Glial gene networks associated with alcohol dependence

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works

WGCNA: an R package for weighted correlation network analysis

Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252 · see citing works

HTSeq—a Python framework to work with high-throughput sequencing data

Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works

Gephi: An Open Source Software for Exploring and Manipulating Networks

Bastian, M., Heymann, S., & Jacomy, M. (2009) · Proceedings of the International AAAI Conference on Web and Social Media · doi:10.1609/icwsm.v3i1.13937 · Cited by 11,675 · see citing works

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw377 · Cited by 10,799 · see citing works

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971 · see citing works

A General Framework for Weighted Gene Co-Expression Network Analysis

Zhang, B., & Horvath, S. (2005) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1128 · Cited by 5,684 · see citing works

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

Zeisel, A., Muñoz-Manchado, A. B., Codeluppi, S., Lönnerberg, P., La Manno, G., Juréus, A., Marques, S., Munguba, H., He, L., Betsholtz, C., et al. (2015) · Science · doi:10.1126/science.aaa1934 · Cited by 3,124 · see citing works

Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632 · see citing works

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543 · see citing works

Gliotransmitters Travel in Time and Space

Araque, A., Carmignoto, G., Haydon, P. G., Oliet, S. H. R., Robitaille, R., & Volterra, A. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.007 · Cited by 1,308 · see citing works

Mapping RNA‐seq Reads with STAR

Dobin, A., & Gingeras, T. (2015) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi1114s51 · Cited by 1,265 · see citing works

Is My Network Module Preserved and Reproducible?

Langfelder, P., Luo, R., Oldham, M. C., & Horvath, S. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1001057 · Cited by 1,012 · see citing works

Astrocyte reactivity and reactive astrogliosis: costs and benefits

Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934 · see citing works

Cell type- and brain region-resolved mouse brain proteome

Sharma, K., Schmitt, S., Bergner, C. G., Tyanova, S., Kannaiyan, N., Manrique-Hoyos, N., Kongi, K., Cantuti, L., Hanisch, U.-K., Philips, M.-A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4160 · Cited by 871 · see citing works

Loss of ‘homeostatic’ microglia and patterns of their activation in active multiple sclerosis

Zrzavy, T., Hametner, S., Wimmer, I., Butovsky, O., Weiner, H. L., & Lassmann, H. (2017) · Brain · doi:10.1093/brain/awx113 · Cited by 684 · see citing works

Neurotransmitter receptors on microglia

Pocock, J. M., & Kettenmann, H. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.07.007 · Cited by 650 · see citing works

Astrocyte-derived ATP modulates depressive-like behaviors

Cao, X., Li, L.-P., Wang, Q., Wu, Q., Hu, H.-H., Zhang, M., Fang, Y.-Y., Zhang, J., Li, S.-J., Xiong, W.-C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3162 · Cited by 615 · see citing works

Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage

Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., & Guerri, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0976-10.2010 · Cited by 579 · see citing works

Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation

Jäkel, S., & Dimou, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00024 · Cited by 501 · see citing works

Toll-like Receptors and Type I Interferons

Uematsu, S., & Akira, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700009200 · Cited by 497 · see citing works

TREM2, microglia, and neurodegenerative diseases

Yeh, F. L., Hansen, D. V., & Sheng, M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.008 · Cited by 440 · see citing works

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

Colonna, M., & Wang, Y. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.7 · Cited by 418 · see citing works

Gene Coexpression Networks in Human Brain Identify Epigenetic Modifications in Alcohol Dependence

Ponomarev, I., Wang, S., Zhang, L., Harris, R. A., & Mayfield, R. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3136-11.2012 · Cited by 377 · see citing works

NMDA Receptors Mediate Neuron-to-Glia Signaling in Mouse Cortical Astrocytes

Lalo, U., Pankratov, Y. V., Kirchhoff, F., North, R. A., & Verkhratsky, A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4689-05.2006 · Cited by 355 · see citing works

Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis

Mulligan, M. K., Ponomarev, I., HITZEMANN, R. J., Belknap, J. K., Tabakoff, B., Harris, R. A., Crabbe, J. C., Blednov, Y. A., Grahame, N. J., Phillips, T. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510188103 · Cited by 347 · see citing works

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

Srinivasan, K., Friedman, B. A., Larson, J. L., Lauffer, B. E., Goldstein, L. D., Appling, L. L., Borneo, J., Poon, C., Ho, T., Cai, F., et al. (2016) · Nature Communications · doi:10.1038/ncomms11295 · Cited by 336 · see citing works

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Zheng, H., Jia, L., Liu, C.-C., Rong, Z., Zhong, L., Yang, L., Chen, X.-F., Fryer, J. D., Wang, X., Zhang, Y.-W., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2459-16.2017 · Cited by 317 · see citing works

Fractalkine regulation of microglial physiology and consequences on the brain and behavior

Paolicelli, R. C., Bisht, K., & Tremblay, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00129 · Cited by 314 · see citing works

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

Hasel, P., Dando, O., Jiwaji, Z., Baxter, P. S., Todd, A., Heron, S., Márkus, N. M., McQueen, J., Hampton, D. W., Torvell, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15132 · Cited by 305 · see citing works

TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage

Taylor, R. A., Chang, C.-F., Goods, B. A., Hammond, M. D., Grory, B. M., Ai, Y., Steinschneider, A. F., Renfroe, S. C., Askenase, M. H., McCullough, L. D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88647 · Cited by 277 · see citing works

Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

Lacagnina, M. J., Rivera, P. D., & Bilbo, S. D. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.121 · Cited by 271 · see citing works

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

Cho, S.-H., Sun, B., Zhou, Y., Kauppinen, T. M., Halabisky, B., Wes, P., Ransohoff, R. M., & Gan, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254268 · Cited by 268 · see citing works

Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals

Liu, J., Lewohl, J. M., Harris, R. A., Iyer, V. R., Dodd, P. R., Randall, P. K., & Mayfield, R. D. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300947 · Cited by 254 · see citing works

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

Blednov, Y. A., Ponomarev, I., Geil, C., Bergeson, S., Koob, G. F., & Harris, R. A. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00284.x · Cited by 251 · see citing works

The Neuroprotective Functions of Transforming Growth Factor Beta Proteins

Dobolyi, Á., Vincze, C., Pál, G., & Lovas, G. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13078219 · Cited by 251 · see citing works

Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice

Lopez, M. F., & Becker, H. C. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0026-3 · Cited by 248 · see citing works

Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization

Lewitus, G. M., Konefal, S., Greenhalgh, A. D., Pribiag, H., Augereau, K., & Stellwagen, D. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.030 · Cited by 244 · see citing works

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness

Papouin, T., Dunphy, J. M., Tolman, M., Dineley, K. T., & Haydon, P. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.021 · Cited by 243 · see citing works

Neuroprotection mediated through estrogen receptor-α in astrocytes

Spence, R. D., Hamby, M. E., Umeda, E. A., Itoh, N., Du, S., Wisdom, A. J., Cao, Y., Bondar, G., Lam, J., Ao, Y., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103833108 · Cited by 236 · see citing works

Inflammatory Mediators Alter the Astrocyte Transcriptome and Calcium Signaling Elicited by Multiple G-Protein-Coupled Receptors

Hamby, M. E., Coppola, G., Ao, Y., Geschwind, D. H., Khakh, B. S., & Sofroniew, M. V. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1256-12.2012 · Cited by 228 · see citing works

Neuroimmune signaling in alcohol use disorder

Erickson, E. K., Grantham, E. K., Warden, A. S., & Harris, R. A. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.12.007 · Cited by 224 · see citing works

G _i/o protein‐coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

Durkee, C. A., Covelo, A., Lines, J., Kofuji, P., Aguilar, J., & Araque, A. (2019) · Glia · doi:10.1002/glia.23589 · Cited by 224 · see citing works

Glial and glutamatergic markers in depression, alcoholism, and their comorbidity

Miguel-Hidalgo, J. J., Waltzer, R., Whittom, A. A., Austin, M. C., Rajkowska, G., & Stockmeier, C. A. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.003 · Cited by 218 · see citing works

MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation

Fricker, M., Neher, J. J., Zhao, J.-W., Théry, C., Tolkovsky, A. M., & Brown, G. C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4837-11.2012 · Cited by 218 · see citing works

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities

Liu, X., Nemeth, D. P., McKim, D. B., Zhu, L., DiSabato, D. J., Berdysz, O., Gorantla, G., Oliver, B., Witcher, K. G., Wang, Y., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.012 · Cited by 218 · see citing works

P2Y12 expression and function in alternatively activated human microglia

Moore, C. S., Ase, A. R., Kinsara, A., Rao, V. T. S., Michell-Robinson, M., Leong, S. Y., Butovsky, O., Ludwin, S. K., Séguéla, P., Bar-Or, A., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000080 · Cited by 212 · see citing works

Astrocytic β ₂ -adrenergic receptors mediate hippocampal long-term memory consolidation

Gao, V., Suzuki, A., Magistretti, P. J., Lengacher, S., Pollonini, G., Steinman, M. Q., & Alberini, C. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605063113 · Cited by 207 · see citing works

Medications development to treat alcohol dependence: a vision for the next decade

Litten, R. Z., Egli, M., Heilig, M. A., Cui, C., Fertig, J. B., Ryan, M. L., Falk, D. E., Moss, H. B., Huebner, R. B., & Noronha, A. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00454.x · Cited by 204 · see citing works

Alzheimer’s disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

Sekar, S., McDonald, J., Cuyugan, L., Aldrich, J., Kurdoglu, A., Adkins, J., Serrano, G., Beach, T. G., Craig, D. W., Valla, J., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.027 · Cited by 199 · see citing works

Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

Scofield, M. D., Boger, H. A., Smith, R. J., Li, H., Haydon, P. G., & Kalivas, P. W. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.016 · Cited by 197 · see citing works

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

Perea, G., Gómez, R., Mederos, S., Covelo, A., Ballesteros, J. J., Schlosser, L., Hernández-Vivanco, A., Martín-Fernández, M., Quintana, R., Rayan, A., et al. (2016) · eLife · doi:10.7554/elife.20362 · Cited by 194 · see citing works

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

Blankman, J. L., Long, J. Z., Trauger, S. A., Siuzdak, G. E., & Cravatt, B. F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217121110 · Cited by 193 · see citing works

Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration

Qin, L., & Crews, F. T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-130 · Cited by 192 · see citing works

Silencing of TGFβ signalling in microglia results in impaired homeostasis

Zöller, T., Schneider, A., Kleimeyer, C., Masuda, T., Potru, P. S., Pfeifer, D., Blank, T., Prinz, M., & Spittau, B. (2018) · Nature Communications · doi:10.1038/s41467-018-06224-y · Cited by 189 · see citing works

Impact of the Innate Immune Response in the Actions of Ethanol on the Central Nervous System

Montesinos, J., Alfonso‐Loeches, S., & Guerri, C. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13208 · Cited by 184 · see citing works

Wnt your brain be inflamed? Yes, it Wnt!

Marchetti, B., & Pluchino, S. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.001 · Cited by 165 · see citing works

Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay

Kamat, S. S., Camara, K., Parsons, W. H., Chen, D., Dix, M. M., Bird, T. D., Howell, A. R., & Cravatt, B. F. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1721 · Cited by 164 · see citing works

Neuroimmune Mechanisms of Alcohol and Drug Addiction

Cui, C., Shurtleff, D., & Harris, R. A. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00001-4 · Cited by 163 · see citing works

Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling

Hines, D. J., Schmitt, L. I., Hines, R. M., Moss, S. J., & Haydon, P. G. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.136 · Cited by 160 · see citing works

Biological roles of CCAAT/Enhancer-binding protein delta during inflammation

Ko, C., Chang, W., & Wang, J. (2015) · Journal of Biomedical Science · doi:10.1186/s12929-014-0110-2 · Cited by 157 · see citing works

Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein δ

Sterneck, E., Paylor, R. E., Jackson-Lewis, V. R., Libbey, M., Przedborski, S., Tessarollo, L., Crawley, J. N., & Johnson, P. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10908 · Cited by 150 · see citing works

Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence

Bull, C., Freitas, K. C., Zou, S., Poland, R. S., Syed, W. A., Urban, D. J., Minter, S. C., Shelton, K. L., Hauser, K. F., Negus, S. S., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.135 · Cited by 145 · see citing works

Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal

Walter, T. J., & Crews, F. T. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0856-z · Cited by 141 · see citing works

The inhibitory neurotransmitter GABA evokes long‐lasting C a 2+ oscillations in cortical astrocytes

Mariotti, L., Losi, G., Sessolo, M., Marcon, I., & Carmignoto, G. (2015) · Glia · doi:10.1002/glia.22933 · Cited by 126 · see citing works

Disruption of blood–brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge‐like drinking model

Rubio‐Araiz, A., Porcu, F., Pérez‐Hernández, M., García‐Gutiérrez, M. S., Aracil‐Fernández, M. A., Gutiérrez‐López, M. D., Guerri, C., Manzanares, J., O’Shea, E., & Colado, M. I. (2016) · Addiction Biology · doi:10.1111/adb.12376 · Cited by 125 · see citing works

Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: Relationship to acamprosate actions

Blednov, Y. A., & Adron Harris, R. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008584 · Cited by 123 · see citing works

Intermittent (Every-Other-Day) Drinking Induces Rapid Escalation of Ethanol Intake and Preference in Adolescent and Adult C57BL/6J Mice

Meléndez, R. I. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01383.x · Cited by 121 · see citing works

Proliferating Reactive Astrocytes Are Regulated by Notch-1 in the Peri-Infarct Area After Stroke

Shimada, I. S., Borders, A., Aronshtam, A., & Spees, J. L. (2011) · Stroke · doi:10.1161/strokeaha.111.623280 · Cited by 118 · see citing works

Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation

Halleskog, C., Dijksterhuis, J., Kilander, M. B. C., Becerril-Ortega, J., Villaescusa, J., Lindgren, E., Arenas, E., & Schulte, G. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-111 · Cited by 115 · see citing works

CRF-Amplified Neuronal TLR4/MCP-1 Signaling Regulates Alcohol Self-Administration

June, H. L., Liu, J., Warnock, K. T., Bell, K., Balan, I. S., Bollino, D. R., Puché, A. C., & Aurelian, L. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.4 · Cited by 108 · see citing works

Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice

Kamens, H. M., Andersen, J., & Picciotto, M. R. (2010) · Psychopharmacology · doi:10.1007/s00213-009-1759-1 · Cited by 100 · see citing works

An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody

Batiuk, M. Y., de Vin, F., Duqué, S. I., Li, C., Saito, T., Saido, T. C., Fiers, M. W. E. J., Belgard, T. G., & Holt, M. G. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.765313 · Cited by 100 · see citing works

Neuroimmune Pathways in Alcohol Consumption: Evidence from Behavioral and Genetic Studies in Rodents and Humans

Robinson, G., Most, D., Ferguson, L. B., Mayfield, J., Harris, R. A., & Blednov, Y. A. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801284-0.00002-6 · Cited by 96 · see citing works

Reciprocal Regulation of Mitochondrial Dynamics and Calcium Signaling in Astrocyte Processes

Jackson, J. G., & Robinson, M. B. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2049-15.2015 · Cited by 96 · see citing works

Anti-ACSA-2 defines a novel monoclonal antibody for prospective isolation of living neonatal and adult astrocytes

Kantzer, C. G., Boutin, C., Herzig, I. D., Wittwer, C., Reiß, S., Tiveron, M.-C., Drewes, J., Rockel, T. D., Ohlig, S., Ninkovic, J., et al. (2017) · Glia · doi:10.1002/glia.23140 · Cited by 96 · see citing works

