Cited by 217Stress Responses and CortisolMemory and Neural MechanismsNeuroscience of respiration and sleep

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Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection

Daviu, Núria, Füzesi, Tamás, Rosenegger, David G., Rasiah, Neilen P., Sterley, Toni-Lee, Peringod, Govind, Bains, Jaideep S.·2020·Nature Neuroscience

DOI 10.1038/s41593-020-0591-0

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Abstract

In humans and rodents, the perception of control during stressful events has lasting behavioral consequences. These consequences are apparent even in situations that are distinct from the stress context, but how the brain links prior stressful experience to subsequent behaviors remains poorly understood. By assessing innate defensive behavior in a looming-shadow task, we show that the initiation of an escape response is preceded by an increase in the activity of corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus (CRH PVN neurons). This anticipatory increase is sensitive to stressful stimuli that have high or low levels of outcome control. Specifically, experimental stress with high outcome control increases CRH PVN neuron anticipatory activity, which increases escape behavior in an unrelated context. By contrast, stress with no outcome control prevents the emergence of this anticipatory activity and decreases subsequent escape behavior. These observations indicate that CRH PVN neurons encode stress controllability and contribute to shifts between active and passive innate defensive strategies.

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Authors: Daviu, N., Füzesi, T., Rosenegger, D. G., Rasiah, N. P., Sterley, T.-L., Peringod, G., & Bains, J. S.
Affiliations: University of Calgary (CA)
Corresponding author: Bains, Jaideep S.
ORCID: Daviu, Núria
Füzesi, Tamás
Rasiah, Neilen P.
Sterley, Toni-Lee
Peringod, Govind
Bains, Jaideep S.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2020-02-17
Volume: 23
Issue: 3
Pages: 398-410
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/s41593-020-0591-0
OpenAlex: W3005833620
Semantic Scholar: 6e976808ecf92218cf242b736a503de494f820f3
Cited by: 217
References: 43
Citations by year: 2026: 31 · 2025: 39 · 2024: 38 · 2023: 34 · 2022: 29 · 2021: 35 · 2020: 10
FWCI: 15.10
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Gouvernement du Canada | Canadian Institutes of Health Research (FDN-148440)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: corticotropin-releasing factor, paraventricular nucleus, hypothalamus, outcome control, defensive behavior, escape behavior, stress memory
MeSH terms: Animals, Corticotropin-Releasing Hormone, Cues, Escape Reaction, Male, Mice, Inbred C57BL, Neurons, Paraventricular Hypothalamic Nucleus, Photic Stimulation, Stress, Psychological, Hindlimb Suspension, Mice, Electrophysiological Phenomena, Anticipation, Psychological, Accelerometry, Optogenetics

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Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection

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