Cited by 583Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and TreatmentsAmyotrophic Lateral Sclerosis Research

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Animal models of neurodegenerative diseases

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Dawson, Ted M., Golde, Todd E., Lagier-Tourenne, Clotilde·2018·Nature Neuroscience

DOI 10.1038/s41593-018-0236-8PMC PMC6615039

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Abstract

Animal models of adult-onset neurodegenerative diseases have enhanced the understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Nevertheless, our understanding of these disorders and the development of mechanistically designed therapeutics can still benefit from more rigorous use of the models and from generation of animals that more faithfully recapitulate human disease. Here we review the current state of rodent models for Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. We discuss the limitations and utility of current models, issues regarding translatability, and future directions for developing animal models of these human disorders.

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Authors: Dawson, T. M., Golde, T. E., & Lagier-Tourenne, C.
Affiliations: Johns Hopkins University (US)
University of Florida (US)
Corresponding author: Dawson, Ted M.
Golde, Todd E.
ORCID: Dawson, Ted M.
Golde, Todd E.
Lagier-Tourenne, Clotilde
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2018-09-24
Volume: 21
Issue: 10
Pages: 1370-1379
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/s41593-018-0236-8
PMC: PMC6615039
OpenAlex: W2891411797
Cited by: 576
References: 151
Citations by year: 2026: 59 · 2025: 73 · 2024: 89 · 2023: 72 · 2022: 88 · 2021: 79 · 2020: 70 · 2019: 41 · 2018: 4
FWCI: 6.37
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG018454, U01AG046139, P50AG047266)
National Cancer Institute (P01CA166009)
National Institute of Neurological Disorders and Stroke (R21NS098006, R01NS087227, R01NS082205, P50NS038377)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: animal models, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, frontotemporal dementia, amyotrophic lateral sclerosis, rodent models, translatability, disease modeling
MeSH terms: Animals, Disease Models, Animal, Humans, Neurodegenerative Diseases

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