Improved Calcium Homeostasis and Force by Selenium Treatment and Training in Aged Mouse Skeletal Muscle
Open accessAbstract
During aging reduction in muscle mass (sarcopenia) and decrease in physical activity lead to partial loss of muscle force and increased fatigability. Deficiency in the essential trace element selenium might augment these symptoms as it can cause muscle pain, fatigue, and proximal weakness. Average voluntary daily running, maximal twitch and tetanic force, and calcium release from the sarcoplasmic reticulum (SR) decreased while reactive oxygen species (ROS) production associated with tetanic contractions increased in aged - 22-month-old - as compared to young - 4-month-old - mice. These changes were accompanied by a decline in the ryanodine receptor type 1 (RyR1) and Selenoprotein N content and the increased amount of a degraded RyR1. Both lifelong training and selenium supplementation, but not the presence of an increased muscle mass at young age, were able to compensate for the reduction in muscle force and SR calcium release with age. Selenium supplementation was also able to significantly enhance the Selenoprotein N levels in aged mice. Our results describe, for the first time, the beneficial effects of selenium supplementation on calcium release from the SR and muscle force in old age while point out that increased muscle mass does not improve physical performance with aging.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In aged C57BL/6 mice, oral supplementation of selenium significantly augments muscle strength.
“In aged C57BL/6 mice, oral supplementation of selenium significantly augments muscle strength [54].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Antioxidants prevent health-promoting effects of physical exercise in humans
Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582 · see citing works
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00260 · Cited by 1,377 · see citing works
Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives
Rolland, Y., Czerwinski, S., van Kan, G. A., Morley, J. E., Cesari, M., Onder, G., Woo, J., Baumgartner, R., Pillard, F., Boirie, Y., et al. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982704 · Cited by 1,071 · see citing works
Does oxidative damage to DNA increase with age?
Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., & Richardson, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171202698 · Cited by 768 · see citing works
Effects of Exercise and Aging on Skeletal MusclePreprint
Distéfano, G., & Goodpaster, B. H. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029785 · Cited by 493 · see citing works
The effect of ageing and immobilization on structure and function of human skeletal muscle fibres
D’Antona, G. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.046276 · Cited by 477 · see citing works
Navarro, A., Gómez, C., López-Cepero, J. M., & Boveris, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2003 · Cited by 460 · see citing works
Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training
Davies, K. J. A., Packer, L., & Brooks, G. A. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90312-x · Cited by 430 · see citing works
Lack of myostatin results in excessive muscle growth but impaired force generation
Amthor, H., Macharia, R., Navarrete, R., Schuelke, M., Brown, S., Otto, A., Voït, T., Francesco Muntoni, A., Vrbovà, G., Partridge, T. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604893104 · Cited by 425 · see citing works
Paulsen, G., Cumming, K. T., Holden, G., Hallén, J., Rønnestad, B. R., Sveen, O., Skaug, A., Paur, I., Bastani, N. E., Østgaard, H. N., et al. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.267419 · Cited by 333 · see citing works
Muscle morphology, enzymatic activity, and muscle strength in elderly men: A follow‐up study
ANIANSSON, A., Hedberg, M., Henning, G., & Grimby, G. (1986) · Muscle & Nerve · doi:10.1002/mus.880090702 · Cited by 314 · see citing works
Yarasheski, K. E., Bhasin, S., Sinha‐Hikim, I., Pak-Loduca, J., & González-Cadavid, N. F. (2002) · PubMed · Cited by 293 · see citing works
Sakellariou, G. K., Vasilaki, A., Palomero, J., Kayani, A., Zibrik, L., McArdle, A., & Jackson, M. J. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4623 · Cited by 276 · see citing works
Impaired calcium release during fatigue
Allen, D. G., Lamb, G. D., & Westerblad, H. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00908.2007 · Cited by 260 · see citing works
Effect of voluntary exercise on longevity of rats
