Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

WGCNA: an R package for weighted correlation network analysis

Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw377 · Cited by 10,799

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Chen, E. Y., Tan, C. M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G. V., Clark, N. R., & Ma’ayan, A. (2013) · BMC Bioinformatics · doi:10.1186/1471-2105-14-128 · Cited by 7,814

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

Corces, M. R., Trevino, A. E., Hamilton, E. G., Greenside, P. G., Sinnott-Armstrong, N. A., Vesuna, S., Satpathy, A. T., Rubin, A. J., Montine, K. S., Wu, B., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4396 · Cited by 2,496

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

Arrasate, M., Mitra, S., Schweitzer, E. S., Segal, M. R., & Finkbeiner, S. (2004) · Nature · doi:10.1038/nature02998 · Cited by 1,979

Huntington Disease

Vonsattel, J. P., & DiFiglia, M. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199805000-00001 · Cited by 1,305

Induction of human neuronal cells by defined transcription factors

Pang, Z. P., Yang, N., Vierbuchen, T., Ostermeier, A., Fuentes, D., Yang, T. Q., Citri, A., Sebastiano, V., Marro, S. G., Südhof, T. C., et al. (2011) · Nature · doi:10.1038/nature10202 · Cited by 1,273

Monitoring and Measuring Autophagy

Yoshii, S. R., & Mizushima, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091865 · Cited by 1,107

Huntington disease: natural history, biomarkers and prospects for therapeutics

Ross, C. A., Aylward, E. H., Wild, E. J., Langbehn, D. R., Long, J. D., Warner, J. H., Scahill, R. I., Leavitt, B. R., Stout, J. C., Paulsen, J. S., et al. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.24 · Cited by 1,016

Non-coding RNAs in disease: from mechanisms to therapeutics

Németh, K., Bayraktar, R., Ferracin, M., & Călin, G. A. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00662-1 · Cited by 953

Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases

Kampmann, M. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00806-0 · Cited by 142

Huntington’s Disease: Complex Pathogenesis and Therapeutic Strategies

Tong, H., Yang, T., Xu, S., Li, X., Liu, L., Zhou, G., Yang, S., Yin, S., Li, X., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073845 · Cited by 142

Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming

Sun, Z., Kwon, J.-S., Ren, Y., Chen, S., Walker, C. K., Lu, X., Cates, K., Karahan, H., Sviben, S., Fitzpatrick, J. A. J., et al. (2024) · Science · doi:10.1126/science.adl2992 · Cited by 77

Sulfide regulation and catabolism in health and disease

Hou, Y., Lv, B., Du, J., Ye, M., Jin, H., Yi, Y., & Huang, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02231-w · Cited by 56

Cellular reprogramming as a tool to model human aging in a dish

Pitrez, P. R., Monteiro, L. M., Borgogno, O., Nissan, X., Mertens, J., & Ferreira, L. (2024) · Nature Communications · doi:10.1038/s41467-024-46004-5 · Cited by 51

Multi-omic analysis of Huntington’s disease reveals a compensatory astrocyte state

Paryani, F., Kwon, J., Ng, C., Jakubiak, K. A., Madden, N., Ofori, K., Tang, A., Lü, H., Xia, S., Li, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50626-0 · Cited by 51

Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine

Summers, R. A., Fagiani, F., Rowitch, D. H., Absinta, M., & Reich, D. S. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.08.004 · Cited by 39

Molecular Mechanisms in Pathophysiology of Mucopolysaccharidosis and Prospects for Innovative Therapy

Ago, Y., Rintz, E., Musini, K. S., Ma, Z., & Tomatsu, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021113 · Cited by 44

Mitophagy’s impacts on cancer and neurodegenerative diseases: implications for future therapies

Huang, J. B., Pham, V. T., Fu, S., Huang, G., Liu, Y., & Zheng, L. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01727-w · Cited by 39

Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation

Pierzynowska, K., Podlacha, M., Gaffke, L., Rintz, E., Wiśniewska, K., Cyske, Z., & Węgrzyn, G. (2023) · Autophagy · doi:10.1080/15548627.2023.2286116 · Cited by 36

