessAbstract
Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Here we review the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Furthermore, the virus facilitates the release of coagulation factors, the secretion of inflammatory cytokines, and the formation of leukocyte-platelet aggregates, which might be important mechanisms leading to thromboembolic complications observed in severe COVID-19 (Ackermann et al., 2020; Gupta et al., 2020; Zhang et al., 2020b).”
From COVID-19 and the human innate immune system (2021) · cites this paper as Gupta et al., 2020
Experimental — accuracy not yet measuredIn the citing paper
“Disease courses range from mainly asymptomatic and mild courses to more severe and critical courses in 10%–20% of symptomatic patients who are at considerable risk of fatality with many different organ systems involved in differing combinations and with variable symptoms (Gupta et al., 2020)”
From COVID-19 and the human innate immune system (2021) · cites this paper as Gupta et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30566-3 · Cited by 27,263
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., et al. (2020) · JAMA · doi:10.1001/jama.2020.1585 · Cited by 20,148
Martínez–González, M. B. (2020) · DSPACE System - Metalibrary (University of the Coast) · Cited by 18,292
Wu, Z., & McGoogan, J. M. (2020) · JAMA · doi:10.1001/jama.2020.2648 · Cited by 17,016
An interactive web-based dashboard to track COVID-19 in real time
Dong, E., Du, H., & Gardner, L. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30120-1 · Cited by 10,048
Research works printed but not linked: 1
- Pilotto, A. et al. Steroid-responsive encephalitis in Covid-19 disease. Ann. Neurol. (2020). · DOI
Cited by
Sorted by citations
Items 101–200 of 1,002
Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts
Wang, Z., & Yang, L. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113869 · Cited by 157
Obesity aggravates COVID‐19: An updated systematic review and meta‐analysis
Yang, J., Tian, C., Chen, Y., Zhu, C., Chi, H., & Li, J. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26677 · Cited by 155
Paranjpe, I., Russak, A. J., Freitas, J. K. D., Lala, A., Miotto, R., Vaid, A., Johnson, K. W., Danieletto, M., Golden, E., Meyer, D., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-040736 · Cited by 155
Sundar, L. K. S., Yu, J., Muzik, O., Kulterer, O. C., Fueger, B. J., Kifjak, D., NAKUZ, T. S., Shin, H. M., Sima, A. K., Kitzmantl, D., et al. (2022) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.264063 · Cited by 156
Postural orthostatic tachycardia syndrome as a sequela of COVID-19
Ormiston, C. K., Świątkiewicz, I., & Taub, P. R. (2022) · Heart Rhythm · doi:10.1016/j.hrthm.2022.07.014 · Cited by 154
Human Gut Microbiota and Its Metabolites Impact Immune Responses in COVID-19 and Its Complications
Nagata, N., Takeuchi, T., Masuoka, H., Aoki, R., Ishikane, M., Iwamoto, N., Sugiyama, M., Suda, W., Nakanishi, Y., Terada-Hirashima, J., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.09.024 · Cited by 154
Mykytyn, A. Z., Breugem, T. I., Riesebosch, S., Schipper, D., van den Doel, P. B., Rottier, R. J., Lamers, M. M., & Haagmans, B. L. (2021) · eLife · doi:10.7554/elife.64508 · Cited by 153
Two Years into the COVID-19 Pandemic: Lessons Learned
da Silva, S. J. R., do Nascimento, J. C. F., Mendes, R. P. G., Guarines, K. M., da Silva, C. T. A., da Silva, P. G., de Magalhães, J. J. F., Vigar, J. R. J., Silva‐Júnior, A., Kohl, A., et al. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00204 · Cited by 155
