NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: A bipartisan affair?
Open accessAbstract
Microglia are the resident immune cells of the brain and play major roles in central nervous system development, maintenance, and disease. Brain insults cause microglia to proliferate, migrate, and transform into one or more activated states. Classical M1 activation triggers the production of proinflammatory factors such as tumor necrosis factor-α, interleukin-1β (IL-1β), nitric oxide, and reactive oxygen species (ROS), which, in excess, can exacerbate brain injury. The mechanisms underlying microglial activation are not fully understood, yet reactive oxygen species are increasingly implicated as mediators of microglial activation. In this review, we highlight studies linking reactive oxygen species, in particular hydrogen peroxide derived from NADPH oxidase-generated superoxide, to the classical activation of microglia. In addition, we critically evaluate controversial evidence suggesting a specific role for mitochondrial reactive oxygen species in the activation of the NLRP3 inflammasome, a multiprotein complex that mediates the production of IL-1β and IL-18. Finally, the limitations of common techniques used to implicate mitochondrial ROS in microglial and inflammasome activation, such as the use of the mitochondrially targeted ROS indicator MitoSOX and the mitochondrially targeted antioxidant MitoTEMPO, are also discussed.
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The selectivity of mitoTEMPO as a mitochondrial-targeted antioxidant has been questioned, especially at higher concentrations.
“However, the selectivity of mitoTEMPO as a mitochondrial-targeted antioxidant has been questioned, especially at higher concentrations [159].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [159]
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Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289 · see citing works
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R., Sherer, T., Mackenzie, G., Garcia-Osuna, M., Panov, A., & Greenamyre, J. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,797 · see citing works
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works
Cellular response to oxidative stress: Signaling for suicide and survival *
Martindale, J., & Holbrook, N. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10119 · Cited by 2,392 · see citing works
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works
Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works
Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792 · see citing works
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623 · see citing works
Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works
The microglial sensome revealed by direct RNA sequencing
Hickman, S. E., Kingery, N. D., Ohsumi, T. K., Borowsky, M. L., Wang, L.-C., Means, T. K., & El Khoury, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3554 · Cited by 1,511 · see citing works
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445 · see citing works
Toxicity of iron and hydrogen peroxide: the Fenton reaction
Winterbourn, C. C. (1995) · Toxicology Letters · doi:10.1016/0378-4274(95)03532-x · Cited by 1,415 · see citing works
Superoxide activates mitochondrial uncoupling proteins
Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382 · see citing works
Mitochondrial metabolism of reactive oxygen species
Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336 · see citing works
Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · cited 1× · see citing works
“However, a subsequent study failed to reproduce this finding [149].”
Microglial cell origin and phenotypes in health and disease
Saijo, K., & Glass, C. K. (2011) · Nature Reviews Immunology · doi:10.1038/nri3086 · Cited by 1,100 · see citing works
Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B. S., Miroux, B., Couplan, E., Alves‐Guerra, M., Goubern, M., Surwit, R. S., et al. (2000) · Nature Genetics · doi:10.1038/82565 · Cited by 1,079 · see citing works
Mechanism of Toxicity in Rotenone Models of Parkinson's Disease
Sherer, T., Betarbet, R. S., Testa, C. M., Seo, B. B., Richardson, J. R., Kim, J. H., Miller, G. W., Yagi, T., Matsuno‐Yagi, A., & Greenamyre, J. T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10756.2003 · Cited by 1,073 · see citing works
Microglial Activation and Chronic Neurodegeneration
Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works
The Role of Microglia in the Healthy Brain: Figure 1.
Tremblay, M.-È., Stevens, B., Sierra, A., Wake, H., Bessis, A., & Nimmerjahn, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4158-11.2011 · Cited by 992 · see citing works
Denu, J. M., & Tanner, K. G. (1998) · Biochemistry · doi:10.1021/bi973035t · Cited by 945 · see citing works
Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation
Iyer, S. S., He, Q., Janczy, J. R., Elliott, E. I., Zhong, Z., Olivier, A. K., Sadler, J. J., Knepper-Adrian, V., Han, R., Qiao, L., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.001 · Cited by 939 · see citing works
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
Melov, S., Ravenscroft, J., Malik, S., Gill, M. S., Walker, D. W., Clayton, P., Wallace, D. C., Malfroy, B., Doctrow, S. R., & Lithgow, G. J. (2000) · Science · doi:10.1126/science.289.5484.1567 · Cited by 913 · see citing works
An essential role for free radicals and derived species in signal transduction
Lander, H. M. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.2.9039953 · Cited by 908 · see citing works
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
Colton, C. A. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9164-4 · Cited by 871 · see citing works
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 863 · see citing works
Bulua, A. C., Simon, A., Maddipati, R., Pelletier, M., Park, H., Kim, K.-Y., Sack, M. N., Kastner, D. L., & Siegel, R. M. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102049 · Cited by 860 · see citing works
Mitochondrial permeability transition and oxidative stress
Kowaltowski, A. J., Castilho, R. F., & Vercesi, A. E. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02316-x · Cited by 832 · see citing works
