The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
Open accessAbstract
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal column of the spinal cord. Here, we hypothesized that an arrangement of electrodes targeting the ensemble of dorsal roots involved in leg and trunk movements would result in superior efficacy, restoring more diverse motor activities after the most severe SCI. To test this hypothesis, we established a computational framework that informed the optimal arrangement of electrodes on a new paddle lead and guided its neurosurgical positioning. We also developed software supporting the rapid configuration of activity-specific stimulation programs that reproduced the natural activation of motor neurons underlying each activity. We tested these neurotechnologies in three individuals with complete sensorimotor paralysis as part of an ongoing clinical trial ( www.clinicaltrials.gov identifier NCT02936453). Within a single day, activity-specific stimulation programs enabled these three individuals to stand, walk, cycle, swim and control trunk movements. Neurorehabilitation mediated sufficient improvement to restore these activities in community settings, opening a realistic path to support everyday mobility with EES in people with SCI.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source doesn’t support the claim as written.
In the citing paper
“However, this recovery required wearable motion sensors to detect motor intentions from residual movements or compensatory strategies to initiate the preprogrammed stimulation sequences5.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [5]
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“He had previously participated in the STIMO clinical trial (clinicaltrials.gov, NCT02936453), which involved a five-month neurorehabilitation programme supported by targeted epidural electrical stimulation of the spinal cord4,5.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The delivery of epidural electrical stimulation over the lumbar spinal cord has enabled many individuals with spinal cord injury to regain adaptive control over the activity of otherwise paralysed muscles.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“First, the physiological principles underlying targeted epidural electrical stimulation of the spinal cord have now been validated in nine out nine treated individuals with incomplete4 and complete5 injuries6.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [5]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“In turn, recruiting these dorsal root entry zones with preprogrammed spatiotemporal sequences replicates the physiological activation of leg motor pools underlying standing and walking4,5,11,13,14.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“In turn, optimized configurations of anodes and cathodes can steer electric fields towards specific subsets of dorsal root entry zones to modulate well-defined ensembles of motor neuron pools5,9,25.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“This programme enabled him to regain the ability to step with the help of a front-wheel walker.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“Indeed, we were able to configure stimulation programs that restored stepping within one day in three participants with complete sensorimotor paralysis5.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“This recovery has been documented in various independent studies, including in participants with complete sensorimotor paralysis5,6,30–34.”
From Walking naturally after spinal cord injury using a brain–spine interface (2023) · cites this paper as [5]
In the citing paper
“The last three participants were implanted with a new paddle lead that was specifically developed to target the dorsal roots involved in the control of trunk and leg movements18 (ONWARD Medical).”
From The neurons that restore walking after paralysis (2022) · cites this paper as [18]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888
Jenkinson, M., Beckmann, C. F., Behrens, T. E. J., Woolrich, M. W., & Smith, S. M. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.015 · Cited by 11,314
A component based noise correction method (CompCor) for BOLD and perfusion based fMRI
Behzadi, Y., Restom, K., Liau, J., & Liu, T. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.042 · Cited by 4,502
Methods to detect, characterize, and remove motion artifact in resting state fMRI
