Skeletal muscle in MuRF1 null mice is not spared in low-gravity conditions, indicating atrophy proceeds by unique mechanisms in space
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Microgravity exposure is associated with loss of muscle mass and strength. The E3 ubiquitin ligase MuRF1 plays an integral role in degrading the contractile apparatus of skeletal muscle; MuRF1 null (KO) mice have shown protection in ground-based models of muscle atrophy. In contrast, MuRF1 KO mice subjected to 21 days of microgravity on the International Space Station (ISS) were not protected from muscle atrophy. In a time course experiment microgravity-induced muscle loss on the ISS showed MuRF1 gene expression was not upregulated. A comparison of the soleus transcriptome profiles between spaceflight and a publicly available data set for hindlimb suspension, a claimed surrogate model of microgravity, showed only marginal commonalities between the models. These findings demonstrate spaceflight induced atrophy is unique, and that understanding of effects of space requires study situated beyond the Earth’s mesosphere.
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MuRF1 knockout mice are not protected from denervation-induced muscle loss at 7 days and only partially protected (around 30%) at 14 days; absence of MuRF1 does not protect from fasting or microgravity-induced atrophy, while muscle mass is spared following glucocorticoid treatment.
“MuRF1 knockout mice are not protected from denervation-induced muscle loss at 7 days and only partially protected (around 30%) at 14 days39. Moreover, the absence of MuRF1 does not protect from fasting or microgravity induced atrophy, while muscle mass is spared following glucocorticoid treatment43,44.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [43]
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Qayyum, S., Lavallee, C., Singh, M., & Wyant, G. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.21.753276
- Authors
- Cadena, S. M., Zhang, Y., Fang, J., Brachat, S., Kuss, P., Giorgetti, E., Stodieck, L. S., Kneissel, M., & Glass, D. J.
- Affiliations
- Novartis (Switzerland) (CH)
- University of Colorado Boulder (US)
- Corresponding author
- Glass, David J.
- Venue
- Scientific Reports
- Published
- 2019-06-28
- Volume
- 9
- Issue
- 1
- Pages
- 9397-9397
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6599046
- OpenAlex
- W2955034262
- Cited by
- 61
- References
- 26
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 12 · 2022: 9 · 2021: 13 · 2020: 8 · 2019: 4
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- The Novartis Repository (Novartis) (submittedVersion, cc-by)
- Funders
- National Aeronautics and Space Administration
- Kennedy Space Center
- Novartis Institutes for BioMedical Research
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Physical Sciences › Engineering › Aerospace Engineering › Space Exploration and Technology
- Keywords
- MuRF1, skeletal muscle atrophy, microgravity, spaceflight, E3 ubiquitin ligase, soleus muscle, hindlimb unloading, transcriptome, muscle mass loss, International Space Station
- MeSH terms
- Tripartite Motif Proteins, Animals, Disease Susceptibility, Gene Expression Regulation, Muscle Proteins, Muscular Atrophy, Organ Size, Space Flight, Mice, Knockout, Hypogravity, Muscle, Skeletal, Hindlimb Suspension, Gene Expression Profiling, Ubiquitin-Protein Ligases, Mice
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