Brain-Derived Neurotrophic Factor Dysregulation as an Essential Pathological Feature in Huntington’s Disease: Mechanisms and Potential Therapeutics

Speidell, A. P., Abid, N. B., & Yano, H. (2023) · Biomedicines · doi:10.3390/biomedicines11082275 · Cited by 33

Autophagy and neurodegeneration: Unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology

Diab, R., Pilotto, F., & Saxena, S. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1086895 · Cited by 34

Neuroinflammatory Proteins in Huntington’s Disease: Insights into Mechanisms, Diagnosis, and Therapeutic Implications

Li, X., Tong, H., Xu, S., Zhou, G., Yang, T., Yin, S., Yang, S., Li, X., & Li, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111787 · Cited by 31

Exploring molecular mechanisms, therapeutic strategies, and clinical manifestations of Huntington’s disease

Shafie, A., Ashour, A. A., Anwar, S., Anjum, F., & Hassan, M. I. (2024) · Archives of Pharmacal Research · doi:10.1007/s12272-024-01499-w · Cited by 29

Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1–TFEB pathway to Huntington’s disease neurodegeneration

Lee, S. W., Oh, Y. M., Victor, M. B., Yang, Y., Chen, S., Strunilin, I., Dahiya, S. M., Dolle, R. E., Pak, S. C., Silverman, G. A., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00538-3 · Cited by 25

Blood exosome sensing via neuronal insulin-like growth factor-1 regulates autism-related phenotypes

Chen, L., Xiong, X., Yao, T.-T., Gui, L.-N., Luo, F., Du, Y., & Cheng, Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106965 · Cited by 25

Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1

Zhang, Q., He, C., Guo, J., Tang, D., Qian, D., Zheng, C. W., Wu, C., & Peng, W. (2025) · Bio-Design and Manufacturing · doi:10.1631/bdm.2400248 · Cited by 21

Spatially resolved microRNA expression in tissues: technologies, challenges, and opportunities

Robles-Remacho, A., Zou, Y., Grillo, M., & Nilsson, M. (2025) · Trends in Genetics · doi:10.1016/j.tig.2025.06.005 · Cited by 22

Targeting the autophagy-lysosomal pathway in Huntington disease: a pharmacological perspective

Yang, J., & Zhang, C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1175598 · Cited by 21

Autophagy–Lysosome Pathway Dysfunction in Neurodegeneration and Cancer: Mechanisms and Therapeutic Opportunities

Du, M., Yu, Y., Wang, J., & Ji, C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010366 · Cited by 22

Modeling Huntington disease through microRNA-mediated neuronal reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegeneration

Oh, Y. M., Lee, S. W., & Yoo, A. S. J. (2023) · Autophagy · doi:10.1080/15548627.2023.2175572 · Cited by 20

An engineered Sox17 induces somatic to neural stem cell fate transitions independently from pluripotency reprogramming

Weng, M., Hu, H., Graus, M. S., Tan, D. S., Gao, Y., Ren, S., Ho, D. H. H., Langer, J., Holzner, M., Huang, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh2501 · Cited by 20

RNA variant assessment using transactivation and transdifferentiation

Nicolas-Martinez, E. C., Robinson, O., Pflueger, C., Gardner, A. E., Corbett, M. A., Ritchie, T., Kroes, T., van Eyk, C. L., Scheffer, I. E., Hildebrand, M. S., et al. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.06.018 · Cited by 18

Recent Advances in the Roles of MicroRNA and MicroRNA-Based Diagnosis in Neurodegenerative Diseases

Zhang, J., Chen, Z., Chen, H., Deng, Y., Li, S., & Jin, L. J. (2022) · Biosensors · doi:10.3390/bios12121074 · Cited by 13

Post-transcriptional mechanisms controlling neurogenesis and direct neuronal reprogramming

Papadimitriou, E., & Thomaidou, D. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390976 · Cited by 14

MicroRNAs regulating autophagy: opportunities in treating neurodegenerative diseases

