Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
Open accessAbstract
Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-d-aspartate receptor-dependent synaptic Wnt3a release, nuclear beta-catenin accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation. These findings suggest that Wnt signaling plays a critical role in regulating synaptic plasticity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Frizzled-mediated Wnt/β-catenin signaling plays an important role in synaptic plasticity.
“Frizzled-mediated Wnt/β-catenin signaling has been shown to play an important role in synaptic plasticity (Chen et al., 2006; Varela-Nallar et al., 2010; Varela-Nallar et al., 2009).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Chen et al., 2006
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,515 · see citing works
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,305 · see citing works
WNT and β-catenin signalling: diseases and therapies
Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763 · see citing works
Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
Yuste, R., & Bonhoeffer, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1071 · Cited by 1,269 · see citing works
Actin-based plasticity in dendritic spines
Matus, A. (2000) · Science · doi:10.1126/science.290.5492.754 · Cited by 815 · see citing works
Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors
Maretto, S., Cordenonsi, M., Dupont, S., Braghetta, P., Broccoli, V., Hassan, A. B., Volpin, D., Bressan, G. M., & Piccolo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0434590100 · Cited by 759 · see citing works
Axonal Remodeling and Synaptic Differentiation in the Cerebellum Is Regulated by WNT-7a Signaling
Hall, A. C., Lucas, F. R., & Salinas, P. C. (2000) · Cell · doi:10.1016/s0092-8674(00)80689-3 · Cited by 687 · see citing works
A local Wnt-3a signal is required for development of the mammalian hippocampus
Lee, S. M. K., Tole, S., Grove, E. A., & McMahon, A. P. (2000) · Development · doi:10.1242/dev.127.3.457 · Cited by 636 · see citing works
WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
Ciani, L., & Salinas, P. C. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1665 · Cited by 631 · see citing works
Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling
Lyuksyutova, A. I., Lu, C.-C., Milanesio, N., King, L. A., Guo, N., Wang, Y., Nathans, J., Tessier‐Lavigne, M., & Zou, Y. (2003) · Science · doi:10.1126/science.1089610 · Cited by 557 · see citing works
Expression of CD44 in Apc and TcfMutant Mice Implies Regulation by the WNT Pathway
Wielenga, V. T., Smits, R., Kořínek, V., Smit, L., Kielman, M. F., Fodde, R., Clevers, H. C., & Pals, S. T. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65297-2 · Cited by 512 · see citing works
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
Zhang, Z., Hartmann, H., Do, V. M., Abramowski, D., Sturchler, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H. C., Säftig, P., et al. (1998) · Nature · doi:10.1038/27208 · Cited by 511 · see citing works
Cadherin Regulates Dendritic Spine Morphogenesis
Togashi, H., Abe, K., Mizoguchi, A., Takaoka, K., Chisaka, O., & Takeichi, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00748-1 · Cited by 485 · see citing works
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C. (2005) · Nature Neuroscience · doi:10.1038/nn1374 · Cited by 485 · see citing works
Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1
Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C.-X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80354-2 · Cited by 470 · see citing works
Mammalian Ryk Is a Wnt Coreceptor Required for Stimulation of Neurite Outgrowth
Lu, W., Yamamoto, V. N., Ortega, B., & Baltimore, D. (2004) · Cell · doi:10.1016/j.cell.2004.09.019 · Cited by 466 · see citing works
Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.Preprint
Gavin, B. J., McMahon, J. A., & McMahon, A. P. (1990) · Genes & Development · doi:10.1101/gad.4.12b.2319 · Cited by 455 · see citing works
β-catenin is critical for dendritic morphogenesis
Yu, X., & Malenka, R. C. (2003) · Nature Neuroscience · doi:10.1038/nn1132 · Cited by 454 · see citing works
Wnt-mediated axon guidance via the Drosophila Derailed receptor