Power, J. D., Mitra, A., Laumann, T. O., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2013.08.048 · Cited by 3,748
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859
Targeting Recovery: Priorities of the Spinal Cord-Injured Population
Anderson, K. D. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1371 · Cited by 2,094
Harkema, S., Gerasimenko, Y., Hodes, J., Burdick, J., Angeli, C., Chen, Y., Ferreira, C., Willhite, A., Rejc, E., Grossman, R. G., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60547-3 · Cited by 1,229
Targeted neurotechnology restores walking in humans with spinal cord injury
Wagner, F. B., Mignardot, J.-B., Le Goff-Mignardot, C. G., Demesmaeker, R., Komi, S., Capogrosso, M., Rowald, A., Seáñez, I., Caban, M., Pirondini, E., et al. (2018) · Nature · doi:10.1038/s41586-018-0649-2 · Cited by 1,087
Self-citationElectronic dura mater for long-term multimodal neural interfaces
Minev, I. R., Musienko, P., Hirsch, A., Barraud, Q., Wenger, N., Moraud, E. M., Gandar, J., Capogrosso, M., Milekovic, T., Asboth, L., et al. (2015) · Science · doi:10.1126/science.1260318 · Cited by 1,082
Self-citationKinaesthetic role of muscle afferents in man, studied by tendon vibration and microneurography
Roll, J., & Vedel, J. (1982) · Experimental Brain Research · doi:10.1007/bf00239377 · Cited by 1,025
Alteration of proprioceptive messages induced by tendon vibration in man: a microneurographic study
Roll, J., Vedel, J. P., & Ribot, E. (1989) · Experimental Brain Research · doi:10.1007/bf00253639 · Cited by 989
Evidence for a Spinal Central Pattern Generator in Humans a
Dimitrijevic, M. R., Gerasimenko, Y. P., & Pinter, M. M. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09062.x · Cited by 800
Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury
van den Brand, R., Heutschi, J., Barraud, Q., DiGiovanna, J., Bartholdi, K., Huerlimann, M., Friedli, L., Vollenweider, I., Moraud, E. M., Duis, S., et al. (2012) · Science · doi:10.1126/science.1217416 · Cited by 767
Self-citationTransformation of nonfunctional spinal circuits into functional states after the loss of brain input
Courtine, G., Gerasimenko, Y., van den Brand, R., Yew, A., Musienko, P., Zhong, H., Song, B., Ao, Y., Ichiyama, R. M., Lavrov, I., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2401 · Cited by 706
Self-citationRecovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury
Angeli, C. A., Boakye, M., Morton, R. A., Vogt, J., Benton, K., Chen, Y., Ferreira, C. K., & Harkema, S. J. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1803588 · Cited by 670
A brain–spine interface alleviating gait deficits after spinal cord injury in primates
Capogrosso, M., Milekovic, T., Borton, D., Wagner, F., Moraud, E. M., Mignardot, J.-B., Buse, N., Gandar, J., Barraud, Q., Xing, D., et al. (2016) · Nature · doi:10.1038/nature20118 · Cited by 635
Self-citationSCT: Spinal Cord Toolbox, an open-source software for processing spinal cord MRI data
Leener, B. D., Lévy, S., Dupont, S. M., Fonov, V., Stikov, N., Collins, D. L., Callot, V., & Cohen‐Adad, J. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.10.009 · Cited by 605
Gill, M. L., Grahn, P. J., Calvert, J. S., Linde, M. B., Lavrov, I. A., Strommen, J. A., Beck, L. A., Sayenko, D. G., Van Straaten, M. G., Drubach, D. I., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0175-7 · Cited by 574
Spinal cord repair: advances in biology and technology
Courtine, G., & Sofroniew, M. V. (2019) · Nature Medicine · doi:10.1038/s41591-019-0475-6 · Cited by 508
Self-citationThe Circuitry of the Human Spinal Cord
Pierrot-Deseilligny, E., & Burke, D. J. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545047 · Cited by 508
A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits
Capogrosso, M., Wenger, N., Raspopovic, S., Musienko, P., Beauparlant, J., Bassi Luciani, L., Courtine, G., & Micera, S. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1688-13.2013 · Cited by 435
Self-citationThe PhysIO Toolbox for Modeling Physiological Noise in fMRI Data
Kasper, L., Bollmann, S., Diaconescu, A. O., Hutton, C., Heinzle, J., Iglesias, S., Hauser, T. U., Sebold, M., Manjaly, Z., Pruessmann, K. P., et al. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2016.10.019 · Cited by 427
Benabid, A. L., Costecalde, T., Eliseyev, A., Charvet, G., Verney, A., Karakas, S., Foerster, M., Lambert, A., Morinière, B., Abroug, N., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30321-7 · Cited by 404