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Lamkanfi, M., Mueller, J. L., Vitari, A. C., Misaghi, S., Fedorova, A., Deshayes, K., Lee, W. P., Hoffman, H. M., & Dixit, V. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903124 · Cited by 820 · see citing works
Selective fluorescent imaging of superoxide <i>in vivo</i> using ethidium-based probes
Robinson, K. M., Janes, M. S., Pehar, M., Monette, J. S., Ross, M. F., Hagen, T. M., Murphy, M. P., & Beckman, J. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601945103 · Cited by 777 · see citing works
Microglia and neurodegeneration: The role of systemic inflammation
Cunningham, C. (2013) · Glia · doi:10.1002/glia.22350 · Cited by 769 · see citing works
Therapeutic Targeting of Mitochondrial Superoxide in Hypertension
Dikalova, A., Bikineyeva, A. T., Budzyn, K., Nazarewicz, R. R., McCann, L. A., Lewis, W., Harrison, D. G., & Dikalov, S. (2010) · Circulation Research · doi:10.1161/circresaha.109.214601 · Cited by 737 · see citing works
Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide
Hogg, N., Darley-Usmar, V. M., Wilson, M. T., & Moncada, S. (1992) · Biochemical Journal · doi:10.1042/bj2810419 · Cited by 698 · see citing works
Chiu, I. M., Morimoto, E. T. A., Goodarzi, H., Liao, J. T., O’Keeffe, S., Phatnani, H. P., Muratet, M., Carroll, M. C., Levy, S., Tavazoie, S., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.06.018 · Cited by 651 · see citing works
Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.013 · Cited by 638 · see citing works
Bauernfeind, F., Bartok, E., Rieger, A., Franchi, L., Núñez, G., & Hornung, V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100613 · Cited by 617 · see citing works
Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention
Kumar, A., & Loane, D. J. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.008 · Cited by 610 · see citing works
Signaling by ROS drives inflammasome activation
Martinon, F. (2010) · European Journal of Immunology · doi:10.1002/eji.200940168 · Cited by 604 · see citing works
Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies
Codolo, G., Plotegher, N., Pozzobon, T., Brucale, M., Tessari, I., Bubacco, L., & de Bernard, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055375 · Cited by 585 · see citing works
Qin, L., Liu, Y., Wang, T., Wei, S.-J., Block, M. L., Wilson, B., Liu, B., & Hong, J.-S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307657200 · Cited by 574 · see citing works
Heid, M. E., Keyel, P. A., Kamga, C., Shiva, S., Watkins, S. C., & Salter, R. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301490 · Cited by 570 · see citing works
Zielonka, J., & Kalyanaraman, B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.028 · Cited by 535 · see citing works
Guillemin, G. J., & Brew, B. J. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0303114 · Cited by 520 · see citing works
Loane, D. J., Kumar, A., Stoica, B. A., Cabatbat, R., & Faden, A. I. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000021 · Cited by 498 · see citing works
P53, cell cycle control and apoptosis: Implications for cancer
Kastan, M. B., Canman, C. E., & Leonard, C. J. (1995) · Cancer and Metastasis Reviews · doi:10.1007/bf00690207 · Cited by 481 · see citing works
The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation
Innamorato, N. G., Rojo, A. I., García‐Yagüe, Á. J., Yamamoto, M. P., CEBALLOS, M. L. D., & Cuadrado, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.680 · Cited by 479 · see citing works
Li, Y., & Trush, M. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9729 · Cited by 470 · see citing works
Selective targeting of an antioxidant to mitochondria
Smith, R. A. J., Porteous, C. M., Coulter, C. V., & Murphy, M. P. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00543.x · Cited by 466 · see citing works
Distinct Role for Microglia in Rotenone-Induced Degeneration of Dopaminergic Neurons
Gao, H., Hong, J., Zhang, W., & Liu, B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00782.2002 · Cited by 439 · see citing works
Brain microglia constitutively express β-2 integrins
Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90055-r · Cited by 430 · see citing works
Redox regulation of glial inflammatory response to lipopolysaccharide and interferonγ
Pawate, S., Shen, Q., Fan, F., & Bhat, N. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20180 · Cited by 428 · see citing works
Drug delivery to mitochondria: the key to mitochondrial medicine
Murphy, M. P., & Smith, R. A. J. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00069-1 · Cited by 426 · see citing works
Biochemical-physiology correlations in studies of the γ-aminobutyric acid system
Roberts, E., & Kuriyama, K. (1968) · Brain Research · doi:10.1016/0006-8993(68)90170-4 · Cited by 410 · see citing works
UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation
Vozza, A., Parisi, G., De Leonardis, F., Lasorsa, F. M., Castegna, A., Amorese, D., Marmo, R., Calcagnile, V. M., Palmieri, L., Ricquier, D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317400111 · Cited by 407 · see citing works
Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease
Rojo, A. I., Innamorato, N. G., Martín-Moreno, A. M., CEBALLOS, M. L. D., Yamamoto, M. P., & Cuadrado, A. (2009) · Glia · doi:10.1002/glia.20947 · Cited by 381 · see citing works
Gao, H.-M., Zhou, H., Zhang, F., Wilson, B. C., Kam, W., & Hong, J.-S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3732-10.2011 · Cited by 369 · see citing works
Inflammasomes: current understanding and open questions
Bauernfeind, F. G., Ablasser, A., Bartok, E., Kim-Hellmuth, S., Schmid-Burgk, J. L., Cavlar, T., & Hornung, V. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0567-4 · Cited by 356 · see citing works
Phagocytosis executes delayed neuronal death after focal brain ischemia
Neher, J. J., Emmrich, J., Fricker, M., Mander, P. K., Théry, C., & Brown, G. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308679110 · Cited by 350 · see citing works
Oxidative damage to macromolecules in human Parkinson disease and the rotenone model
Sanders, L. H., & Greenamyre, J. T. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.003 · Cited by 347 · see citing works