Yoshikawa, S., McKinnon, R. D., Kokel, M., & Thomas, J. B. (2003) · Nature · doi:10.1038/nature01522 · Cited by 416 · see citing works
The Drosophila Wnt, Wingless, Provides an Essential Signal for Pre- and Postsynaptic Differentiation
Packard, M. C., Koo, E. S., Gorczyca, M. G., Sharpe, J., Cumberledge, S., & Budnik, V. (2002) · Cell · doi:10.1016/s0092-8674(02)01047-4 · Cited by 410 · see citing works
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
Galcerán, J., Miyashita-Lin, E. M., Devaney, E. J., Rubenstein, J. L. R., & Grosschedl, R. (2000) · Development · doi:10.1242/dev.127.3.469 · Cited by 399 · see citing works
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemüller, A. J. M., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G. C., & Nicoletti, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1381-04.2004 · Cited by 394 · see citing works
Hsieh, J.-C., Rattner, A., Smallwood, P. M., & Nathans, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3546 · Cited by 349 · see citing works
Murase, S., Mosser, E. A., & Schuman, E. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00764-x · Cited by 337 · see citing works
Ferrari, G. V. D., Chacón, M. A., Barría, M. I., Garrido, J., Godoy, J. A., Olivares, G. H., Reyes, A. E., Alvarez, A. R., Bronfman, M., & Inestrosa, N. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001208 · Cited by 331 · see citing works
Role of β-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly
Bamji, S. X., Shimazu, K., Kimes, N. E., Huelsken, J., Birchmeier, W., Lu, B., & Reichardt, L. F. (2003) · Neuron · doi:10.1016/s0896-6273(03)00718-9 · Cited by 310 · see citing works
Miwa, N., Furuse, M., Tsukita, S., et al. (2001) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504001108747477 · Cited by 299 · see citing works
Wnt–Ryk signalling mediates medial–lateral retinotectal topographic mapping
Schmitt, A. M., Shi, J., Wolf, A. M., Lu, C.-C., King, L. A., & Zou, Y. (2006) · Nature · doi:10.1038/nature04334 · Cited by 292 · see citing works
Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract
Liu, Y., Shi, J., Lu, C.-C., Wang, Z.-B., Lyuksyutova, A. I., Song, X., & Zou, Y. (2005) · Nature Neuroscience · doi:10.1038/nn1520 · Cited by 264 · see citing works
Nishimura, M., Yu, G., Lévesque, G., Zhang, D. M., Ruel, L., Chen, F., Milman, P., Holmes, E., Liang, Y., Kawarai, T., et al. (1999) · Nature Medicine · doi:10.1038/5526 · Cited by 218 · see citing works
Longo, K. A., Kennell, J. A., Ochocinska, M. J., Ross, S. E., Hahn, W. S., & MacDougald, O. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206402200 · Cited by 212 · see citing works
Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons
Alvarez, A. R., Godoy, J. A., Müllendorff, K., Olivares, G. H., Bronfman, M., & Inestrosa, N. C. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.02.028 · Cited by 211 · see citing works
Krylova, O. Y., Herreros, J., Cleverley, K., Ehler, E., Henríquez, J. P., Hughes, S. M., & Salinas, P. C. (2002) · Neuron · doi:10.1016/s0896-6273(02)00860-7 · Cited by 199 · see citing works
Zhou, C. J., Zhao, C., & Pleasure, S. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4071-03.2004 · Cited by 196 · see citing works
Alimohamad, H., Rajakumar, N., Seah, Y.-H., & Rushlow, W. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.036 · Cited by 187 · see citing works
Roelink, H., Wagenaar, E., da Silva, S. L., & Nusse, R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4519 · Cited by 187 · see citing works
LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesisPreprint
Galcerán, J., Sustmann, C., Hsu, S.-C., Roessler, S. K., & Grosschedl, R. (2004) · Genes & Development · doi:10.1101/gad.1249504 · Cited by 184 · see citing works
Hofmann, M., Schuster-Gossler, K., Watabe‐Rudolph, M., Aulehla, A., Herrmann, B. G., & Gossler, A. (2004) · Genes & Development · doi:10.1101/gad.1248604 · Cited by 175 · see citing works
Increased expression of Wnt-1 in schizophrenic brains
Miyaoka, T., Seno, H., & Ishino, H. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00179-0 · Cited by 161 · see citing works
Abnormalities of Wnt signalling in schizophrenia – evidence for neurodevelopmental abnormality
Cotter, D., Kerwin, R. W., Al-Sarraji, S., Brion, J., Chadwich, A., Lovestone, S., Anderton, B. H., & Everall, I. (1998) · Neuroreport · doi:10.1097/00001756-199805110-00024 · Cited by 152 · see citing works
