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The Interplay of Genetic Predisposition, Circadian Misalignment, and Metabolic Regulation in Obesity

Halder, S. K., & Melkani, G. C. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00613-3 · Cited by 23 · see citing works

Aging, Skeletal Muscle, and Epigenetics

Stewart, C. E., & Sharples, A. P. (2021) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000009670 · Cited by 22 · see citing works

Skeletal Muscles of Sedentary and Physically Active Aged People Have Distinctive Genic Extrachromosomal Circular DNA Profiles

Daniela Gerovska, D., & Araúzo-Bravo, M. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032736 · Cited by 22 · see citing works

Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women

Rodrigues, G. D. S., Noma, I. H. Y., Noronha, N., Watanabe, L. M., Sobrinho, A. C. D. S., de Lima, J. R. D., Sae-Lee, C., Benjamim, C. J. R., Nonino, C., & Bueno, C. (2023) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2023.2228388 · Cited by 14 · see citing works

Exercise epigenetics is fueled by cell bioenergetics: Supporting role on brain plasticity and cognition

Gómez‐Pinilla, F., & Thapak, P. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.04.237 · Cited by 21 · see citing works

Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study

You, Y., Li, J., Zhang, Y., Liu, Q., Ablitip, A., Lao, Y., Wang, J., Xu, K., Yao, Z., Chen, Y., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.11.047 · Cited by 20 · see citing works

Associations of combined genetic and epigenetic scores with muscle size and muscle strength: a pilot study in older women

He, L., Khanal, P., Morse, C. I., Williams, A. G., & Thomis, M. A. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12585 · Cited by 20 · see citing works

Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Neumann, A., Sammallahti, S., Cosín-Tomás, M., Reese, S. E., Suderman, M., Alemany, S., Almqvist, C., Andrušaitytė, S., Arshad, S. H., Bakermans-Kranenburg, M., et al. (2024) · Genome Medicine · doi:10.1186/s13073-025-01451-7 · Cited by 22 · see citing works

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers

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Converging protective pathways: Exploring the linkage between physical exercise, extracellular vesicles and oxidative stress

Lisi, V., Senesi, G., & Balbi, C. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.09.021 · Cited by 16 · see citing works

Epigenetic memory as crucial contributing factor in directing the differentiation of human iPSC into pancreatic β-cells in vitro

Diane, A., Mu-U-Min, R. B. A., & Al-Siddiqi, H. (2025) · Cell and Tissue Research · doi:10.1007/s00441-025-03952-8 · Cited by 14 · see citing works

The impact of physical activity on promoter-specific methylation of genes involved in the redox-status and disease progression: A longitudinal study on post-surgery female breast cancer patients undergoing medical treatment

Moulton, C., Murri, A., Benotti, G., Fantini, C., Duranti, G., Ceci, R., Grazioli, E., Cerulli, C., Sgrò, P., Rossi, C., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103033 · Cited by 16 · see citing works

Physical Activity Level Influences MTHFR Gene Methylation Profile in Diabetic Patients

Diniz, T. G., Silva, A. S., Nunes, M. K. D. S., Ribeiro, M. D., Filho, J. M., do Nascimento, R. A. F., Gomes, C. N. A. P., Evangelista, I. W. D. Q., de Oliveira, N. F. P., & Persuhn, D. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.618672 · Cited by 14 · see citing works

Exercise Cuts Both Ways with ROS in Remodifying Innate and Adaptive Responses: Rewiring the Redox Mechanism of the Immune System during Exercise

Thirupathi, A., Gu, Y., & Pinho, R. A. (2021) · Antioxidants · doi:10.3390/antiox10111846 · Cited by 14 · see citing works

Muscle health in Hispanic women. REDLINC VIII

Blümel, J. E., Salinas, C., Danckers, L., Tserotas, K., Ojeda, E., Vallejo, M. S., & Arteaga, E. (2019) · Climacteric · doi:10.1080/13697137.2019.1656186 · Cited by 14 · see citing works