Formento, E., Minassian, K., Wagner, F., Mignardot, J. B., Le Goff-Mignardot, C. G., Rowald, A., Bloch, J., Micera, S., Capogrosso, M., & Courtine, G. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0262-6 · Cited by 370
Self-citationWenger, N., Moraud, E. M., Gandar, J., Musienko, P., Capogrosso, M., Baud, L., Le Goff, C. G., Barraud, Q., Pavlova, N., Dominici, N., et al. (2016) · Nature Medicine · doi:10.1038/nm.4025 · Cited by 369
Self-citationAsboth, L., Friedli, L., Beauparlant, J., Martinez-Gonzalez, C., Anil, S., Rey, E., Baud, L., Pidpruzhnykova, G., Anderson, M. A., Shkorbatova, P., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0093-5 · Cited by 324
Self-citationGros, C., Leener, B. D., Badji, A., Maranzano, J., Eden, D., Dupont, S. M., Talbott, J. F., Zhuoquiong, R., Liu, Y., Granberg, T., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.09.081 · Cited by 304
Constrained linear basis sets for HRF modelling using Variational Bayes
Woolrich, M. W., Behrens, T. E. J., & Smith, S. M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.024 · Cited by 295
Gomez‐Perez, S. L., Haus, J. M., Sheean, P., Patel, B., Mar, W., Chaudhry, V., McKeever, L., & Braunschweig, C. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115604149 · Cited by 275
Updates for the International Standards for Neurological Classification of Spinal Cord Injury
Kirshblum, S., & Waring, W. P. (2014) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2014.04.001 · Cited by 264
Darrow, D., Balser, D., Netoff, T. I., Krassioukov, A., Phillips, A., Parr, A., & Samadani, U. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6006 · Cited by 254
Physiological noise modelling for spinal functional magnetic resonance imaging studies
Brooks, J. C. W., Beckmann, C. F., Miller, K. L., Wise, R. G., Porro, C. A., Tracey, I., & Jenkinson, M. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.018 · Cited by 243
Spinal cord stimulation facilitates functional walking in a chronic, incomplete spinal cord injured
Herman, R. M., He, J., D'Luzansky, S., Willis, W. T., & Dilli, S. (2002) · Spinal Cord · doi:10.1038/sj.sc.3101263 · Cited by 230
Moraud, E. M., Capogrosso, M., Formento, E., Wenger, N., DiGiovanna, J., Courtine, G., & Micera, S. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.009 · Cited by 220
Self-citationWenger, N., Moraud, E. M., Raspopovic, S., Bonizzato, M., DiGiovanna, J., Musienko, P., Morari, M., Micera, S., & Courtine, G. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008325 · Cited by 209
Greiner, N., Barra, B., Schiavone, G., Lorach, H., James, N., Conti, S., Kaeser, M., Fallegger, F., Borgognon, S., Lacour, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20703-1 · Cited by 199
Self-citationNeuroprosthetic baroreflex controls haemodynamics after spinal cord injury
Squair, J. W., Gautier, M., Mahe, L., Soriano, J. E., Rowald, A., Bichat, A., Cho, N., Anderson, M. A., James, N. D., Gandar, J., et al. (2021) · Nature · doi:10.1038/s41586-020-03180-w · Cited by 182
Self-citationSpatiotemporal Activation of Lumbosacral Motoneurons in the Locomotor Step Cycle
Yakovenko, S., Mushahwar, V. K., VanderHorst, V., Holstege, G., & Procházka, A. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00479.2001 · Cited by 176
Human spinal locomotor control is based on flexibly organized burst generators
Danner, S. M., Hofstoetter, U. S., Freundl, B., Binder, H., Mayr, W., Rattay, F., & Minassian, K. (2015) · Brain · doi:10.1093/brain/awu372 · Cited by 175
Self-citationStep Training Reinforces Specific Spinal Locomotor Circuitry in Adult Spinal Rats
Ichiyama, R. M., Courtine, G., Gerasimenko, Y., Yang, G. J., van den Brand, R., Lavrov, I. A., Zhong, H., Roy, R. R., & Edgerton, V. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1881-08.2008 · Cited by 167
Self-citationSpinal cord reflexes induced by epidural spinal cord stimulation in normal awake rats
Gerasimenko, Y., Lavrov, I. A., Courtine, G., Ichiyama, R. M., Dy, C. J., Zhong, H., Roy, R. R., & Edgerton, V. R. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.05.004 · Cited by 162
Self-citationBrain-controlled modulation of spinal circuits improves recovery from spinal cord injury
Bonizzato, M., Pidpruzhnykova, G., DiGiovanna, J., Shkorbatova, P., Pavlova, N., Micera, S., & Courtine, G. (2018) · Nature Communications · doi:10.1038/s41467-018-05282-6 · Cited by 149
Self-citationProprio-tactile integration for kinesthetic perception: An fMRI study