IDENTIFICATION OF LINOTTE , A NEW GENE AFFECTING LEARNING AND MEMORY IN DROSOPHILA MELANOGASTER
Dura, J., Préat, T., & Tully, T. (2007) · Journal of Neurogenetics · doi:10.1080/01677060701693479 · Cited by 132 · see citing works
Signal transduction during amyloid-β-peptide neurotoxicity: role in Alzheimer disease
Fuentealba, R. A., Farı́as, G. G., Scheu, J., Bronfman, M., Marzolo, M., & Inestrosa, N. C. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.018 · Cited by 126 · see citing works
Identification ofLinotte, a New Gene Affecting Learning and Memory inDrosophila Melanogaster
Dura, J., Préat, T., & Tully, T. (1993) · Journal of Neurogenetics · doi:10.3109/01677069309167272 · Cited by 121 · see citing works
Dreier, L., Burbea, M., & Kaplan, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.058 · Cited by 94 · see citing works
Reduced GSK-3? mRNA levels in postmortem dorsolateral prefrontal cortex of schizophrenic patients
Kozlovsky, N., Weickert, C. S., Tomaskovic‐Crook, E., Kleinman, J. E., Belmaker, R. H., & Agam, G. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0166-3 · Cited by 90 · see citing works
Katsu, T., Ujike, H., Nakano, T., Tanaka, Y., Nomura, A., Nakata, K., Takaki, M., Sakai, A., Uchida, N., Imamura, T., et al. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.017 · Cited by 80 · see citing works
Association study of the human FZD3 locus with schizophrenia
Yang, J., Si, T., Ling, Y., Ruan, Y., Han, Y., Wang, X., Zhang, H., Kong, Q., Li, X., Liu, C., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00291-9 · Cited by 66 · see citing works
Direct interaction of Frizzled‐1, ‐2, ‐4, and ‐7 with PDZ domains of PSD‐95
Hering, H., & Sheng, M. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02831-4 · Cited by 65 · see citing works
Dura, J., Taillebourg, E., & Préat, T. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00847-3 · Cited by 64 · see citing works
Cadherins Communicate Structural Plasticity of Presynaptic and Postsynaptic Terminals
Goda, Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00765-1 · Cited by 60 · see citing works
Ftouh, S., Akbar, M. T., Hirsch, S. R., & de Belleroche, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03239.x · Cited by 49 · see citing works
Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation
Ziegler, S., Röhrs, S., Tickenbrock, L., et al. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04581.x · Cited by 46 · see citing works
Kawamura, Y., Kikuchi, A., Takada, R., Takada, S., Sudoh, S., Shibamoto, S., Yanagisawa, K., & Komano, H. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02197.x · Cited by 36 · see citing works
Presenilin function: connections to Alzheimer's disease and signal transduction
Fraser, P. E., Yu, G., Lévesque, L., et al. (2001) · Biochemical Society Symposia · doi:10.1042/bss0670089 · Cited by 29 · see citing works
Novikova, S. I., He, F., Bai, J., & Lidow, M. S. (2005) · Synapse · doi:10.1002/syn.20134 · Cited by 24 · see citing works
Wehrle, C., Lickert, H., & Kemler, R. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50613-6 · Cited by 23 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Roelink, H., Wagenaar, E., Silva, S., and Nusse, R. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 4519 -4523
- Maretto, S., Cordenonsi, M., Dupont, S., Braghetta, P., Broccoli, V., Hassan, A. B., Volpin, D., Bressan, G. M., and Piccolo, S. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 3299 -3304
- Hsieh, J.-C., Rattner, A., Smallwood, P. M., and Nathans, J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3546 -3551
- Klein, P. S., and Melton, D. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 8455-8459
- Grimwood, P. D., Martin, S. J., and Morris, R. G. M. (2001) in Synases (Cowan, W. M., Sudhof, T. C., and Stevens, C. F., eds), pp. 519 -570, The Johns Hopkins University Press, Baltimore
Cited by
Sorted by citations
The GSK3 hypothesis of Alzheimer’s disease
Hooper, C., Killick, R., & Lovestone, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05194.x · Cited by 1,191 · see citing works
Jessberger, S., Clark, R. E., Broadbent, N. J., Clemenson, G. D., Consiglio, A., Lie, D. C., Squire, L. R., & Gage, F. H. (2009) · Learning & Memory · doi:10.1101/lm.1172609 · Cited by 654 · see citing works