Expression of ?2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells

Marzolo, M., Rommy von Bernhardi, M., Bu, G., & Inestrosa, N. C. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000501)60:3 · Cited by 87 · see citing works

Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1

Pignataro, L., Miller, A. N., Ma, L., Midha, S., Protiva, P., Herrera, D. G., & Harrison, N. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4142-07.2007 · Cited by 83 · see citing works

Gene Expression in Brain and Liver Produced by Three Different Regimens of Alcohol Consumption in Mice: Comparison with Immune Activation

Osterndorff-Kahanek, E. A., Ponomarev, I., Blednov, Y. A., & Harris, R. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059870 · Cited by 82 · see citing works

Novel Applications of Magnetic Cell Sorting to Analyze Cell-Type Specific Gene and Protein Expression in the Central Nervous System

Holt, L. M., & Olsen, M. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150290 · Cited by 81 · see citing works

G protein-coupled receptor heteromers are key players in substance use disorder

Derouiche, L., & Massotte, D. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.026 · Cited by 76 · see citing works

Chronic Ethanol Exposure Produces Time- and Brain Region-Dependent Changes in Gene Coexpression Networks

Osterndorff-Kahanek, E. A., Becker, H. C., Lopez, M. F., Farris, S. P., Tiwari, G. R., Núnez, Y. O., Harris, R. A., & Mayfield, R. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121522 · Cited by 75 · see citing works

Attenuation of Ethanol Withdrawal by Ceftriaxone-Induced Upregulation of Glutamate Transporter EAAT2

Abulseoud, O. A., Çamsarı, U. M., Ruby, C. L., Kasasbeh, A. S., Choi, S. H., & Choi, D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.14 · Cited by 75 · see citing works

Brain region‐specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice

Meléndez, R. I., McGinty, J. F., Kalivas, P. W., & Becker, H. C. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00357.x · Cited by 75 · see citing works

Transforming growth factor-β1 produced by hippocampal cells modulates microglial reactivity in culture

Herrera‐Molina, R., & Rommy von Bernhardi, M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.003 · Cited by 74 · see citing works

Chronic ethanol consumption: role of TLR3/TRIF ‐dependent signaling

McCarthy, G. M., Warden, A. S., Bridges, C. R., Blednov, Y. A., & Harris, R. A. (2017) · Addiction Biology · doi:10.1111/adb.12539 · Cited by 70 · see citing works

SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia

Lloyd-Burton, S. M., York, E. M., Anwar, M. A., Vincent, A. J., & Roskams, A. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3585-12.2013 · Cited by 67 · see citing works

Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel

Wu, S.-Y., Chen, Y., Tsai, S., Wu, S., Shih, Y., Jiang‐Shieh, Y., Yang, T.-T., & Kuo, Y. (2016) · Scientific Reports · doi:10.1038/srep22864 · Cited by 67 · see citing works

Striatal Adenosine Signaling Regulates EAAT2 and Astrocytic AQP4 Expression and Alcohol Drinking in Mice

Lee, M. R., Ruby, C. L., Hinton, D. J., Choi, S. H., Adams, C. A., Kang, N. Y., & Choi, D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.198 · Cited by 64 · see citing works

Alcohol dependence and free-choice drinking in mice

Griffin, W. C. (2014) · Alcohol · doi:10.1016/j.alcohol.2013.11.006 · Cited by 64 · see citing works

Cyfip1 Regulates Presynaptic Activity during Development

Hsiao, K., Harony-Nicolas, H., Buxbaum, J. D., Bozdagi-Gunal, O., & Benson, D. L. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0511-15.2016 · Cited by 64 · see citing works

Ethanol Consumption in Mice Lacking CD14, TLR2, TLR4, or MyD88

Blednov, Y. A., Black, M., Chernis, J., Costa, A. D., Mayfield, J., & Harris, R. A. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13316 · Cited by 61 · see citing works

Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice

Warden, A. S., Azzam, M. M., DaCosta, A., Mason, S., Blednov, Y. A., Messing, R. O., Mayfield, R. D., & Harris, R. A. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.12.004 · Cited by 61 · see citing works

