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Cited by 193Skin Protection and AgingAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

Skin Lycopene Is Destroyed Preferentially over β-Carotene during Ultraviolet Irradiation in Humans

Ribaya-Mercado, Judy D., Garmyn, Marjan, Gilchrest, Barbara A., Russell, Robert M.·1995·The Journal of Nutrition
DOI 10.1093/jn/125.7.1854
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Abstract

This placebo-controlled study examined in healthy women the effects of ingestion of a single large dose of beta-carotene (120 mg) on the concentrations of beta-carotene and lycopene in plasma and skin, and the effects of UV light exposure on the concentrations of beta-carotene and lycopene in the skin. Ingestion of beta-carotene increased plasma beta-carotene concentration by 127%, from 0.26 +/- 0.06 (mean +/- SEM) to 0.59 +/- 0.07 mumol/L after 1 d, and the level remained elevated at 0.54 +/- 0.11 mumol/L after 5 d. beta-Carotene in skin, analyzed after 6 d, increased by 23%, from 1.41 +/- 0.74 to 1.74 +/- 0.72 nmol/g. beta-Carotene ingestion had no effect on the lycopene concentrations of plasma (0.37 +/- 0.11 mumol/L) or skin (1.60 +/- 0.62 nmol/g). A single exposure of a small area of one volar forearm to a dose of solar-simulated light (three times the individually determined minimal erythema dose) resulted in 31 to 46% reductions in skin lycopene concentration compared with an adjacent non-exposed area. The same UV dose did not result in significant changes in skin beta-carotene concentration. We conclude that a single 120-mg dose of beta-carotene increases plasma and skin beta-carotene concentrations and has no effect on plasma and skin lycopene concentrations. The amounts of lycopene in plasma and skin are comparable to or even greater than those of beta-carotene. When skin is subjected to UV light stress, more skin lycopene is destroyed compared with beta-carotene, suggesting a role of lycopene in mitigating oxidative damage in tissues.

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Crossref · 10.1093/jn/125.7.1854

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  • Lycopene was reported as the most quickly depleted antioxidant in skin upon exposure to solar radiation and might play a role of protection against UVR.

    “Lycopene was reported as the most quickly depleted antioxidant in skin upon exposure to solar radiation [9] and might play a role of protection against UVR.”

    From The Effect of Lycopene Preexposure on UV‐B‐Irradiated Human Keratinocytes (2016) · cites this paper as [9]

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Authors
Ribaya-Mercado, J. D., Garmyn, M., Gilchrest, B. A., & Russell, R. M.
Affiliations
  • Tufts University (US)
  • Boston University (US)
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
1995-08
Volume
125
Issue
7
Pages
1854-1859
ISSN
0022-3166 (ISSN-L)
DOI
10.1093/jn/125.7.1854
OpenAlex
W1962915086
Cited by
193
References
37
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2022: 8 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 6
FWCI
4.13
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of New England
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
lycopene, beta-carotene, UV irradiation, skin carotenoids, plasma carotenoid concentrations, simulated sunlight, oxidative damage, photoprotection
MeSH terms
Lycopene, Administration, Oral, Aged, Carotenoids, Female, Humans, Middle Aged, Skin, Ultraviolet Rays, beta Carotene

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