Dietary tomato paste protects against ultraviolet light-induced erythema in humans
Open accessAbstract
Carotenoids are efficient antioxidants capable of scavenging reactive oxygen species generated under conditions of photooxidative stress. It has been shown that supplementation with high doses of beta-carotene protects skin against UV-induced erythema. This study was designed to investigate whether intervention with a natural dietary source rich in lycopene protects against UV-induced erythema in humans. Tomato paste (40 g), providing approximately 16 mg/d of lycopene, was ingested with 10 g of olive oil over a period of 10 wk by 9 volunteers. Controls (n = 10) received olive oil only. Erythema was induced by illumination of dorsal skin (scapular region) with a solar simulator at the beginning of the study, after 4 wk and after 10 wk. Intensity of erythema was measured by chromatometry; the a-value was determined directly before and 24 h after irradiation. Serum carotenoid levels were measured by HPLC. At the beginning of the study, carotenoid levels did not differ between the two groups. Serum levels of lycopene increased in supplemented subjects; the other carotenoids did not change significantly, and no change in serum carotenoids was observed in the control group. At wk 10, dorsal erythema formation was 40% lower in the group that consumed tomato paste compared with controls (P = 0.02; Wilcoxon-Mann-Whitney test). No significant difference between groups was found at wk 4 of treatment. The data demonstrate that it is feasible to achieve protection against UV light-induced erythema by ingestion of a commonly consumed dietary source of lycopene.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies in humans supplemented with beta-carotene or a mix of carotenoids showed that induction of erythema was less pronounced after UV exposure.
“Furthermore, studies conducted in humans supplemented with betacarotene or with a mix of carotenoids showed that the induction of erythema was less pronounced after UV exposure [181][182][183].”
From Sunlight damage to cellular DNA: focus on oxidatively generated lesions (2017) · cites this paper as [183]
A carotenoid-rich diet decreases erythema size upon UV radiation exposure, but at least ten weeks is necessary for successful intervention.
“The photoprotective effects of several carotenoids have been investigated by intervention studies in humans, in which a carotenoid-rich diet has been investigated for its ability to decrease the erythema size upon UV radiation exposure [104–106], even though a long period (at least ten weeks) is necessary for successful intervention [106].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [104]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lycopene as the most efficient biological carotenoid singlet oxygen quencher
Mascio, P. D., Kaiser, S., & Sies, H. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90467-0 · Cited by 2,238 · see citing works
Self-citationβ-Carotene: an Unusual Type of Lipid Antioxidant
Burton, G. W., & Ingold, K. U. (1984) · Science · doi:10.1126/science.6710156 · Cited by 2,150 · see citing works
Vitamins E and C, beta-carotene, and other carotenoids as antioxidants
Sies, H., & Stahl, W. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1315s · Cited by 1,075 · see citing works
Self-citationAntioxidant activities of carotenes and xanthophylls
Miller, N. J., Sampson, J., Candeias, L. P., Bramley, P. M., & Rice-Evans, C. A. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00323-7 · Cited by 1,030 · see citing works
Beta‐carotene, carotenoids, and disease prevention in humans
Mayne, S. T. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.7.8635686 · Cited by 862 · see citing works
Lycopene: A Biologically Important Carotenoid for Humans?
Stahl, W., & Sies, H. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0525 · Cited by 712 · see citing works
Self-citationLycopene is more bioavailable from tomato paste than from fresh tomatoes
Gärtner, C., Stahl, W., & Sies, H. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.1.116 · Cited by 694 · see citing works
Self-citationFree Radicals in Cutaneous Biology
Darr, D. J., & Fridovich, I. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12374036 · Cited by 402 · see citing works
The singlet oxygen and carotenoid interaction
Conn, P. F., Schalch, W., & Truscott, T. G. (1991) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(91)80266-k · Cited by 373 · see citing works
Why Do We Expect Carotenoids to be Antioxidantsin vivo?