Kavounoudias, A., Roll, J., Anton, J., Nazarian, B., Roth, M., & Roll, R. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.10.002 · Cited by 144
Self-citationChen, C.-L., Yeung, K.-T., Bih, L.-I., Wang, C.-H., Chen, M.-I., & Chien, J.-C. (2003) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(03)00200-4 · Cited by 138
Herrity, A. N., Williams, C. S., Angeli, C., Harkema, S. J., & Hubscher, C. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-26602-2 · Cited by 126
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics
Capogrosso, M., Wagner, F. B., Gandar, J., Moraud, E. M., Wenger, N., Milekovic, T., Shkorbatova, P. Y., Pavlova, N., Евгеньевич, М. П., Bézard, E., et al. (2018) · Nature Protocols · doi:10.1038/s41596-018-0030-9 · Cited by 125
Self-citationSoft, Implantable Bioelectronic Interfaces for Translational Research
Schiavone, G., Fallegger, F., Kang, X., Barra, B., Vachicouras, N., Roussinova, E., Furfaro, I., Jiguet, S., Seáñez, I., Borgognon, S., et al. (2020) · Advanced Materials · doi:10.1002/adma.201906512 · Cited by 116
Self-citationBarra, B., Conti, S., Perich, M. G., Zhuang, K., Schiavone, G., Fallegger, F., Galan, K., James, N. D., Barraud, Q., Delacombaz, M., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01106-5 · Cited by 114
Self-citationEpidural stimulation of the spinal cord in spinal cord injury: current status and future challenges
Edgerton, V. R., & Harkema, S. J. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.129 · Cited by 111
Courtine, G., Nunzio, A. M. D., Schmid, M., Beretta, M. V., & Schieppati, M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00764.2006 · Cited by 110
Self-citationFully automatic and fast segmentation of the femur bone from 3D-CT images with no shape prior
Krčah, M., Székely, G., & Blanc, R. (2011) · IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI) · doi:10.1109/isbi.2011.5872823 · Cited by 98
Heuristic map of myotomal innervation in humans using direct intraoperative nerve root stimulation
Schirmer, C. M., Shils, J. L., Arle, J. E., Cosgrove, G. R., Dempsey, P. K., Tarlov, E. C., Kim, S., Martin, C. J., Feltz, C., Moul, M., et al. (2011) · Journal of Neurosurgery Spine · doi:10.3171/2011.2.spine1068 · Cited by 93
Neuromodulation of lower limb motor control in restorative neurology
Minassian, K., Hofstoetter, U. S., Tansey, K. E., & Mayr, W. (2012) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2012.03.013 · Cited by 85
Self-citationAssessment of physiological noise modelling methods for functional imaging of the spinal cord
Kong, Y., Jenkinson, M., Andersson, J., Tracey, I., & Brooks, J. C. W. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.077 · Cited by 84
Mechanisms of Electrical Stimulation with Neural Prostheses
Rattay, F., Resatz, S., Lutter, P., Minassian, K., Jilge, B., & Dimitrijevic, M. R. (2003) · Neuromodulation Technology at the Neural Interface · doi:10.1046/j.1525-1403.2003.03006.x · Cited by 71
Self-citationDenoising spinal cord fMRI data: Approaches to acquisition and analysis
Eippert, F., Kong, Y., Jenkinson, M., Tracey, I., & Brooks, J. C. W. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.09.065 · Cited by 67
Migration of Motor Pool Activity in the Spinal Cord Reflects Body Mechanics in Human Locomotion
Cappellini, G., Ivanenko, Y. P., Dominici, N., Poppele, R. E., & Lacquaniti, F. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00318.2010 · Cited by 61
Kinany, N., Pirondini, E., Micera, S., & Ville, D. V. D. (2020) · Neuron · doi:10.1016/j.neuron.2020.07.024 · Cited by 60
Self-citationMignardot, J.-B., Goff, C. G. L., van den Brand, R., Capogrosso, M., Fumeaux, N., Vallery, H., Anil, S., Lanini, J., Fodor, I., Eberle, G., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah3621 · Cited by 58
Self-citationPatient-Specific Analysis of Neural Activation During Spinal Cord Stimulation for Pain
Lempka, S. F., Zander, H. J., Anaya, C. J., Wyant, A., Ozinga, J. G., & Machado, A. G. (2019) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13037 · Cited by 52
Enhancement of Voluntary Motor Function Following Spinal Cord Stimulation - Case Study
Barolat, G., Myklebust, J. B., & Wenninger, W. J. (1986) · Stereotactic and Functional Neurosurgery · doi:10.1159/000100160 · Cited by 49
Principles of Cord Activation During Spinal Cord Stimulation
Molnar, G., & Barolat, G. (2014) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12171 · Cited by 48