Returning to physical activity after covid-19
Salman, D., Vishnubala, D., Feuvre, P. A. L., Beaney, T. E., Korgaonkar, J., Majeed, A., & McGregor, A. H. (2021) · BMJ · doi:10.1136/bmj.m4721 · Cited by 150
Eljilany, I., & Elzouki, A.-N. Y. (2020) · Vascular Health and Risk Management · doi:10.2147/vhrm.s280962 · Cited by 149
The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections
Hsu, R., Yu, W.-C., Peng, G.-R., Ye, C.-H., Hu, S., Chong, P. C. T., Yap, K. Y., Lee, J. Y. C., Lin, W., & Yu, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.832394 · Cited by 148
The Syndemics and Structural Violence of the COVID Pandemic: Anthropological Insights on a Crisis
Singer, M. C., & Rylko‐Bauer, B. (2020) · Open Anthropological Research · doi:10.1515/opan-2020-0100 · Cited by 147
Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants
Sun, C., Xie, C., Bu, G., Zhong, L., & Zeng, M. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01039-2 · Cited by 149
Cates, J., Lucero-Obusan, C. A., Dahl, R. M., Schirmer, P., Garg, S., Oda, G., Hall, A. J., Langley, G., Havers, F. P., Holodniy, M., et al. (2020) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6942e3 · Cited by 146
Severely low testosterone in males with COVID‐19: A case‐control study
Salonia, A., Pontillo, M., Capogrosso, P., Gregori, S., Tassara, M. G., Boeri, L., Carenzi, C., Abbate, C., Cignoli, D., Ferrara, A. M., et al. (2021) · Andrology · doi:10.1111/andr.12993 · Cited by 146
Santos, A., Magro, D. O., Poderoso, R. E., & Saad, M. J. A. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00639-2 · Cited by 143
Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology
Deigendesch, N., Sironi, L., Kutza, M., Wischnewski, S., Fuchs, V., Hench, J., Frank, A., Nienhold, R., Mertz, K. D., Cathomas, G., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02213-y · Cited by 142
Multiple Neuroinvasive Pathways in COVID-19
Bougakov, D., Podell, K., & Goldberg, E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02152-5 · Cited by 142
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection
Wettstein, L., Weil, T., Conzelmann, C., Müller, J. A., Groß, R. M., Hirschenberger, M., Seidel, A., Klute, S., Zech, F., Bozzo, C. P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21972-0 · Cited by 142
Antibody Responses in COVID-19: A Review
Chvatal‐Medina, M., Cortina, Y. A. M., Grajales, P. J. P., Velilla, P. A., & Rugeles, M. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.633184 · Cited by 142
Accili, D. (2021) · Nature Metabolism · doi:10.1038/s42255-020-00339-7 · Cited by 141
Self-citationMartínez-Colón, G. J., Ratnasiri, K., Chen, R., Jiang, S., ZANLEY, E. J., Rustagi, A., Verma, R., Chen, H. M., Andrews, J. R., Mertz, K. D., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm9151 · Cited by 140
Review: Roles of human serum albumin in prediction, diagnoses and treatment of COVID-19
Rabbani, G., & Ahn, S. N. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.10.095 · Cited by 139
Seasonal trends in COVID-19 cases, hospitalizations, and mortality in the United States and Europe
Wiemken, T. L., Khan, F., Puzniak, L., Yang, W., Simmering, J., Polgreen, P., Nguyen, J. L., Jodar, L., & McLaughlin, J. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-31057-1 · Cited by 138
Vaes, A. W., Goërtz, Y. M. J., Herck, M. V., Machado, F. V. C., Meys, R., Delbressine, J. M., Houben‐Wilke, S., Gaffron, S., Maier, D., Burtin, C., et al. (2021) · ERJ Open Research · doi:10.1183/23120541.00141-2021 · Cited by 138
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?