Rice-Evans, C. A., Sampson, J., Bramley, P. M., & Holloway, D. E. (1997) · Free Radical Research · doi:10.3109/10715769709097818 · Cited by 347 · see citing works
Stahl, W., Heinrich, U., Jungmann, H., Sies, H., & Tronnier, H. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.3.795 · Cited by 317 · see citing works
Self-citationPhotoaging/photodamage and photoprotection
Taylor, C. R., Stern, R. S., Leyden, J. J., & Gilchrest, B. A. (1990) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(90)70001-x · Cited by 288 · see citing works
Ahuja, J. K. C., Holden, J. M., Forman, M. R., Mangels, A. R., Beecher, G. R., & Lanza, E. (1993) · Journal of the American Dietetic Association · doi:10.1016/0002-8223(93)91559-9 · Cited by 258 · see citing works
Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?
Riso, P., Pinder, A. C., Santangelo, A., & Porrini, M. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.4.712 · Cited by 223 · see citing works
The Macular Pigment: A Possible Role in Protection from Age-Related Macular Degeneration
Landrum, J. T., Bonet, R. A., & Kilburn, M. D. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60998-9 · Cited by 204 · see citing works
Relations among aging, antioxidant status, and cataract
Taylor, A. W., Jacques, P., & Epstein, E. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1439s · Cited by 177 · see citing works
Stahl, W. (1997) · Carcinogenesis · doi:10.1093/carcin/18.1.89 · Cited by 176 · see citing works
Self-citationFuchs, J. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00161-0 · Cited by 174 · see citing works
Paetau, I., Khachik, F., Beecher, G. R., Kramer, T., Chittams, J. L., & Clevidence, B. A. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1187 · Cited by 170 · see citing works
Pathak, M. A. (1982) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(82)70117-3 · Cited by 170 · see citing works
Mathews‐Roth, M. M., Pathak, M. A., Parrish, J. A., Fitzpatrick, T. B., Kass, E. H., Toda, K., & Clemens, W. (1972) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12627408 · Cited by 163 · see citing works
Absorption of lycopene from single or daily portions of raw and processed tomato
Porrini, M., Riso, P., & Testolin, G. (1998) · British Journal Of Nutrition · doi:10.1017/s000711459800141x · Cited by 163 · see citing works
Separation of beta-carotene and lycopene geometrical isomers in biological samples
Stahl, W., Sundquist, A. R., Hanusch, M., Schwarz, W., & Sies, H. (1993) · Clinical Chemistry · doi:10.1093/clinchem/39.5.810 · Cited by 161 · see citing works
Self-citationStahl, W., Heinrich, U., Jungmann, H., von Laar, J., Schietzel, M., Sies, H., & Tronnier, H. (1998) · Journal of Nutrition · doi:10.1093/jn/128.5.903 · Cited by 157 · see citing works
Self-citationCarotenoid Supplementation Reduces Erythema in Human Skin After Simulated Solar Radiation Exposure
Lee, J., Jiang, S., Levine, N. S., & WATSON, R. R. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22323.x · Cited by 148 · see citing works
Effect of beta‐carotene supplementation on the human sunburn reaction
Garmyn, M., Ribaya‐Mercado, J. D., Russel, R. M., Bhawan, J., & Gilchrest, B. A. (1995) · Experimental Dermatology · doi:10.1111/j.1600-0625.1995.tb00231.x · Cited by 113 · see citing works
Xanthophyll Esters in Human Skin
Wingerath, T., Sies, H., & Stahl, W. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0734 · Cited by 112 · see citing works
Self-citationMüller, H., Bub, A., Watzl, B., & Rechkemmer, G. (1999) · European Journal of Nutrition · doi:10.1007/s003940050044 · Cited by 94 · see citing works
The Carotenoids of the Human Retina
Schalch, W., Dayhaw‐Barker, P., & Barker, F. M. (2021) · CRC Press eBooks · doi:10.1201/9781003208785-12 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The role of antioxidants in the chemistry of oxidative stress: A review
Pisoschi, A. M., & Pop, A. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.04.040 · Cited by 2,844 · see citing works
Antioxidant activity of carotenoids
Stahl, W., & Sies, H. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(03)00030-x · Cited by 1,415 · see citing works
