Cited by 209Gut microbiota and healthNutrition and Health in AgingGastrointestinal motility and disorders

Age-dependent changes in GI physiology and microbiota: time to reconsider?

Open access
An, Ran, Wilms, Ellen, Masclee, Ad A M, Smidt, Hauke, Zoetendal, Erwin G, Jonkers, Daisy·2018·Gut

Abstract

Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microbiota is considered a key player in our health, and a variety of studies have reported that microbiota composition is changing during ageing. Since ageing is associated with a decline in GI function and adaptive capacity, it is crucial to obtain insights into this decline and how this is related to the intestinal microbiota in the elderly. Hence, in this review we focus on age-related changes in GI physiology and function, changes of the intestinal microbiota with ageing and frailty, how these are associated and how intestinal microbiota-targeted interventions may counteract these changes.

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Crossref · 10.1136/gutjnl-2017-315542

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Authors
An, R., Wilms, E., Masclee, A. A. M., Smidt, H., Zoetendal, E. G., & Jonkers, D.
Affiliations
  • Wageningen University & Research (NL)
  • Maastricht University Medical Centre (NL)
Corresponding author
Zoetendal, Erwin G
Venue
Gut
Publisher
BMJ
Published
2018-09-07
Volume
67
Issue
12
Pages
2213-2222
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
OpenAlex
W2891347336
Cited by
209
References
95
Citations by year
2026: 9 · 2025: 23 · 2024: 27 · 2023: 24 · 2022: 28 · 2021: 39 · 2020: 30 · 2019: 29
FWCI
2.52
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
NWO-CCC partnership
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
aging, digestive physiology, gut microbiota, frailty, nutrient digestion and absorption, microbiota-targeted interventions, older adults, age-related decline
MeSH terms
Gastrointestinal Microbiome, Aged, Aging, Bacteria, Feces, Humans, Dietary Supplements, Gastrointestinal Tract

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