Tomatoes protect against development of UV-induced keratinocyte carcinoma via metabolomic alterations
Open accessAbstract
Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin cancer. SKH-1 hairless and immunocompetent mice (n = 180) were fed AIN-93G or AIN-93G + 10% tangerine or red tomato powder for 35 weeks. From weeks 11–20, mice (n = 120) were exposed to 2240 J/m 2 UV-B light, 3x/week, and tumors were tracked weekly. Control mice were fed the same diets but not exposed to UV. Tumor number was significantly lower in male mice consuming red tomato diets (1.73 ± 0.50, P = 0.015) or pooled tomato diets (2.03 ± 0.45, P = 0.017) compared to controls (4.04 ± 0.65). Carotenoid levels in plasma and skin were quantitated, with total lycopene higher in skin of tangerine fed animals despite a lower dose. Metabolomic analyses elucidated compounds derived from tomato glycoalkaloids (including tomatidine and hydroxylated-tomatidine) as significantly different metabolites in skin after tomato exposure. Here, we describe that tomato consumption can modulate risk for keratinocyte carcinomas; however, the role of the newly identified specific phytochemicals possibly responsible for this action require further investigation.
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In hairless and immunocompetent mice, tomato consumption protected against development of UVB-induced keratinocyte carcinoma.
“Moreover, it has been recently showed that, in hairless and immunocompetent mice, tomato consumption was able to protect against the development of UVB-induced keratinocyte carcinoma [113].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [113]
Supplementation of tomato paste before UV exposure dampened skin erythema and reduced mitochondrial DNA damage.
“In particular, supplementation of tomato paste before UV exposure was able to dampen skin erythema and to reduce mitochondrial DNA damage [112, 113].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [113]
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- Authors
- Cooperstone, J. L., Tober, K. L., Riedl, K. M., Teegarden, M. D., Cichon, M. J., Francis, D. M., Schwartz, S. J., & Oberyszyn, T. M.
- Affiliations
- The Ohio State University (US)
- The Ohio State University Wexner Medical Center (US)
- Corresponding author
- Oberyszyn, Tatiana M.
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-07-11
- Volume
- 7
- Issue
- 1
- Pages
- 5106-5106
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5506060
- OpenAlex
- W2731222978
- Cited by
- 66
- References
- 46
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 4
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (CA016058)
- National Cancer Institute (R21CA158625, P30CA016058)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- tomato consumption, skin cancer prevention, carotenoids, lycopene, tomatidine, metabolomics, UVB exposure, dietary phytochemicals, SKH-1 mice, Citrus reticulata
- MeSH terms
- Lycopene, Animals, Biological Products, Carotenoids, Chromatography, High Pressure Liquid, Disease Models, Animal, Male, Plant Extracts, Skin Neoplasms, Ultraviolet Rays, Solanum lycopersicum, Mice, Tandem Mass Spectrometry, Metabolomics
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