Self-citationBioactivity and protective effects of natural carotenoids
Stahl, W., & Sies, H. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.12.006 · Cited by 898 · see citing works
Self-citationThe role of carotenoids in the prevention of human pathologies
Tapiero, H., Townsend, D. M., & Tew, K. D. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2003.12.006 · Cited by 647 · see citing works
Sunlight damage to cellular DNA: focus on oxidatively generated lesions
Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436 · see citing works
An Update on the Health Effects of Tomato Lycopene
Story, E. N., Kopec, R. E., Schwartz, S. J., & Harris, G. K. (2010) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.102308.124120 · Cited by 432 · see citing works
Nutritional protection against skin damage from sunlight
Sies, H., & Stahl, W. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132320 · Cited by 307 · see citing works
Self-citationBiological Relevance of Terpenoids
Wagner, K., & Elmadfa, I. (2003) · Annals of Nutrition and Metabolism · doi:10.1159/000070030 · Cited by 302 · see citing works
Fruit and vegetable phytochemicals: chemistry, nutritional value and stability
la Rosa, L. A. D., ́Álvarez-Parrilla, E., & González-Aguilar, G. A. (2009) · Andalas University Repository (Andalas University) · Cited by 294 · see citing works
Antioxidants from Plants Protect against Skin Photoaging
Petruk, G., Del Giudice, R., Rigano, M. M., & Monti, D. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1454936 · Cited by 283 · see citing works
β-Carotene and other carotenoids in protection from sunlight
Stahl, W., & Sies, H. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.034819 · Cited by 277 · see citing works
Self-citationCalabrese, E. J. (2008) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2008.03243.x · Cited by 263 · see citing works
Offord, E. A., Gautier, J.-C., Avanti, O., Scaletta, C., Runge, F., Krämer, K., & Applegate, L. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00831-6 · Cited by 254 · see citing works
Plants used to treat skin diseases
Tabassum, N., & Hamdani, M. (2014) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.125531 · Cited by 254 · see citing works
Palombo, P., Fabrizi, G., Ruocco, V., Ruocco, E., Fluhr, J., Roberts, R., & Morganti, P. (2007) · Skin Pharmacology and Physiology · doi:10.1159/000101807 · Cited by 253 · see citing works
Tomatoes and Tomato Products as Dietary Sources of Antioxidants
Borguini, R. G., & Torres, E. A. F. D. S. (2009) · Food Reviews International · doi:10.1080/87559120903155859 · Cited by 247 · see citing works
Heinrich, U., Wiebusch, M., Tronnier, H., Gärtner, C., Eichler, O., Sies, H., & Stahl, W. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.1.98 · Cited by 246 · see citing works
Self-citationMeléndez‐Martínez, A. J., Stinco, C. M., & Mapelli‐Brahm, P. (2019) · Nutrients · doi:10.3390/nu11051093 · Cited by 234 · see citing works
Nutritional Quality and Health Benefits of Vegetables: A Review
Dias, J. S. (2012) · Food and Nutrition Sciences · doi:10.4236/fns.2012.310179 · Cited by 239 · see citing works
Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals
Anunciato, T. P., & da Rocha Filho, P. A. (2012) · Journal of Cosmetic Dermatology · doi:10.1111/j.1473-2165.2011.00600.x · Cited by 219 · see citing works
Functional Properties of Carotenoids in Human Health
Perera, C. O., & Yen, G. M. (2007) · International Journal of Food Properties · doi:10.1080/10942910601045271 · Cited by 209 · see citing works
Aust, O., Stahl, W., Sies, H., Tronnier, H., & Heinrich, U. (2005) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.75.1.54 · Cited by 207 · see citing works
Self-citationAjjoun, M., Kharchoufa, L., Merrouni, I. A., & Elachouri, M. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115532 · Cited by 195 · see citing works
Heinrich, U., Neukam, K., Tronnier, H., Sies, H., & Stahl, W. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.6.1565 · Cited by 191 · see citing works
