Cited by 53Muscle Physiology and DisordersSelenium in Biological SystemsNutrition and Health in Aging

Improved Calcium Homeostasis and Force by Selenium Treatment and Training in Aged Mouse Skeletal Muscle

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Fodor, János, Al-Gaadi, Dána, Czirják, Tamás, Oláh, Tamás, Dienes, Beatrix, Csernoch, László, Szentesi, Péter·2020·Scientific Reports

Abstract

During aging reduction in muscle mass (sarcopenia) and decrease in physical activity lead to partial loss of muscle force and increased fatigability. Deficiency in the essential trace element selenium might augment these symptoms as it can cause muscle pain, fatigue, and proximal weakness. Average voluntary daily running, maximal twitch and tetanic force, and calcium release from the sarcoplasmic reticulum (SR) decreased while reactive oxygen species (ROS) production associated with tetanic contractions increased in aged - 22-month-old - as compared to young - 4-month-old - mice. These changes were accompanied by a decline in the ryanodine receptor type 1 (RyR1) and Selenoprotein N content and the increased amount of a degraded RyR1. Both lifelong training and selenium supplementation, but not the presence of an increased muscle mass at young age, were able to compensate for the reduction in muscle force and SR calcium release with age. Selenium supplementation was also able to significantly enhance the Selenoprotein N levels in aged mice. Our results describe, for the first time, the beneficial effects of selenium supplementation on calcium release from the SR and muscle force in old age while point out that increased muscle mass does not improve physical performance with aging.

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Authors
Fodor, J., Al-Gaadi, D., Czirják, T., Oláh, T., Dienes, B., Csernoch, L., & Szentesi, P.
Affiliations
University of Debrecen (HU)
Corresponding author
Szentesi, Péter
Venue
Scientific Reports
Published
2020-02-03
Volume
10
Issue
1
Pages
1707-1707
ISSN
2045-2322 (ISSN-L)
OpenAlex
W3004062245
Cited by
53
References
51
Citations by year
2026: 7 · 2025: 7 · 2024: 15 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 7
FWCI
1.95
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • European Commission (EFOP-3.6.2-16-2017-0006)
  • Magyar Tudományos Akadémia (GINOP-2.3.2-15-2016-00040)
  • Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (GINOP-2.3.2.-15-2016-00040, GINOP-2, EFOP-3.6.2-16-2017-0006, GINOP-2.3.2, GINOP-2.3.2-15, K-115461)
  • European Regional Development Fund (GINOP-2.3.2-15-2016-00040, GINOP-2.3.2)
  • National Research, Development and Innovation Office (GINOP 2.3.2.-15.2016-00040)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
selenium supplementation, sarcopenia, skeletal muscle aging, sarcoplasmic reticulum calcium release, RyR1, selenoprotein N, muscle force, muscle fatigue, reactive oxygen species, muscle mass, tetanic contraction, aged mice
MeSH terms
Aging, Animals, Calcium, Homeostasis, Humans, Motor Activity, Muscle Contraction, Muscle Proteins, Sarcoplasmic Reticulum, Selenium, Muscle, Skeletal, Dietary Supplements, Ryanodine Receptor Calcium Release Channel, Selenoproteins, Mice, Sarcopenia

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