Cited by 298Neuroscience and Neuropharmacology ResearchWnt/β-catenin signaling in development and cancerMemory and Neural Mechanisms

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

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Chen, Jianyong, Park, Chang Sin, Tang, Shao-Jun·2006·Journal of Biological Chemistry

Abstract

Wnts are important for various developmental and oncogenic processes. Here we show that Wnt signaling functions at synapses in hippocampal neurons. Tetanic stimulations induce N-methyl-d-aspartate receptor-dependent synaptic Wnt3a release, nuclear beta-catenin accumulations, and the activation of Wnt target genes. Suppression of Wnt signaling impairs long term potentiation. Conversely, activation of Wnt signaling facilitates long term potentiation. These findings suggest that Wnt signaling plays a critical role in regulating synaptic plasticity.

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  1. Roelink, H., Wagenaar, E., Silva, S., and Nusse, R. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 4519 -4523
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Authors
Chen, J., Park, C. S., & Tang, S.-J.
Affiliations
University of California, Irvine (US)
Corresponding author
Tang, Shao-Jun
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2006-04
Volume
281
Issue
17
Pages
11910-11916
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2073855709
Cited by
298
References
58
Citations by year
2026: 8 · 2025: 10 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 17 · 2020: 10 · 2019: 12 · 2018: 20 · 2017: 16 · 2016: 14 · 2015: 13 · 2014: 25 · 2013: 23 · 2012: 23
FWCI
6.06
Type
journal article
Language
en
Open access
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • U.S. Army
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
Wnt signaling, Wnt3a, long-term potentiation, hippocampus, synaptic plasticity, NMDA receptor, tetanic stimulation, β-catenin, Wnt target genes
MeSH terms
Action Potentials, Animals, Cell Nucleus, Hippocampus, Synaptic Transmission, Neurons, Signal Transduction, Long-Term Potentiation, Wnt Proteins, beta Catenin, Mice, Wnt3 Protein, Wnt3A Protein

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