Characterizing the mucin-degrading capacity of the human gut microbiota

The carbohydrate-active enzymes database (CAZy) in 2013

Lombard, V., Ramulu, H. G., Drula, É., Coutinho, P. M., & Henrissat, B. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1178 · Cited by 6,355 · see citing works

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

Cantarel, B. L., Coutinho, P. M., Rancurel, C., Bernard, T., Lombard, V., & Henrissat, B. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn663 · Cited by 5,947 · see citing works

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Bäckhed, F., Roswall, J., Peng, Y., Feng, Q., Jia, H., Kovatcheva-Datchary, P., Li, Y., Xia, Y., Xie, H., Zhong, H., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.004 · Cited by 3,315 · see citing works

A classification of glycosyl hydrolases based on amino acid sequence similarities.

Henrissat, B. (1991) · Biochemical Journal · doi:10.1042/bj2800309 · Cited by 3,188 · see citing works

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

Desai, M. S., Seekatz, A. M., Koropatkin, N. M., Kamada, N., Hickey, C. A., Wolter, M., Pudlo, N. A., Kitamoto, S., Terrapon, N., Muller, A., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.043 · Cited by 2,805 · see citing works

Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · see citing works

New families in the classification of glycosyl hydrolases based on amino acid sequence similarities

Henrissat, B., & Bairoch, A. (1993) · Biochemical Journal · doi:10.1042/bj2930781 · Cited by 1,974 · see citing works

The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

Kaoutari, A. E., Armougom, F., Gordon, J. I., Raoult, D., & Henrissat, B. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3050 · Cited by 1,683 · see citing works

Mucin dynamics and enteric pathogens

McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428 · see citing works

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364 · see citing works

Glycan foraging in vivo by an intestine-adapted bacterial symbiont

Sonnenburg, J. L., Xu, J., Leip, D. D., Chen, C.-H., Westover, B. P., Weatherford, J., Buhler, J. D., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1109051 · Cited by 1,184 · see citing works

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

Mcdole, J. R., Wheeler, L. W., McDonald, K. G., Wang, B., Konjufca, V. H., Knoop, K. A., Newberry, R. D., & Miller, M. J. (2012) · Nature · doi:10.1038/nature10863 · Cited by 976 · see citing works

Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont

Martens, E. C., Chiang, H. C., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.007 · Cited by 919 · see citing works

Mucin glycan foraging in the human gut microbiome

Tailford, L. E., Crost, E. H., Kavanaugh, D. W., & Juge, N. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00081 · Cited by 851 · see citing works

Early life dynamics of the human gut virome and bacterial microbiome in infants

Lim, E. S., Zhou, Y., Zhao, G., Bauer, I. K., Droit, L., Ndao, I. M., Warner, B. B., Tarr, P. I., Wang, D., & Holtz, L. R. (2015) · Nature Medicine · doi:10.1038/nm.3950 · Cited by 644 · see citing works

Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon

Salyers, A. A., West, S. E. H., Vercellotti, J. R., & Wilkins, T. D. (1977) · Applied and Environmental Microbiology · doi:10.1128/aem.34.5.529-533.1977 · Cited by 471 · see citing works

The IMG/M data management and analysis system v.6.0: new tools and advanced capabilities

Chen, I.-M. A., Chu, K., Palaniappan, K., Ratner, A., Huang, J., Huntemann, M., Hajek, P. P., Ritter, S., Varghese, N. J., Seshadri, R., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa939 · Cited by 433 · see citing works

Complex Carbohydrate Utilization by the Healthy Human Microbiome

Cantarel, B. L., Lombard, V., & Henrissat, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028742 · Cited by 378 · see citing works

Genome analysis of <i>Bifidobacterium bifidum</i> PRL2010 reveals metabolic pathways for host-derived glycan foraging

Turroni, F., Bottacini, F., Foroni, E., Mulder, I., Kim, J.-H., Zomer, A., Sánchez, B., Bidossi, A., Ferrarini, A., Giubellini, V., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011100107 · Cited by 364 · see citing works

Functional Genomic and Metabolic Studies of the Adaptations of a Prominent Adult Human Gut Symbiont, Bacteroides thetaiotaomicron, to the Suckling Period

Bjursell, M. K., Martens, E. C., & Gordon, J. I. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606509200 · Cited by 338 · see citing works