Extracellular superoxide dismutase and cardiovascular disease
Fukai, T. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00328-0 · Cited by 345 · see citing works
Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons
Gao, H., Liu, B., & Hong, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06181.2003 · Cited by 338 · see citing works
Simple quantitative detection of mitochondrial superoxide production in live cells
Mukhopadhyay, P., Rajesh, M., Kashiwaya, Y., Haskó, G., & Pacher, P. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.106 · Cited by 328 · see citing works
The Multifaceted Profile of Activated Microglia
Lynch, M. A. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8077-9 · Cited by 323 · see citing works
Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
Meissner, F., Molawi, K., & Zychlinsky, A. (2008) · Nature Immunology · doi:10.1038/ni.1633 · Cited by 302 · see citing works
NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage
Ma, Q., Chen, S., Hu, Q., Feng, H., Zhang, J. H., & Tang, J. (2013) · Annals of Neurology · doi:10.1002/ana.24070 · Cited by 296 · see citing works
Reactive Oxygen Species and Antioxidants in Signal Transduction and Gene Expression
Palmer, H. J., & Paulson, K. E. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1997.tb01561.x · Cited by 278 · see citing works
Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate In vitro
Hecht, D., & Zick, Y. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91123-8 · Cited by 273 · see citing works
Meissner, F., Seger, R. A., Moshous, D., Fischer, A., Reichenbach, J., & Zychlinsky, A. (2010) · Blood · doi:10.1182/blood-2010-01-264218 · Cited by 269 · see citing works
Horvath, R. J., Nutile‐McMenemy, N., Alkaitis, M. S., & DeLeo, J. A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05633.x · Cited by 264 · see citing works
The selective detection of mitochondrial superoxide by live cell imaging
Robinson, K. M., Janes, M. S., & Beckman, J. S. (2008) · Nature Protocols · doi:10.1038/nprot.2008.56 · Cited by 263 · see citing works
Simard, J.-C., Césaro, A., Chapeton-Montes, J. A., Tardif, M. R., Antoine, F., Girard, D., & Tessier, P. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072138 · Cited by 263 · see citing works
Sex, glia, and development: Interactions in health and disease
Schwarz, J. M., & Bilbo, S. D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.018 · Cited by 247 · see citing works
Kumar, A., Stoica, B. A., Sabirzhanov, B., Burns, M. P., Faden, A. I., & Loane, D. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.013 · Cited by 244 · see citing works
Allam, R., Lawlor, K. E., Yu, E. C.-W., Mildenhall, A., Moujalled, D. M., Lewis, R. S., Ke, F., Mason, K. D., White, M. J., Stacey, K. J., et al. (2014) · EMBO Reports · doi:10.15252/embr.201438463 · Cited by 238 · see citing works
Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production
Kim, S. H., Smith, C. J., & Eldik, L. J. V. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00126-x · Cited by 234 · see citing works
Parajuli, B., Sonobe, Y., Horiuchi, H., Takeuchi, H., Mizuno, T., & Suzumura, A. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.503 · Cited by 232 · see citing works
Voloboueva, L. A., Emery, J. F., Sun, X., & Giffard, R. G. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.01.067 · Cited by 230 · see citing works
Mitochondrially targeted compounds and their impact on cellular bioenergetics
Reily, C., Mitchell, T., Chacko, B. K., Benavides, G. A., Murphy, M. P., & Darley-Usmar, V. M. (2013) · Redox Biology · doi:10.1016/j.redox.2012.11.009 · Cited by 227 · see citing works
Choi, S., Aïd, S., Kim, H., Jackson, S. H., & Bosetti, F. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07572.x · Cited by 222 · see citing works
Up-regulation of Microglial CD11b Expression by Nitric Oxide
Roy, A., Fung, Y. K., Liu, X., & Pahan, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600236200 · Cited by 214 · see citing works
Zhang, Q.-G., Laird, M. D., Han, D., Nguyen, K., Scott, E., Dong, Y., Dhandapani, K. M., & Brann, D. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034504 · Cited by 211 · see citing works
Qin, L., Li, G., Qian, X., Liu, Y., Wu, X., Liu, B., Hong, J., & Block, M. L. (2005) · Glia · doi:10.1002/glia.20225 · Cited by 210 · see citing works
Neniškytė, U., Neher, J. J., & Brown, G. C. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.267583 · Cited by 208 · see citing works
Dashdorj, A., Jyothi, K. R., Lim, S., Jo, A., Nguyen, M. N., Ha, J., Yoon, K., Kim, H. J., Park, J., Murphy, M. P., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-178 · Cited by 206 · see citing works
Classical Inhibitors of NOX NAD(P)H Oxidases Are Not Specific
Aldieri, E., Riganti, C., Polimeni, M., Gazzano, E., Lussiana, C., Campia, I., & Ghigo, D. (2008) · Current Drug Metabolism · doi:10.2174/138920008786049285 · Cited by 201 · see citing works
Majander, A. S., Finel, M., & Wikström, M. K. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31926-9 · Cited by 200 · see citing works
Microglia Proliferation Is Regulated by Hydrogen Peroxide from NADPH Oxidase
Mander, P. K., Jekabsone, A., & Brown, G. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.1046 · Cited by 198 · see citing works
Moss, D. W., & Bates, T. E. (2001) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2001.01418.x · Cited by 192 · see citing works
Nguyen, T. T. M., Stevens, M. V., Kohr, M. J., Steenbergen, C., Sack, M. N., & Murphy, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.243469 · Cited by 189 · see citing works
Selective Vulnerability of Dopaminergic Neurons to Microtubule Depolymerization
Ren, Y., Liu, W., Jiang, H., Jiang, Q., & Feng, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503483200 · Cited by 188 · see citing works
Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease
Wilkinson, K., & Khoury, J. B. E. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/489456 · Cited by 186 · see citing works
Choi, W.-S., Palmiter, R. D., & Xia, Z. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009132 · Cited by 183 · see citing works
Uncoupling proteins: A role in protection against reactive oxygen species—or not?
