Whitening of odor representations by the wiring diagram of the olfactory bulb
Open accessPublished version of a preprint
Abstract
Neuronal computations underlying higher brain functions depend on synaptic interactions among specific neurons. A mechanistic understanding of such computations requires wiring diagrams of neuronal networks. In this study, we examined how the olfactory bulb (OB) performs 'whitening', a fundamental computation that decorrelates activity patterns and supports their classification by memory networks. We measured odor-evoked activity in the OB of a zebrafish larva and subsequently reconstructed the complete wiring diagram by volumetric electron microscopy. The resulting functional connectome revealed an over-representation of multisynaptic connectivity motifs that mediate reciprocal inhibition between neurons with similar tuning. This connectivity suppressed redundant responses and was necessary and sufficient to reproduce whitening in simulations. Whitening of odor representations is therefore mediated by higher-order structure in the wiring diagram that is adapted to natural input patterns.
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- Authors
- Wanner, A. A., & Friedrich, R. W.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Friedrich, Rainer W.
- Venue
- Nature Neuroscience
- Published
- 2020-01-20
- Volume
- 23
- Issue
- 3
- Pages
- 433-442
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC7101160
- OpenAlex
- W3000124408
- Cited by
- 79
- References
- 57
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 8 · 2023: 15 · 2022: 15 · 2021: 13 · 2020: 6 · 2019: 1
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Novartis Research Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CRSII3_130470/1, 310030B_152833)
- Human Frontier Science Program (rgp0015/2010)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- olfactory bulb, whitening, wiring diagrams, functional connectome, reciprocal inhibition, odor representation, zebrafish larvae, neural network reconstruction, pattern classification, memory networks
- MeSH terms
- Algorithms, Animals, Larva, Memory, Models, Neurological, Nerve Net, Odorants, Olfactory Bulb, Olfactory Pathways, Synapses, Zebrafish, Olfactory Perception, Electrophysiological Phenomena, Connectome
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