Mohseni, M., Behzad, G., Farhadi, A., Behroozi, J., Mohseni, H., & Valipour, B. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1397106 · Cited by 12

Pathobiology of the autophagy-lysosomal pathway in the Huntington’s disease brainPreprint

Berg, M. J., Veeranna, Rosa, C. M., Kumar, A. R., Mohan, P. S., Stavrides, P. H., Marchionini, D. M., Yang, D., & Nixon, R. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.29.596470 · Cited by 12

Gastrodin Improves the Activity of the Ubiquitin–Proteasome System and the Autophagy–Lysosome Pathway to Degrade Mutant Huntingtin

Sun, H., Li, M., Li, Y., Na, Z., Li, J., Li, X., Liu, Y., Ji, Q., Zhou, L., Su, J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147709 · Cited by 11

Small molecule modulation of p75NTR engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's disease

Simmons, D. A., Alexander, N., Cao, G., Rippin, I., Lugassy, Y., Eldar-Finkelman, H., & Longo, F. M. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00495 · Cited by 10

Fate erasure logic of gene networks underlying direct neuronal conversion of somatic cells by microRNAs

Cates, K., Yuan, L., Yang, Y., & Yoo, A. S. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115153 · Cited by 11

Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease

Liu, M., Ma, S., Tai, W., Zhong, X., Ni, H., Zou, Y., Wang, J., & Zhang, C. (2024) · Cell Death and Disease · doi:10.1038/s41419-023-06395-7 · Cited by 10

REM Sleep Loss-Induced Elevated Noradrenaline Plays a Significant Role in Neurodegeneration: Synthesis of Findings to Propose a Possible Mechanism of Action from Molecule to Patho-Physiological Changes

Giri, S., Mehta, R., & Mallick, B. N. (2023) · Brain Sciences · doi:10.3390/brainsci14010008 · Cited by 9

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia

Mirfakhar, F. S., Marsh, J. A., Sato, C., Schache, K. J., Minaya, M., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., Macauley, S. L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70473-5 · Cited by 9

Age‐ and disease‐related autophagy impairment in Huntington disease: New insights from direct neuronal reprogramming

Luo, C., & Yang, J. (2024) · Aging Cell · doi:10.1111/acel.14285 · Cited by 9

Pathogenesis of polyglutamine diseases: Piecing together a complex molecular puzzle

Gonzalez, E. V., & Zoghbi, H. Y. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241336 · Cited by 9

Autophagy–NAD+ axis: emerging insights into neuronal homeostasis and neurodegenerative diseases

Koçak, G., Dimas, M. M., Silva, L., Silva-Amaral, D., Sun, C., Cruddas, S., Barrett, T. G., Martins‐de‐Souza, D., Cunha‐Neto, E., Brocardo, P. S., et al. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1695486 · Cited by 8

Patient-derived neuron model: Capturing age-dependent adult-onset degenerative pathology in Huntington’s disease

Oh, Y. M., & Lee, S. W. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100046 · Cited by 7

Deciphering disease signatures and molecular targets in vascular Ehlers-Danlos syndrome through transcriptome and miRNome sequencing of dermal fibroblasts

Chiarelli, N., Cinquina, V., Martini, P. G. V., Bertini, V., Zoppi, N., Venturini, M., Ritelli, M., & Colombi, M. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166915 · Cited by 7

Multiple Genes Core to ERAD, Macroautophagy and Lysosomal Degradation Pathways Participate in the Proteostasis Response in α1-Antitrypsin Deficiency

Li, J., Moretti, F., Hidvegi, T., Sviben, S., Fitzpatrick, J. A. J., Sundaramoorthi, H., Pak, S. C., Silverman, G. A., Knapp, B., Filipuzzi, I., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.02.006 · Cited by 6

Advancing Ischemic Stroke Prognosis: Key Role of MiR-155 Non-Coding RNA

Hering, C., & Conover, G. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26093947 · Cited by 7

Absence of Rab39b-induced macroautophagy impairment increases neurotoxic α-synuclein and causes degeneration of substantia nigra dopaminergic neurons in mouse model of X-linked Parkinson's disease