Utilisation of Mucin Glycans by the Human Gut Symbiont Ruminococcus gnavus Is Strain-Dependent

Crost, E. H., Tailford, L. E., Gall, G. L., Fons, M., Henrissat, B., & Juge, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076341 · Cited by 315 · see citing works

CAZymes Analysis Toolkit (CAT): Web service for searching and analyzing carbohydrate-active enzymes in a newly sequenced organism using CAZy database

Park, B. H., Karpinets, T. V., Syed, M. H., Leuze, M. R., & Uberbacher, E. C. (2010) · Glycobiology · doi:10.1093/glycob/cwq106 · Cited by 304 · see citing works

Mother-to-Infant Transmission of Intestinal Bifidobacterial Strains Has an Impact on the Early Development of Vaginally Delivered Infant's Microbiota

Makino, H., Kushiro, A., Ishikawa, E., Kubota, H., Gawad, A., Sakai, T., Oishi, K., Martı́n, R., Amor, K. B., Knol, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078331 · Cited by 304 · see citing works

Mucin Degradation in Human Colon Ecosystems

Hoskins, L. C., & Boulding, E. T. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110009 · Cited by 277 · see citing works

Mucin degradation in the human colon: production of sialidase, sialate O-acetylesterase, N-acetylneuraminate lyase, arylesterase, and glycosulfatase activities by strains of fecal bacteria

Corfield, A. P., Wagner, S. A., Clamp, J. R., Kriaris, M. S., & Hoskins, L. C. (1992) · Infection and Immunity · doi:10.1128/iai.60.10.3971-3978.1992 · Cited by 267 · see citing works

Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis

Fang, J. C., Wang, H., Zhou, Y., Zhang, H., Zhou, H., & Zhang, X. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00617-8 · Cited by 242 · see citing works

Mucin Degradation by Bifidobacterium Strains Isolated from the Human Intestinal Microbiota

Ruas‐Madiedo, P., Gueimonde, M., Fernández-García, M., Reyes‐Gavilán, C. G. D. L., & Margollés, A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02509-07 · Cited by 222 · see citing works

Trefoil Factor Peptides and Gastrointestinal Function

Aihara, E., Engevik, K. A., & Montrose, M. H. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105447 · Cited by 201 · see citing works

Symbiotic Human Gut Bacteria with Variable Metabolic Priorities for Host Mucosal Glycans

Pudlo, N. A., Urs, K., Kumar, S. S., German, J. B., Mills, D. A., & Martens, E. C. (2015) · mBio · doi:10.1128/mbio.01282-15 · Cited by 187 · see citing works

A refined palate: Bacterial consumption of host glycans in the gut

Marcobal, A. M., Southwick, A. M., Earle, K. A., & Sonnenburg, J. L. (2013) · Glycobiology · doi:10.1093/glycob/cwt040 · Cited by 178 · see citing works

Identification of mucin degraders of the human gut microbiota

Raimondi, S., Musmeci, E., Candeliere, F., Amaretti, A., & Rossi, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-90553-4 · Cited by 173 · see citing works

Mucin degradation in human colon ecosystems

Miller, R. S., & Hoskins, L. C. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90503-5 · Cited by 166 · see citing works

Mucin Cross-Feeding of Infant Bifidobacteria and Eubacterium hallii

Bunešová, V., Lacroix, C., & Schwab, C. (2017) · Microbial Ecology · doi:10.1007/s00248-017-1037-4 · Cited by 149 · see citing works

Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown

Crouch, L. I., Liberato, M. V., Urbanowicz, P. A., Baslé, A., Lamb, C. A., Stewart, C. J., Cooke, K., Doona, M., Needham, S. J., Brady, R. R. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17847-5 · Cited by 146 · see citing works

Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

Bell, A., Brunt, J., Crost, E. H., Vaux, L., Nepravishta, R., Owen, C. D., Latousakis, D., Xiao, A., Li, W., Chen, X., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0590-7 · Cited by 137 · see citing works

Comparative Genomic Analysis of the Human Gut Microbiome Reveals a Broad Distribution of Metabolic Pathways for the Degradation of Host-Synthetized Mucin Glycans and Utilization of Mucin-Derived Monosaccharides

Ravcheev, D. A., & Thiele, I. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00111 · Cited by 136 · see citing works

Development of Chemically Defined Media Supporting High-Cell-Density Growth of Lactococci, Enterococci, and Streptococci

