3D microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells
Open accessAbstract
Immunotherapy efficacy relies on the crosstalk within the tumor microenvironment between cancer and dendritic cells (DCs) resulting in the induction of a potent and effective antitumor response. DCs have the specific role of recognizing cancer cells, taking up tumor antigens (Ags) and then migrating to lymph nodes for Ag (cross)-presentation to naïve T cells. Interferon-α-conditioned DCs (IFN-DCs) exhibit marked phagocytic activity and the special ability of inducing Ag-specific T-cell response. Here, we have developed a novel microfluidic platform recreating tightly interconnected cancer and immune systems with specific 3D environmental properties, for tracking human DC behaviour toward tumor cells. By combining our microfluidic platform with advanced microscopy and a revised cell tracking analysis algorithm, it was possible to evaluate the guided efficient motion of IFN-DCs toward drug-treated cancer cells and the succeeding phagocytosis events. Overall, this platform allowed the dissection of IFN-DC-cancer cell interactions within 3D tumor spaces, with the discovery of major underlying factors such as CXCR4 involvement and underscored its potential as an innovative tool to assess the efficacy of immunotherapeutic approaches.
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More dendritic cells migrated and infiltrated to treated tumor cells than to non-treated tumor cells.
“More DCs migrated and infiltrated to treated tumor cells than to non-treated tumor cells (Figure 4C)”
From Cancer-on-chip models for metastasis: importance of the tumor microenvironment (2024) · cites this paper as [107]
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Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250 · see citing works
The present and future role of microfluidics in biomedical research
Sackmann, E. K., Fulton, A. L., & Beebe, D. J. (2014) · Nature · doi:10.1038/nature13118 · Cited by 2,995 · see citing works
Soft lithography for micro- and nanoscale patterning
Qin, D., Xia, Y., & Whitesides, G. M. (2010) · Nature Protocols · doi:10.1038/nprot.2009.234 · Cited by 2,339 · see citing works
From 3D cell culture to organs-on-chips
Huh, D., Hamilton, G. A., & Ingber, D. E. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.09.005 · Cited by 1,834 · see citing works
Methods for cell and particle tracking.
Meijering, E., Dzyubachyk, O., & Smal, I. (2012) · Methods in Enzymology · doi:10.1016/b978-0-12-391857-4.00009-4 · Cited by 1,471 · see citing works
Type I interferons in anticancer immunity
Zitvogel, L., Galluzzi, L., Kepp, O., Smyth, M. J., & Kroemer, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3845 · Cited by 1,305 · see citing works
Organs-on-chips at the frontiers of drug discovery
Esch, E. W., Bahinski, A., & Huh, D. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4539 · Cited by 1,185 · see citing works
Jongbloed, S. L., Kassianos, A. J., McDonald, K. J., Clark, G. J., Ju, X., Angel, C. E., Chen, C. J., Dunbar, P. R., Wadley, R. B., Jeet, V., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092140 · Cited by 1,019 · see citing works
Dendritic Cells and Cancer Immunity
Gardner, A., & Ruffell, B. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.006 · Cited by 896 · see citing works
Mechanical modes of ‘amoeboid’ cell migration
Lämmermann, T., & Sixt, M. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.05.003 · Cited by 669 · see citing works
Collagen-based cell migration models in vitro and in vivo
Wolf, K., Alexander, S., Schacht, V., Coussens, L. M., von Andrian, U. H., van Rheenen, J., Deryugina, E., & Friedl, P. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.08.005 · Cited by 637 · see citing works
Microfluidic assay for simultaneous culture of multiple cell types on surfaces or within hydrogels
Shin, Y., Han, S., Jeon, J. S., Yamamoto, K., Zervantonakis, I. K., Sudo, R., Kamm, R. D., & Chung, S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.051 · Cited by 617 · see citing works
Engineered In Vitro Disease Models
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554 · see citing works
Doyle, A. D., Carvajal, N., Jin, A. J., Matsumoto, K., & Yamada, K. M. (2015) · Nature Communications · doi:10.1038/ncomms9720 · Cited by 462 · see citing works
Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1
Vacchelli, E., Ma, Y., Baracco, E. E., Sistigu, A., Enot, D. P., Pietrocola, F., Yang, H., Adjemian, S., Chaba, K., Semeraro, M., et al. (2015) · Science · doi:10.1126/science.aad0779 · Cited by 452 · see citing works
Self-citationDendritic Cells: Master Regulators of the Immune Response
Mellman, I. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0102 · Cited by 329 · see citing works
Dendritic cell biology and regulation of dendritic cell trafficking by chemokines