Michalski, J. E., Kurche, J. S., & Schwartz, D. A. (2021) · Translational research · doi:10.1016/j.trsl.2021.09.001 · Cited by 139
Endothelial cells are not productively infected by SARS‐CoV‐2
Schimmel, L., Chew, K. Y., Stocks, C. J., Yordanov, T. E., Essebier, P., Kulasinghe, A., Monkman, J. H., Miggiolaro, A. F. R. D. S., Cooper, C. L., de Noronha, L., et al. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1350 · Cited by 136
Tejerina, F., Catalán, P., Rodríguez‐Grande, C., Adán‐Jiménez, J., Rodríguez, C., Muñóz, P., Aldámiz‐Echevarría, T., Díez, C., Latorre, L. P., Fanciulli, C., et al. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07153-4 · Cited by 135
COVID-19 and cognitive impairment: neuroinvasive and blood‒brain barrier dysfunction
Chen, Y., Yang, W., Chen, F., & Cui, L. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02579-8 · Cited by 134
Kong, W., Montaño, M., Corley, M. J., Helmy, E. W., Kobayashi, H., Kinisu, M., Suryawanshi, R. K., Luo, X., Royer, L. A., Roan, N. R., et al. (2022) · mBio · doi:10.1128/mbio.02308-22 · Cited by 134
Shi, Z., de Vries, H. J., Vlaar, A. P. J., van der Hoeven, J., Boon, R. A., Heunks, L. M. A., Ottenheijm, C. A. C., & Dutch COVID-19 Diaphragm Investigators (2020) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2020.6278 · Cited by 127
The Impact of COVID-19 Viral Infection on the Hypothalamic-Pituitary-Adrenal Axis
Alzahrani, A. S., Mukhtar, N. N., Aljomaiah, A., Aljamei, H. S., BAKHSH, A. M. K., Alsudani, N., Elsayed, T., Alrashidi, N., Fadel, R., Alqahtani, E., et al. (2020) · Endocrine Practice · doi:10.1016/j.eprac.2020.10.014 · Cited by 126
COVID-19 and Preexisting Comorbidities: Risks, Synergies, and Clinical Outcomes
Bigdelou, B., Sepand, M. R., Najafikhoshnoo, S., Negrete, J. A. T., Sharaf, M., Ho, J. Q., Sullivan, I., Chauhan, P. S., Etter, M. M., Shekarian, T., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.890517 · Cited by 126
Zakeri, A., Jadhav, A. P., Sullenger, B. A., & Nimjee, S. M. (2020) · Journal of NeuroInterventional Surgery · doi:10.1136/neurintsurg-2020-016794 · Cited by 124
Mesenchymal stem cell therapy for severe COVID-19
Shi, L., Wang, L., Xu, R., Zhang, C., Xie, Y., Liu, K., Li, T., Hu, W., Zhen, C., & Wang, F. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00754-6 · Cited by 124
Qin, J., Wang, W., Gao, L., & Yao, S. Q. (2022) · Chemical Science · doi:10.1039/d1sc06269g · Cited by 124
Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage
Costa, T. J. D., Potje, S. R., Fraga‐Silva, T. F. D. C., da Silva-Neto, J. A., Barros, P. R., Rodrigues, D., Machado, M. R., Júnior, R. B. M., Eichler, R. A. D. S., Benatti, M. N., et al. (2021) · Vascular Pharmacology · doi:10.1016/j.vph.2021.106946 · Cited by 123
Multi-organ impairment in low-risk individuals with long COVIDPreprint
Dennis, A., Wamil, M., Kapur, S., Alberts, J., Badley, A. D., Decker, G. A., Rizza, S. A., Banerjee, R., & Banerjee, A. (2020) · medRxiv · doi:10.1101/2020.10.14.20212555 · Cited by 122
Flaumenhaft, R. C., Enjyoji, K., & Schmaier, A. A. (2022) · Blood · doi:10.1182/blood.2021012250 · Cited by 121
Cesta, M. C., Zippoli, M., Marsiglia, C., Gavioli, E. M., Cremonesi, G., Khan, A., Mantelli, F., Allegretti, M., & BALK, R. A. (2022) · European Journal of Immunology · doi:10.1002/eji.202250010 · Cited by 120
Topol, E. J. (2020) · Science · doi:10.1126/science.abe2813 · Cited by 119
Armando, F., Beythien, G., Kaiser, F. K., Allnoch, L., Heydemann, L., Rosiak, M., Becker, S., González-Hernández, M., Lamers, M. M., Haagmans, B. L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31200-y · Cited by 118
Koczulla, A. R., Ankermann, T., Behrends, U., Berlit, P., Berner, R., Böing, S., Brinkmann, F., Frank, U., Franke, C., Glöckl, R., et al. (2022) · Pneumologie · doi:10.1055/a-1946-3230 · Cited by 118
Lifestyle factors in the prevention of COVID-19
