The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection
Abstract
In humans and rodents, the perception of control during stressful events has lasting behavioral consequences. These consequences are apparent even in situations that are distinct from the stress context, but how the brain links prior stressful experience to subsequent behaviors remains poorly understood. By assessing innate defensive behavior in a looming-shadow task, we show that the initiation of an escape response is preceded by an increase in the activity of corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus (CRH PVN neurons). This anticipatory increase is sensitive to stressful stimuli that have high or low levels of outcome control. Specifically, experimental stress with high outcome control increases CRH PVN neuron anticipatory activity, which increases escape behavior in an unrelated context. By contrast, stress with no outcome control prevents the emergence of this anticipatory activity and decreases subsequent escape behavior. These observations indicate that CRH PVN neurons encode stress controllability and contribute to shifts between active and passive innate defensive strategies.
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“Persistent activity seems to be a hallmark of hypothalamic neurons, which can be highly interconnected and have long integration periods42–45.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [45]
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Metadata
- Authors
- Daviu, N., Füzesi, T., Rosenegger, D. G., Rasiah, N. P., Sterley, T.-L., Peringod, G., & Bains, J. S.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Bains, Jaideep S.
- Venue
- Nature Neuroscience
- Published
- 2020-02-17
- Volume
- 23
- Issue
- 3
- Pages
- 398-410
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W3005833620
- Semantic Scholar
- 6e976808ecf92218cf242b736a503de494f820f3
- Cited by
- 217
- References
- 43
- Citations by year
- 2026: 31 · 2025: 39 · 2024: 38 · 2023: 34 · 2022: 29 · 2021: 35 · 2020: 10
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gouvernement du Canada | Canadian Institutes of Health Research (FDN-148440)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- corticotropin-releasing factor, paraventricular nucleus, hypothalamus, outcome control, defensive behavior, escape behavior, stress memory
- MeSH terms
- Animals, Corticotropin-Releasing Hormone, Cues, Escape Reaction, Male, Mice, Inbred C57BL, Neurons, Paraventricular Hypothalamic Nucleus, Photic Stimulation, Stress, Psychological, Hindlimb Suspension, Mice, Electrophysiological Phenomena, Anticipation, Psychological, Accelerometry, Optogenetics
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