Zhang, G., Mills, D. A., & Block, D. E. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01416-08 · Cited by 132 · see citing works

Importance of Glycans to the Host-Bacteroides Mutualism in the Mammalian Intestine

Comstock, L. E. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.010 · Cited by 114 · see citing works

Mucosal glycan degradation of the host by the gut microbiota

Bell, A., & Juge, N. (2020) · Glycobiology · doi:10.1093/glycob/cwaa097 · Cited by 111 · see citing works

Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila

Trastoy, B., Naegeli, A., Anso, I., Sjögren, J., & Guerin, M. E. (2020) · Nature Communications · doi:10.1038/s41467-020-18696-y · Cited by 102 · see citing works

α-N-Acetylgalactosaminidase from Infant-associated Bifidobacteria Belonging to Novel Glycoside Hydrolase Family 129 Is Implicated in Alternative Mucin Degradation Pathway

Kiyohara, M., Nakatomi, T., Kurihara, S., Fushinobu, S., Suzuki, H., Tanaka, T., Shoda, S., Kitaoka, M., Katayama, T., Yamamoto, K., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277384 · Cited by 97 · see citing works

Establishment of a Mucin-Degrading Intestinal Microflora During the First Two Years of Human Life

Midtvedt, A., Carlstedt‐Duke, B., & Midtvedt, T. (1994) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199404000-00012 · Cited by 61 · see citing works

The glycoconjugate-degrading enzymes of Clostridium perfringens: Tailored catalysts for breaching the intestinal mucus barrier

Low, K. E., Smith, S. P., Abbott, D. W., & Boraston, A. B. (2020) · Glycobiology · doi:10.1093/glycob/cwaa050 · Cited by 36 · see citing works

Draft genome sequence of Fermentimonas caenicola strain SIT8, isolated from the human gut

Beye, M., Bakour, S., Traore, S. I., Rathored, J., Labas, N., Raoult, D., & Fournier, P. (2018) · Standards in Genomic Sciences · doi:10.1186/s40793-018-0310-6 · Cited by 12 · see citing works

The Family Victivallaceae

Plugge, C. M., & Zoetendal, E. G. (2014) · Springer eBooks · doi:10.1007/978-3-642-38954-2_150 · Cited by 7 · see citing works

Gut microbiota-derived short-chain fatty acids and their role in human health and disease

Mukhopadhya, I., & Louis, P. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01183-w · Cited by 586 · see citing works

The gut microbiota and its biogeography

McCallum, G., & Tropini, C. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00969-0 · Cited by 342 · see citing works

The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids

Holmberg, S. M., Feeney, R. H., K., V., Puértolas-Balint, F., Singh, D. K., Wongkuna, S., Zandbergen, L. M., Hauner, H., Brandl, B., Nieminen, A. I., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47594-w · Cited by 256 · see citing works

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria

Shuoker, B., Pichler, M. J., Jin, C., Sakanaka, H., Wu, H., Gascueña, A. M., Liu, J., Nielsen, T. S., Holgersson, J., Karlsson, E. N., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37533-6 · Cited by 190 · see citing works

Host control of the microbiome: Mechanisms, evolution, and disease

Wilde, J., Slack, E. M. C., & Foster, K. R. (2024) · Science · doi:10.1126/science.adi3338 · Cited by 159 · see citing works

Lignocellulose degradation by rumen bacterial communities: New insights from metagenome analyses

Gharechahi, J., Vahidi, M. F., Sharifi, G., Ariaeenejad, S., Ding, X., Han, J., & Salekdeh, G. H. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115925 · Cited by 152 · see citing works

Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron

Schaus, S. R., Pereira, G. V., Luis, A. S., Madlambayan, E., Terrapon, N., Ostrowski, M. P., Jin, C., Henrissat, B., Hansson, G. C., & Martens, E. C. (2024) · mBio · doi:10.1128/mbio.00039-24 · Cited by 127 · see citing works

Neurodegenerative and Neurodevelopmental Diseases and the Gut-Brain Axis: The Potential of Therapeutic Targeting of the Microbiome

Bicknell, B. T., Liebert, A. D., Borody, T. J., Herkes, G., McLachlan, C. S., & Kiat, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119577 · Cited by 129 · see citing works

Implications of microbe-derived ɣ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer’s disease

Conn, K. A., Borsom, E. M., & Cope, E. K. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2371950 · Cited by 105 · see citing works

Correlation between the structures of natural polysaccharides and their properties in regulating gut microbiota: Current understanding and beyond

Keung, W.-S., Zhang, W.-H., Luo, H.-Y., Chan, K.-C., Chan, Y.-M., & Xu, J. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.123209 · Cited by 100 · see citing works

Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization

Horrocks, V., King, O. G., Yip, A. Y. G., Marques, I. M., & McDonald, J. A. K. (2023) · Microbiology · doi:10.1099/mic.0.001377 · Cited by 104 · see citing works

Could Microplastics Be a Driver for Early Onset Colorectal Cancer?