Caux, C., Aït‐Yahia, S., Chemin, K., de BOUTEILLER, O., Dieu‐Nosjean, M., Homey, B., Massacrier, C., Vanbervliet, B., Zlotnik, A., & Vicari, A. P. (2000) · Springer Seminars in Immunopathology · doi:10.1007/s002810000053 · Cited by 313 · see citing works
Mechanisms of tumor cell extravasation in an in vitro microvascular network platform
Chen, M. B., Whisler, J. A., Jeon, J. S., & Kamm, R. D. (2013) · Integrative Biology · doi:10.1039/c3ib40149a · Cited by 308 · see citing works
Immunotherapy and tumor microenvironment
Tang, H., Qiao, J., & Fu, Y. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.009 · Cited by 306 · see citing works
Parlato, S., Santini, S. M., Lapenta, C., Pucchio, T. D., Logozzi, M., Spada, M., Giammarioli, A. M., Malorni, W., Fais, S., & Belardelli, F. (2001) · Blood · doi:10.1182/blood.v98.10.3022 · Cited by 259 · see citing works
Self-citationVanbervliet, B., Bendriss‐Vermare, N., Massacrier, C., Homey, B., de BOUTEILLER, O., Brière, F., Trinchieri, G., & Caux, C. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20020437 · Cited by 248 · see citing works
Jacobelli, J., Friedman, R. S., Conti, M. A., Lennon‐Duménil, A., Piel, M., Sorensen, C. M., Adelstein, R. S., & Krummel, M. F. (2010) · Nature Immunology · doi:10.1038/ni.1936 · Cited by 234 · see citing works
Microfluidics: A New Tool for Modeling Cancer–Immune Interactions
Boussommier-Calleja, A., Li, R., Chen, M. B., Wong, S. C., & Kamm, R. D. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2015.12.003 · Cited by 224 · see citing works
A microengineered pathophysiological model of early-stage breast cancer
Choi, Y., Hyun, E., Seo, J., Blundell, C., Kim, H. C., Lee, E., Lee, S. H., Moon, A., Moon, W. K., & Huh, D. (2015) · Lab on a Chip · doi:10.1039/c5lc00514k · Cited by 222 · see citing works
Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells
Vargas, P., Maiuri, P., Bretou, M., Sáez, P. J., Pierobon, P., Maurin, M., Chabaud, M., Lankar, D., Obino, D., Terriac, E., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3284 · Cited by 220 · see citing works
Augmenting Antitumor Immune Responses with Epigenetic Modifying Agents
Héninger, E., Krueger, T. E. G., & Lang, J. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00029 · Cited by 194 · see citing works
Human-on-chip for therapy development and fundamental science
Luni, C., Serena, E., & Elvassore, N. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.08.015 · Cited by 169 · see citing works
Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment
Businaro, L., De Ninno, A., Schiavoni, G., Lucarini, V., Ciasca, G., Gerardino, A., Belardelli, F., Gabriele, L., & Mattei, F. (2013) · Lab Chip · doi:10.1039/c2lc40887b · Cited by 162 · see citing works
Self-citationThe Immune System in Cancer Prevention, Development and Therapy
Candéias, S. M., & Gaipl, U. S. (2015) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520615666150824153523 · Cited by 153 · see citing works
Dendritic Cells as Pharmacological Tools for Cancer Immunotherapy
Anguille, S., Smits, E., Bryant, C. E., Acker, H. H. V., Goossens, H., Lion, E., Fromm, P. D., Hart, D. N. J., Tendeloo, V. F. V., & Berneman, Z. N. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009456 · Cited by 152 · see citing works
Spadaro, F., Lapenta, C., Donati, S., Abalsamo, L., Barnaba, V., Belardelli, F., Santini, S. M., & Ferrantini, M. (2011) · Blood · doi:10.1182/blood-2011-06-363564 · Cited by 150 · see citing works
Constantino, J., Gomes, C. M. F., Falcão, A. C., Cruz, M. T., & Neves, B. M. (2015) · Translational research · doi:10.1016/j.trsl.2015.07.008 · Cited by 147 · see citing works
Migration of dendritic cells: physical principles, molecular mechanisms, and functional implications
Heuzé, M. L., Vargas, P., Chabaud, M., Berre, M. L., Liu, Y., Collin, O., Solanes, P., Voituriez, R., Piel, M., & Lennon‐Duménil, A. (2013) · Immunological Reviews · doi:10.1111/imr.12108 · Cited by 134 · see citing works
Cell stretching devices as research tools: engineering and biological considerations
Kamble, H., Barton, M., Jun, M., Park, S., & Nguyen, N. (2016) · Lab on a Chip · doi:10.1039/c6lc00607h · Cited by 112 · see citing works
Microfluidic platform for the quantitative analysis of leukocyte migration signatures
Boneschansker, L., Yan, J., Wong, E. A., Briscoe, D. M., & Irimia, D. (2014) · Nature Communications · doi:10.1038/ncomms5787 · Cited by 108 · see citing works
Blasio, S. D., Wortel, I. M. N., van Bladel, D. A. G., de Vries, L. E., Boer, T. D., Worah, K., de Haas, N., Buschow, S. I., de Vries, I. J. M., Figdor, C. G., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1192739 · Cited by 105 · see citing works
Ma, Y., Adjemian, S., Yang, H., Catani, J. P. P., Hannani, D., Martins, I., Michaud, M., Kepp, O., Sukkurwala, A. Q., Vacchelli, E., et al. (2013) · OncoImmunology · doi:10.4161/onci.24568 · Cited by 97 · see citing works
Microfluidic single-cell analysis for systems immunology