Automatic spinal cord localization, robust to MRI contrasts using global curve optimization
Gros, C., Leener, B. D., Dupont, S. M., Martin, A. R., Fehlings, M. G., Bakshi, R., Tummala, S., Auclair, V., McLaren, D. G., Callot, V., et al. (2017) · Medical Image Analysis · doi:10.1016/j.media.2017.12.001 · Cited by 47
Moraud, E. M., Zitzewitz, J. V., Miehlbradt, J., Wurth, S. M., Formento, E., DiGiovanna, J., Capogrosso, M., Courtine, G., & Micera, S. (2018) · Scientific Reports · doi:10.1038/s41598-017-18293-y · Cited by 39
Self-citationAge-Related Impairment of Hand Movement Perception Based on Muscle Proprioception and Touch
Landelle, C., Ahmadi, A. E., & Kavounoudias, A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.04.015 · Cited by 38
Self-citationGill, M. L., Linde, M., Fautsch, K. J., Hale, R. F., Lopez, C., Veith, D. D., Calvert, J. S., Beck, L. A., Garlanger, K. L., Edgerton, V. R., et al. (2020) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2020.569337 · Cited by 35
A modular strategy for next-generation upper-limb sensory-motor neuroprostheses
Shokur, S., Mazzoni, A., Schiavone, G., Weber, D. J., & Micera, S. (2021) · Med · doi:10.1016/j.medj.2021.05.002 · Cited by 35
Self-citationLandelle, C., Anton, J., Nazarian, B., Sein, J., Gharbi, A., Félician, O., & Kavounoudias, A. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117056 · Cited by 34
Self-citationMeeting Proceedings for SCI 2020: Launching a Decade of Disruption in Spinal Cord Injury Research
Morse, L. R., Field-Fote, E. C., Contreras-Vidal, J. L., Noble‐Haeusslein, L. J., Rodreick, M., SCI 2020 Working Group, Shields, R. K., Sofroniew, M. V., Wudlick, R., Zanca, J. M., et al. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7174 · Cited by 27
Self-citationA novel medical image data-based multi-physics simulation platform for computational life sciences
Neufeld, E., Szczerba, D., Chavannes, N., & Kuster, N. (2013) · Interface Focus · doi:10.1098/rsfs.2012.0058 · Cited by 24
Self-citationBarra, B., Conti, S., Perich, M. G., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.13.379750 · Cited by 18
Soloukey, S., de Rooij, J. D., Osterthun, R., Drenthen, J., Zeeuw, C. I. D., Huygen, F. J. P. M., & Harhangi, B. S. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13235 · Cited by 16
Ditterline, B. L., Wade, S., Ugiliweneza, B., Singam, N. S. V., Harkema, S. J., Stoddard, M. F., & Hirsch, G. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.554018 · Cited by 16
Venous effect in spinal cord fMRI: insights from intrinsic optical imaging and laser speckle
Cohen‐Adad, J., Gauthier, C. J., Brooks, J., Leblond, H., Hoge, R. D., Fisher, J., Beaumont, É., Dubeau, S., Lesage, F., Doyon, J., et al. (2009) · NeuroImage · doi:10.1016/s1053-8119(09)72063-4 · Cited by 5
Cited by
Sorted by citations
Spinal cord injury: molecular mechanisms and therapeutic interventions
Hu, X., Xu, W., Ren, Y., Wang, Z., He, X., Huang, R., Ma, B., Zhao, J., Zhu, R., & Cheng, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01477-6 · Cited by 840
Walking naturally after spinal cord injury using a brain–spine interface
Lorach, H., Galvez, A., Spagnolo, V., Martel, F., Karakas, S., Intering, N., Vat, M., Faivre, O., Harte, C., Komi, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06094-5 · Cited by 631
Self-citationHe, X., Li, Y., Deng, B., Lin, A., Zhang, G., Ma, M., Wang, Y., Yang, Y., & Kang, X. (2022) · Cell Proliferation · doi:10.1111/cpr.13275 · Cited by 347
The neurons that restore walking after paralysis
Kathe, C., Skinnider, M. A., Hutson, T. H., Regazzi, N., Gautier, M., Demesmaeker, R., Komi, S., Ceto, S., James, N. D., Cho, N., et al. (2022) · Nature · doi:10.1038/s41586-022-05385-7 · Cited by 304
“…a surgically implanted neurostimulator interfaced to a multi-electrode paddle lead that enables closed-loop control of biomimetic EES protocols 1,2,18 , and overground neurorehabilitation supported in a multidirectional robotic support system 1,22 (Fig. showing the transitioning from sitting to…”
MethodSelf-citationEpidural stimulation of the cervical spinal cord for post-stroke upper-limb paresis
Powell, M. P., Verma, N., Sorensen, E., Carranza, E., Boos, A., Fields, D. P., Roy, S., Ensel, S., Barra, B., Balzer, J. R., et al. (2023) · Nature Medicine · doi:10.1038/s41591-022-02202-6 · Cited by 220
“Given the short duration of our study compared to similar works in SCI 22,52 we did not expect to observe restorative effects.”
