Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids

Baehr, Leslie M.; Furlow, J. David; Bodine, Sue C.

doi:10.1113/jphysiol.2011.212845

Cited by 234Muscle Physiology and DisordersMuscle metabolism and nutritionNutrition and Health in Aging

Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids

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Baehr, Leslie M., Furlow, J. David, Bodine, Sue C.·2011·The Journal of Physiology

DOI 10.1113/jphysiol.2011.212845PMC PMC3213422

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Abstract

Non‐Technical Summary Skeletal muscle has the capacity to modify its size in response to external cues such as mechanical load, neural activity, hormones, stress and nutritional status. Pathological muscle loss or ‘atrophy’ occurs as the result of a number of disparate conditions including ageing, immobilization, diabetes, cancer, sepsis and as a serious side effect of corticosteroid hormone treatment. Synthetic glucocorticoids are often used to treat inflammation; however, high doses and chronic use of these hormones can lead to the loss of skeletal muscle mass and weakness. We show that in mice with a deletion of the MuRF1 protein, but not the MAFbx protein, the loss of muscle mass is attenuated relative to normal mice following 14 days of glucocorticoid treatment. Knowledge of how the MuRF1 protein functions in skeletal muscle to regulate skeletal muscle mass could lead to the development of therapeutics to prevent muscle atrophy under various conditions including glucocorticoid treatment.

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Inhibition of Atrogin-1 does not block denervation- and glucocorticoid-induced muscle loss and does not protect from aging sarcopenia.
“Inhibition of Atrogin-1 does not block denervation- and glucocorticoids-induced muscle loss19,44 and does not protect from aging sarcopenia46.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [44]
MuRF1 knockout mice are not protected from denervation-induced muscle loss at 7 days and only partially protected (around 30%) at 14 days; absence of MuRF1 does not protect from fasting or microgravity-induced atrophy, while muscle mass is spared following glucocorticoid treatment.
“MuRF1 knockout mice are not protected from denervation-induced muscle loss at 7 days and only partially protected (around 30%) at 14 days39. Moreover, the absence of MuRF1 does not protect from fasting or microgravity induced atrophy, while muscle mass is spared following glucocorticoid treatment43,44.”
From Mechanisms of muscle atrophy and hypertrophy: implications in health and disease (2021) · cites this paper as [44]
Animal models that lack MURF-1 expression are protected from atrophy.
“Animal models that lack MURF-1 expression are protected from atrophy [71,72].”
From Omega-3 Fatty Acids and Skeletal Muscle Health (2015) · cites this paper as [72]

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Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model
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The Role of MuRF1 in Glucocorticoid Induced Skeletal Muscle Atrophy
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Self-citation
The E3 Ligase MuRF1 Degrades Myosin Heavy Chain Protein in Dexamethasone-Treated Skeletal Muscle
Clarke, B. A., Drujan, D., Willis, M. S., Murphy, L. O., Corpina, R. A., Burova, E., Rakhilin, S. V., Stitt, T. N., Patterson, C., Latres, E., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.009 · Cited by 683 · see citing works
A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure
Watson, M. L., Baehr, L. M., Reichardt, H. M., Tuckermann, J. P., Bodine, S. C., & Furlow, J. D. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2011 · Cited by 120 · see citing works
Self-citation
Altered gene expression patterns in muscle ring finger 1 null mice during denervation- and dexamethasone-induced muscle atrophy
Furlow, J. D., Watson, M. L., Waddell, D. S., Neff, E. S., Baehr, L. M., Ross, A. P., & Bodine, S. C. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00022.2013 · Cited by 59 · see citing works
Self-citation
Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes
Castillero, E., Alamdari, N., Lecker, S. H., & Hasselgren, P.-O. (2013) · Metabolism · doi:10.1016/j.metabol.2013.05.018 · Cited by 88 · see citing works

Authors: Baehr, L. M., Furlow, J. D., & Bodine, S. C.
Affiliations: University of California, Davis (US)
ORCID: Baehr, Leslie M.
Bodine, Sue C.
Venue: The Journal of Physiology
Publisher: Wiley
Published: 2011-09-29
Volume: 589
Issue: 19
Pages: 4759-4776
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.2011.212845
PMC: PMC3213422
OpenAlex: W1590930560
Cited by: 234
References: 63
Citations by year: 2026: 7 · 2025: 19 · 2024: 14 · 2023: 15 · 2022: 15 · 2021: 18 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 18 · 2016: 12 · 2015: 22 · 2014: 21 · 2013: 26 · 2012: 15
FWCI: 8.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
University of California, Davis
National Cancer Institute (P30CA093373)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-75801, R01DK075801)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords: skeletal muscle atrophy, MuRF1, atrogin-1, dexamethasone, protein synthesis, protein degradation, ubiquitin-proteasome system, fiber cross-sectional area, muscle tension, triceps surae, tibialis anterior, gastrocnemius, knockout mice
MeSH terms: Tripartite Motif Proteins, Animals, Dexamethasone, Female, Glucocorticoids, Male, Mice, Inbred C57BL, Muscle Contraction, Muscle Proteins, Muscular Atrophy, Protein Biosynthesis, Mice, Knockout, Muscle, Skeletal, Ubiquitin, Ubiquitin-Protein Ligases, SKP Cullin F-Box Protein Ligases, Proteasome Endopeptidase Complex, Mice, Forkhead Transcription Factors, RING Finger Domains, Proteolysis

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Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids

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