Junkin, M., & Tay, S. (2014) · Lab on a Chip · doi:10.1039/c3lc51182k · Cited by 96 · see citing works
Vermi, W., Fisogni, S., Salogni, L., Schärer, L., Kutzner, H., Sozzani, S., Lonardi, S., Rossini, C., Calzavara‐Pinton, P., LeBoit, P. E., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.256 · Cited by 94 · see citing works
Cancer-driven dynamics of immune cells in a microfluidic environment
Agliari, E., Biselli, E., De Ninno, A., Schiavoni, G., Gabriele, L., Gerardino, A., Mattei, F., Barra, A., & Businaro, L. (2014) · Scientific Reports · doi:10.1038/srep06639 · Cited by 91 · see citing works
Self-citationGunzer, M., Friedl, P., Niggemann, B., Bröcker, E., Kämpgen, E., & Zänker, K. S. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.5.622 · Cited by 83 · see citing works
‘Organs-on-chips’ go mainstream
Reardon, S. (2015) · Nature · doi:10.1038/523266a · Cited by 81 · see citing works
Parlato, S., Romagnoli, G., Spadaro, F., Canini, I., Sirabella, P., Borghi, P., Ramoni, C., Filesi, I., Biocca, S., Gabriele, L., et al. (2009) · Blood · doi:10.1182/blood-2009-07-234468 · Cited by 79 · see citing works
Self-citationSpel, L., Boelens, J. J., Nierkens, S., & Boes, M. L. (2013) · OncoImmunology · doi:10.4161/onci.26403 · Cited by 74 · see citing works
Gabriele, L., Borghi, P., Rozera, C., Sestili, P., Andreotti, M., Guarini, A. R., Montefusco, E., Foà, R., & Belardelli, F. (2003) · Blood · doi:10.1182/blood-2003-03-0981 · Cited by 73 · see citing works
Self-citationGouwy, M., Buck, M. D., Pörtner, N., Opdenakker, G., Proost, P., Struyf, S., & Damme, J. V. (2014) · European Journal of Immunology · doi:10.1002/eji.201444818 · Cited by 69 · see citing works
Quatrini, L., Molfetta, R., Zitti, B., Peruzzi, G., Fionda, C., Capuano, C., Galandrini, R., Cippitelli, M., Santoni, A., & Paolini, R. (2015) · Science Signaling · doi:10.1126/scisignal.aab2724 · Cited by 68 · see citing works
Self-citationTaking the lymphatic route: dendritic cell migration to draining lymph nodes
Teijeira, Á., Russo, E., & Halin, C. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-013-0410-8 · Cited by 66 · see citing works
Take two: Combining immunotherapy with epigenetic drugs to tackle cancer
Weintraub, K. (2016) · Nature Medicine · doi:10.1038/nm0116-8 · Cited by 62 · see citing works
Chemokines, Costimulatory Molecules and Fusion Proteins for the Immunotherapy of Solid Tumors
Lechner, M. G., Russell, S. M., Bass, R. S., & Epstein, A. L. (2011) · Immunotherapy · doi:10.2217/imt.11.115 · Cited by 58 · see citing works
Mattei, F., Schiavoni, G., Sestili, P., Spadaro, F., Fragale, A., Sistigu, A., Lucarini, V., Spada, M., Sanchez, M., Scala, S., et al. (2012) · Neoplasia · doi:10.1593/neo.121444 · Cited by 57 · see citing works
Self-citationRizza, P., Moretti, F., Capone, I., & Belardelli, F. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.10.002 · Cited by 48 · see citing works
Dendritic Cell Interactions with Lymphatic Endothelium
Russo, E., Nitschké, M., & Halin, C. (2013) · Lymphatic Research and Biology · doi:10.1089/lrb.2013.0008 · Cited by 41 · see citing works
Rozera, C., Cappellini, G. A., D’Agostino, G., Santodonato, L., Castiello, L., Urbani, F., Macchia, I., Aricò, E., Casorelli, I., Sestili, P., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0473-5 · Cited by 41 · see citing works
Lei, K. F., Tseng, H.-P., Lee, C., & Tsang, N. (2016) · Scientific Reports · doi:10.1038/srep25557 · Cited by 38 · see citing works
Therapy-induced microenvironmental changes in cancer
Ma, Y., Yang, H., Pitt, J. M., Kroemer, G., & Zitvogel, L. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1401-8 · Cited by 32 · see citing works
Buoncervello, M., Romagnoli, G., Buccarelli, M., Fragale, A., Toschi, E., Parlato, S., Lucchetti, D., Macchia, D., Spada, M., Canini, I., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8379 · Cited by 31 · see citing works
Self-citationStudy of dendritic cell migration using micro-fabrication
Vargas, P., Chabaud, M., Thiam, H. R., Lankar, D., Piel, M., & Lennon‐Duménil, A. (2015) · Journal of Immunological Methods · doi:10.1016/j.jim.2015.12.005 · Cited by 30 · see citing works
Loss of Gadkin Affects Dendritic Cell Migration In Vitro
Schachtner, H., Weimershaus, M., Stache, V., Plewa, N., Legler, D. F., Höpken, U. E., & Maritzen, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143883 · Cited by 21 · see citing works
IFN-α Regulates Blimp-1 Expression via miR-23a and miR-125b in Both Monocytes-Derived DC and pDC
Parlato, S., Bruni, R., Fragapane, P., Salerno, D., Marcantonio, C., Borghi, P., Tataseo, P., Ciccaglione, A. R., Presutti, C., Romagnoli, G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072833 · Cited by 20 · see citing works
Self-citationExploiting dendritic cells in the development of cancer vaccines
Bracci, L., Capone, I., Moschella, F., Proietti, E., & Belardelli, F. (2013) · Expert Review of Vaccines · doi:10.1586/14760584.2013.836905 · Cited by 18 · see citing works