Self-citationDietary Carotenoids Contribute to Normal Human Skin Color and UV Photosensitivity
Alaluf, S., Heinrich, U., Stahl, W., Tronnier, H., & Wiseman, S. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.3.399 · Cited by 180 · see citing works
Self-citationRevisiting carotenoids as dietary antioxidants for human health and disease prevention
Terao, J. (2023) · Food & Function · doi:10.1039/d3fo02330c · Cited by 187 · see citing works
Lycopene-rich products and dietary photoprotection
Stahl, W., Heinrich, U., Aust, O., Tronnier, H., & Sies, H. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b505312a · Cited by 175 · see citing works
Self-citationCarotenoids and Flavonoids Contribute to Nutritional Protection against Skin Damage from Sunlight
Stahl, W., & Sies, H. (2007) · Molecular Biotechnology · doi:10.1007/s12033-007-0051-z · Cited by 170 · see citing works
Self-citationCamera, E., Mastrofrancesco, A., Fabbri, C., Daubrawa, F., Picardo, M., Sies, H., & Stahl, W. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00790.x · Cited by 170 · see citing works
Self-citationRizwan, M., Rodriguez-Blanco, I., Harbottle, A., Birch-Machin, M. A., Watson, R. E. B., & Rhodes, L. E. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10057.x · Cited by 167 · see citing works
Grether-Beck, S., Marini, A., Jaenicke, T., Stahl, W., & Krutmann, J. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15080 · Cited by 166 · see citing works
Self-citationD’Angelo, S., Ingrosso, D., Migliardi, V., Sorrentino, A., Donnarumma, G., Baroni, A., Masella, L., Tufano, M. A., Zappia, M., & Galletti, P. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.015 · Cited by 166 · see citing works
Mediterranean diet and cancer: epidemiological evidence and mechanism of selected aspects
Grosso, G., Buscemi, S., Galvano, F., Mistretta, A., Marventano, S., Vela, V. L., Drago, F., Gangi, S., Basile, F., & Biondi, A. (2013) · BMC Surgery · doi:10.1186/1471-2482-13-s2-s14 · Cited by 149 · see citing works
Tomato Consumption and Health: Emerging Benefits
Burton‐Freeman, B. M., & Reimers, K. J. (2010) · American Journal of Lifestyle Medicine · doi:10.1177/1559827610387488 · Cited by 147 · see citing works
Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms
Dinkova-Kostova, A. (2008) · Planta Medica · doi:10.1055/s-2008-1081296 · Cited by 136 · see citing works
Natural agents: Cellular and molecular mechanisms of photoprotection
Afaq, F. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.12.007 · Cited by 136 · see citing works
Fruit and Vegetable Phytochemicals
(2009) · Wiley eBooks · doi:10.1002/9780813809397 · Cited by 137 · see citing works
Photoprotection by dietary carotenoids: Concept, mechanisms, evidence and future development
Stahl, W., & Sies, H. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100232 · Cited by 132 · see citing works
Self-citationDarvin, M. E., Patzelt, A., Knorr, F., Blume-Peytavi, U., Sterry, W., & Lademann, J. (2008) · Journal of Biomedical Optics · doi:10.1117/1.2952076 · Cited by 125 · see citing works
Skin bioavailability of dietary vitamin E, carotenoids, polyphenols, vitamin C, zinc and selenium
Myriam, M., Sabatier, M., Steiling, H., & Williamson, G. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061817 · Cited by 117 · see citing works
Sies, H., & Stahl, W. (2004) · Photochemical & Photobiological Sciences · doi:10.1039/b316082c · Cited by 113 · see citing works
Self-citationMayne, S. T., Cartmel, B., Scarmo, S., Jahns, L., Ermakov, I. V., & Gellermann, W. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.06.007 · Cited by 112 · see citing works
Skin protection against UV light by dietary antioxidants
Fernández-García, E. (2014) · Food & Function · doi:10.1039/c4fo00280f · Cited by 108 · see citing works
The Role of Phytonutrients in Skin Health
Evans, J. A., & Johnson, E. J. (2010) · Nutrients · doi:10.3390/nu2080903 · Cited by 107 · see citing works
Terao, J., Minami, Y., & Bando, N. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-008fr · Cited by 106 · see citing works
Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?
