Small intestinal permeability in older adults
Open accessAbstract
It is not yet clear whether intestinal mucosal permeability changes with advancing age in humans. This question is of high importance for drug and nutrition approaches for older adults. Our main objective was to answer the question if small intestinal barrier integrity deteriorates with healthy aging. We conducted a cross‐sectional study including the pooled data of 215 nonsmoking healthy adults (93 female/122 male), 84 of whom were aged between 60 and 82 years. After a 12‐h fast, all participants ingested 10 g of lactulose and 5 g of mannitol. Urine was collected for 5 h afterwards and analyzed for test sugars. The permeability index (PI = lactulose/mannitol) was used to assess small intestinal permeability. Low‐grade inflammation defined by high‐sensitivity C‐reactive protein ≥1 mL/L and kidney function (estimated glomerular filtration rate) were determined in the older age group. The PI was similar in older compared to younger adults (P = 0.887). However, the urinary recovery of lactulose and mannitol was lower in the older adults and this change was neither associated with urinary volume nor glomerular filtration rate. The PI was not significantly correlated with low‐grade inflammation or presence of noninsulin‐dependent type 2 diabetes. However, it significantly deteriorated in the copresence of both conditions compared to low‐grade inflammation alone (P = 0.043) or type 2 diabetes alone (P = 0.015). Small intestinal mucosal barrier does not deteriorate with age per se. But low‐grade inflammation coupled with minor disease challenges, such as type 2 diabetes, can compromise the small intestinal barrier.
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Changes in gut microbiota are more closely related with inflammatory processes rather than solely being a consequence of aging.
“This suggests that the changes in gut microbiota are more closely related with inflammatory processes rather than solely being a consequence of aging (Fig. 3).187,188”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [187]
The Abstract and Discussion address small-intestinal permeability, finding that it does not deteriorate with age per se and can be compromised when low-grade inflammation co-occurs with type 2 diabetes. A search for microbiota found only a Limitations passage about bacterial degradation of the test sugars; our copy does not assess whether gut microbiota changes are more closely related to inflammation than to aging. (LLM, conf=0.76)
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Grape Seed Proanthocyanidins: A Potential Microbiome‐Targeted Intervention for Healthy Aging in Rats
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New indicator of small intestinal ageing in senescence-accelerated mice
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The Ageing of the Human Lower Bowel
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Role of Nutraceuticals in Modulation of Gut-Brain Axis in Elderly Persons
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Nutritional Status and Gastrointestinal Health in the Elderly
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Self-citationEffects of Aging, Long-Term and Lifelong Exercise on the Urinary Metabolic Footprint of Rats
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- Authors
- Valentini, L., Ramminger, S., Haas, V., Postrach, E., Werich, M., Fischer, A., Koller, M., Swidsinski, A., Bereswill, S., Lochs, H., & Schulzke, J.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- University Hospital Regensburg (DE)
- Innsbruck Medical University (AT)
- Corresponding author
- Valentini, Luzia
- ORCID
- Venue
- Physiological Reports
- Publisher
- Wiley
- Published
- 2014-04
- Volume
- 2
- Issue
- 4
- Pages
- e00281-e00281
- ISSN
- 2051-817X (ISSN-L)
- PMC
- PMC4001874
- OpenAlex
- W2138909753
- Cited by
- 73
- References
- 40
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 12 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 8
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Physiological Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Yakult Europe
- Yakult Germany
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
- Keywords
- small intestinal permeability, intestinal barrier integrity, aging, older adults, low-grade inflammation, C-reactive protein, type 2 diabetes, glomerular filtration rate, healthy aging
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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