Study of Chemotaxis and Cell–Cell Interactions in Cancer with Microfluidic Devices
Sai, J., Rogers, M., Hockemeyer, K., Wikswo, J. P., & Richmond, A. J. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2015.09.023 · Cited by 18 · see citing works
Patel, V. I., & Metcalf, J. P. (2016) · Journal of Investigative Medicine · doi:10.1136/jim-2016-000072 · Cited by 18 · see citing works
Dendritic Cells in the Context of Human Tumors: Biology and Experimental Tools
Volovitz, I., Melzer, S., Amar, S., Bocsi, J., Bloch, M., Efroni, S., Ram, Z., & Tárnok, A. (2016) · International Reviews of Immunology · doi:10.3109/08830185.2015.1096935 · Cited by 18 · see citing works
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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Buqué, A., Chan, T. A.-T., Coukos, G., Demaria, S., Deutsch, É., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000337 · Cited by 1,151 · see citing works
Self-citationRecent advances in microfluidic technologies for cell-to-cell interaction studies
Rothbauer, M., Zirath, H., & Ertl, P. (2018) · Lab on a Chip · doi:10.1039/c7lc00815e · Cited by 277 · see citing works
Personalized Cancer Medicine: An Organoid Approach
Es, H. A., Montazeri, L., Aref, A. R., Vosough, M., & Baharvand, H. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2017.12.005 · Cited by 277 · see citing works
Organ-on-a-chip meets artificial intelligence in drug evaluation
Deng, S., Li, C., Cao, J., Cui, Z., Du, J., Fu, Z. H., Yang, H., & Chen, P. (2023) · Theranostics · doi:10.7150/thno.87266 · Cited by 272 · see citing works
Nguyen, M., De Ninno, A., Mencattini, A., Mermet-Meillon, F., Fornabaio, G., Evans, S. S., Cossutta, M., Khira, Y., Han, W., Sirven, P., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.12.015 · Cited by 184 · see citing works
Self-citationZoetemelk, M., Rausch, M., Colin, D., Dormond, O., & Nowak-Sliwinska, P. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-42836-0 · Cited by 149 · see citing works
Applications of tumor chip technology
Hachey, S. J., & Hughes, C. C. W. (2018) · Lab on a Chip · doi:10.1039/c8lc00330k · Cited by 128 · see citing works
Tumor-on-chip modeling of organ-specific cancer and metastasis
Piccolo, N. D., Shirure, V. S., Bi, Y., Goedegebuure, S. P., Gholami, S., Hughes, C. C. W., Fields, R. C., & George, S. C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.008 · Cited by 130 · see citing works
Metastasis in context: modeling the tumor microenvironment with cancer-on-a-chip approaches
Sleeboom, J. J. F., Eslami Amirabadi, H., Nair, P., Sahlgren, C. M., & den Toonder, J. M. J. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.033100 · Cited by 122 · see citing works
Evaluating CAR‐T Cell Therapy in a Hypoxic 3D Tumor Model
Ando, Y., Siegler, E. L., Ta, H. P., Cinay, G. E., Zhou, H., Gorrell, K. A., Au, H., Jarvis, B. M., Wang, P., & Shen, K. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900001 · Cited by 114 · see citing works
3D Bioprinting of Tumor Models for Cancer Research
Kang, Y., Datta, P., Shanmughapriya, S., & Ozbolat, I. T. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00791 · Cited by 112 · see citing works
An Overview of Organs-on-Chips Based on Deep Learning
Li, J., Chen, J., Bai, H., Wang, H., Hao, S., Ding, Y., Peng, B., Zhang, J., Li, L., & Huang, W. (2022) · Research · doi:10.34133/2022/9869518 · Cited by 113 · see citing works
3D models in the new era of immune oncology: focus on T cells, CAF and ECM
Modugno, F. D., Colosi, C., Trono, P., Antonacci, G., Ruocco, G., & Nisticò, P. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1086-2 · Cited by 111 · see citing works
Shim, S., Belanger, M. C., Harris, A. R., Munson, J. M., & Pompano, R. R. (2019) · Lab on a Chip · doi:10.1039/c8lc00957k · Cited by 108 · see citing works
Racioppi, L., Nelson, E. R., Huang, W., Mukherjee, D., Lawrence, S. A., Lento, W. E., Masci, A. M., Jiao, Y., Park, S. H., York, B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10424-5 · Cited by 103 · see citing works
Self-citationA multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions
Moore, N., Doty, D. T., Zielstorff, M., Kariv, I., Moy, L. Y., Gimbel, A. A., Chevillet, J. R., Lowry, N., Santos, J. A. L., Mott, V. L., et al. (2018) · Lab on a Chip · doi:10.1039/c8lc00256h · Cited by 106 · see citing works
Zhang, J., Tavakoli, H., Ma, L., Li, X., Han, L., & Li, X. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114365 · Cited by 110 · see citing works
Dadgar, N., Gonzalez-Suarez, A. M., Fattahi, P., Hou, X., Weroha, J. S., Gaspar-Maia, A., Stybayeva, G., & Revzin, A. (2020) · Microsystems & Nanoengineering · doi:10.1038/s41378-020-00201-6 · Cited by 99 · see citing works
The emergence of 3D bioprinting in organ-on-chip systems
Fetah, K., Tebon, P. J., Goudie, M. J., Eichenbaum, J., Ren, L. M., de Barros, N. R., Nasiri, R., Ahadian, S., Ashammakhi, N. A., Dokmeci, M. R., et al. (2019) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ab23df · Cited by 99 · see citing works