Lange, K. W., & Nakamura, Y. (2020) · Global Health Journal · doi:10.1016/j.glohj.2020.11.002 · Cited by 119
Comprehensive analysis of COVID-19 during pregnancy
Moore, K. M., & Suthar, M. S. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.12.064 · Cited by 116
Chung, Y.-S., Lam, C.-Y., Tan, P.-H., Tsang, H. F., & Wong, S. C. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158155 · Cited by 120
Puig‐Domingo, M., Marazuela, M., Yıldız, B. O., & Giustina, A. (2021) · Endocrine · doi:10.1007/s12020-021-02734-w · Cited by 116
Liu, X., Raghuvanshi, R., Ceylan, F. D., & Bolling, B. W. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c05064 · Cited by 114
Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity
Mengist, H. M., Kombe, A. J. K., Mekonnen, D. S., Abebaw, A., Getachew, M., & Jin, T. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101533 · Cited by 115
Postacute Sequelae of SARS-CoV-2 in Children
Rao, S., Gross, R. S., Mohandas, S., Stein, C. R., Case, A., Dreyer, B. P., Pajor, N. M., Bunnell, H. T., Warburton, D., Berg, E. A., et al. (2024) · PEDIATRICS · doi:10.1542/peds.2023-062570 · Cited by 113
COVID-19 and cerebrovascular diseases: a comprehensive overview
Tsivgoulis, G. K., Palaiodimou, L., Zand, R., Lioutas, V., Krogias, C., Katsanos, A. H., Shoamanesh, A., Sharma, V. K., Shahjouei, S., Baracchini, C., et al. (2020) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286420978004 · Cited by 112
Spontaneous, persistent, T cell–dependent IFN-γ release in patients who progress to Long Covid
Krishna, B. A., Lim, E. Y., Metaxaki, M., Jackson, S. E., Mactavous, L., BioResource, N., Lyons, P., Döffinger, R., Bradley, J. R., Smith, K. G. C., et al. (2024) · Science Advances · doi:10.1126/sciadv.adi9379 · Cited by 112
Nurputra, D. K., Kusumaatmaja, A., Hakim, M. S., Hidayat, S. N., Julian, T., Sumanto, B., Mahendradhata, Y., Saktiawati, A. M. I., Wasisto, H. S., & Trıyana, K. (2022) · npj Digital Medicine · doi:10.1038/s41746-022-00661-2 · Cited by 111
McElvaney, O. J., Hobbs, B. D., Qiao, D., McElvaney, O. F., Moll, M. R., McEvoy, N. L., Clarke, J., O’Connor, E., Walsh, S., Cho, M. H., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103026 · Cited by 110
Coronavirus disease 2019 (COVID-19) mortality and neighborhood characteristics in Chicago
Bryan, M. S., Sun, J., Jagai, J. S., Horton, D. E., Montgomery, A., Sargis, R. M., & Argos, M. (2020) · Annals of Epidemiology · doi:10.1016/j.annepidem.2020.10.011 · Cited by 110
Animal models for COVID-19: advances, gaps and perspectives
Fan, C., Wu, Y., Xiong, R., Yang, Y., Ling, C., Liu, S., Liu, S., & Wang, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01087-8 · Cited by 110
Laryngeal complications of COVID ‐19
Naunheim, M. R., Zhou, A. S., Puka, E., Franco, R. A., Carroll, T. L., Teng, S. E., Mallur, P. S., & Song, P. C. (2020) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.484 · Cited by 109
Krüger, J., Groß, R. M., Conzelmann, C., Müller, J. A., Koepke, L., Sparrer, K. M. J., Weil, T., Schütz, D., Seufferlein, T. T. W., Barth, T. F. E., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.11.003 · Cited by 109
Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut
Triana, S., Metz‐Zumaran, C., Ramírez, C. D., Kee, C., Doldan, P., Shahraz, M., Schraivogel, D., Gschwind, A. R., Sharma, A. K., Steinmetz, L. M., et al. (2021) · Molecular Systems Biology · doi:10.15252/msb.202110232 · Cited by 111
Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19
Dupont, A., Rauch, A., Staessens, S., Moussa, M. D., Rosa, M., Corseaux, D., Jeanpierre, E., Goutay, J., Caplan, M., Varlet, P., et al. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315595 · Cited by 108
Reyes, M., Filbin, M. R., Bhattacharyya, R. P., Sonny, A., Mehta, A., Billman, K., Kays, K. R., Pinilla-Vera, M., Benson, M. E., MGH COVID-19 Collection & Processing Team, et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe9599 · Cited by 109