Therapeutic Targets in Amyotrophic Lateral Sclerosis: Focus on Ion Channels and Skeletal Muscle

Tarantino, N., Canfora, I., Camerino, G. M., & Pierno, S. (2022) · Cells · doi:10.3390/cells11030415 · Cited by 14 · see citing works

Move to Remember: The Role of Physical Activity and Exercise in Preserving and Enhancing Cognitive Function in Aging—A Narrative Review

Martín-Rodríguez, A., Dalamitros, A. A., Madrigal-Cerezo, R., Sánchez-Conde, P., Clemente‐Suárez, V. J., & Tornero-Aguilera, J. F. (2025) · Geriatrics · doi:10.3390/geriatrics10060143 · Cited by 16 · see citing works

Exercise-induced redox modulation as a mediator of DNA methylation in health maintenance and disease prevention

Caporossi, D., & Dimauro, I. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.023 · Cited by 11 · see citing works

Dose response of leisure time physical activity and biological aging in type 2 diabetes: a cross sectional study

Wu, D., Jia, Y., Liu, Y., Pan, X., Li, P., & Shang, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-77359-w · Cited by 11 · see citing works

Physical Exercise–Induced DNA Methylation in Disease-Related Genes in Healthy Adults—A Systematic Review With Bioinformatic Analysis

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Exercise to Mitigate Cerebrovascular Aging: A Geroscience Perspective

Norling, A. M., & Lipsitz, L. A. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae083 · Cited by 11 · see citing works

Histone modifications as molecular drivers of cardiac aging: Metabolic alterations, epigenetic mechanisms, and emerging therapeutic strategies

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The Interplay of Epigenetic, Genetic, and Traditional Risk Factors on Blood Pressure: Findings from the Health and Retirement Study

Zhang, X., Ammous, F., Lin, L., Ratliff, S. M., Ware, E. B., Faul, J. D., Zhao, W., Kardia, S. L. R., & Smith, J. A. (2022) · Genes · doi:10.3390/genes13111959 · Cited by 10 · see citing works

Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes

Dye, C. K., Corley, M. J., Ing, C. T., Lum‐Jones, A., Li, D., Mau, M. K. L. M., & Maunakea, A. K. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01307-6 · Cited by 9 · see citing works

Leveraging DNA methylation to predict treatment response in major depressive disorder: A critical review

Dahrendorff, J., Currier, G. W., & Uddin, M. (2024) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32985 · Cited by 8 · see citing works

Exploring the Relationships between Lifestyle Patterns and Epigenetic Biological Age Measures in Men

Ke, T., Lophatananon, A., & Muir, K. R. (2024) · Biomedicines · doi:10.3390/biomedicines12091985 · Cited by 8 · see citing works

Cardiometabolic disease management: influences from epigenetics

Atzemian, N., Mohammed, S. A., Venanzio, L. D., Gorica, E., Costantino, S., Ruschitzka, F. T., & Paneni, F. (2025) · Epigenomics · doi:10.1080/17501911.2025.2489921 · Cited by 8 · see citing works

Higher mitochondrial oxidative capacity is the primary molecular differentiator in muscle of rats with high and low intrinsic cardiorespiratory fitness

Fleischman, J. Y., den Bergh, F. V., Collins, N. L., Bowers, M., Beard, D. A., & Burant, C. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101793 · Cited by 8 · see citing works

Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models

Choi, P. G., Kim, H. S., Park, S., Seo, H., Hahm, J., Huh, Y. H., Jeon, T., Ahn, J., & Jung, C. H. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.04.027 · Cited by 7 · see citing works

The association between weekly exercise patterns and acceleration of aging: Evidence from a population-based study

Jiang, G., Zhang, W., Kang, H., Wang, J., Liu, Z., Wang, Z., Huang, D., & Gao, A. (2024) · Preventive Medicine · doi:10.1016/j.ypmed.2024.108091 · Cited by 7 · see citing works

Exercise-mediated epigenetic modifications in cardiovascular diseases.