Engineering approaches for studying immune-tumor cell interactions and immunotherapy
Shelton, S. E., Nguyen, H. T., Barbie, D. A., & Kamm, R. D. (2021) · iScience · doi:10.1016/j.isci.2020.101985 · Cited by 93 · see citing works
Organs on chip approach: a tool to evaluate cancer -immune cells interactions
Biselli, E., Agliari, E., Barra, A., Bertani, F. R., Gerardino, A., De Ninno, A., Mencattini, A., Di Giuseppe, D., Mattei, F., Schiavoni, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13070-3 · Cited by 91 · see citing works
Self-citationSabhachandani, P., Sarkar, S., McKenney, S., Ravi, D., Evens, A. M., & Konry, T. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.010 · Cited by 86 · see citing works
Radhakrishnan, J., Varadaraj, S., Dash, S. K., Sharma, A., & Verma, R. S. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.03.002 · Cited by 87 · see citing works
Intestinal organ chips for disease modelling and personalized medicine
Özkan, A., LoGrande, N., Feitor, J. F., Goyal, G., & Ingber, D. E. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00968-3 · Cited by 89 · see citing works
Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
Maulana, T. I., Kromidas, E., Wallstabe, L., Cipriano, M., Alb, M., Zaupa, C., Hudecek, M., Fogal, B., & Loskill, P. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.015 · Cited by 82 · see citing works
How single-cell immunology is benefiting from microfluidic technologies
Jammes, F., & Maerkl, S. J. (2020) · Microsystems & Nanoengineering · doi:10.1038/s41378-020-0140-8 · Cited by 73 · see citing works
Immune Organs and Immune Cells on a Chip: An Overview of Biomedical Applications
Morsink, M., Willemen, N., Leijten, J., Bansal, R., & Shin, S. (2020) · Micromachines · doi:10.3390/mi11090849 · Cited by 73 · see citing works
Al-Samadi, A., Poor, B., Tuomainen, K., Liu, V., Hyytiäinen, A., Sulymanova, I., Mesimaki, K., Wilkman, T., Mäkitie, A., Saavalainen, P., et al. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111508 · Cited by 63 · see citing works
Inflammation-on-a-Chip: Probing the Immune System Ex Vivo
Irimia, D., & Wang, X. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.03.011 · Cited by 73 · see citing works
Microsystem Advances through Integration with Artificial Intelligence
Tsai, H., Podder, S., & Chen, P. (2023) · Micromachines · doi:10.3390/mi14040826 · Cited by 69 · see citing works
Kumar, V., & Varghese, S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801198 · Cited by 68 · see citing works
Mencattini, A., Giuseppe, D. D., Comes, M. C., Casti, P., Corsi, F., Bertani, F. R., Ghibelli, L., Businaro, L., Natale, C. D., Parrini, M. C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-64246-3 · Cited by 68 · see citing works
Self-citationCancer-on-chip models for metastasis: importance of the tumor microenvironment
Jouybar, M., de Winde, C. M., Wolf, K., Friedl, P., Mebius, R. E., & den Toonder, J. M. J. (2024) · Trends in Biotechnology · doi:10.1016/j.tibtech.2023.10.001 · Cited by 66 · see citing works
In Vitro Immune Organs-on-Chip for Drug Development: A Review
Shanti, A., Teo, J. C. M., & Stefanini, C. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040278 · Cited by 68 · see citing works
Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy
Parlato, S., Grisanti, G., Sinibaldi, G., Peruzzi, G., Casciola, C. M., & Gabriele, L. (2020) · Lab on a Chip · doi:10.1039/d0lc00799d · Cited by 67 · see citing works
Self-citationMarzagalli, M., Pelizzoni, G., Fedi, A., Vitale, C., Fontana, F., Bruno, S., Poggi, A. D., Dondero, A., Aiello, M., Castriconi, R., et al. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.945149 · Cited by 63 · see citing works
3D Immunocompetent Organ‐on‐a‐Chip Models
Maharjan, S., Cecen, B., & Zhang, Y. S. (2020) · Small Methods · doi:10.1002/smtd.202000235 · Cited by 62 · see citing works
Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology
Pradhan, S., Banda, O. A., Farino, C. J., Sperduto, J. L., Keller, K. A., Taitano, R. A., & Slater, J. H. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901255 · Cited by 61 · see citing works
Song, J., Choi, H., Koh, S. K., Park, D., Yu, J., Kang, H., Kim, Y., Cho, D., & Jeon, N. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.733317 · Cited by 59 · see citing works
Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies
Bouquerel, C., Dubrova, A., Hofer, I., Phan, D. T. T., Bernheim, M., Ladaigue, S., Cavaniol, C., Maddalo, D., Cabel, L., Mechta-Grigoriou, F., et al. (2023) · Lab on a Chip · doi:10.1039/d3lc00531c · Cited by 58 · see citing works
AI-Powered Microfluidics: Shaping the Future of Phenotypic Drug Discovery
Liu, J., Du, H., Huang, L., Xie, W., Liu, K., Zhang, X., Chen, S., Zhang, Y., Li, D., & Pan, H. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c07665 · Cited by 59 · see citing works