Holloszy, J. O., Smith, E. K., Vining, M., & Adams, S. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.3.826 · Cited by 231 · see citing works
Excitation-calcium release uncoupling in aged single human skeletal muscle fibers
Delbono, O., O’Rourke, K. S., & Ettinger, W. H. (1995) · The Journal of Membrane Biology · doi:10.1007/bf00235039 · Cited by 221 · see citing works
Histochemical characteristics of human skeletal muscle during aging
LARSSON, L. (1983) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1983.tb00024.x · Cited by 219 · see citing works
Age, Gender, and Muscular Strength
Evans, W. J., & Hurley, B. F. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.special_issue.41 · Cited by 199 · see citing works
Understanding the importance of selenium and selenoproteins in muscle function
Rederstorff, M., Krol, A., & Lescure, A. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5313-y · Cited by 198 · see citing works
Modulation of reactive oxygen species in skeletal muscle by myostatin is mediated through NF-κB
Sriram, S., Subramanian, S., Sathiakumar, D., Venkatesh, R., Salerno, M. S., McFarlane, C. D., Kambadur, R., & Sharma, M. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00734.x · Cited by 189 · see citing works
Marty, I., Robert‐Genthon, M., Villaz, M., Jongh, K. S. D., Lai, Y. Y., Catterall, W. A., & Ronjat, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2270 · Cited by 159 · see citing works
Dihydropyridine Receptor-Ryanodine Receptor Uncoupling in Aged Skeletal Muscle
Renganathan, M., Messi, M. L., & Delbono, O. (1997) · The Journal of Membrane Biology · doi:10.1007/s002329900233 · Cited by 155 · see citing works
Harsini, S. G., Habibian, M., Moeini, M. M., & Abdolmohammadi, A. (2012) · Biological Trace Element Research · doi:10.1007/s12011-012-9374-0 · Cited by 152 · see citing works
Systemic and mitochondrial adaptive responses to moderate exercise in rodents
Boveris, A., & Navarro, A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.015 · Cited by 151 · see citing works
Moore, A. Z., Caturegli, G., Metter, E. J., Makrogiannis, S., Resnick, S. M., Harris, T. B., & Ferrucci, L. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12653 · Cited by 144 · see citing works
Elemental, Nano-Sized (100-500 nm) Selenium Production by Probiotic Lactic Acid Bacteria
Eszenyi, P., Sztrik, A., Babka, B., & Prokisch, J. (2011) · International Journal of Bioscience, Biochemistry and Bioinformatics · doi:10.7763/ijbbb.2011.v1.27 · Cited by 136 · see citing works
Skeletal Muscle Disorders Associated with Selenium Deficiency in Humans
Chariot, P., & Bignani, O. (2003) · Muscle & Nerve · doi:10.1002/mus.10304 · Cited by 133 · see citing works
Marzani, B., Balage, M., Vénien, A., Astruc, T., Papet, I., Dardevet, D. P., & Mosoni, L. (2008) · Journal of Nutrition · doi:10.3945/jn.108.094029 · Cited by 121 · see citing works
EXERCISE AS HYPERTENSION THERAPY
Kokkinos, P. F., Narayan, P., & Papademetriou, V. (2001) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70232-0 · Cited by 114 · see citing works
Löfstedt, J. (1997) · Veterinary Clinics of North America Equine Practice · doi:10.1016/s0749-0739(17)30262-6 · Cited by 108 · see citing works
González, E., Messi, M. L., Zheng, Z., & Delbono, O. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.048165 · Cited by 99 · see citing works
Neurogenesis of Excitation-Contraction Uncoupling in Aging Skeletal Muscle
Payne, A. M., & Delbono, O. (2004) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200401000-00008 · Cited by 97 · see citing works
Meissner, G., & Lu, X. (1995) · Bioscience Reports · doi:10.1007/bf01788371 · Cited by 78 · see citing works
Novoselov, S. V., Kim, H.-Y., Hua, D., Lee, B. C., Astle, C. M., Harrison, D. E., Friguet, B., Moustafa, M. E., Carlson, B. A., Hatfield, D. L., et al. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2895 · Cited by 65 · see citing works
Russ, D. W., Grandy, J. S., Toma, K., & Ward, C. W. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02191.x · Cited by 61 · see citing works
Szentesi, P., Jacquemond, V., Kovács, L., & Csernoch, L. J. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.371bb.x · Cited by 53 · see citing works
Self-citationUngvári, É., Monori, I., Megyeri, A., Csiki, Z., Prokisch, J., Sztrik, A., Jávor, A., & Benkő, I. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.12.004 · Cited by 53 · see citing works
ISHIHARA, H., Kanda, F., MATSUSHITA, T., et al. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.6.829 · Cited by 49 · see citing works