A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation
Nascimento, D. D. C., Rolnick, N. D., Neto, I. V. D. S., Severin, R. S., & Beal, F. L. R. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.808622 · Cited by 111
Chieregato, M., Frangiamore, F., Morassi, M., Baresi, C., Nici, S., Bassetti, C., Bnà, C., & Galelli, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-07890-1 · Cited by 105
Quan, M., Wang, X., Gong, M., Wang, Q., Li, Y., & Jia, J. (2023) · The Lancet Regional Health - Western Pacific · doi:10.1016/j.lanwpc.2023.100836 · Cited by 105
Zhang, C., Wang, X., Wang, C., He, C., Ma, Q., Li, J., Wang, W., Xu, Y., & Wang, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.790072 · Cited by 102
Hull, M., Parnes, M., & Jankovic, J. J. (2021) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000001082 · Cited by 101
Hypocalcemia in COVID-19: Prevalence, clinical significance and therapeutic implications
di Filippo, L., Doga, M., Frara, S., & Giustina, A. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09655-z · Cited by 101
Current and Emerging Knowledge in COVID-19
Jeong, Y. J., Wi, Y. M., Park, H., Lee, J. E., Kim, S., & Lee, K. S. (2023) · Radiology · doi:10.1148/radiol.222462 · Cited by 97
Frara, S., Allora, A., Castellino, L., di Filippo, L., Loli, P., & Giustina, A. (2021) · Pituitary · doi:10.1007/s11102-021-01148-1 · Cited by 101
Oral Manifestations in Patients with COVID-19: A 6-Month Update
dos Santos, J. A., Normando, A. G. C., da Silva, R. L. C., Acevedo, A. C., Canto, G. D. L., Sugaya, N. N., Santos‐Silva, A. R., & Guerra, E. N. S. (2021) · Journal of Dental Research · doi:10.1177/00220345211029637 · Cited by 100
Recent advances in the research and management of sepsis-associated DIC
Iba, T., Connors, J. M., Nagaoka, I., & Levy, J. H. (2021) · International Journal of Hematology · doi:10.1007/s12185-020-03053-y · Cited by 99
Postmortem Findings Associated With SARS-CoV-2
Satturwar, S. P., Fowkes, M. E., Farver, C. F., Wilson, A. M., Eccher, A., Girolami, I., Pujadas, E., Bryce, C., Salem, F. E., Jamal, S. M. E., et al. (2021) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001650 · Cited by 99
Kyrou, I., Randeva, H. S., Spandidos, D. A., & Karteris, E. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00460-9 · Cited by 99
Zaid, Y., Doré, É., Dubuc, I., Archambault, A., Flamand, O., Laviolette, M., Flamand, N., Boilard, É., & Flamand, L. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.05.032 · Cited by 100
Britton, G. J., Chen-Liaw, A., Cossarini, F., Livanos, A. E., Spindler, M. P., Plitt, T., Eggers, J., Mogno, I., Gonzalez-Reiche, A. S., Siu, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-92740-9 · Cited by 99
Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases
El-Arif, G., Khazaal, S., Farhat, A., Harb, J., Annweiler, C., Wu, Y., Cao, Z., Kovacic, H., Khattar, Z. A., Fajloun, Z., et al. (2022) · Molecules · doi:10.3390/molecules27072048 · Cited by 99
Zhao, M., Zhu, Y., Zhang, L., Zhong, G., Tai, L., Liu, S., Yin, G., Lü, J., He, Q., Li, M.-J., et al. (2022) · Cell Discovery · doi:10.1038/s41421-022-00419-w · Cited by 99
Ioannou, G. N., Baraff, A. J., Fox, A., Shahoumian, T. A., Hickok, A. W., O’Hare, A. M., Bohnert, A. S. B., Boyko, E. J., Maciejewski, M. L., Bowling, C. B., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.24359 · Cited by 99
Gamberini, L., Tonetti, T., Spadaro, S., Zani, G., Mazzoli, C. A., Capozzi, C., Giampalma, E., Reggiani, M. L. B., Bertellini, E., Castelli, A., et al. (2020) · Journal of Intensive Care · doi:10.1186/s40560-020-00499-4 · Cited by 97
Hematological manifestations of SARS‐CoV‐2 in children
Kosmeri, C., Koumpis, E., Tsabouri, S., Siomou, E. C., & Makis, A. C. (2020) · Pediatric Blood & Cancer · doi:10.1002/pbc.28745 · Cited by 96
