SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

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Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

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Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies

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Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain

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D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation

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A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification

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Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

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A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

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Evolution of the SARS-CoV-2 Omicron Variants: Genetic Impact on Viral Fitness

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A single intranasal dose of a live-attenuated parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in hamsters

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Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry

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High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

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Millisecond dynamic of SARS‐CoV‐2 spike and its interaction with ACE2 receptor and small extracellular vesicles

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Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses

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Rapid development of an updated mRNA vaccine against the SARS-CoV-2 Omicron variant

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Emerging SARS-CoV-2 variants: Why, how, and what's next?

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Preclinical evaluation of a SARS-CoV-2 mRNA vaccine PTX-COVID19-B

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Expression and characterization of SARS-CoV-2 spike proteins

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In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding

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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

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Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge

Zhu, C., He, G., Yin, Q., Zeng, L., Ye, X., Shi, Y., & Xu, W. (2021) · Journal of Medical Virology · doi:10.1002/jmv.27132 · Cited by 61

The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron

Toelzer, C., Gupta, K., Yadav, S. K. N., Hodgson, L. R., Williamson, M. K., Buzas, D., Borucu, U., Powers, K. T., Stenner, R., Vasileiou, K., et al. (2022) · Science Advances · doi:10.1126/sciadv.adc9179 · Cited by 49

Why All the Fury over Furin?

Osman, E. E. A., Rehemtulla, A., & Neamati, N. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00518 · Cited by 54

Structural Plasticity and Immune Evasion of SARS-CoV-2 Spike Variants

Ghimire, D., Han, Y., & Lu, M. (2022) · Viruses · doi:10.3390/v14061255 · Cited by 44

Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core

Pak, A. J., Yu, A., Ke, Z., Briggs, J. A. G., & Voth, G. A. (2022) · Nature Communications · doi:10.1038/s41467-022-28654-5 · Cited by 47

Evolutionary Dynamics and Epidemiology of Endemic and Emerging Coronaviruses in Humans, Domestic Animals, and Wildlife

Islam, A., Ferdous, J., Islam, S., Sayeed, M. A., Choudhury, S. D., Saha, O., Hassan, M. M., & Shirin, T. (2021) · Viruses · doi:10.3390/v13101908 · Cited by 52

Mechanisms of Lung Injury Induced by SARS-CoV-2 Infection

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The Genetic Variant of SARS-CoV-2: Would it matter for Controlling the Devastating Pandemic?

Guo, S., Liu, K., & Zheng, J. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.59137 · Cited by 46

A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination

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Molecular insights into the adaptive evolution of SARS-CoV-2 spike protein

Yao, Z., Zhang, L., Duan, Y., Tang, X., & Lü, J. (2024) · Journal of Infection · doi:10.1016/j.jinf.2024.106121 · Cited by 49

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses

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Structure and Mutations of SARS-CoV-2 Spike Protein: A Focused Overview

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Expanded ACE2 dependencies of diverse SARS-like coronavirus receptor binding domains

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Profiles of current COVID-19 vaccines

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Computational screening of 645 antiviral peptides against the receptor-binding domain of the spike protein in SARS-CoV-2

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Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview

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Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spike

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Discovering covalent inhibitors of protein–protein interactions from trillions of sulfur(VI) fluoride exchange-modified oligonucleotides

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Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 Variants

van Oosten, L., Altenburg, J. J., Fougeroux, C. E., Geertsema, C., van den End, F., Evers, W. A. C., Westphal, A. H., Lindhoud, S., van den Berg, W., Swarts, D. C., et al. (2021) · mBio · doi:10.1128/mbio.01813-21 · Cited by 43

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage

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Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding DomainsPreprint

Zhou, T., Tsybovsky, Y., Olia, A. S., Gorman, J., Rapp, M., Cerutti, G., Chuang, G., Katsamba, P. S., Nazzari, A. F., Sampson, J. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.04.187989 · Cited by 48

The Importance of Research on the Origin of SARS-CoV-2

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Brief review on repurposed drugs and vaccines for possible treatment of COVID-19

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Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes

Mikolajek, H., Weckener, M., Brotzakis, Z. F., Huo, J., Dalietou, E. V., Bas, A. L., Sormanni, P., Harrison, P. J., Ward, P. N., Truong, S. D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205412119 · Cited by 39

Effects of SARS-CoV-2 Inflammation on Selected Organ Systems of the Human Body

Kopańska, M., Barnaś, E., Błajda, J., Kuduk, B., Łagowska, A., & Banaś-Ząbczyk, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084178 · Cited by 45

Spike residue 403 affects binding of coronavirus spikes to human ACE2

Zech, F., Schniertshauer, D., Jung, C., Herrmann, A., Cordsmeier, A., Xie, Q., Nchioua, R., Bozzo, C. P., Volčič, M., Koepke, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27180-0 · Cited by 47