Balić, A., & Mokos, M. (2019) · Antioxidants · doi:10.3390/antiox8080259 · Cited by 104 · see citing works
Periago, M. J., García‐Alonso, J., Jacob, K., Olivares, A. B., Bernal, M. J., Iniesta, M. D., Martínez‐Graciá, C., & Ros, G. (2009) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637480701833457 · Cited by 102 · see citing works
Carotenoids of Microalgae Used in Food Industry and Medicine
Gâteau, H., Solymosi, K., Marchand, J., & Schoefs, B. (2016) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557516666160808123841 · Cited by 101 · see citing works
Effect of Supplemented and Topically Applied Antioxidant Substances on Human Tissue
Darvin, M. E., Zastrow, L., Sterry, W., & Lademann, J. M. (2006) · Skin Pharmacology and Physiology · doi:10.1159/000093979 · Cited by 97 · see citing works
Oral Photoprotection: Effective Agents and Potential Candidates
Parrado, C., Philips, N. E., Gilaberte, Y., Juarranz, Á., & González, S. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00188 · Cited by 97 · see citing works
McArdle, F., Rhodes, L. E., Parslew, R., Close, G. L., Jack, C. I. A., Friedmann, P. S., & Jackson, M. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1270 · Cited by 93 · see citing works
Topical beta‐carotene protects against infra‐red‐light–induced free radicals
Darvin, M. E., Fluhr, J. W., Meinke, M. C., Zastrow, L., Sterry, W., & Lademann, J. M. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2010.01191.x · Cited by 92 · see citing works
Scarmo, S., Cartmel, B., Lin, H., Leffell, D. J., Welch, E., Bhosale, P., Bernstein, P. S., & Mayne, S. T. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.07.004 · Cited by 91 · see citing works
Eichler, O., Sies, H., & Stahl, W. (2002) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2002)0750503dololc2.0.co2 · Cited by 91 · see citing works
Self-citationChemistry, Stability, and Biological Actions of Carotenoids
Yahia, E. M., & Ornelas‐Paz, J. D. J. (2009) · doi:10.1002/9780813809397.ch7 · Cited by 91 · see citing works
Mixture Approach for Optimizing Lycopene Extraction from Tomato and Tomato Products
Periago, M. J., Rincón, F., Agüera, M. D., & Ros, G. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049345h · Cited by 85 · see citing works
Zerres, S., & Stahl, W. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158588 · Cited by 84 · see citing works
Self-citationMayer‐Miebach, E., Behsnilian, D., Regier, M., & Schuchmann, H. P. (2005) · Food Research International · doi:10.1016/j.foodres.2005.03.018 · Cited by 81 · see citing works
Sumiyoshi, M., & Kimura, Y. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.06.003 · Cited by 79 · see citing works
Rojo de la Vega, M., Krajisnik, A., Zhang, D., & Wondrak, G. (2017) · Nutrients · doi:10.3390/nu9121371 · Cited by 77 · see citing works
Findings in redox biology: From H2O2 to oxidative stress
Sies, H. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.x120.015651 · Cited by 77 · see citing works
Self-citationNutrient synergy: definition, evidence, and future directions
Townsend, J. R., Kirby, T. O., Sapp, P. A., Gonzalez, A. M., Marshall, T. M., & Esposito, R. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1279925 · Cited by 77 · see citing works
Laranjeira, T., Costa, A., Faria‐Silva, C., Ribeiro, D., de Oliveira, J. M. P. F., Simões, S., & Ascenso, A. (2022) · Molecules · doi:10.3390/molecules27051701 · Cited by 74 · see citing works
Skin Protection by Carotenoid Pigments
Flieger, J., Raszewska-Famielec, M., Radzikowska-Büchner, E., & Flieger, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031431 · Cited by 75 · see citing works
Blume‐Peytavi, U., Rolland, A., Darvin, M. E., Constable, A., Pineau, I., Voit, C. A., Zappel, K., Schäfer-Hesterberg, G., Meinke, M. C., Clavez, R. L., et al. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.04.017 · Cited by 72 · see citing works
Tulah, A. S., & Birch‐Machin, M. A. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.11.007 · Cited by 72 · see citing works
Synthetic and tomato-based lycopene have identical bioavailability in humans
Hoppe, P. P., Krämer, K., van den Berg, H., Steenge, G. R., & van Vliet, T. (2003) · European Journal of Nutrition · doi:10.1007/s00394-003-0421-7 · Cited by 71 · see citing works
Anbualakan, K., Urus, N. Q. T., Makpol, S., Jamil, A., Ramli, E. S. M., Pauzi, S. H. M., & Muhammad, N. (2022) · Nutrients · doi:10.3390/nu15010092 · Cited by 66 · see citing works
Raman Spectroscopy of Carotenoid Compounds for Clinical Applications—A Review
Udensi, J., Loughman, J., Loskutova, E., & Byrne, H. J. (2022) · Molecules · doi:10.3390/molecules27249017 · Cited by 65 · see citing works
Cooperstone, J. L., Tober, K. L., Riedl, K. M., Teegarden, M. D., Cichon, M. J., Francis, D. M., Schwartz, S. J., & Oberyszyn, T. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-05568-7 · Cited by 66 · see citing works
Darvin, M. E., Gersonde, I. H., Albrecht, H., Sterry, W., & Lademann, J. M. (2007) · Laser Physics Letters · doi:10.1002/lapl.200710004 · Cited by 66 · see citing works
Lycopene - antioxidant with radioprotective and anticancer properties. A review.