Perspectives on cavitation enhanced endothelial layer permeability
Peruzzi, G., Sinibaldi, G., Silvani, G., Ruocco, G., & Casciola, C. M. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.02.027 · Cited by 58 · see citing works
3D Cancer Models: Depicting Cellular Crosstalk within the Tumour Microenvironment
Franchi-Mendes, T., Eduardo, R., Domenici, G., & Brito, C. (2021) · Cancers · doi:10.3390/cancers13184610 · Cited by 57 · see citing works
Monolithic, 3D-Printed Microfluidic Platform for Recapitulation of Dynamic Tumor Microenvironments
Beckwith, A. L., Borenstein, J. T., & Velásquez–García, L. F. (2018) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2018.2869327 · Cited by 56 · see citing works
Tumor Microenvironment and Hydrogel-Based 3D Cancer Models for In Vitro Testing Immunotherapies
Vitale, C., Marzagalli, M., Scaglione, S., Dondero, A., Bottino, C., & Castriconi, R. (2022) · Cancers · doi:10.3390/cancers14041013 · Cited by 54 · see citing works
In vitro immunity: an overview of immunocompetent organ-on-chip models
Morrison, A. I., Sjoerds, M. J., Vonk, L. A., Gibbs, S., & Koning, J. J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1373186 · Cited by 56 · see citing works
Lymph Nodes-On-Chip: Promising Immune Platforms for Pharmacological and Toxicological Applications
Shanti, A., Hallfors, N., Petroianu, G. A., Planelles, L., & Stefanini, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.711307 · Cited by 49 · see citing works
Microfluidic technologies for immunotherapy studies on solid tumours
Paterson, K., Zanivan, S. R., Glasspool, R. M., Coffelt, S. B., & Zagnoni, M. (2021) · Lab on a Chip · doi:10.1039/d0lc01305f · Cited by 48 · see citing works
Kumar, D., Nadda, R., & Repaka, R. (2024) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-024-03062-7 · Cited by 48 · see citing works
Micro-engineering and nano-engineering approaches to investigate tumour ecosystems
Kim, M., Panagiotakopoulou, M., Chen, C., Ruiz, S. B., Ganesh, K., Tammela, T., & Heller, D. A. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00593-3 · Cited by 49 · see citing works
Oncoimmunology Meets Organs-on-Chip
Mattei, F., Andreone, S., Mencattini, A., Ninno, A. D., Businaro, L., Martinelli, E., & Schiavoni, G. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.627454 · Cited by 46 · see citing works
Self-citationFridman, I. B., Kostas, J. C., Greguš, M., Ray, S., Sullivan, M. R., Ivanov, A. R., Cohen, S., & Konry, T. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.025 · Cited by 46 · see citing works
Assessing personalized responses to anti-PD-1 treatment using patient-derived lung tumor-on-chip
Veith, I., Nurmik, M., Mencattini, A., Damei, I., Lansche, C., Brosseau, S., Gropplero, G., Corgnac, S., Filippi, J., Poté, N., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101549 · Cited by 49 · see citing works
Self-citationPreclinical models and technologies to advance nanovaccine development
Peres, C., Matos, A. I., Moura, L. I. F., Acúrcio, R. C., Carreira, B., Pozzi, S., Vaskovich‐Koubi, D., Kleiner, R., Satchi‐Fainaro, R., & Florindo, H. F. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.001 · Cited by 45 · see citing works
Comes, M. C., Casti, P., Mencattini, A., Giuseppe, D. D., Mermet‐Meillon, F., Ninno, A. D., Parrini, M. C., Businaro, L., Natale, C. D., & Martinelli, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-42475-5 · Cited by 44 · see citing works
Self-citationCancer-on-a-chip for precision cancer medicine
Liu, L., Wang, H., Chen, R., Song, Y., Wei, W., Baek, D. S. H., Gillin, M., Kurabayashi, K., & Chen, W. (2025) · Lab on a Chip · doi:10.1039/d4lc01043d · Cited by 47 · see citing works
Cascarano, P., Comes, M. C., Mencattini, A., Parrini, M. C., Piccolomini, E. L., & Martinelli, E. (2021) · Medical Image Analysis · doi:10.1016/j.media.2021.102124 · Cited by 42 · see citing works
Self-citationMicrophysiological systems for solid tumor immunotherapy: opportunities and challenges
Abizanda-Campo, S., Virumbrales-Muñoz, M., Humayun, M., Mármol, I., Beebe, D. J., Ochoa, I., Oliván, S., & Ayuso, J. M. (2023) · Microsystems & Nanoengineering · doi:10.1038/s41378-023-00616-x · Cited by 41 · see citing works
New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development
Parrish, J., Lim, K. S., Zhang, B., Radisic, M., & Woodfield, T. B. F. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.04.009 · Cited by 41 · see citing works
Ravi, K., Manoharan, T. J. M., Wang, K.-C., Pockaj, B. A., & Nikkhah, M. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122428 · Cited by 42 · see citing works
Mencattini, A., Lansche, C., Veith, I., Erbs, P., Balloul, J., Quéméneur, É., Descroix, S., Mechta‐Grigoriou, F., Zalcman, G., Zaupa, C., et al. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114571 · Cited by 41 · see citing works
