Age-dependent changes in GI physiology and microbiota: time to reconsider?
Open accessAbstract
Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microbiota is considered a key player in our health, and a variety of studies have reported that microbiota composition is changing during ageing. Since ageing is associated with a decline in GI function and adaptive capacity, it is crucial to obtain insights into this decline and how this is related to the intestinal microbiota in the elderly. Hence, in this review we focus on age-related changes in GI physiology and function, changes of the intestinal microbiota with ageing and frailty, how these are associated and how intestinal microbiota-targeted interventions may counteract these changes.
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- Authors
- An, R., Wilms, E., Masclee, A. A. M., Smidt, H., Zoetendal, E. G., & Jonkers, D.
- Affiliations
- Wageningen University & Research (NL)
- Maastricht University Medical Centre (NL)
- Corresponding author
- Zoetendal, Erwin G
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2018-09-07
- Volume
- 67
- Issue
- 12
- Pages
- 2213-2222
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2891347336
- Cited by
- 209
- References
- 95
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 27 · 2023: 24 · 2022: 28 · 2021: 39 · 2020: 30 · 2019: 29
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- NWO-CCC partnership
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- aging, digestive physiology, gut microbiota, frailty, nutrient digestion and absorption, microbiota-targeted interventions, older adults, age-related decline
- MeSH terms
- Gastrointestinal Microbiome, Aged, Aging, Bacteria, Feces, Humans, Dietary Supplements, Gastrointestinal Tract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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