Inheritance and Mapping of Compact (Cmpt), a New Mutation Causing Hypermuscularity in Mice
Varga, L., Szabó, G., Darvasi, A., et al. (1997) · Genetics · doi:10.1093/genetics/147.2.755 · Cited by 48 · see citing works
Manring, H. R., de Abreu, E. L., Brotto, L. S., Weisleder, N. L., & Brotto, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00037 · Cited by 46 · see citing works
Dietary selenium augments sarcoplasmic calcium release and mechanical performance in mice
Bodnár, D., Ruzsnavszky, O., Oláh, T., Dienes, B., Balatoni, I., Ungvári, É., Benkő, I., Babka, B., Prokisch, J., Csernoch, L. J., et al. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0134-6 · Cited by 43 · see citing works
Self-citationVoltage‐controlled Ca2+ release and entry flux in isolated adult muscle fibres of the mouse
Ursu, D., Schuhmeier, R. P., & Melzer, W. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.073882 · Cited by 41 · see citing works
Franzini‐Armstrong, C. (2009) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h09-017 · Cited by 40 · see citing works
Anderson, A. A., Altafaj, X., Zheng, Z., Wang, Z., Delbono, O., Ronjat, M., Treves, S., & Zorzato, F. (2006) · Journal of Cell Science · doi:10.1242/jcs.02935 · Cited by 36 · see citing works
Hypermuscular mice with mutation in the myostatin gene display altered calcium signalling
Bodnár, D., Geyer, N., Ruzsnavszky, O., Oláh, T., Hegyi, B., Sztretye, M. T., Fodor, J., Dienes, B., Balogh, Á., Papp, Z., et al. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.261958 · Cited by 33 · see citing works
Self-citationvan Dijk, M., Dijk, F. J., Bunschoten, A., van Dartel, D. A. M., van Norren, K., Walrand, S., Jourdan, M., Verlaan, S., & Luiking, Y. C. (2016) · Oncotarget · doi:10.18632/oncotarget.7800 · Cited by 31 · see citing works
Physical Activity and Diabetes Mellitus
Bhaskarabhatla, K. V., & Birrer, R. B. (2005) · Comprehensive Therapy · doi:10.1385/comp:31:4:291 · Cited by 30 · see citing works
Fodor, J., Gönczi, M., Sztretye, M. T., et al. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.160457 · Cited by 25 · see citing works
Self-citationSuccessful control of dyslipidemia in patients with metabolic syndrome: focus on lifestyle changes
Stone, N. J. (2006) · Clinical cornerstone · doi:10.1016/s1098-3597(06)80004-9 · Cited by 17 · see citing works
Heart failure with preserved ejection fraction and skeletal muscle physiology
Farris, S. D., Moussavi‐Harami, F., & Stempien‐Otero, A. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9603-x · Cited by 14 · see citing works
Effect of TPEN on the calcium release of cultured C2C12 mouse myotubes
Sztretye, M. T., Deli, T., Szentesi, P., et al. (2007) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-008-9135-z · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Chen, M., Wang, Y., Deng, S., Lian, Z., & Yu, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.964130 · Cited by 187 · see citing works
Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
- Authors
- Fodor, J., Al-Gaadi, D., Czirják, T., Oláh, T., Dienes, B., Csernoch, L., & Szentesi, P.
- Affiliations
- University of Debrecen (HU)
- Corresponding author
- Szentesi, Péter
- Venue
- Scientific Reports
- Published
- 2020-02-03
- Volume
- 10
- Issue
- 1
- Pages
- 1707-1707
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6997352
- OpenAlex
- W3004062245
- Cited by
- 53
- References
- 51
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 15 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 7
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- European Commission (EFOP-3.6.2-16-2017-0006)
- Magyar Tudományos Akadémia (GINOP-2.3.2-15-2016-00040)
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (GINOP-2.3.2.-15-2016-00040, GINOP-2, EFOP-3.6.2-16-2017-0006, GINOP-2.3.2, GINOP-2.3.2-15, K-115461)
- European Regional Development Fund (GINOP-2.3.2-15-2016-00040, GINOP-2.3.2)
- National Research, Development and Innovation Office (GINOP 2.3.2.-15.2016-00040)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- selenium supplementation, sarcopenia, skeletal muscle aging, sarcoplasmic reticulum calcium release, RyR1, selenoprotein N, muscle force, muscle fatigue, reactive oxygen species, muscle mass, tetanic contraction, aged mice
- MeSH terms
- Aging, Animals, Calcium, Homeostasis, Humans, Motor Activity, Muscle Contraction, Muscle Proteins, Sarcoplasmic Reticulum, Selenium, Muscle, Skeletal, Dietary Supplements, Ryanodine Receptor Calcium Release Channel, Selenoproteins, Mice, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review