Gajowik, A., & Dobrzyńska, M. M. (2014) · PubMed · Cited by 62 · see citing works
Synergistic Anti-Oxidative Effects of Lycopene with Other Bioactive Compounds
Shixian, Q., Dai, Y., Kakuda, Y., Shi, J., Mittal, G. S., Yeung, D., & Jiang, Y. (2005) · Food Reviews International · doi:10.1080/fri-200061612 · Cited by 60 · see citing works
Role of ingestible carotenoids in skin protection: A review of clinical evidence
Baswan, S., Klosner, A. E., Weir, C., Salter-Venzon, D., Gellenbeck, K., Leverett, J., & Krutmann, J. (2021) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/phpp.12690 · Cited by 49 · see citing works
Carotenoid Changes of Intact Watermelons after Storage
Perkins-Veazie, P. M., & Collins, J. K. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0532664 · Cited by 59 · see citing works
Darvin, M. E., Gersonde, I. H., Albrecht, H., Sterry, W., & Lademann, J. M. (2006) · Laser Physics · doi:10.1134/s1054660x06050148 · Cited by 58 · see citing works
Recent Insights Into Health Benefits of Carotenoids
Cooperstone, J. L., & Schwartz, S. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100371-8.00020-8 · Cited by 56 · see citing works
Absorption, Transport, Distribution in Tissues and Bioavailability
Canene‐Adams, K., & Erdman, J. W. (2009) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7501-0_7 · Cited by 56 · see citing works
Nutrition and nutritional supplementation
Piccardi, N., & Manissier, P. (2009) · Dermato-Endocrinology · doi:10.4161/derm.1.5.9706 · Cited by 56 · see citing works
Chemistry, Stability, and Biological Actions of Carotenoids
Yahia, E. M., Ornelas‐Paz, J. D. J., Emanuelli, T., Lopes, E. J., Zepka, L. Q., & Cervantes‐Paz, B. (2017) · doi:10.1002/9781119158042.ch15 · Cited by 54 · see citing works
Jenkins, G., Wainwright, L., Holland, R. L., Barrett, K. E., & Casey, J. (2013) · International Journal of Cosmetic Science · doi:10.1111/ics.12087 · Cited by 51 · see citing works
Darvin, M. E., Sterry, W., & Lademann, J. M. (2009) · Journal of Biophotonics · doi:10.1002/jbio.200910060 · Cited by 50 · see citing works
Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System
Ben-Yehuda Greenwald, M., Ben-Sasson, S., Bianco-Peled, H., & Kohen, R. (2016) · Cosmetics · doi:10.3390/cosmetics3010001 · Cited by 49 · see citing works
Hormesis: wound healing and fibroblasts
Calabrese, E. J., Dhawan, G., Kapoor, R., Agathokleous, E., & Calabrese, V. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106449 · Cited by 46 · see citing works
The Impact of Antioxidants on Vitiligo and Melasma: A Scoping Review and Meta-Analysis
Speeckaert, R., Bulat, V., Speeckaert, M. M., & van Geel, N. (2023) · Antioxidants · doi:10.3390/antiox12122082 · Cited by 46 · see citing works
Torres-Contreras, A. M., Garcia-Baeza, A., Vidal-Limon, H. R., Balderas-Renteria, I., Ramírez-Cabrera, M. A., & Ramirez-Estrada, K. (2022) · Plants · doi:10.3390/plants11020220 · Cited by 46 · see citing works
Bando, N., Hayashi, H., Wakamatsu, S., Inakuma, T., Miyoshi, M., Nagao, A., Yamauchi, R., & Terao, J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.09.004 · Cited by 46 · see citing works
Goisser, S., Wittmann, S., Fernandes, M., Mempel, H., & Ulrichs, C. (2020) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2020.111232 · Cited by 45 · see citing works