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442 · see citing works
Wnt signaling in the nervous system and in Alzheimer's disease
Inestrosa, N. C., & Varela-Nallar, L. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjt051 · Cited by 324 · see citing works
Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease
Jia, L., Piña-Crespo, J., & Li, Y. (2019) · Molecular Brain · doi:10.1186/s13041-019-0525-5 · Cited by 288 · see citing works
Wnt signaling in neural circuit assembly
Salinas, P. C., & Zou, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125649 · Cited by 274 · see citing works
WNT signaling in neuronal maturation and synaptogenesis
Rosso, S. B., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00103 · Cited by 272 · see citing works
Varela-Nallar, L., Alfaro, I. E., Serrano, F. G., Parodi, J., & Inestrosa, N. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010011107 · Cited by 197 · see citing works
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
Oliva, C. A., Vargas, J. Y., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00224 · Cited by 162 · see citing works
Gao, C., Hölscher, C., Liu, Y., & Li, L. (2012) · revneuro · doi:10.1515/rns.2011.061 · Cited by 164 · see citing works
A review of the evidence for the canonical Wnt pathway in autism spectrum disorders
Kalkman, H. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-10 · Cited by 142 · see citing works
Laksitorini, M. D., Yathindranath, V., Xiong, W., Hombach-Klonisch, S., & Miller, D. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-56075-w · Cited by 105 · see citing works
Wnt/β-Catenin Signaling in Alzheimer’s Disease
Ferrari, G., Avila, M., Medina, M., Perez-Palma, E., Bustos, B., & Alarcon, M. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527312666131223113900 · Cited by 95 · see citing works
Role of the Wnt receptor Frizzled-1 in presynaptic differentiation and function
Varela-Nallar, L., Grabowski, C. P., Alfaro, I. E., Alvarez, A. R., & Inestrosa, N. C. (2009) · Neural Development · doi:10.1186/1749-8104-4-41 · Cited by 97 · see citing works
Shi, X., Miller, J. S., Harper, L. J., Poole, R. L., Gould, T. J., & Unterwald, E. M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3491-8 · Cited by 79 · see citing works
Dysregulated Wnt Signalling in the Alzheimer’s Brain
Aghaizu, N. D., Jin, H., & Whiting, P. J. (2020) · Brain Sciences · doi:10.3390/brainsci10120902 · Cited by 70 · see citing works
Aberrant Wnt signaling pathway in medial temporal lobe structures of Alzheimer’s disease
Riise, J., Plath, N., Pakkenberg, B., & Parachikova, A. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1375-7 · Cited by 66 · see citing works
Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer’s Disease
Vyas, Y., Montgomery, J. M., & Cheyne, J. E. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00266 · Cited by 66 · see citing works
Wisniewska, M. B., Misztal, K., Michowski, W., Szczot, M., Purta, E., Lesniak, W., Klejman, M. E., Dabrowski, M., Filipkowski, R. K., Nagalski, A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1425-09.2010 · Cited by 64 · see citing works
Zhang, W., Shi, Y., Peng, Y., Zhong, L., Zhu, S., Zhang, W., & Tang, S.-J. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002840 · Cited by 59 · see citing works
Self-citation
- Authors
- Chen, J., Park, C. S., & Tang, S.-J.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Tang, Shao-Jun
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 281
- Issue
- 17
- Pages
- 11910-11916
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2073855709
- Cited by
- 298
- References
- 58
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 10 · 2019: 12 · 2018: 20 · 2017: 16 · 2016: 14 · 2015: 13 · 2014: 25 · 2013: 23 · 2012: 23
- FWCI
- 6.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- U.S. Army
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Wnt signaling, Wnt3a, long-term potentiation, hippocampus, synaptic plasticity, NMDA receptor, tetanic stimulation, β-catenin, Wnt target genes
- MeSH terms
- Action Potentials, Animals, Cell Nucleus, Hippocampus, Synaptic Transmission, Neurons, Signal Transduction, Long-Term Potentiation, Wnt Proteins, beta Catenin, Mice, Wnt3 Protein, Wnt3A Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review