Cited by 76Adipose Tissue and MetabolismAutophagy in Disease and TherapyMitochondrial Function and Pathology

Mitophagy is required for brown adipose tissue mitochondrial homeostasis during cold challenge

Open access
Lu, Yuan, Fujioka, Hisashi, Joshi, Dinesh, Li, Qiaoyuan, Sangwung, Panjamaporn, Hsieh, Paishiun, Zhu, Jiyun, Torio, Jose +6 more·2018·Scientific Reports

Abstract

Brown adipose tissue (BAT) is a specialized thermogenic organ in mammals. The ability of BAT mitochondria to generate heat in response to cold-challenge to maintain core body temperature is essential for organismal survival. While cold activated BAT mitochondrial biogenesis is recognized as critical for thermogenic adaptation, the contribution of mitochondrial quality control to this process remains unclear. Here, we show mitophagy is required for brown adipocyte mitochondrial homeostasis during thermogenic adaptation. Mitophagy is significantly increased in BAT from cold-challenged mice (4 °C) and in β-agonist treated brown adipocytes. Blockade of mitophagy compromises brown adipocytes mitochondrial oxidative phosphorylation (OX-PHOS) capacity, as well as BAT mitochondrial integrity. Mechanistically, cold-challenge induction of BAT mitophagy is UCP1-dependent. Furthermore, our results indicate that mitophagy coordinates with mitochondrial biogenesis, maintaining activated BAT mitochondrial homeostasis. Collectively, our in vivo and in vitro findings identify mitophagy as critical for brown adipocyte mitochondrial homeostasis during cold adaptation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41598-018-26394-5

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

1 of the 74 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Lu, Y., Fujioka, H., Joshi, D., Li, Q., Sangwung, P., Hsieh, P., Zhu, J., Torio, J., Sweet, D., Wang, L., Chiu, S. Y., Croniger, C., Liao, X., & Jain, M. K.
Affiliations
  • University Hospitals of Cleveland (US)
  • Case Western Reserve University (US)
  • University of Wisconsin–Madison (US)
  • Capital Medical University (CN)
  • Illinois Mathematics and Science Academy (US)
Corresponding author
  • Lu, Yuan
  • Jain, Mukesh K.
Venue
Scientific Reports
Published
2018-05-29
Volume
8
Issue
1
Pages
8251-8251
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2807640547
Cited by
76
References
74
Citations by year
2026: 5 · 2025: 8 · 2024: 11 · 2023: 13 · 2022: 8 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 1
FWCI
5.33
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • American Heart Association (R01HL119195)
  • National Institutes of Health
  • National Institute on Aging (F30AG054237)
  • National Heart, Lung, and Blood Institute (F30HL139014, R35HL135789, R01HL086548, R01HL119195, R01HL123098)
  • National Institute of General Medical Sciences (T32GM007250)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK111468)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
mitophagy, brown adipose tissue, mitochondrial homeostasis, cold adaptation, thermogenesis, mitochondrial biogenesis, UCP1, oxidative phosphorylation, mitochondrial quality control, beta-adrenergic agonists, brown adipocytes
MeSH terms
Uncoupling Protein 1, Adrenergic beta-Agonists, Animals, Organelle Biogenesis, Adipose Tissue, Brown, Cells, Cultured, Cold Temperature, Homeostasis, Hypothermia, Mice, Inbred C57BL, Mitochondria, Oxidative Phosphorylation, Adipocytes, Mice, Knockout, Thermogenesis, Mice, Mitophagy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review