Influence of oral antioxidants on ultraviolet radiation‐induced skin damage in humans
Swindells, K. J., & Rhodes, L. E. (2004) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2004.00121.x · Cited by 44 · see citing works
Plant-Based Foods for Skin Health: A Narrative Review
Fam, V. W., Charoenwoodhipong, P., Sivamani, R. K., Holt, R. R., Keen, C. L., & Hackman, R. M. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2021.10.024 · Cited by 43 · see citing works
Pappas, A., Liakou, A. Ι., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9374-z · Cited by 46 · see citing works
Determinants of skin sensitivity to solar irradiation
Broekmans, W. M. R., Vink, A. A., Boelsma, E., Klöpping-Ketelaars, W. A. A., Tijburg, L. B. M., Veer, P. V., van Poppel, G., & Kardinaal, A. F. M. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601672 · Cited by 40 · see citing works
Zhuang, C., Yuan, J., Du, Y., Zeng, J., Sun, Y., Wu, Y., Gao, X., & Chen, H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.754707 · Cited by 39 · see citing works
Simitzis, P. (2018) · Cosmetics · doi:10.3390/cosmetics5040058 · Cited by 39 · see citing works
Groten, K., Marini, A., Grether‐Beck, S., Jaenicke, T., Ibbotson, S. H., Moseley, H., Ferguson, J., & Krutmann, J. (2019) · Skin Pharmacology and Physiology · doi:10.1159/000497104 · Cited by 39 · see citing works
Safety evaluation of a natural tomato oleoresin extract derived from food-processing tomatoes
Matulka, R. A., Hood, A., & Griffiths, J. C. (2004) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2004.03.005 · Cited by 38 · see citing works
López‐Yerena, A., Domínguez‐López, I., Abuhabib, M. M., Lamuela-Raventós, R. M., Vallverdú‐Queralt, A., & Pérez, M. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2226211 · Cited by 34 · see citing works
Yeh, S.-L., Hu, M.-L., & Huang, C.-S. (2005) · European Journal of Nutrition · doi:10.1007/s00394-004-0536-5 · Cited by 33 · see citing works
Zhang, X., Zhou, Q., Qi, Y., Chen, X., Deng, J., Zhang, Y., Li, R., & Fan, J. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2164557 · Cited by 39 · see citing works
Herbal sun protection agents: Human studies
Rabinovich, L., & Kazlouskaya, V. (2018) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2018.03.014 · Cited by 32 · see citing works
- Authors
- Stahl, W., Eichler, O., Sies, H., Heinrich, U., Wiseman, S., & Tronnier, H.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Witten/Herdecke University (DE)
- Unilever Research and Development Vlaardingen (NL)
- Corresponding author
- Stahl, Wilhelm
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 131
- Issue
- 5
- Pages
- 1449-1451
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2131097530
- Cited by
- 243
- References
- 30
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 15 · 2022: 11 · 2021: 10 · 2020: 8 · 2019: 8 · 2018: 14 · 2017: 9 · 2016: 10 · 2015: 10 · 2014: 17 · 2013: 9 · 2012: 8
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- tomato paste, lycopene, dietary carotenoids, photooxidative stress, skin photoprotection, serum carotenoid levels, beta-carotene, olive oil, solar simulator irradiation
- MeSH terms
- Lycopene, Adult, Aged, Carotenoids, Diet, Erythema, Female, Humans, Male, Middle Aged, Skin, Ultraviolet Rays, Solanum lycopersicum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review