Cannon, B., Shabalina, I. G., Kramarova, T. V., Petrovic, N., & Nedergaard, J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.016 · Cited by 182 · see citing works
Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages
Emre, Y., Hurtaud, C., Nübel, T., Criscuolo, F., Ricquier, D., & Cassard, A. (2007) · Biochemical Journal · doi:10.1042/bj20061430 · Cited by 172 · see citing works
Johnson-Cadwell, L. I., Jekabsons, M. B., Wang, A., Polster, B. M., & Nicholls, D. G. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04516.x · Cited by 165 · see citing works
Self-citationHaddad, J. J., & Land, S. C. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704467 · Cited by 163 · see citing works
Zhang, W., Dallas, S., Zhang, D., Guo, J., Pang, H., Wilson, B. C., Miller, D. S., Chen, B., Zhang, W., McGeer, P. L., et al. (2007) · Glia · doi:10.1002/glia.20532 · Cited by 161 · see citing works
Inflammasome activation and IL‐1β/IL‐18 processing are influenced by distinct pathways in microglia
Hanamsagar, R. M., Torres, V. J., & Kielian, T. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07481.x · Cited by 160 · see citing works
Bracey, N. A., Gershkovich, B., Chun, J., Vilaysane, A., Meijndert, H. C., Wright, J. R., Fedak, P. W. M., Beck, P. L., Muruve, D. A., & Duff, H. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.550624 · Cited by 156 · see citing works
Fricker, M., Oliva-Martín, M. J., & Brown, G. C. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-196 · Cited by 153 · see citing works
NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis
Kaushik, D. K., Gupta, M., Kumawat, K. L., & Basu, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032270 · Cited by 146 · see citing works
Kizaki, T., Suzuki, K., Hitomi, Y., Taniguchi, N., Saitoh, D., Watanabe, K., Onoé, K., Day, N. K. B., Good, R. A., & Ohno, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142206299 · Cited by 137 · see citing works
Bai, Y., Onuma, H., Bai, X., Medvedev, A. V., Misukonis, M. A., Weinberg, J. B., Cao, W., Robidoux, J., Floering, L. M., Daniel, K. W., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500566200 · Cited by 135 · see citing works
Roy, A., Jana, A., Yatish, K., Freidt, M. B., Fung, Y. K., Martinson, J., & Pahan, K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.026 · Cited by 131 · see citing works
Sulforaphane suppresses LPS-induced inflammation in primary rat microglia
Brandenburg, L., Kipp, M., Lucius, R., Pufe, T., & Wruck, C. J. (2009) · Inflammation Research · doi:10.1007/s00011-009-0116-5 · Cited by 126 · see citing works
Oh, J. Y., Ko, J. H., Lee, H. J., Yu, J. M., Choi, H., Kim, M. K., Wee, W. R., & Prockop, D. J. (2014) · Stem Cells · doi:10.1002/stem.1608 · Cited by 125 · see citing works
Hu, X., Zhang, D., Pang, H., Caudle, W. M., Li, Y., Gao, H., Liu, Y., Li, Q., Wilson, B. C., Monte, D. A. D., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7194 · Cited by 125 · see citing works
Tosun, Ç., Kurland, D. B., Mehta, R. I., Castellani, R. J., deJong, J. L., Kwon, M. S., Woo, S. K., Gerzanich, V., & Simard, J. M. (2013) · Stroke · doi:10.1161/strokeaha.113.002904 · Cited by 121 · see citing works
Rotenone inhibition of tubulin self-assembly
Marshall, L. E., & Himes, R. H. (1978) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(78)90315-x · Cited by 120 · see citing works
Effects of mitochondrial dysfunction on the immunological properties of microglia
Ferger, A. I., Campanelli, L., Reimer, V., Muth, K. N., Merdian, I., Ludolph, A. C., & Witting, A. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-45 · Cited by 120 · see citing works
Loane, D. J., Stoica, B. A., Pajoohesh‐Ganji, A., Byrnes, K. R., & Faden, A. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806139200 · Cited by 119 · see citing works
Lambert, A. J., Buckingham, J. A., Boysen, H. M., & Brand, M. D. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.005 · Cited by 117 · see citing works
Zeng, K.-W., Zhang, T., Fu, H., Liu, G.-X., & Wang, X.-M. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.05.030 · Cited by 116 · see citing works
Rotenone inhibition of spindle microtubule assembly in mammalian cells
Brinkley, B. R., Barham, S. S., BARRANCO, S. C., & Fuller, G. M. (1974) · Experimental Cell Research · doi:10.1016/0014-4827(74)90210-9 · Cited by 115 · see citing works
The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
Shi, F., Yang, L., Kouadir, M., Yang, Y., Wang, J., Zhou, X., Yin, X., & Zhao, D. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-73 · Cited by 109 · see citing works
De Bilbao, F., Arsenijevic, D., Vallet, P., Hjelle, O. P., Ottersen, O. P., Bouras, C., Raffin, Y., Abou, K., Langhans, W., Collins, S., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02432.x · Cited by 108 · see citing works
Pei, Z., Pang, H., Qian, L., Yang, S., Wang, T., Zhang, W., Wu, X., Dallas, S., Wilson, B., Reece, J. M., et al. (2007) · Glia · doi:10.1002/glia.20545 · Cited by 105 · see citing works
Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome
Wynosky-Dolfi, M. A., Snyder, A. G., Philip, N. H., Doonan, P. J., Poffenberger, M. C., Avizonis, D. Z., Zwack, E. E., Riblett, A. M., Hu, B., Strowig, T., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20130627 · Cited by 104 · see citing works
Li, Y., Wu, Y., Ren, X., Liu, Q., Wang, J., & Liu, X. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1854-9 · Cited by 99 · see citing works
Ball, W. B., Kar, S., Mukherjee, M., Chande, A. G., Mukhopadhyaya, R., & Das, P. K. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004237 · Cited by 97 · see citing works
Loane, D. J., Stoica, B. A., Byrnes, K. R., Jeong, W. J., & Faden, A. I. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2589 · Cited by 96 · see citing works
Rotenone Directly Induces BV2 Cell Activation via the p38 MAPK Pathway
Gao, F., Chen, D., Hu, Q., & Wang, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072046 · Cited by 91 · see citing works
Jabaut, J., Ather, J. L., Taracanova, A., Poynter, M. E., & Ckless, K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.01.025 · Cited by 89 · see citing works
Kim, S., Park, Y., Min, J., Sun, H.-N., Han, Y., Hua, J.-M., Lee, T., Lee, S., Chang, K.-T., Kang, S. W., et al. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.03.006 · Cited by 88 · see citing works
Zhang, D., Hu, X., Li, Q., Chen, S., Zhou, H., Wilson, B. C., Miller, D. S., & Hong, J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-3 · Cited by 87 · see citing works