Self-citationMencattini, A., Mattei, F., Schiavoni, G., Gerardino, A., Businaro, L., Natale, C. D., & Martinelli, E. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00100 · Cited by 39 · see citing works
Self-citationEngineered in vitro tumor models for cell-based immunotherapy
Ando, Y., Mariano, C. F., & Shen, K. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.076 · Cited by 38 · see citing works
Frenkel, N. C., Poghosyan, S., Alarcon, C. R., García, S. B., Queiroz, K. C. S., van den Bent, L., Laoukili, J., Rinkes, I. H. M. B., Vulto, P., Kranenburg, O., et al. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01378 · Cited by 38 · see citing works
Integration of immune cells in organs-on-chips: a tutorial
van Os, L., Engelhardt, B., & Guenat, O. T. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1191104 · Cited by 39 · see citing works
Microfluidic Devices in the Fast‐Growing Domain of Single‐Cell Analysis
Khan, M., Mao, S., Li, W., & Lin, J. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201800305 · Cited by 36 · see citing works
Cancer Immunotherapies and Humanized Mouse Drug Testing Platforms
Chen, Q., Wang, J., Liu, W. N., & Zhao, Y. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.04.020 · Cited by 36 · see citing works
Lucarini, V., Melaiu, O., D’Amico, S., Pastorino, F., Tempora, P., Scarsella, M., Pezzullo, M., Ninno, A. D., Doria, V., Cilli, M., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02525-9 · Cited by 35 · see citing works
Self-citationLiver-on-a-chip: Considerations, advances, and beyond
Yang, Z., Liu, X., Cribbin, E. M., Kim, A. M., Li, J. J., & Yong, K. (2022) · Biomicrofluidics · doi:10.1063/5.0106855 · Cited by 34 · see citing works
D’Orazio, M., Murdocca, M., Mencattini, A., Casti, P., Filippi, J., Antonelli, G., Giuseppe, D. D., Comes, M. C., Natale, C. D., Sangiuolo, F. C., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-12364-5 · Cited by 33 · see citing works
Self-citationOvercoming biological barriers to improve solid tumor immunotherapy
Ukidve, A., Cu, K., Kumbhojkar, N., Lahann, J., & Mitragotri, S. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00923-8 · Cited by 33 · see citing works
A 3D pancreatic tumor model to study T cell infiltration
Mollica, H., Teo, Y. J., Tan, A. S. M., Tan, D. Z. M., Decuzzi, P., Pavesi, A., & Adriani, G. (2021) · Biomaterials Science · doi:10.1039/d1bm00210d · Cited by 32 · see citing works
On-chip modeling of tumor evolution: Advances, challenges and opportunities
Li, C., Holman, J. B., Shi, Z., Qiu, B., & Ding, W. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100724 · Cited by 32 · see citing works
Chen, S.-C., Wu, P.-C., Wang, C.-Y., & Kuo, P.-L. (2020) · Scientific Reports · doi:10.1038/s41598-020-70694-8 · Cited by 31 · see citing works
Advances in Modeling the Immune Microenvironment of Colorectal Cancer
Yoon, P., Piccolo, N. D., Shirure, V. S., Peng, Y., Kirane, A., Canter, R. J., Fields, R. C., George, S. C., & Gholami, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.614300 · Cited by 31 · see citing works
In Vitro Modeling of Tumor–Immune System Interaction
Mengus, C., Muraro, M. G., Mele, V., Amicarella, F., Manfredonia, C., Foglietta, F., Muenst, S. E., Soysal, S. D., Iezzi, G., & Spagnoli, G. C. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00077 · Cited by 31 · see citing works
Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing
Perucca, A., Gómez‐Llonín, A., Benach, O. M., Hallopeau, C., Rivas, E. I., Linares, J., Garrido, M., Sallent-Aragay, A., Golde, T., Colombelli, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56275-1 · Cited by 31 · see citing works
Engineered fluidic systems to understand lymphatic cancer metastasis
Greenlee, J. D., & King, M. R. (2020) · Biomicrofluidics · doi:10.1063/1.5133970 · Cited by 30 · see citing works
Engineered models of tumor metastasis with immune cell contributions
Graney, P. L., Tavakol, D. N., Chramiec, A. G., Ronaldson-Bouchard, K., & Vunjak‐Novakovic, G. (2021) · iScience · doi:10.1016/j.isci.2021.102179 · Cited by 29 · see citing works
Recent advances in microfluidic-based cancer immunotherapy-on-a-chip strategies
Ngo, T. K. N., Kuo, C., & Tu, T. (2023) · Biomicrofluidics · doi:10.1063/5.0108792 · Cited by 28 · see citing works
Comes, M. C., Filippi, J., Mencattini, A., Casti, P., Cerrato, G., Sauvat, A., Vacchelli, E., Ninno, A. D., Giuseppe, D. D., D’Orazio, M., et al. (2020) · Neural Computing and Applications · doi:10.1007/s00521-020-05226-6 · Cited by 27 · see citing works
Self-citationMencattini, A., Rizzuto, V., Antonelli, G., Giuseppe, D. D., D’Orazio, M., Filippi, J., Comes, M. C., Casti, P., Corrons, J. L. V., Garcı́a-Bravo, M., et al. (2023) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2023.114187 · Cited by 27 · see citing works
Self-citationNguyen, O. T. P., Misun, P. M., Lohasz, C., Lee, J., Wang, W., Schroeder, T., & Hierlemann, A. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.781337 · Cited by 26 · see citing works