Astrocytes phagocytose focal dystrophies from shortening myelin segments in the optic nerve of Xenopus laevis at metamorphosis

Mills, E. A., Davis, C.-H. O., Bushong, E. A., Boassa, D., Kim, K.-Y., Ellisman, M. H., & Marsh‐Armstrong, N. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506486112 · Cited by 60 · see citing works

Microglial-specific transcriptome changes following chronic alcohol consumption

McCarthy, G. M., Farris, S. P., Blednov, Y. A., Harris, R. A., & Mayfield, R. D. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.10.035 · Cited by 57 · see citing works

SPARC triggers a cell-autonomous program of synapse elimination

López-Murcia, F. J., Terni, B., & Llobet, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512202112 · Cited by 56 · see citing works

Astrocyte-specific transcriptome responses to chronic ethanol consumption

Erickson, E. K., Farris, S. P., Blednov, Y. A., Mayfield, R. D., & Harris, R. A. (2018) · The Pharmacogenomics Journal · doi:10.1038/s41397-017-0012-2 · Cited by 56 · see citing works

Genes and Alcohol Consumption

Mayfield, J., Arends, M. A., Harris, R. A., & Blednov, Y. A. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.02.014 · Cited by 54 · see citing works

GLAST But Not Least—Distribution, Function, Genetics and Epigenetics of l-Glutamate Transport in Brain—Focus on GLAST/EAAT1

Šerý, O., Sultana, N., Kashem, M. A., Pow, D. V., & Balcar, V. J. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1605-2 · Cited by 52 · see citing works

TRIL, a Functional Component of the TLR4 Signaling Complex, Highly Expressed in Brain

Carpenter, S. B., Carlson, T. J., Dellacasagrande, J., Garcia, A., Gibbons, S., Hertzog, P. J., Lyons, A., Lin, L., Lynch, M. A., Monie, T. P., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901518 · Cited by 52 · see citing works

CRF 1 Receptor‐Dependent Increases in Irritability‐Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure

Kimbrough, A., de Guglielmo, G., Kononoff, J., Kallupi, M., Zorrilla, E. P., & George, O. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13484 · Cited by 51 · see citing works

Resilience Dysregulation in Major Depressive Disorder: Focus on Glutamatergic Imbalance and Microglial Activation

Réus, G. Z., de Moura, A. B., da Silva, R. H., Resende, W. R., & Quevedo, J. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170630164715 · Cited by 50 · see citing works

CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons

Pardo, L., Valor, L. M., Eraso‐Pichot, A., Barco, Á., Golbano, A., Hardingham, G. E., Masgrau, R., & Galea, E. (2017) · Scientific Reports · doi:10.1038/s41598-017-06231-x · Cited by 50 · see citing works

The sequenced rat brain transcriptome – its use in identifying networks predisposing alcohol consumption

Saba, L. M., Flink, S. C., Vanderlinden, L. A., Israel, Y., Tampier, L., Colombo, G., Kiianmaa, K., Bell, R. L., Printz, M. P., Flodman, P. L., et al. (2015) · FEBS Journal · doi:10.1111/febs.13358 · Cited by 49 · see citing works

A Review of the Potential Mechanisms of Action of Baclofen in Alcohol Use Disorder

de Beaurepaire, R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00506 · Cited by 49 · see citing works

Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation

Wang, S., Lim, S.-W., Wang, Y.-H., Lin, H.-Y., Lai, M.-D., Ko, C., & Wang, J. (2018) · Redox Biology · doi:10.1016/j.redox.2018.02.011 · Cited by 48 · see citing works

The Neuroimmune Basis of Excessive Alcohol Consumption

Mayfield, J., & Harris, R. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.177 · Cited by 45 · see citing works

Nalmefene Prevents Alcohol‐Induced Neuroinflammation and Alcohol Drinking Preference in Adolescent Female Mice: Role of TLR4

Montesinos, J., Gil, A., & Guerri, C. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13416 · Cited by 45 · see citing works

Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST

Karlsson, R.-M., Adermark, L., Molander, A., Perreau-Lenz, S., Singley, E., Solomon, M., Holmes, A., Tanaka, K., Lovinger, D. M., Spanagel, R., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.027 · Cited by 44 · see citing works

Increase of Zinc Finger Protein 179 in Response to CCAAT/Enhancer Binding Protein Delta Conferring an Antiapoptotic Effect in Astrocytes of Alzheimer’s Disease

Wang, S., Lee, Y., Ko, C., Lai, M. D., Lin, D.-Y., Pao, P., Chi, J.-Y., Hsiao, Y., Liu, T. L., & Wang, J. M. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8714-9 · Cited by 42 · see citing works

Microglia: first responders in the central nervous system.

Cătălin, B., Cupido, A., Iancău, M., Albu, C. V., & Kirchhoff, F. (2013) · PubMed · Cited by 41 · see citing works

Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge

González-Peña, D., Nixon, S. E., O’Connor, J. C., Southey, B. R., Lawson, M. A., McCusker, R. H., Borras, T., Machuca, D., Hernández, Á. G., Dantzer, R., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150858 · Cited by 41 · see citing works

Effects of Acamprosate on Attentional Set‐Shifting and Cellular Function in the Prefrontal Cortex of Chronic Alcohol‐Exposed Mice

Hu, W., Morris, B., Carrasco, A., & Kroener, S. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12722 · Cited by 37 · see citing works

GABA B receptor-mediated activation of astrocytes by gamma-hydroxybutyric acid

Gould, T. M., Chen, L., Emri, Z., Pirttimäki, T., Errington, A. C., Crunelli, V., & Parri, H. R. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0607 · Cited by 37 · see citing works

CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression.

Valente, T., Straccia, M., Gresa-arribas, N., Dentesano, G., Tusell, J. M., Serratosa, J., Mancera, P., Solà, C., & Saura, J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.007 · Cited by 35 · see citing works

Milk Fat Globule-EGF Factor VIII Attenuates CNS Injury by Promoting Neural Stem Cell Proliferation and Migration after Cerebral Ischemia

Cheyuo, C., Aziz, M., Yang, W., Jacob, A., Zhou, M., & Wang, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122833 · Cited by 34 · see citing works

Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression

Bray, J. G., Reyes, K. C., Roberts, A. J., Ransohoff, R. M., & Gruol, D. L. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.007 · Cited by 34 · see citing works

Persistent Overexposure to N-Methyl-d-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes

Skowrońska, K., Obara‐Michlewska, M., Czarnecka, A. M., et al. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9958-3 · Cited by 34 · see citing works

Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats

Miguel-Hidalgo, J. J., Shoyama, Y., & Wanzo, V. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108091074 · Cited by 31 · see citing works

Brief alcohol exposure alters transcription in astrocytes via the heat shock pathway

Pignataro, L., Varodayan, F. P., Tannenholz, L., Protiva, P., & Harrison, N. L. (2013) · Brain and Behavior · doi:10.1002/brb3.125 · Cited by 30 · see citing works

Astrocytic CCAAT/Enhancer Binding Protein δ Regulates Neuronal Viability and Spatial Learning Ability via miR-135a

Chu, Y., Ko, C., Wang, W., Wang, S., Gean, P., Kuo, Y., & Wang, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9359-z · Cited by 29 · see citing works

Chronic alcoholics have substantial glial pathology in the forebrain and diencephalon.