Zhou, F., Wu, J., Sun, X., Yao, H., Ding, J., & Hu, G. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301381 · Cited by 85 · see citing works
Chao, C., Weng, C.-S., Chang, N., Lin, J.-S., Kao, S.-T., & Ho, F. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.10.011 · Cited by 85 · see citing works
Opening of microglial KATP channels inhibits rotenone‐induced neuroinflammation
Zhou, F., Yao, H., Wu, J., Ding, J., Sun, T., & Hu, G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00144.x · Cited by 84 · see citing works
Esch, F. S., Lin, K., Hills, A., Zaman, K., Baraban, J. M., Chatterjee, S., Rubin, L. L., Ash, D. E., & Ratan, R. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04083.1998 · Cited by 83 · see citing works
Yang, C., Lee, H., Ji-Yeon, L., Kim, J., Lee, S. J., Shin, D., Lee, Y., Lee, D., Benna, J. E., & Jo, E. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-27 · Cited by 77 · see citing works
Glibenclamide for the Treatment of Acute CNS Injury
Kurland, D. B., Tosun, Ç., Pampori, A., Karimy, J. K., Caffes, N. M., Gerzanich, V., & Simard, J. M. (2013) · Pharmaceuticals · doi:10.3390/ph6101287 · Cited by 73 · see citing works
Reactive oxygen species mediate A??(25-35)-induced activation of BV-2 microglia
Kang, J., Park, E. J., Jou, I., Kim, J., & Joe, E.-H. (2001) · Neuroreport · doi:10.1097/00001756-200105250-00030 · Cited by 68 · see citing works
The generation of free radicals by nitric oxide synthase
Porasuphatana, S., Tsai, P., & Rosen, G. M. (2003) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/s1532-0456(02)00271-5 · Cited by 68 · see citing works
Davenport, C. M., Sevastou, I. G., Hooper, C., & Pocock, J. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06485.x · Cited by 67 · see citing works
Vexler, Z. S., Wong, A. L., Francisco, C., Manabat, C., Christen, S., Täuber, M. G., Ferriero, D. M., & Gregory, G. A. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03777-0 · Cited by 65 · see citing works
Love and death: microglia, NLRP3 and the Alzheimer's brain
Goldmann, T., Tay, T. L., & Prinz, M. (2013) · Cell Research · doi:10.1038/cr.2013.24 · Cited by 63 · see citing works
Impact of endogenous nitric oxide on microglial cell energy metabolism and labile iron pool
Chénais, B., Morjani, H., & Drapier, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00864.x · Cited by 55 · see citing works
An Essential Role for Lipopolysaccharide-Binding Protein in Pulmonary Innate Immune Responses
Fan, M.-H., Klein, R. D., Steinstraesser, L., Merry, A. C., Nemzek, J. A., Remick, D. G., Wang, S. C., & Su, G. L. (2002) · Shock · doi:10.1097/00024382-200209000-00008 · Cited by 54 · see citing works
Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox
Zhou, H., Zhang, F., Chen, S., Zhang, D., Wilson, B. C., Hong, J., & Gao, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.488 · Cited by 54 · see citing works
Wang, T., Liu, B., Qin, L., Wilson, B. C., & Hong, J. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.040 · Cited by 51 · see citing works
Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release
Klintworth, H. M., Garden, G. A., & Xia, Z. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.06.065 · Cited by 51 · see citing works
Transcription factor p53 influences microglial activation phenotype
Jayadev, S., Nesser, N. K., Hopkins, S., Myers, S. J., Case, A., Lee, R. J., Seaburg, L., Uo, T., Murphy, S. P., Morrison, R. S., et al. (2011) · Glia · doi:10.1002/glia.21178 · Cited by 50 · see citing works
Integrin Mac-1 and β-amyloid in microglial release of nitric oxide
Goodwin, J. L., Kehrli, M. E., & Uemura, E. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00653-7 · Cited by 49 · see citing works
Rotenone Could Activate Microglia Through NFκB Associated Pathway
Yuan, Y., Sun, J., Wu, M., Hu, J., Peng, S.-Y., & Chen, N. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1055-7 · Cited by 41 · see citing works
Lijia, Z., Zhao, S., Wang, X., Wu, C., & Yang, J. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.09.002 · Cited by 40 · see citing works
Kasahara, E., Sekiyama, A., Hori, M., Hara, K., Takahashi, N., Konishi, M., Sato, E. F., Matsumoto, S., Okamura, H., & Inoue, M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.049 · Cited by 39 · see citing works
Neuroprotection through Stimulation of Mitochondrial Antioxidant Protein Expression
Greco, T., & Fiskum, G. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100519 · Cited by 34 · see citing works
Zheng, W., Zheng, X.-X., Liu, S., Ouyang, H., Levitt, R., Candiotti, K., & Hao, S.-L. (2012) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2012.03.068 · Cited by 30 · see citing works
sCD14 prevents endotoxin inducible oxidative burst response of human monocytes.
Schütt, C., Schilling, T., & Krüger, C. L. (1991) · PubMed · Cited by 29 · see citing works
Kim, Y., Park, T. Y., Baik, E. C., & Lee, S. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.12.011 · Cited by 25 · see citing works
Eguchi, H., Fujiwara, N., Sakiyama, H., Yoshihara, D., & Suzuki, K. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.047 · Cited by 22 · see citing works
Davis, D. S., & Carson, M. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_1 · Cited by 9 · see citing works
Yoshino, Y., Yamamoto, S., Kohsaka, S., Oshiro, S., & Nakajima, K. (2011) · Brain Research · doi:10.1016/j.brainres.2011.09.009 · Cited by 9 · see citing works
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Microglial <scp>M1/M2</scp> polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070 · see citing works
Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044 · see citing works
Tan, H.-Y., Wang, N., Li, S., Hong, M., Wang, X., & Feng, Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2795090 · Cited by 657 · see citing works
Microglial cell dysregulation in brain aging and neurodegeneration
von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works
Zhao, Y., Zhang, J., Zheng, Y., Zhang, Y., Zhang, X. J., Wang, H., Du, Y., Guan, J., Wang, X., & Fu, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02250-8 · Cited by 356 · see citing works
Sarkar, S., Malovic, E., Harischandra, D. S., Ghaisas, S., Panicker, N., Charli, A., Palanisamy, B. N., Rokad, D., Jin, H., Anantharam, V., et al. (2017) · npj Parkinson s Disease · doi:10.1038/s41531-017-0032-2 · Cited by 283 · see citing works
Oxidative Stress‐Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives
Ermakov, E. A., Dmitrieva, E. M., Parshukova, D. A., Kazantseva, D. V., Vasilieva, A. R., & Smirnova, L. P. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8881770 · Cited by 252 · see citing works
Old Maids: Aging and Its Impact on Microglia Function
Koellhoffer, E. C., McCullough, L. D., & Ritzel, R. M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040769 · Cited by 205 · see citing works
7-Ketocholesterol in disease and aging
Anderson, A., Campo, A., Fulton, E. C., Corwin, A., Jerome, W. G., & O’Connor, M. S. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101380 · Cited by 194 · see citing works
Antioxidant peptides, the guardian of life from oxidative stress
Zhu, Y., Wang, K., Jia, X., Fu, C., Yu, H., & Wang, Y. (2023) · Medicinal Research Reviews · doi:10.1002/med.21986 · Cited by 192 · see citing works
Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders
Zhou, K., Shi, L., Wang, Y., Chen, S., & Zhang, J. (2016) · Journal of Immunology Research · doi:10.1155/2016/9238290 · Cited by 175 · see citing works
Antioxidative nanomaterials and biomedical applications
Liu, Y., & Shi, J. (2019) · Nano Today · doi:10.1016/j.nantod.2019.05.008 · Cited by 173 · see citing works
Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aat9900 · Cited by 171 · see citing works
Haslund‐Vinding, J., McBean, G., Jaquet, V, & Vilhardt, F. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13425 · Cited by 169 · see citing works
Cell Culture Models of Fatty Acid Overload: Problems and Solutions
Alsabeeh, N., Chausse, B., Kakimoto, P. A., Kowaltowski, A. J., & Shirihai, O. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.11.006 · Cited by 167 · see citing works
Ballance, W. C., Qin, E. C., Chung, H. J., Gillette, M. U., & Kong, H. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119292 · Cited by 156 · see citing works
Shen, Y., Cao, B., Snyder, N. R., Woeppel, K. M., Eles, J. R., & Cui, X. T. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0340-7 · Cited by 149 · see citing works
Neuroinflammation in Schizophrenia: The Key Role of the WNT/β-Catenin Pathway
Vallée, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052810 · Cited by 153 · see citing works
HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy
Thangaraj, A., Periyasamy, P., Liao, K., Bendi, V. S., Callen, S. E., Pendyala, G., & Buch, S. J. (2018) · Autophagy · doi:10.1080/15548627.2018.1476810 · Cited by 147 · see citing works
Oxidative Stress and the Pathophysiology and Symptom Profile of Schizophrenia Spectrum Disorders
Murray, A., Rogers, J. C., Katshu, M. Z. U. H., Liddle, P. F., & Upthegrove, R. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.703452 · Cited by 147 · see citing works
Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy
Clayton, K. A., Enoo, A. A. V., & Ikezu, T. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00680 · Cited by 132 · see citing works
Brand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123 · see citing works
Michalak, K. P., & Michalak, A. Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1558263 · Cited by 132 · see citing works
Mongan, D., Ramesar, M., Föcking, M., Cannon, M., & Cotter, D. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.12859 · Cited by 123 · see citing works
Ghosh, A., Langley, M. R., Harischandra, D. S., Neal, M. P., Jin, H., Anantharam, V., Joseph, J., Brenza, T. M., Narasimhan, B., Kanthasamy, A., et al. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9650-4 · Cited by 107 · see citing works
Han, Y., Liu, X., Jin, M., Sun, H., & Kwon, T. (2023) · Inflammation Research · doi:10.1007/s00011-023-01790-4 · Cited by 109 · see citing works
Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia
Bozic, I., Savic, D., Laketa, D., Bjelobaba, I., Milenkovic, I., Pekovic, S., Nedeljkovic, N., & Lavrnja, I. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118372 · Cited by 101 · see citing works
Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?
Jodeiri Farshbaf, M., Ghaedi, K., Megraw, T. L., Curtiss, J., Shirani Faradonbeh, M., Vaziri, P., & Nasr-Esfahani, M. H. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8370-x · Cited by 101 · see citing works
Huang, J., Wang, X., Li, N., Fan, W., Li, X., Qian, Z., Liu, J., Li, W., Zhang, Z., Liu, X., et al. (2024) · Advanced Science · doi:10.1002/advs.202308031 · Cited by 100 · see citing works
Ye, J., Jiang, Z., Chen, X., Liu, M., Li, J., & Liu, N. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14042 · Cited by 92 · see citing works
New insights into targeting mitochondria in ischemic injury
Jia, J., Jin, H., Nan, D., Yu, W., & Huang, Y. (2021) · APOPTOSIS · doi:10.1007/s10495-021-01661-5 · Cited by 94 · see citing works
Qi, G., Mi, Y., Fan, R., Li, R., Liu, Z., & Liu, X. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00133 · Cited by 95 · see citing works
Jung, J., Choi, M., Lee, Y., Moon, B., Park, J., & Kim, H.-S. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b05147 · Cited by 92 · see citing works
Microglia energy metabolism in metabolic disorder
Kalsbeek, M. J. T., Mulder, L., & Yi, C. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.028 · Cited by 93 · see citing works
Roelofs, B. A., Ge, S. X., Studlack, P. E., & Polster, B. M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.032 · Cited by 92 · see citing works
Self-citationSchilling, S., Chausse, B., Dikmen, H. O., Almouhanna, F., Hollnagel, J., Lewen, A., & Kann, O. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.013 · Cited by 91 · see citing works
Pozzo, E. D., Tremolanti, C., Costa, B., Giacomelli, C., Milenkovic, V. M., Bader, S. M., Wetzel, C. H., Rupprecht, R., Taliani, S., Settimo, F. D., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184467 · Cited by 82 · see citing works
Mendiratta, S., hussein, M., Nasser, H. A., & Ali, A. (2019) · Particle & Particle Systems Characterization · doi:10.1002/ppsc.201900195 · Cited by 86 · see citing works
Emerging roles of microglial cathepsins in neurodegenerative disease
Lowry, J. R., & Klegeris, A. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.02.014 · Cited by 77 · see citing works
Cui, Y., Yu, H., Bu, Z., Wen, L., Yan, L.-L., & Feng, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.894298 · Cited by 79 · see citing works
Ye, J., Jiang, Z., Chen, X., Liu, M., Li, J., & Liu, N. (2015) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.026 · Cited by 76 · see citing works