Chiu, C., Weng, Y.-H., Yeh, T., Chen, W.-S., Liu, S.-Y., Chiu, T.-J., Li, A. H.-L., & Wang, H. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123789 · Cited by 6

Insights and applications of direct neuronal reprogramming

Schaukowitch, K., Janas, J. A., & Wernig, M. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102128 · Cited by 8

Inborn errors of canonical autophagy in neurodegenerative diseases

Freisem, D., Hoenigsperger, H., Catanese, A., & Sparrer, K. M. J. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae179 · Cited by 6

Comparison of Oncogenes, Tumor Suppressors, and MicroRNAs Between Schizophrenia and Glioma: The Balance of Power

Brown, J. S. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105206 · Cited by 6

Reversing memory/cognitive impairment with medicinal plants targeting inflammation and its crosstalk with other pathologies

Tyler, S. E. B., & Tyler, L. D. K. (2023) · Brain Disorders · doi:10.1016/j.dscb.2023.100094 · Cited by 6

Microbiota dysbiosis impact on the immune system dysregulation in Huntington’s disease (HD)

Acharjee, P., Prasad, S. K., Singh, V. V., Ray, M., & Acharjee, A. (2025) · International review of neurobiology · doi:10.1016/bs.irn.2025.04.002 · Cited by 5

Moving CNS axon growth and regeneration research into human model systems

Lear, B. P., & Moore, D. L. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1198041 · Cited by 5

Dedifferentiation-like reprogramming of degenerative nucleus pulposus cells into notochordal-like cells by defined factors

Zhang, Y., Liang, C., Xu, H., Li, Y., Xia, K., Wang, L., Huang, X., Chen, J., Shu, J., Cheng, F., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.06.018 · Cited by 6

Pathobiology of the autophagy-lysosomal pathway in the Huntington’s disease brain

Berg, M. J., Veeranna, Rosa, C. M., Kumar, A. R., Mohan, P. S., Stavrides, P. H., Darji, S., Marchionini, D. M., Yang, D., & Nixon, R. A. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02131-8 · Cited by 15

Navigating the Autophagy Maze: ATG and Their Impact on Neurodegenerative Diseases

Amirian, R., Merati, A., Babamohamadi, M., Mirahmadi, Y., Esfahani, M. L., Rahmani, S., Izadi, Z., & Rezazadeh, D. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05332-3 · Cited by 4

Fountain of youth—Targeting autophagy in aging

Danics, L., Abbas, A. A., Kis, B., & Pircs, K. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1125739 · Cited by 4

Programming human cell fate: overcoming challenges and unlocking potential through technological breakthroughs

Lin, H., Makhlouf, A., Echegaray, C. V., Zawada, D. M., & Simões, F. C. (2023) · Development · doi:10.1242/dev.202300 · Cited by 4

Direct Reprogramming of Somatic Skin Cells from a Patient with Huntington’s Disease into Striatal Neurons to Create Models of Pathology

Kraskovskaya, N., Георгиевич, Х. М., Tomilin, A. N., & Mikhailova, N. (2024) · Doklady Biological Sciences · doi:10.1134/s0012496623700849 · Cited by 4

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte statePreprint

Paryani, F., Kwon, J., Ng, C. W., Madden, N., Ofori, K., Tang, A., Lü, H., Li, J., Mahajan, A., Davidson, S. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.08.556867 · Cited by 4

Efficacy of therapy by MK-28 PERK activation in the Huntington's disease R6/2 mouse model

Shacham, T., Offen, D., & Lederkremer, G. Z. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00335 · Cited by 3

Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice

Ou, K., Wang, X., Guo, M., Li, D., Zhang, C., Chen, L., Hou, J., Jia, Q., Zhu, L., Yang, S., et al. (2025) · Autophagy · doi:10.1080/15548627.2025.2549109 · Cited by 3

Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes

Kraskovskaya, N., Linkova, N. S., Sakhenberg, E. I., Kriger, D. V., Polyakova, V. O., Медведев, Д. С., Krasichkov, A. S., Георгиевич, Х. М., & Ryzhak, G. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111363 · Cited by 4

Metabolism-Mediated FGF5 Association with Stroke: Based on Mendelian Randomization and Bioinformatics Analysis

Xu, C., Xu, Y., Gao, L., Wang, M., Wang, G., & Wang, G. (2025) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s529168 · Cited by 2

MicroRNAs in neurodegenerative diseases: from molecular mechanisms to clinical biomarkers, detection methods and therapeutic strategies—advances and challenges

Azam, H. M. H., Mumtaz, M., Rödiger, S., Schierack, P., Hussain, N., & Ambreen, A. (2025) · Neurological Sciences · doi:10.1007/s10072-025-08419-w · Cited by 3

Targeting UCHL3 attenuates pathological markers in neuronal models of Huntington’s disease

Ishtayeh, H., Battistoni, E., Pochtar, S., McHugh, T. L. M., Tshilenge, K., Rossmiller, B. P., Amer‐Sarsour, F., Berdichevsky, Y., Muchtar, N., Weil, M., et al. (2026) · Brain · doi:10.1093/brain/awag028 · Cited by 2

SerpinA3N inhibits mitochondrial complex I activity to prevent neuron ferroptosis following cerebral ischemic stroke

Liu, X., Li, G., Guo, Y., Li, R., Yi, S., Ding, S., & Wan, J. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115370 · Cited by 2

Autophagy and Huntington's disease

Croce, K. R., Jasutkar, H. G., & Yamamoto, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95672-7.00018-2 · Cited by 2

Chemical screens in aging-relevant human motor neurons identify MAP4Ks as therapeutic targets for amyotrophic lateral sclerosisPreprint

Liu, M., Ma, S., Tai, W., Zhong, X., Ni, H., Zou, Y., wang, J., & Zhang, C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.24.538014 · Cited by 2

Robust CRISPR/dCas13 RNA blockers specifically perturb miRNA-target interactions and rescue type 1 myotonic dystrophy pathologyPreprint

Hanifi, M., Ateş, P. S., Wen, S., Fischer, M., Kroesen, A. E., Yu, Z., Wood, M., Thongjuea, S., Mead, A. J., Fulga, T. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.16.612263 · Cited by 2

Striatal neuronal models of Huntington's disease via direct conversion: Modeling age-dependent disease phenotypes

Oh, Y. M., Lee, S. W., & Yoo, A. S. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95672-7.00012-1 · Cited by 1

Autophagy-mediated cell death: Mechanisms and implications in neurodegenerative disorders

Zhang, L., Lü, Y., & Liu, B. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-32852-7.00017-6 · Cited by 1

Genetic dissection of Huntington’s disease modification by variation at RRM2B

Lee, K., Shin, B., Kim, M., Lee, S. W., Oh, Y. M., Kim, K., Jiang, A., Ko, K., Gillis, T., Lucente, D. E., et al. (2025) · Human Molecular Genetics · doi:10.1093/hmg/ddaf150 · Cited by 1

Hydrogen Sulfide Signaling in Neurodegenerative Movement Disorders

Pieper, A. A., & Paul, B. D. (2025) · Handbook of experimental pharmacology · doi:10.1007/164_2025_757 · Cited by 1

Targeting STAT3 in Alzheimer's disease: Potential mechanisms and therapeutic implications

Chen, P., Wang, R., Zhou, T., Sun, Y. N., Kirchhoff, F., Miao, Z., & Zhuang, C. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118785 · Cited by 1

DHCR24 in cholesterol metabolism and diseases of the nervous system

Zhu, H. G., Li, S., Yang, Y. Z., 张似青, Wang, Y., & Xiong, T. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-026-02954-x · Cited by 1

Three-dimensional direct neuronal reprogramming for modeling Alzheimer’s disease neuropathology

Sun, Z., Lee, Y., Walker, C. K., Karch, C. M. M., & Yoo, A. S. J. (2026) · Nature Protocols · doi:10.1038/s41596-026-01388-0 · Cited by 1