Long, Q., Li, J., Hu, X., Bai, Y., Zheng, Y., & Gao, Z. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.702635 · Cited by 96
Role of miR-2392 in driving SARS-CoV-2 infection
McDonald, J. T., Enguita, F. J., Taylor, D. M., Griffin, R. J., Priebe, W., Emmett, M. R., Sajadi, M. M., Harris, A. D., Clement, J., Dybas, J. M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109839 · Cited by 96
Cheng, A. P., Cheng, M. P., Gu, W., Lenz, J. S., Hsu, E. D., Schurr, E., Bourque, G., Bourgey, M., Ritz, J., Marty, F. M., et al. (2021) · Med · doi:10.1016/j.medj.2021.01.001 · Cited by 95
Pulmonary Dysfunction after Pediatric COVID-19
Heiss, R., Wagner, A., Tan, L., Schmidt, S., Regensburger, A. P., Ewert, F., Mammadova, D., Büehler, A., Vogel‐Claussen, J., Voskrebenzev, A., et al. (2022) · Radiology · doi:10.1148/radiol.221250 · Cited by 95
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey
Izzo, R., Trimarco, V., Mone, P., Aloè, T., Marzani, M. C., Diana, A., Fazio, G., Mallardo, M., Maniscalco, M., Marazzi, G., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106360 · Cited by 94
Overview of COVID-19 inflammatory pathogenesis from the therapeutic perspective
Lee, C.-H., & Choi, W. J. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-020-01301-7 · Cited by 93
Pathophysiology of coronavirus-19 disease acute lung injury
Camporota, L., Cronin, J. N., Busana, M., Gattinoni, L., & Formenti, F. (2021) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000911 · Cited by 93
Revzin, M. V., Raza, S., Srivastava, N. C., Warshawsky, R., D’Agostino, C. A., Malhotra, A., Bader, A. S., Patel, R. D., Chen, K., Kyriakakos, C., et al. (2020) · Radiographics · doi:10.1148/rg.2020200195 · Cited by 91
COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction
Queisser, K. A., Mellema, R. A., Middleton, E. A., Portier, I., Manne, B. K., Denorme, F., Beswick, E. J., Rondina, M. T., Campbell, R. A., & Petrey, A. C. (2021) · JCI Insight · doi:10.1172/jci.insight.147472 · Cited by 91
Testicular pathology in fatal COVID‐19: A descriptive autopsy study
Duarte‐Neto, A. N., Teixeira, T. A., Caldini, E. T. E. G., Kanamura, C. T., Gomes‐Gouvêa, M. S., Santos, A. B. G., Monteiro, R. A. D. A., Pinho, J. R. R., Mauad, T., da Silva, L. F. F., et al. (2021) · Andrology · doi:10.1111/andr.13073 · Cited by 90
The relevance of magnesium homeostasis in COVID-19
Trapani, V., Rosanoff, A., Baniasadi, S., Barbagallo, M., Castiglioni, S., Guerrero‐Romero, F., Iotti, S., Mazur, A., Micke, O., Pourdowlat, G., et al. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02704-y · Cited by 90
Extrapulmonary Clinical Manifestations in COVID-19 Patients
Sarkesh, A., Sorkhabi, A. D., Sheykhsaran, E., Alinezhad, F., Mohammadzadeh, N., Hemmat, N., & Baghi, H. B. (2020) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.20-0986 · Cited by 89
SARS-CoV-2 and Oral Manifestation: An Observational, Human Study
Sinjari, B., D’Ardes, D., Santilli, M., Rexhepi, I., D’Addazio, G., Carlo, P. D., Chiacchiaretta, P., Caputi, S., & Cipollone, F. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9103218 · Cited by 89
Complement Activation in Kidneys of Patients With COVID-19
Pfister, F., Vonbrunn, E., Ries, T., Jäck, H., Überla, K., Lochnit, G., Sheriff, A., i, M. H., Büttner-Herold, M. J., Amann, K., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594849 · Cited by 91
Ramírez, S., Fernandez-Antunez, C., Galli, A., Underwood, A. P., Pham, L. V., Ryberg, L. A., Feng, S., Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., et al. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00097-21 · Cited by 89
Combined Metabolic Activators Accelerates Recovery in Mild‐to‐Moderate COVID‐19
Altay, O., Arif, M., Li, X., Yang, H., Aydın, M., Alkurt, G., Kim, W., Akyol, D., Zhang, C., Dinler‐Doganay, G., et al. (2021) · Advanced Science · doi:10.1002/advs.202101222 · Cited by 88