Yang, X.-Y., Zhang, Y., Wang, X., Chen, S., Zheng, Y., Hou, X., Wang, S., Zheng, X., Li, Q.-F., Sun, Y., et al. (2024) · Epigenomics · doi:10.1080/17501911.2024.2447811 · Cited by 8 · see citing works

Polyphenol‐Based Nutritional Strategies Combined With Exercise for Brain Function and Glioma Control: Focus on Epigenetic Modifications, Cognitive Function, Learning and Memory Processes

Yang, G., Yang, W., & Kiarasi, F. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70758 · Cited by 7 · see citing works

Characterization of methylation patterns associated with lifestyle factors and vitamin D supplementation in a healthy elderly cohort from Southwest Sweden

Cruz, M. A. D., Ulfenborg, B., Blomstrand, P., Faresjö, M., Ståhl, F. L., & Karlsson, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-15924-x · Cited by 8 · see citing works

Oxidative Stress in Military Missions—Impact and Management Strategies: A Narrative Analysis

Rădulescu, D., Mihai, F.-D., Trasca, M. E.-T., Căluianu, E. I., Calafeteanu, C. D. M., Radulescu, P.-M., Mercuţ, R., Ciupeanu-Călugăru, E. D., Marinescu, G.-A., Siloşi, C. A., et al. (2024) · Life · doi:10.3390/life14050567 · Cited by 7 · see citing works

Skeletal muscle in spinal muscular atrophy: Critical insights from pathogenesis to therapeutic strategies

Ottoboni, L. K., Panicucci, C., Magni, G., Gagliardi, D., Ripolone, M., Napoli, L., Moggio, M. G., Comi, G. P., Bruno, C., & Corti, S. P. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107324 · Cited by 6 · see citing works

Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle

Katayama, M., Nomura, K., Mudry, J. M., Chibalin, A., Krook, A., & Zierath, J. R. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102081 · Cited by 5 · see citing works

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis: State of the Art 2025

Duranti, E. (2025) · Muscles · doi:10.3390/muscles4030022 · Cited by 5 · see citing works

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Turner, D. C., Raastad, T., Ullrich, M., Christiansen, S. F., Sutherland, H., Boot, J. R., Woźniak, E. L., Mein, C. A., Dalbram, E., Treebak, J. T., et al. (2026) · Advanced Science · doi:10.1002/advs.202522726 · Cited by 5 · see citing works

What is Evidence-Based Functional Medicine in the 21st Century?

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Epigenetic mechanisms underlying the beneficial effects of cardiac rehabilitation. An overview from the working groups of “cellular and molecular biology of the heart” and “cardiac rehabilitation and cardiovascular prevention” of the Italian Society of Cardiology (SIC)

Visco, V., Forte, M., Giallauria, F., D’Ambrosio, L., Piccoli, M., Schiattarella, G. G., Mancusi, C., Salerno, N., Cesaro, A., Perrone, M. A., et al. (2025) · International Journal of Cardiology · doi:10.1016/j.ijcard.2025.133166 · Cited by 4 · see citing works

Environmental Influence on Epigenetics

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Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis

Chambers, J., Roscoe, C. M. P., Chidley, C., Lovett, A., & Duggirala, A. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22040637 · Cited by 4 · see citing works

Epigenetic regulation of Hutchinson-Gilford progeria syndrome: from molecular mechanisms to targeted interventions

Liu, X., Yang, S., Jiang, J., Dong, S., & Zhang, Y. (2025) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2025.9610013 · Cited by 3 · see citing works

Exercise modulates redox homeostasis in cardiovascular and metabolic diseases: from bench to clinic

Wang, J., Zhang, J., Zhang, H., Yu, F., Tian, Z., & Jia, D. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03131-1 · Cited by 3 · see citing works

Paradoxical effects of obesity on pre‑ vs. post‑menopausal breast cancer: The epigenetic mechanisms (Review)

Frederick, A. M., Racicot, R., & Liu, Z. (2021) · International Journal of Epigenetics · doi:10.3892/ije.2021.4 · Cited by 3 · see citing works