Li, S., Keenan, J. I., Shaw, I. C., & Frizelle, F. (2023) · Cancers · doi:10.3390/cancers15133323 · Cited by 96 · see citing works

Akkermansia in the gastrointestinal tract as a modifier of human health

Panzetta, M. E., & Valdivia, R. H. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2406379 · Cited by 92 · see citing works

Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion

Bakshani, C. R., Ojuri, T. O., Pilgaard, B., Holck, J., McInnes, R. S., Kozak, R. P., Zakhour, M. I., Çakaj, S., Kerouedan, M., Newton, E., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-024-01911-7 · Cited by 97 · see citing works

Pathogenicity and virulence of Entamoeba histolytica , the agent of amoebiasis

Guillén, N. (2022) · Virulence · doi:10.1080/21505594.2022.2158656 · Cited by 81 · see citing works

Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life

Roager, H. M., Stanton, C., & Hall, L. J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2192151 · Cited by 68 · see citing works

Microplastics and environmental effects: investigating the effects of microplastics on aquatic habitats and their impact on human health

Yarahmadi, A., Heidari, S., Sepahvand, P., Afkhami, H., & Kheradjoo, H. (2024) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1411389 · Cited by 68 · see citing works

Treatment of Dyslipidemia through Targeted Therapy of Gut Microbiota

Flaig, B., Garza, R., Singh, B., Hamamah, S., & Covașă, M. (2023) · Nutrients · doi:10.3390/nu15010228 · Cited by 64 · see citing works

Western diet–induced mouse model of non-alcoholic fatty liver disease associated with metabolic outcomes: Features of gut microbiome-liver-adipose tissue axis

Romualdo, G. R., Valente, L. C., dos Santos, A. C. S., Bacil, G. P., de Souza, I. P., Rodrigues, J., Rodrigues, M. A. M., Vinken, M., Cogliati, B., & Barbisan, L. F. (2022) · Nutrition · doi:10.1016/j.nut.2022.111836 · Cited by 56 · see citing works

Research progress on the mechanism of functional activity of edible fungi polysaccharides—focusing intestinal mucus as a key and entry point

Yu, Y., Duan, Y., Ma, S., Hu, Q., & Ma, G. (2024) · Food & medicine homology. · doi:10.26599/fmh.2025.9420042 · Cited by 56 · see citing works

Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice

Panyod, S., Wu, W., Chang, C.-T., Wada, N., Ho, H., Lo, Y.-L., Tsai, S.-P., Chen, R.-A., Huang, H., Liu, P., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06224-3 · Cited by 54 · see citing works

Effect of in vitro cultivation on human gut microbiota composition using 16S rDNA amplicon sequencing and metabolomics approach

Średnicka, P., Roszko, M. Ł., Popowski, D., Kowalczyk, M., Wójcicki, M., Emanowicz, P., Szczepańska, M., Kotyrba, D., & Juszczuk‐Kubiak, E. (2023) · Scientific Reports · doi:10.1038/s41598-023-29637-2 · Cited by 51 · see citing works

Gut microbiota response to in vitro transit time variation is mediated by microbial growth rates, nutrient use efficiency and adaptation to in vivo transit time

Minnebo, Y., Delbaere, K., Goethals, V., Raes, J., de Wiele, T. V., & Paepe, K. D. (2023) · Microbiome · doi:10.1186/s40168-023-01691-y · Cited by 52 · see citing works

Nutrient acquisition strategies by gut microbes

Muramatsu, M. K., & Winter, S. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.05.011 · Cited by 50 · see citing works

Health Effects and Therapeutic Potential of the Gut Microbe Akkermansia muciniphila

Aja, E., Zeng, A.-P., Gray, W. R., Connelley, K. K., Chaganti, A., & Jacobs, J. P. (2025) · Nutrients · doi:10.3390/nu17030562 · Cited by 51 · see citing works