Cullen, K. M., & Halliday, G. M. (1994) · PubMed · Cited by 29 · see citing works

Alcohol vapor exposure differentially impacts mesocorticolimbic cytokine expression in a sex-, region-, and duration-specific manner

Baxter-Potter, L. N., Henricks, A. M., Berger, A. L., Bieniasz, K. V., Lugo, J. M., & McLaughlin, R. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.01.015 · Cited by 29 · see citing works

Haploinsufficiency of the schizophrenia and autism risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanisms

Haan, N., Westacott, L. J., Carter, J., Owen, M. J., Gray, W. P., Hall, J., & Wilkinson, L. S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01415-6 · Cited by 29 · see citing works

Possible roles of astrocytes in estrogen neuroprotection during cerebral ischemia

Wang, C., Jie, C., & Dai, X. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0055 · Cited by 28 · see citing works

Effect of gabapentin on sleep and delta and theta EEG power in adult rats exposed to chronic intermittent ethanol vapor and protracted withdrawal during adolescence

Ehlers, C. L., Sánchez-Alavez, M., & Wills, D. N. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4888-6 · Cited by 27 · see citing works

TRIL Is Involved in Cytokine Production in the Brain following Escherichia coli Infection

Wochal, P., Rathinam, V. A. K., Dunne, A., Carlson, T. J., Kuang, W., Seidl, K. J., Hall, J. P., Lin, L., Collins, M. A., Schattgen, S., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302392 · Cited by 26 · see citing works

Exploring the Role of Central Astrocytic Glutamate Uptake in Ethanol Reward in Mice

Smith, K. L., John, C. S., Sypek, E. I., Öngür, D., Cohen, B. M., Barry, S. M., & Bechtholt, A. J. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12361 · Cited by 19 · see citing works

Alcohol Regulates BK Surface Expression via Wnt/β-Catenin Signaling

Velázquez‐Marrero, C., Burgos, A., García, J., Palacio, S., Marrero, H. G., Bernardo, A., Laspiur, J. P., Rivera-Oliver, M., Seale, G. E., & Treistman, S. N. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0491-16.2016 · Cited by 18 · see citing works

Transgenic mice with increased astrocyte expression of CCL2 show altered behavioral effects of alcohol

Bray, J. G., Roberts, A. J., & Gruol, D. L. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.009 · Cited by 15 · see citing works

An ethanol vapor chamber system for small animals

Wang, J., Jiang, L., Du, H., et al. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.04.017 · Cited by 11 · see citing works

Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling

Terunuma, M., Haydon, P. G., Pangalos, M. N., & Moss, S. J. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.015 · Cited by 11 · see citing works

Resilience dysregulation in major depressive disorder: focus on glutamatergic imbalance and microglial activation

Réus, G. Z., de Moura, A. B., da Silva, R. H., et al. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170703113726 · Cited by 5 · see citing works

Haploinsufficiency of the psychiatric risk gene Cyfip1 causes abnormal postnatal hippocampal neurogenesis through microglial and Arp2/3 mediated actin dependent mechanismsPreprint

Haan, N., Westacott, L. J., Carter, J., Owen, M. J., Gray, W. P., Hall, J., & Wilkinson, L. S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/417832 · Cited by 2 · see citing works

Single cell transcriptome profiling of the human alcohol-dependent brain

Brenner, E., Tiwari, G. R., Kapoor, M., Liu, Y., Brock, A., & Mayfield, R. D. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa038 · Cited by 118 · see citing works

Astrocyte Stimulates Microglial Proliferation and M2 Polarization in vitro through Cross-Talk between Astrocyte and MicrogliaPreprint

Kim, S., & Son, Y. (2021) · Preprints.org · doi:10.20944/preprints202107.0331.v1

Asiaticoside counteracts the in vitro activation of microglia and astrocytes: Innuendo for multiple sclerosis

Madhu, K., & Prakash, T. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.08.010 · Cited by 9 · see citing works

STIMULATED MICROGLIA SUPERNATANTS INDUCED OVEREXPRESSION OF NEURONAL NITRIC OXIDE GENE IN ASTROCYTES

Esen, N., & Savlı, H. (2003) · International Journal of Neuroscience · doi:10.1080/00207450390204013 · Cited by 1 · see citing works

Reactive glia as rivals in regulating neuronal survival

Giulian, D. (1993) · Glia · doi:10.1002/glia.440070116 · Cited by 296 · see citing works

Substance P Receptors on O‐2A Progenitor Cells and Type‐2 Astrocytes In Vitro

Marriott, D. R., & Wilkin, G. P. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03593.x · Cited by 35 · see citing works