Trimpert, J., Vladimirova, D., Dietert, K., Abdelgawad, A., Kunec, D., Dökel, S., Voß, A., Gruber, A. D., Bertzbach, L. D., & Osterrieder, N. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108488 · Cited by 89
Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients
DeKosky, S. T., Kochanek, P. M., Valadka, A. B., Clark, R. S. B., Chou, S., Au, A. K., Horvat, C. M., Jha, R. M., Mannix, R., Wisniewski, S. R., et al. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7332 · Cited by 87
The prognostic value of the SOFA score in patients with COVID-19
Yang, Z., Hu, Q., Huang, F., Xiong, S., & Sun, Y. (2021) · Medicine · doi:10.1097/md.0000000000026900 · Cited by 87
Francis, M. E., Goncin, U., Kroeker, A., Swan, C. L., Ralph, R., Lu, Y. W. W., Etzioni, A. L., Falzarano, D., Gerdts, V., Machtaler, S., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009705 · Cited by 88
Metadata
- Authors
- Gupta, A., Madhavan, M. V., Sehgal, K., Nair, N., Mahajan, S., Sehrawat, T. S., Bikdeli, B., Ahluwalia, N., Ausiello, J. C., Wan, E. Y., Freedberg, D. E., Kirtane, A. J., Parikh, S. A., Maurer, M. S., Nordvig, A. S., Accili, D., Bathon, J. M., Mohan, S., Bauer, K. A., Leon, M. B., Krumholz, H. M., Uriel, N., Mehra, M. R., Elkind, M. S. V., Stone, G. W., Schwartz, A., Ho, D. D., Bilezikian, J. P., & Landry, D. W.
- Affiliations
- Yale New Haven Hospital (US)
- Columbia University Irving Medical Center (US)
- Beth Israel Deaconess Medical Center (US)
- Mayo Clinic (US)
- Icahn School of Medicine at Mount Sinai (US)
- Cardiovascular Research Foundation (US)
- NewYork–Presbyterian Hospital (US)
- Brigham and Women's Hospital (US)
- Aaron Diamond AIDS Research Center (US)
- Corresponding author
- Landry, Donald W.
- ORCID
- Gupta, Aakriti
- Madhavan, Mahesh V.
- Sehgal, Kartik
- Mahajan, Shiwani
- Sehrawat, Tejasav S.
- Bikdeli, Behnood
- Ahluwalia, Neha
- Ausiello, John C.
- Wan, Elaine Y.
- Freedberg, Daniel E.
- Kirtane, Ajay J.
- Parikh, Sahil A.
- Maurer, Mathew S.
- Nordvig, Anna S.
- Accili, Domenico
- Bathon, Joan M.
- Mohan, Sumit
- Bauer, Kenneth A.
- Leon, Martin B.
- Krumholz, Harlan M.
- Uriel, Nir
- Mehra, Mandeep R.
- Elkind, Mitchell S. V.
- Stone, Gregg W.
- Schwartz, Allan
- Ho, David D.
- Bilezikian, John P.
- Landry, Donald W.
- Venue
- Nature Medicine
- Published
- 2020-07
- Volume
- 26
- Issue
- 7
- Pages
- 1017-1032
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC11972613
- OpenAlex
- W3040801404
- Cited by
- 3,185
- References
- 261
- Citations by year
- 2026: 125 · 2025: 182 · 2024: 333 · 2023: 558 · 2022: 751 · 2021: 965 · 2020: 261
- FWCI
- 29.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (T32 - HL007854, K23- DK111847)
- U.S. Department of Defense (PR-181960)
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (5T32 - NS007153)
- U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 - AR050026, U01- AR068043)
- U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R01 - MD014161, U01- DK116066)
- U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (K08-HL122526, R01 - HL152236, R03 - HL146881)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Dermatology › Dermatological and COVID-19 studies
- Keywords
- COVID-19 pandemic, SARS-CoV-2, extrapulmonary manifestations, thrombotic complications, cardiac dysfunction, cardiac arrhythmias, acute coronary syndrome, acute kidney injury, gastrointestinal symptoms, hepatocyte injury, hyperglycemia, ketosis, neurological complications, ocular symptoms, skin complications, ACE2 receptor, thromboinflammation, endothelial injury, immune dysregulation
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Endothelium, Vascular, Humans, Inflammation, Organ Specificity, Pneumonia, Viral, Renin-Angiotensin System, Thrombosis, Coronavirus Infections, Disease Progression, Virus Internalization, Adaptive Immunity, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