Development of the Neonatal Intestinal Barrier, Microbiome, and Susceptibility to NEC

Golubkova, A., & Hunter, C. J. (2023) · Microorganisms · doi:10.3390/microorganisms11051247 · Cited by 50 · see citing works

Infant Formula Supplemented with Five Human Milk Oligosaccharides Shifts the Fecal Microbiome of Formula-Fed Infants Closer to That of Breastfed Infants

Holst, A. Q., Myers, P. N., Rodríguez-García, P., Hermes, G. D. A., Melsæther, C., Baker, A., Jensen, S. R., & Parschat, K. (2023) · Nutrients · doi:10.3390/nu15143087 · Cited by 49 · see citing works

The Gut–Heart Axis: Molecular Perspectives and Implications for Myocardial Infarction

Rivera, K., González, L., Bravo, L., Manjarres, L., & Andía, M. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212465 · Cited by 50 · see citing works

Breaking down barriers: is intestinal mucus degradation by Akkermansia muciniphila beneficial or harmful?

Tingler, A. M., & Engevik, M. A. (2025) · Infection and Immunity · doi:10.1128/iai.00503-24 · Cited by 53 · see citing works

Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function

Segui-Perez, C., Huang, L. Z. X., Paganelli, F. L., Lievens, E., & Strijbis, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-92125-2 · Cited by 45 · see citing works

Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome

Andreani, N. A., Sharma, A., Dahmen, B., Specht, H. E., Mannig, N., Ruan, V., Keller, L., Baines, J. F., Herpertz‐Dahlmann, B., Dempfle, A., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2304158 · Cited by 44 · see citing works

The role of the Mediterranean diet in modulating the gut microbiome: A review of current evidence

Gündoğdu, A., & Nalbantoğlu, Ö. U. (2023) · Nutrition · doi:10.1016/j.nut.2023.112118 · Cited by 42 · see citing works

Bifidobacterium and the intestinal mucus layer

Gutierrez, A., Puckett, B., & Engevik, M. A. (2023) · Microbiome Research Reports · doi:10.20517/mrr.2023.37 · Cited by 43 · see citing works

Gut microbiota and derived metabolomic profiling in glaucoma with progressive neurodegeneration

Zhang, Y., Zhou, X., & Lu, Y. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.968992 · Cited by 41 · see citing works

Mucin glycans and their degradation by gut microbiota

Yamaguchi, M., & Yamamoto, K. (2023) · Glycoconjugate Journal · doi:10.1007/s10719-023-10124-9 · Cited by 41 · see citing works

Food additives impair gut microbiota from healthy individuals and IBD patients in a colonic in vitro fermentation model

Gonza, I., Goya‐Jorge, E., Douny, C., Boutaleb, S., Taminiau, B., Daube, G., Scippo, M., Louis, E. J., & Delcenserie, V. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114157 · Cited by 40 · see citing works

A Bacteroides thetaiotaomicron genetic locus encodes activities consistent with mucin O-glycoprotein processing and N-acetylgalactosamine metabolism

Ndeh, D. A., Nakjang, S., Kwiatkowski, K. J., Sawyers, C., Koropatkin, N. M., Hirt, R. P., & Bolam, D. N. (2025) · Nature Communications · doi:10.1038/s41467-025-58660-2 · Cited by 36 · see citing works

Exploring and evaluating microbiome resilience in the gut

Zhou, H., Tang, L., Fenton, K. A., & Song, X. (2025) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiaf046 · Cited by 37 · see citing works

Potential Effects of Functional Foods and Dietary Supplements on Metabolic-Associated Fatty Liver Disease and the Underlying Mechanisms: A Narrative Review with a Focus on the Modulation of the Gut Microbiota

Chang, Z., Xu, X., Xu, Y., Wei, X., Yang, G., Guo, P., Jia, J., Chen, Y., Song, X., Zheng, Y., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c05587 · Cited by 39 · see citing works

Spaceflight alters host-gut microbiota interactions

González, E., Lee, M., Tierney, B. T., Lytell, N., Flores, P., Mishra, M., Beckett, L., Finkelstein, A., Mo, A., Walton, P., et al. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00545-1 · Cited by 36 · see citing works

O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases

Labourel, A., Parrou, J., Deraison, C., Mercier‐Bonin, M., Lajus, S., & Potocki-Véronèse, G. (2023) · Essays in Biochemistry · doi:10.1042/ebc20220153 · Cited by 35 · see citing works