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

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SARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype

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XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against emerging SARS-CoV-2 variantsPreprint

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COVID-19 vaccines uptake: Public knowledge, awareness, perception and acceptance among adult Africans

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Allosteric perspective on the mutability and druggability of the SARS-CoV-2 Spike protein

Tan, Z. W., Tee, W.-V., Samsudin, F., Guarnera, E., Bond, P. J., & Berezovsky, I. N. (2022) · Structure · doi:10.1016/j.str.2021.12.011 · Cited by 38

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike functionPreprint

Martin, D. P., Lytras, S., Lucaci, A. G., Maier, W., Grüning, B. A., Shank, S. D., Weaver, S., MacLean, O. A., Orton, R. J., Lemey, P., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.14.476382 · Cited by 40

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Tan, C. C. S., Trew, J., Peacock, T. P., Mok, K. Y., Hart, C., Lau, K., Ni, D., Orme, C. D. L., Ransome, E., Pearse, W. D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38717-w · Cited by 34

Should we discount the laboratory origin of COVID-19?

Segreto, R., Deigin, Y., McCairn, K., Sousa, A., Sirotkin, D., Sirotkin, K. M., Couey, J. J., Jones, A., & Zhang, D. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01211-0 · Cited by 42

SARS‐CoV‐2 variants preferentially emerge at intrinsically disordered protein sites helping immune evasion

Quaglia, F., Salladini, E., Carraro, M., Minervini, G., Tosatto, S. C. E., & Mercier, P. L. (2022) · FEBS Journal · doi:10.1111/febs.16379 · Cited by 36

Variant-driven early warning via unsupervised machine learning analysis of spike protein mutations for COVID-19

de Hoffer, A., Vatani, S., Cot, C., Cacciapaglia, G., Chiusano, M. L., Cimarelli, A., Conventi, F., Giannini, A., Hohenegger, S., & Francesco Sannino, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-12442-8 · Cited by 39

Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses

Ou, X., Xu, G. Z., Li, P., Liu, Y., Zan, F., Liu, P., Hu, J., Lu, X., Dong, S., Zhou, Y., et al. (2023) · Cell Discovery · doi:10.1038/s41421-023-00581-9 · Cited by 35

Characterization of an attenuated SARS-CoV-2 variant with a deletion at the S1/S2 junction of the spike protein

Wang, P., Lau, S.-Y., Deng, S., Chen, P., Mok, B. W.-Y., Zhang, J., Lee, A. C.-Y., Chan, K., Tam, R. C.-Y., Xu, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23166-0 · Cited by 37

Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications

Higashikuni, Y., Liu, W., Obana, T., & Sata, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112081 · Cited by 38

SARS-CoV-2 B.1.617 emergence and sensitivity to vaccine-elicited antibodies

Mlčochová, P., Kemp, S. A., Dhar, M. S., Papa, G., Meng, B., Mishra, S., Whittaker, C., Mellan, T. A., Ferreira, I., Datir, R. P., et al. (2021) · Greater South Information System · doi:10.60692/dy28a-h7650 · Cited by 44

Targeting Crucial Host Factors of SARS-CoV-2

Tharappel, A. M., Samrat, S. K., Li, Z., & Li, H. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00456 · Cited by 36

TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restriction

Khan, H., Winstone, H., Jiménez-Guardeño, J. M., Graham, C., Doores, K. J., Goujon, C., Matthews, D. A., Davidson, A. D., Rihn, S. J., Palmarini, M., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009820 · Cited by 34

Analysis of Glycosylation and Disulfide Bonding of Wild-Type SARS-CoV-2 Spike Glycoprotein

Zhang, S., Go, E. P., Ding, H., Anang, S., Kappes, J. C., Desaire, H., & Sodroski, J. (2021) · Journal of Virology · doi:10.1128/jvi.01626-21 · Cited by 39

Adaptive Evolution of the Spike Protein in Coronaviruses

Tang, X., Qian, Z., Lu, X., & Lü, J. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad089 · Cited by 36

The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2

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Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

Gupta, K., Toelzer, C., Williamson, M. K., Shoemark, D. K., Oliveira, A. S. F., Matthews, D. A., Almuqrin, A., Staufer, O., Yadav, S. K. N., Borucu, U., et al. (2022) · Nature Communications · doi:10.1038/s41467-021-27881-6 · Cited by 37

Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2Preprint

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Insights on the mutational landscape of the SARS-CoV-2 Omicron variantPreprint

Miller, N. L., Clark, T., Raman, R., & Sasisekharan, R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.06.471499 · Cited by 35

Host range, transmissibility and antigenicity of a pangolin coronavirus

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Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike

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Evolution of a globally unique SARS-CoV-2 Spike E484T monoclonal antibody escape mutation in a persistently infected, immunocompromised individual

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