N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases
Li, J., Xu, L., Deng, X., Jiang, C., Pan, C., Chen, L., Han, Y., Dai, W., Hu, L., Zhang, G., et al. (2016) · Pain · doi:10.1097/j.pain.0000000000000575 · Cited by 71 · see citing works
Park, J., Choi, H., Kim, B., Chae, U., Lee, D. G., Lee, S.-R., Lee, S., Lee, H., & Lee, D. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.08.030 · Cited by 71 · see citing works
Ladwig, A., Walter, H. L., Hucklenbroich, J., Willuweit, A., Langen, K., Fink, G. R., Rueger, M. A., & Schroeter, M. (2017) · Mediators of Inflammation · doi:10.1155/2017/7189421 · Cited by 64 · see citing works
Structure and function of a novel antioxidant peptide from the skin of tropical frogs
Barbosa, É. A., Oliveira, A. L. S., Plácido, A., Socodato, R., Portugal, C. C., Mafud, A. C., Ombredane, A. S., Moreira, D. C., Vale, N., Bessa, L. J., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.001 · Cited by 64 · see citing works
Mutemberezi, V., Buisseret, B., Masquelier, J., Guillemot‐Legris, O., Alhouayek, M., & Muccioli, G. G. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1114-8 · Cited by 62 · see citing works
Loss of Microglial Parkin Inhibits Necroptosis and Contributes to Neuroinflammation
Dionísio, P. A., Oliveira, S. R., Amaral, J. D., & Rodrigues, C. M. P. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1264-9 · Cited by 62 · see citing works
Pap, R., Pandur, E., Jánosa, G., Sipos, K., Agócs, A., & Deli, J. (2021) · Antioxidants · doi:10.3390/antiox10030363 · Cited by 61 · see citing works
Miyamoto, S., Zhang, G., Hall, D., Oates, P. J., Maity, S., Madesh, M., Han, X., & Sharma, K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011110 · Cited by 60 · see citing works
Distinct metabolic patterns during microglial remodeling by oleate and palmitate
Chausse, B., Kakimoto, P. A., Caldeira-da-Silva, C. C., Chaves-Filho, A. B., Yoshinaga, M. Y., da Silva, R. P., Miyamoto, S., & Kowaltowski, A. J. (2019) · Bioscience Reports · doi:10.1042/bsr20190072 · Cited by 59 · see citing works
Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response
Bordt, E. A., Smith, C. J., Demarest, T. G., Bilbo, S. D., & Kingsbury, M. A. (2019) · Neurotoxicity Research · doi:10.1007/s12640-018-9962-7 · Cited by 58 · see citing works
Self-citationBlue and Long-Wave Ultraviolet Light Induce in vitro Neutrophil Extracellular Trap (NET) Formation
Neubert, E., Bach, K. M., Busse, J., Bogeski, I., Schön, M. P., Kruss, S., & Erpenbeck, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02428 · Cited by 57 · see citing works
Neuropathophysiological Mechanisms and Treatment Strategies for Post-traumatic Epilepsy
Sharma, S., Tiarks, G., Haight, J. A., & Bassuk, A. G. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.612073 · Cited by 57 · see citing works
Glial mitochondrial function and dysfunction in health and neurodegeneration
McAvoy, K., & Kawamata, H. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103417 · Cited by 57 · see citing works
Sutherland, T. C., & Geoffroy, C. G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00190 · Cited by 54 · see citing works
Hara‐Chikuma, M., Tanaka, M., Verkman, A. S., & Yasui, M. (2020) · Nature Communications · doi:10.1038/s41467-020-19491-5 · Cited by 52 · see citing works
Oka, S., Leon, J., Sakumi, K., Abolhassani, N., Sheng, Z., Tsuchimoto, D., LaFerla, F. M., & Nakabeppu, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-84640-9 · Cited by 51 · see citing works
Modulation of BV-2 microglia functions by novel quercetin pivaloyl ester
Mrvová, N., Škandík, M., Kuniaková, M., & Račková, L. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.09.005 · Cited by 50 · see citing works
Huang, P., Zhang, L., Tan, Y., & Chen, S. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00337-1 · Cited by 50 · see citing works
Role of metabolic programming in the modulation of microglia phagocytosis by lipids
Nadjar, A. (2018) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2018.07.006 · Cited by 49 · see citing works
Sirabella, R., Sisalli, M. J., Costa, G., Omura, K. M., Ianniello, G., Pinna, A., Morelli, M., Renzo, G. D., Annunziato, L., & Scorziello, A. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0775-7 · Cited by 48 · see citing works
Alvariño, R., Alonso, E., Lacret, R., Oves‐Costales, D., Genilloud, O., Reyes, F., Alfonso, A., & Botana, L. M. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01090 · Cited by 48 · see citing works
Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
Pan, C., Wang, C., Zhang, L., Song, L., Chen, Y., Liu, B., Liu, W., Hu, L., & Pan, Y. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1182-9 · Cited by 46 · see citing works
Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury
Strogulski, N. R., Portela, L. V., Polster, B. M., & Loane, D. J. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15959 · Cited by 45 · see citing works
Self-citationNeuroinflammation in Amyotrophic Lateral Sclerosis: Role of Redox (dys)Regulation
D’Ambrosi, N., Cozzolino, M., & Carrı̀, M. T. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7271 · Cited by 44 · see citing works
Aquaporin 4: A key player in Parkinson's disease
Tamtaji, O. R., Behnam, M., Pourattar, M. A., Jafarpour, H., & Asemi, Z. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28871 · Cited by 44 · see citing works
Morris, G., Puri, B. K., Maes, M. H. J., OLIVE, L. S., Berk, M., & Carvalho, A. F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109858 · Cited by 41 · see citing works
Sousa, N. A., de Oliveira, G. A. L., de Oliveira, A. P., Lopes, A. L. F., Iles, B., Nogueira, K. D. M., Araújo, T. S. L., de Souza, L. K. M., de Araújo, A. R., Ramos‐Jesus, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59665-1 · Cited by 42 · see citing works
Yosri, H., El‐Kashef, D. H., El‐Sherbiny, M., Said, E., & Salem, H. A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113758 · Cited by 42 · see citing works
Zha, Z., Liu, S., Liu, Y., Li, C., & Wang, L. (2022) · Antioxidants · doi:10.3390/antiox11081495 · Cited by 42 · see citing works
Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells
Bozic, I. D., Savić, D. Z., Stevanović, I. D., Peković, S., Nedeljković, N., & Lavrnja, I. C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00351 · Cited by 41 · see citing works
O'Brien, J. A., & Austin, P. J. (2019) · Biomolecules · doi:10.3390/biom9080381 · Cited by 41 · see citing works