Giuseppe, D. D., Corsi, F., Mencattini, A., Comes, M. C., Casti, P., Natale, C. D., Ghibelli, L., & Martinelli, E. (2019) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2019.2897825 · Cited by 25 · see citing works
Self-citationLi, M., Song, X., Jin, S., & Ye, K. (2021) · Bio-Design and Manufacturing · doi:10.1007/s42242-021-00134-7 · Cited by 24 · see citing works
Krysko, D. V., Demuynck, R., Efimova, I., Naessens, F., Krysko, O., & Catanzaro, E. (2022) · Cells · doi:10.3390/cells11223705 · Cited by 25 · see citing works
Mechanical Signaling: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets
Long, Y., Wang, P., Lei, J., Su, B., Wei, Q., & Liu, X. (2025) · MedComm · doi:10.1002/mco2.70523 · Cited by 25 · see citing works
Making In Vitro Tumor Models Whole Again
Wu, K. Z., Adine, C., Mitriashkin, A., Aw, B. J. J., Iyer, N. G., & Fong, E. L. S. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202279 · Cited by 22 · see citing works
Analysis of Leukocyte Behaviors on Microfluidic Chips
Liu, Y., Yang, Q., Cao, L., & Xu, F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801406 · Cited by 22 · see citing works
Modeling the tumor immune microenvironment for drug discovery using 3D culture
Lee, J. Y., & Chaudhuri, O. (2021) · APL Bioengineering · doi:10.1063/5.0030693 · Cited by 22 · see citing works
Construction of cancer-on-a-chip for drug screening
Liu, Y., Yang, Q., Zhang, H., Han, S., Liu, N., Ren, H. J., Guo, H., & Xu, F. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.03.006 · Cited by 22 · see citing works
Immunity‐on‐a‐Chip: Integration of Immune Components into the Scheme of Organ‐on‐a‐Chip Systems
Ramadan, Q., Hazaymeh, R., & Zourob, M. M. (2023) · Advanced Biology · doi:10.1002/adbi.202200312 · Cited by 21 · see citing works
Advancements in 3D In Vitro Models for Colorectal Cancer
Vitale, S., Calapà, F., Colonna, F., Luongo, F., Biffoni, M., Maria, R. D., & Fiori, M. E. (2024) · Advanced Science · doi:10.1002/advs.202405084 · Cited by 21 · see citing works
Comes, M. C., Filippi, J., Mencattini, A., Corsi, F., Casti, P., Ninno, A. D., Giuseppe, D. D., D’Orazio, M., Ghibelli, L., Mattei, F., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-72605-3 · Cited by 20 · see citing works
Self-citationIn vitro models as tools for screening treatment options of head and neck cancer
Seliger, B., Al‐Samadi, A., Yang, B., Salo, T. A., & Wickenhauser, C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.971726 · Cited by 20 · see citing works
Zhou, L., Liu, L., Chang, M. A., Ma, C., Chen, W., & Chen, P. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115064 · Cited by 20 · see citing works
Tak, S., Han, G., Leem, S., Lee, S.-Y., Paek, K., & Kim, J. A. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1302983 · Cited by 19 · see citing works
Casti, P., Cardarelli, S., Comes, M. C., D’Orazio, M., Filippi, J., Antonelli, G., Mencattini, A., Natale, C. D., & Martinelli, E. (2023) · Expert Systems with Applications · doi:10.1016/j.eswa.2023.120861 · Cited by 18 · see citing works
Self-citationMicrophysiological Systems for Cancer Immunotherapy Research and Development
Peng, Y., & Lee, E. (2023) · Advanced Biology · doi:10.1002/adbi.202300077 · Cited by 17 · see citing works
Seo, J., Ha, G., Lee, G., Nasiri, R., & Lee, J. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.10.036 · Cited by 19 · see citing works
- Authors
- Parlato, S., De Ninno, A., Molfetta, R., Toschi, E., Salerno, D., Mencattini, A., Romagnoli, G., Fragale, A., Roccazzello, L., Buoncervello, M., Canini, I., Bentivegna, E., Falchi, M., Bertani, F. R., Gerardino, A., Martinelli, E., Natale, C., Paolini, R., Businaro, L., & Gabriele, L.
- Affiliations
- Istituto Superiore di Sanità (IT)
- Istituto Pasteur (IT)
- Italian Institute of Technology (IT)
- University of Rome Tor Vergata (IT)
- National Research Council (IT)
- Corresponding author
- Businaro, Luca
- Gabriele, Lucia
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-04-24
- Volume
- 7
- Issue
- 1
- Pages
- 1093-1093
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5430848
- OpenAlex
- W2606007772
- Cited by
- 181
- References
- 64
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 18 · 2023: 24 · 2022: 18 · 2021: 27 · 2020: 25 · 2019: 21 · 2018: 16 · 2017: 6
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR-PRIN2012, SIR 2014, PRIN2012, RBSI14TX20, RBSI14TX20-MUSIC, 20125NMMLA)
- Associazione Italiana per la Ricerca sul Cancro (#11610)
- Istituto Italiano di Tecnologia
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- dendritic cells, immunotherapy efficacy, phagocytosis, CXCR4, tumor microenvironment, antitumor immunity, cancer immunotherapy
- MeSH terms
- Cells, Cultured, Colonic Neoplasms, Dendritic Cells, Humans, Immunologic Factors, Immunotherapy, Microscopy, Models, Biological, Treatment Outcome, Interferon-alpha, Microfluidics, Cell Tracking
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