Roles of autophagy in brain homeostasis and disease

Kim, H., Wickstead, E. S., Zhou, X., Choi, I., & Yue, Z. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02426-6 · Cited by 1

Advancements in personalized stem cell models for aging-related neurodegenerative disorders

Weng, M., & Jauch, R. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01793 · Cited by 1

Suppression of the lncRNA TUG1 alleviates neuropathic pain in rats with chronic contractile injury via the miR-29b-3p/HMGB1 axis

Dong, J., Ding, Y., Xia, G., Guo, X., Jiang, L., & Ouyang, A. (2024) · Folia Neuropathologica · doi:10.5114/fn.2024.141512 · Cited by 1

Dermal Fibroblast Cell Line from a Patient with the Huntington’s Disease as a Promising Model for Studying Disease Pathogenesis: Production and Characterization

Kraskovskaya, N., Koltsova, A. M., Parfenova, P. S., Shatrova, A. N., Yartseva, N., Назаров, В. Д., Devyatkina, E., Георгиевич, Х. М., & Mikhailova, N. (2024) · Biochemistry (Moscow) · doi:10.1134/s000629792407006x · Cited by 1

Diagnostic Value of Serum miR-499a-5p in Chinese Children with Autism Spectrum Disorders

Ren, J., Bai, Y., Gao, J., Hou, Y., Mao, J., Gao, F., & Wang, J. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02296-2 · Cited by 1

Age-maintained human neurons demonstrate a developmental loss of intrinsic neurite growth abilityPreprint

Lear, B. P., Thompson, E. A. N., Rodriguez, K., Arndt, Z. P., Khullar, S., Klosa, P. C., Lu, R. J., Morrow, C. S., Risgaard, R. D., Peterson, E. R., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.23.541995 · Cited by 1

SAK3 confers neuroprotection in the neurodegeneration model of X-linked Dystonia-ParkinsonismPreprint

Aryal, S., Chen, S., Burbach, K. F., Yang, Y., Capano, L. S., Kim, W. K., Bragg, D. C., & Yoo, A. S. J. (2024) · Research Square · doi:10.21203/rs.3.rs-4068432/v1 · Cited by 1

Autophagic enhancer rescues Tau accumulation in a stem cell model of frontotemporal dementiaPreprint

Mirfakhar, F. S., Marsh, J. A., Minaya, M., Pak, S. C., Silverman, G. A., Perlmutter, D. H., Macauley, S. L., & Karch, C. M. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.30.615921 · Cited by 1

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Passarella, S., Brandes, K., Dankert, E., Cavalli, P., Kröger, A., Dieterich, D. C., & Landgraf, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.25.559304

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Fossel, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15500-0.00005-0

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Yoo, A. S. J., Church, V. A., Krzyżosiak, A., Chen, S., Kwon, J., Victor, M. B., Miao, B., Zhang, B., Dahiya, S. M., & Bertolotti, A. (2024) · Research Square · doi:10.21203/rs.3.rs-4104643/v1

Direct reprogramming of somatic skin cells from a patient with Huntington's disease into striatal neurons to create models of pathology

Kraskovskaya, N., Георгиевич, Х. М., Tomilin, A. N., & Mikhailova, N. (2024) · Доклады Российской академии наук Науки о жизни · doi:10.31857/s2686738924010131

Dermal Fibroblast Lines from a Patient with Huntington’s Disease as a Promising Model for Studying the Pathogenesis of the Disease: Production and Characterization

Kraskovskaya, N., Koltsova, A. M., Parfenova, P. S., Shatrova, A. N., Yartseva, N., Назаров, В. Д., Devyatkina, E., Георгиевич, Х. М., & Mikhailova, N. (2024) · Biochemistry (Moscow) · doi:10.31857/s0320972524070046

spRefine Denoises and Imputes Spatial Transcriptomics with a Reference-Free Framework Powered by Genomic Language ModelPreprint

Liu, T., Huang, T., Jin, W., Chu, T., Ying, R., & Zhao, H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.22.649977

Post-transcriptional regulation in intervertebral disc degeneration

Li, X., Liang, H., Du, Z., Shi, R., Song, Y., & Yang, C. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102037

Decoding Non-Neuronal Mechanisms and Therapeutic Targets in Huntington’s Disease Through Integrative Transcriptomics and Machine Learning

Gupta, H., Singh, S., Kaushik, A. C., Awasthi, A. K., & Sahi, S. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02463-z

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD- associated Transcriptomic Networks and PathologyPreprint

Langfelder, P., Wang, N., Ramanathan, L., Oh, Y. M., Lee, S., Gao, F., Gu, X., Stricos, M., Plascencia, M., Vaca, R., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.02.709091

Deubiquitinases at organelle quality control bottlenecks in neurodegeneration

Ellerby, L., & Ashkenazi, A. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.05.006

CDKN1A protects medium spiny neurons from Huntington's disease pathology

Lee, S. W., Upshaw, T. J., Bailey, D. J., Lee, S.-A., Kim, J., Joshi, P., Smith, G. E., Swinford, S., & Oh, Y. M. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107522

Direct neuronal reprogramming for neurological diseases: applications, translational Challenges, and future directions

Chen, Y., Zheng, Z., Zhao, P., Zhu, J., Sun, H., Zhu, H., Zeng, Y., Shang, B., Zhang, A., Pan, Y., et al. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1889859

Sequalae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons

Klinman, E., Kwon, J.-S., Dolle, R. E., Pak, S. C., Silverman, G. A., Perlmutter, D. H., & Yoo, A. S. J. (2026) · Autophagy · doi:10.1080/15548627.2026.2719435 · Cited by 1

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Li, J., Duan, H., Hao, P., Zhao, W., Gao, Y., Yang, Z., & Li, X. (2026) · Translational research · doi:10.1016/j.trsl.2026.08.005

Identification of Age-Associated Upstream Regulators to Promote Neuronal Resilience in HD Patient-Derived Neurons

Oh, Y. M., Bacallao, E. A., Lee, S.-A., Kim, J., Swinford, S., Smith, G. E., Britt, B., Abdalla, S. M., & Lee, S. W. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01711-5

miR-196a reduces mutant Huntingtin aggregates by Rad23b-mediated degradation in Huntington’s disease

Tung, C.-W., Chan, S. C., Chen, Y.-C., Wu, P., Cheng, P., Chen, C., & Yang, S. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-026-01292-5

Modeling human neurodegeneration with iPSCs: opportunities, limitations, and the challenge of aging

Wang, S., Elia, L., Liu, W., & Finkbeiner, S. M. (2026) · Journal of Clinical Investigation · doi:10.1172/jci209602

Neuroprotective Role of Withaferin A in Huntington’s Disease: Current Evidence and Future Perspectives

Kumari, R., Gupta, V., Devi, K., Chand, D., Dhanasekaran, M., & Agarwal, S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06274-0

HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space

Ramos, E. S., Boeddrich, A., Haenig, C., Trepte, P., Ammar, O., Secker, C., Popp, O., Ivanov, A., Beetz, S., Roth, L., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2611301123 · Cited by 2

Modeling Huntington disease through microRNA-mediated neuronal reprogramming identifies age-associated autophagy dysfunction driving the onset of neurodegeneration

Oh, Y. M., Lee, S. W., & Yoo, A. S. J. (2023) · Autophagy · doi:10.1080/15548627.2023.2175572 · Cited by 20

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Oh, Y. M., Lee, S. W., & Yoo, A. S. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95672-7.00012-1 · Cited by 1

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Luo, C., & Yang, J. (2024) · Aging Cell · doi:10.1111/acel.14285 · Cited by 9

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Identification of Age-Associated Upstream Regulators to Promote Neuronal Resilience in HD Patient-Derived Neurons

Oh, Y. M., Bacallao, E. A., Lee, S.-A., Kim, J., Swinford, S., Smith, G. E., Britt, B., Abdalla, S. M., & Lee, S. W. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-026-01711-5