Disruption of intestinal oxygen balance in acute colitis alters the gut microbiome

Zong, W., Friedman, E. S., Allu, S., Firrman, J., Tu, V., Daniel, S. G., Bittinger, K. L., Liu, L., Vinogradov, S. A., & Wu, G. D. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2361493 · Cited by 33 · see citing works

Adenosine in Intestinal Epithelial Barrier Function

Stepanova, M., & Aherne, C. M. (2024) · Cells · doi:10.3390/cells13050381 · Cited by 32 · see citing works

Pasteurized Akkermansia muciniphila HB05 (HB05P) Improves Muscle Strength and Function: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Kang, C.-H., Jung, E.-S., Jung, S., Han, Y., Chae, S., Jeong, D. Y., Kim, B., Lee, S., & Yoon, S. (2024) · Nutrients · doi:10.3390/nu16234037 · Cited by 38 · see citing works

Gut microbiota and derived metabolites mediate obstructive sleep apnea induced atherosclerosis

Xue, J., Allaband, C., Zuffa, S., Poulsen, O., Meadows, J. D., Zhou, D., Dorrestein, P. C., Knight, R. D., & Haddad, G. G. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2474142 · Cited by 35 · see citing works

The role of goblet cells in Crohn’ s disease

Wang, Z., & Shen, J. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01220-w · Cited by 33 · see citing works

Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease

Schmit, K. J., Garcia, P., Sciortino, A., Aho, V. T. E., Rodriguez, B. P., Thomas, M. H., Gérardy, J., Acha, I. B., Halder, R., Cialini, C., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113071 · Cited by 31 · see citing works

Loss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease

Opron, K., Begley, L., Erb‐Downward, J. R., Li, G., Alexis, N. E., Barjaktarević, I., Barr, R. G., Bleecker, E. R., Boucher, R. C., Bowler, R. P., et al. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202303-0489oc · Cited by 32 · see citing works

Ghrelin as a Biomarker of “Immunometabolic Depression” and Its Connection with Dysbiosis

Gajewska, A., Strzelecki, D., & Gawlik-Kotelnicka, O. (2023) · Nutrients · doi:10.3390/nu15183960 · Cited by 27 · see citing works

Insights into early evolutionary adaptations of the Akkermansia genus to the vertebrate gut

González, D., Morales-Olavarria, M., Vidal-Veuthey, B., & Cárdenas, J. P. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1238580 · Cited by 30 · see citing works

Potential Benefits of Egg White Proteins and Their Derived Peptides in the Regulation of the Intestinal Barrier and Gut Microbiota: A Comprehensive Review

Yang, Q., Lyu, S., Xu, M., Li, S., Du, Z., Liu, X., Shang, X., Yu, Z., Liu, J., & Zhang, T. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c03230 · Cited by 28 · see citing works

The effect of dietary zinc and zinc physiological status on the composition of the gut microbiome in vivo

Cheng, J., Kolba, N., & Tako, E. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2169857 · Cited by 29 · see citing works

The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system

Crouch, L. I., Rodrigues, C. S., Bakshani, C. R., Tavares-Gomes, L., Gaifem, J., & Pinho, S. S. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2024.101891 · Cited by 29 · see citing works

Faecalibacterium prausnitzii regulates carbohydrate metabolic functions of the gut microbiome in C57BL/6 mice

Geng, P., Zhao, N., Zhou, Y., Harris, R. S., & Ge, Y. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2455503 · Cited by 25 · see citing works

A history of repeated antibiotic usage leads to microbiota-dependent mucus defects

Krigul, K. L., Feeney, R. H., Wongkuna, S., Aasmets, O., Holmberg, S. M., Andreson, R., Puértolas-Balint, F., Pantiukh, K., Sootak, L., Org, T., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2377570 · Cited by 23 · see citing works

Functional Fermented Milk with Fruit Pulp Modulates the In Vitro Intestinal Microbiota

Borgonovi, T. F., Salgaço, M. K., de Oliveira, G. L. V., de Carvalho, L. A. L., Pinheiro, D. G., Todorov, S. D., Sivieri, K., Casarotti, S. N., & Penna, A. L. B. (2022) · Foods · doi:10.3390/foods11244113 · Cited by 24 · see citing works

Intestinal mucin-type O -glycans: the major players in the host-bacteria-rotavirus interactions