Brain organoids: A promising model to assess oxidative stress‐induced central nervous system damage
Oyefeso, F. A., Muotri, A. R., Wilson, C. G., & Pecaut, M. J. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22828 · Cited by 44 · see citing works
Recent Progress in Autocatalytic Ceria Nanoparticles-Based Translational Research on Brain Diseases
Choi, S. W., & Kim, J. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.9b02243 · Cited by 39 · see citing works
Electroconvulsive stimulation attenuates chronic neuroinflammation
Goldfarb, S., Fainstein, N., & Ben‐Hur, T. (2020) · JCI Insight · doi:10.1172/jci.insight.137028 · Cited by 41 · see citing works
Wang, W., Tam, K. C., Ng, T. C., Goit, R. K., Chan, K. L.-S., & Lo, A. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001519 · Cited by 39 · see citing works
Nanomaterials as novel agents for amelioration of Parkinson’s disease
Wu, J., Cui, X., Ke, P. C., Mortimer, M., Wang, X., Bao, L., & Chen, C. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101328 · Cited by 38 · see citing works
Barnett, D., Zimmer, T. S., Booraem, C., Palaguachi, F., Meadows, S. M., Xiao, H., Wong, M. Y., Luo, W., Gan, L., Chouchani, E. T., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01390-y · Cited by 39 · see citing works
Tylek, K., Trojan, E., Leśkiewicz, M., Regulska, M., Bryniarska, N., Curzytek, K., Lacivita, E., Leopoldo, M., & Basta‐Kaim, A. (2021) · Cells · doi:10.3390/cells10092373 · Cited by 36 · see citing works
Crous, A., & Abrahamse, H. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10142-w · Cited by 36 · see citing works
Zhang, H., Yang, S., Lu, Y., Zhou, L., Dong, M., Chu, Y., Pang, X., Chen, L., Xu, L., Zhang, L., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103473 · Cited by 36 · see citing works
Pilipović, K., Župan, Ž., Dolenec, P., Mršić‐Pelčić, J., & Župan, G. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.003 · Cited by 35 · see citing works
Yu, S., Fu, J., Wang, J., Zhao, Y., Liu, B., Wei, J., Yan, X., & Su, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010135 · Cited by 33 · see citing works
Bastioli, G., Piccirillo, S., Graciotti, L., Carone, M., Sprega, G., Taoussi, O., Preziuso, A., & Castaldo, P. (2024) · Cells · doi:10.3390/cells13151301 · Cited by 37 · see citing works
Mayer, A. M. S., Murphy, J., Macadam, D., Osterbauer, C., Baseer, I., Hall, M. L. M., Fehér, D., & Williams, P. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv251 · Cited by 34 · see citing works
Pampuščenko, K., Morkūnienė, R., Krasauskas, L., Smirnovas, V., Brown, G. C., & Borutaitė, V. (2023) · Scientific Reports · doi:10.1038/s41598-023-37887-3 · Cited by 31 · see citing works
Cheng, C., Cui, J. Z., Ji, X., & Yao, L. (2020) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0311 · Cited by 32 · see citing works
PapRIV, a BV-2 microglial cell activating quorum sensing peptide
Janssens, Y., Debunne, N., Spiegeleer, A. D., Wynendaele, E., Planas, M., Feliu, L., Quarta, A., Claes, C., Dam, D. V., Deyn, P. P. D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90030-y · Cited by 32 · see citing works
Influential role of 7-Ketocholesterol in the progression of Alzheimer’s disease
Mahalakshmi, K., Parimalanandhini, D., Sangeetha, R., Livya Catherene, M., Beulaja, M., Thiagarajan, R., Arumugam, M., Janarthanan, S., & Manikandan, R. (2021) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2021.106582 · Cited by 32 · see citing works
Milosevic, K., Stevanović, I. D., Bozic, I. D., Milosevic, A., Janjic, M. M., Laketa, D., Bjelobaba, I. M., Lavrnja, I. C., & Savić, D. Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073561 · Cited by 31 · see citing works
Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner
Benusa, S. D., George, N. M., Sword, B. A., DeVries, G. H., & Dupree, J. L. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0889-3 · Cited by 31 · see citing works
Li, Z., Liao, W., Yin, X., Liu, L., Zhao, Z., Lü, X., Xu, F., Lin, X., Chen, Y., Song, J., et al. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113601 · Cited by 31 · see citing works
Zhang, W., Jiao, B., Yu, S., Zhang, K., Sun, J., Liu, B., & Zhang, X. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.12.004 · Cited by 32 · see citing works
Wu, Z., Zhou, L., Sun, L., Xie, Y., Xiao, L., Wang, H., & Wang, G. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.03.016 · Cited by 31 · see citing works
Chen, C., Yang, C.-H., Tsai, Y., Liaw, C., Chang, W.-Y., & Hwang, T. (2016) · Redox Biology · doi:10.1016/j.redox.2016.12.018 · Cited by 33 · see citing works
Avola, R., Furnari, A. G., Graziano, A. C. E., Russo, A., & Cardile, V. (2024) · Antioxidants · doi:10.3390/antiox13020178 · Cited by 30 · see citing works
Electric neurostimulation regulates microglial activation via retinoic acid receptor α signaling
Goldfarb, S., Fainstein, N., Ganz, T., Vershkov, D., Lachish, M., & Ben‐Hur, T. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.05.007 · Cited by 32 · see citing works
Yan, X., Maixner, D. W., Li, F., & Weng, H. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13952 · Cited by 29 · see citing works
An association between mitochondria and microglia effector function: what do we think we know?
Harry, G. J., Childers, G. M., Giridharan, S., & Hernandes, I. L. (2020) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2020.07 · Cited by 27 · see citing works
Ling, J., Wu, Y., Zou, X., Chang, Y., Li, G., & Fang, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2657713 · Cited by 27 · see citing works
- Authors
- Bordt, E. A., & Polster, B. M.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Polster, Brian M.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 76
- Pages
- 34-46
- ISSN
- 0891-5849 (ISSN-L)
- PMC
- PMC4252610
- OpenAlex
- W1971167579
- Cited by
- 202
- References
- 163
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 19 · 2021: 24 · 2020: 16 · 2019: 18 · 2018: 20 · 2017: 16 · 2016: 15 · 2015: 12 · 2014: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 NS085165)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- microglial activation, reactive oxygen species, NADPH oxidase, mitochondrial reactive oxygen species, hydrogen peroxide, superoxide, M1 macrophage polarization, NLRP3 inflammasome, IL-1β, IL-18, MitoSOX, MitoTEMPO, neuroinflammation, brain injury
- MeSH terms
- Animals, Humans, Mitochondria, Reactive Oxygen Species, Microglia, Inflammation Mediators, NADPH Oxidases
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