Hypothalamic CRH neurons orchestrate complex behaviours after stress
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All organisms possess innate behavioural and physiological programmes that ensure survival. In order to have maximum adaptive benefit, these programmes must be sufficiently flexible to account for changes in the environment. Here we show that hypothalamic CRH neurons orchestrate an environmentally flexible repertoire of behaviours that emerge after acute stress in mice. Optical silencing of CRH neurons disrupts the organization of individual behaviours after acute stress. These behavioural patterns shift according to the environment after stress, but this environmental sensitivity is blunted by activation of PVN CRH neurons. These findings provide evidence that PVN CRH cells are part of a previously unexplored circuit that matches precise behavioural patterns to environmental context following stress. Overactivity in this network in the absence of stress may contribute to environmental ambivalence, resulting in context-inappropriate behavioural strategies.
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PVN CRF neurons are central to orchestrating rapid behavioral adaptations after acute stress.
“PVN CRF neurons are pivotal in orchestrating the rapid, complex behavioral adaptations that occur following acute stress (potentially via glutamate coreleasing projections to neighboring hypothalamic regions)76.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [76]
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- Authors
- Füzesi, T., Daviu, N., Wamsteeker Cusulin, J. I., Bonin, R. P., & Bains, J. S.
- Affiliations
- University of Calgary (CA)
- University of Toronto (CA)
- Corresponding author
- Bains, Jaideep S.
- Venue
- Nature Communications
- Published
- 2016-06-16
- Volume
- 7
- Issue
- 1
- Pages
- 11937-11937
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4912635
- OpenAlex
- W2436596660
- Cited by
- 316
- References
- 45
- Citations by year
- 2026: 32 · 2025: 44 · 2024: 43 · 2023: 29 · 2022: 40 · 2021: 33 · 2020: 30 · 2019: 28 · 2018: 17 · 2017: 16 · 2016: 4
- FWCI
- 13.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Calgary
- Fondation Brain Canada
- Alberta Innovates - Health Solutions
- Alberta Innovates
- Canadian Institutes of Health Research (86501)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- corticotropin-releasing hormone neurons, hypothalamus, paraventricular nucleus, acute stress, behavioral flexibility, environmental context, stress response, behavioral repertoire
- MeSH terms
- Channelrhodopsins, Adaptation, Physiological, Animals, Corticotropin-Releasing Hormone, Electroshock, Exploratory Behavior, Grooming, Light, Male, Mice, Transgenic, Neurons, Paraventricular Hypothalamic Nucleus, Sleep, Stress, Physiological, Gene Expression, Genes, Reporter, Freezing Reaction, Cataleptic, Mice, Optogenetics
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