Molecular Profiling of DNA Methylation and Alternative Splicing of Genes in Skeletal Muscle of Obese Rabbits

Li, Y., Wang, J., Elzo, M. A., Fan, H., Du, K., Xia, S., Shao, J., Lai, T., Hu, S., Jia, X., et al. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb43030110 · Cited by 3 · see citing works

Biological aging partly mediates the association between physical activity and overactive bladder: evidence from NHANES 2007–2020

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The epigenetic control of inflammaging in skeletal muscle and adipose tissue

de Melo, D. G., Rodrigues, V. C. D. C., Pereira, G. J. D. S., Fernandes, C. J. D. C., & de Moura, L. P. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112205 · Cited by 2 · see citing works

Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study

Gao, T., Zheng, Y., Joyce, B. T., Kho, M., Terry, J. G., Wang, J., Nannini, D. R., Carr, J. J., Nair, S., Zhang, K., et al. (2023) · The Journals of Gerontology Series A · doi:10.1093/gerona/glad261 · Cited by 2 · see citing works

Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics ConsortiumPreprint

Neumann, A., Sammallahti, S., Cosín‐Tomás, M., Reese, S. E., Suderman, M. J., Alemany, S., Almqvist, C., Andrušaitytė, S., Arshad, S. H., Bakermans‐Kranenburg, M. J., et al. (2024) · medRxiv · doi:10.1101/2024.02.29.24303506 · Cited by 2 · see citing works

Physical fitness is associated with slower epigenetic aging in US adults: evidence from the National Health and Nutrition Examination Survey

Khodasevich, D., Gladish, N., Daredia, S., Bozack, A. K., Shen, H., Nwanaji‐Enwerem, J. C., Needham, B. L., Rehkopf, D. H., & Cárdenas, A. (2025) · AJE Advances Research in Epidemiology · doi:10.1093/ajeadv/uuaf023 · Cited by 1 · see citing works

Exercise-Epigenetic Axis: Metabolic Alignment to Oxidative Stress and Redox Status

Davison, G. W., Mohammed, A., Irwin, R., Lees-Murdock, D., & Walsh, C. P. (2025) · Epigenetics and human health · doi:10.1007/978-3-032-08045-5_7 · Cited by 1 · see citing works

Does leisure activity matter for epigenetic aging? Analyses of arts engagement and physical activity in the UK Household Longitudinal Study

Fancourt, D. E., Masebo, L., Finn, S., Mak, H. W., & Bu, F. (2026) · Innovation in Aging · doi:10.1093/geroni/igag038 · Cited by 1 · see citing works

The Role of Epigenetic Mechanisms in Skeletal Muscle Aging

Babayeva, Z. (2025) · NATURE AND SCIENCE · doi:10.36719/2707-1146/58/4-7

DNA methylation signatures in skeletal muscle associated with physical function in healthy older adults

Wen, X., Chen, M., Miao, G., Wu, C., Picca, A., Tamargo, J. A., Lou, X., Wu, K., Anton, S. A., Leeuwenburgh, C., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02410-9

Tissue‐specific methylomic responses to a lifestyle intervention in older adults associate with metabolic and physiological health improvements

Sinke, L., Beekman, M., Raz, Y., Gehrmann, T., Moustakas, I., Boulinguiez, A., Lakenberg, N., Suchiman, H. E. D., Bogaards, F. A., Bizzarri, D., et al. (2024) · Aging Cell · doi:10.1111/acel.14431 · Cited by 3 · see citing works

Global DNA methylation and physical fitness of elderly athletes with lifelong endurance activity

Lendvorský, L., Smolková, B., Buociková, V., Wachsmannová, L., & Bielik, V. (2020) · Journal of Human Sport and Exercise · doi:10.14198/jhse.2021.164.15 · Cited by 1 · see citing works

Age-Related DNA Methylation Changes: Potential Impact on Skeletal Muscle Aging in Humans

Gensous, N., Bacalini, M. G., Franceschi, C., Meskers, C. G. M., Maier, A. B., & Garagnani, P. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00996 · Cited by 53 · see citing works