Raev, S. A., Amimo, J. O., Saif, L. J., & Vlasova, A. N. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2197833 · Cited by 22 · see citing works

Bifidobacterium animalis subsp. lactis Probio-M8 alleviates abnormal behavior and regulates gut microbiota in a mouse model suffering from autism

Miao, Z., Chen, L., Zhang, Y., Zhang, J., & Zhang, H. (2023) · mSystems · doi:10.1128/msystems.01013-23 · Cited by 27 · see citing works

Nutrition of Escherichia coli within the intestinal microbiome

Doranga, S., Krogfelt, K. A., Cohen, P. S., & Conway, T. (2024) · EcoSal Plus · doi:10.1128/ecosalplus.esp-0006-2023 · Cited by 21 · see citing works

Narrative review on bacteria-derived metabolites in the pathogenesis of ulcerative colitis

Tambovtseva, R. S., ARSLAN, L., Grigoryeva, T., Abdulkhakov, S. R., Doludin, Y. V., Стома, И. О., Rizvanov, A. A., Рифкатовна, М. Р., & Gabdoulkhakova, A. G. (2025) · Clinical Microbiology Reviews · doi:10.1128/cmr.00210-24 · Cited by 22 · see citing works

Development of an In Vitro Model of the Gut Microbiota Enriched in Mucus-Adhering Bacteria

Calvigioni, M., Panattoni, A., Biagini, F., Donati, L., Mazzantini, D., Massimino, M., Daddi, C., Celandroni, F., Vozzi, G., & Ghelardi, E. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00336-23 · Cited by 21 · see citing works

Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait

Esteban-Torres, M., Ruíz, L., Rossini, V., Nally, K., & van Sinderen, D. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2235067 · Cited by 20 · see citing works

Interindividual differences in aronia juice tolerability linked to gut microbiome and metabolome changes—secondary analysis of a randomized placebo-controlled parallel intervention trial

Lackner, S., Mahnert, A., Moissl‐Eichinger, C., Madl, T., Habisch, H., Meier‐Allard, N., Kumpitsch, C., Lahousen, T., Kohlhammer-Dohr, A., Mörkl, S., et al. (2024) · Microbiome · doi:10.1186/s40168-024-01774-4 · Cited by 21 · see citing works

Intestinal bacteria-derived tryptamine and its impact on human gut microbiota

Otaru, N., Greppi, A., Plüss, S., Zünd, J. N., Mujezinovic, D., Baur, J., Koleva, E., Lacroix, C., & Pugin, B. (2024) · Frontiers in Microbiomes · doi:10.3389/frmbi.2024.1373335 · Cited by 21 · see citing works

The influence of pre- and postnatal exposure to air pollution and green spaces on infant’s gut microbiota: Results from the MAMI birth cohort study

Cruells, A., Cabrera‐Rubio, R., Bustamante, M., Pelegrí-Sisó, D., Cirach, M., Jiménez-Arenas, P., Samarra, A., Martínez‐Costa, C., Collado, M. C., & Gascón, M. (2024) · Environmental Research · doi:10.1016/j.envres.2024.119283 · Cited by 20 · see citing works

Deciphering the personalized functional redundancy hierarchy in the gut microbiome

Jiang, Y., Che, L., & Li, S. C. (2025) · Microbiome · doi:10.1186/s40168-025-02273-w · Cited by 22 · see citing works

Mucin-driven ecological interactions in an in vitro synthetic community of human gut microbes

Berkhout, M. D., Ioannou, A., de Ram, C., Boeren, S. A., Plugge, C. M., & Belzer, C. (2024) · Glycobiology · doi:10.1093/glycob/cwae085 · Cited by 20 · see citing works

Gut microbiota dysbiosis orchestrates vitiligo-related oxidative stress through the metabolite hippuric acid

Ni, Q., Xia, L., Huang, Y., Yuan, X., Gu, W., Chen, Y., Wang, Y., Nian, M., Wu, S., Cai, H., et al. (2025) · Microbiome · doi:10.1186/s40168-025-02102-0 · Cited by 19 · see citing works

Pulses: A way to encourage sustainable fiber consumption

Biscarrat, P., Bedu-Ferrari, C., Langella, P., & Cherbuy, C. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104281 · Cited by 19 · see citing works

Impact of complementary feeding on infant gut microbiome, metabolites and early development

Shi, Y., