Cited by 23Ovarian cancer diagnosis and treatmentPARP inhibition in cancer therapyBRCA gene mutations in cancer

Can integrative biomarker approaches improve prediction of platinum and PARP inhibitor response in ovarian cancer?

Funingana, Ionut-Gabriel, Reinius, Marika A.V., Petrillo, Angelica, Ang, Joo Ern, Brenton, James D.·2021·Seminars in Cancer Biology

Abstract

Epithelial ovarian carcinoma (EOC) encompasses distinct histological, molecular and genomic entities that determine intrinsic sensitivity to platinum-based chemotherapy. Current management of each subtype is determined by factors including tumour grade and stage, but only a small number of biomarkers can predict treatment response. The recent incorporation of PARP inhibitors into routine clinical practice has underscored the need to personalise ovarian cancer treatment based on tumour biology. In this article, we review the strengths and limitations of predictive biomarkers in current clinical practice and highlight integrative strategies that may inform the development of future personalised medicine programs and composite biomarkers.

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Crossref · 10.1016/j.semcancer.2021.02.008

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Authors
Funingana, I.-G., Reinius, M. A. V., Petrillo, A., Ang, J. E., & Brenton, J. D.
Affiliations
  • University of Cambridge (GB)
  • University of Campania "Luigi Vanvitelli" (IT)
Corresponding author
Petrillo, Angelica
Venue
Seminars in Cancer Biology
Publisher
Elsevier BV
Published
2021-12
Volume
77
Pages
67-82
ISSN
1044-579X (ISSN-L)
OpenAlex
W3132039413
Cited by
23
References
217
Citations by year
2026: 3 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Cancer Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
GlaxoSmithKline
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
  • Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Keywords
epithelial ovarian cancer, predictive biomarkers, platinum chemotherapy response, PARP inhibitors, treatment response prediction, composite biomarker, personalized medicine, tumor subtypes
MeSH terms
Poly(ADP-ribose) Polymerase Inhibitors, Carcinoma, Ovarian Epithelial, Animals, Antineoplastic Agents, Female, Humans, Biomarkers, Tumor, Treatment Outcome, Platinum Compounds, Drug Resistance, Neoplasm, Precision Medicine

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