Self-citation
Metadata
- Authors
- Rowald, A., Komi, S., Demesmaeker, R., Baaklini, E., Hernandez-Charpak, S. D., Paoles, E., Montanaro, H., Cassara, A., Becce, F., Lloyd, B., Newton, T., Ravier, J., Kinany, N., D’Ercole, M., Paley, A., Hankov, N., Varescon, C., McCracken, L., Vat, M., Caban, M., Watrin, A., Jacquet, C., Bole-Feysot, L., Harte, C., Lorach, H., Galvez, A., Tschopp, M., Herrmann, N., Wacker, M., Geernaert, L., Fodor, I., Radevich, V., Van Den Keybus, K., Eberle, G., Pralong, E., Roulet, M., Ledoux, J.-B., Fornari, E., Mandija, S., Mattera, L., Martuzzi, R., Nazarian, B., Benkler, S., Callegari, S., Greiner, N., Fuhrer, B., Froeling, M., Buse, N., Denison, T., Buschman, R., Wende, C., Ganty, D., Bakker, J., Delattre, V., Lambert, H., Minassian, K., van den Berg, C. A. T., Kavounoudias, A., Micera, S., Van De Ville, D., Barraud, Q., Kurt, E., Kuster, N., Neufeld, E., Capogrosso, M., Asboth, L., Wagner, F. B., Bloch, J., & Courtine, G.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- ETH Zurich (CH)
- Foundation for Research on Information Technologies in Society (CH)
- Scuola Superiore Sant'Anna (IT)
- École Polytechnique Fédérale de Lausanne (CH)
- University Medical Center Utrecht (NL)
- Centre National de la Recherche Scientifique (FR)
- Medtronic (United States) (US)
- Technical University of Munich (DE)
- Medical University of Vienna (AT)
- Radboud University Medical Center (NL)
- University of Fribourg (CH)
- Corresponding author
- Bloch, Jocelyne
- Courtine, Grégoire
- ORCID
- Rowald, Andreas
- Komi, Salif
- Demesmaeker, Robin
- Baaklini, Edeny
- Hernandez-Charpak, Sergio Daniel
- Montanaro, Hazael
- Cassara, Antonino
- Becce, Fabio
- Lloyd, Bryn
- Newton, Taylor
- Kinany, Nawal
- Hankov, Nicolas
- Varescon, Camille
- McCracken, Laura
- Caban, Miroslav
- Lorach, Henri
- Fodor, Isabelle
- Eberle, Grégoire
- Ledoux, Jean-Baptiste
- Fornari, Eleonora
- Mandija, Stefano
- Martuzzi, Roberto
- Nazarian, Bruno
- Callegari, Simone
- Greiner, Nathan
- Fuhrer, Benjamin
- Froeling, Martijn
- Buschman, Rik
- Minassian, Karen
- Kavounoudias, Anne
- Micera, Silvestro
- Van De Ville, Dimitri
- Barraud, Quentin
- Kurt, Erkan
- Kuster, Niels
- Neufeld, Esra
- Capogrosso, Marco
- Asboth, Leonie
- Wagner, Fabien B.
- Bloch, Jocelyne
- Courtine, Grégoire
- Venue
- Nature Medicine
- Published
- 2022-02
- Volume
- 28
- Issue
- 2
- Pages
- 260-271
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W4210917455
- Cited by
- 455
- References
- 72
- Citations by year
- 2026: 83 · 2025: 113 · 2024: 94 · 2023: 93 · 2022: 72
- FWCI
- 62.99
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- IRIS (submittedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- epidural stimulation, spinal cord injury, complete paralysis, dorsal root stimulation, neurorehabilitation, swimming, standing
- MeSH terms
- Humans, Leg, Paralysis, Spinal Cord, Spinal Cord Injuries, Walking, Spinal Cord Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
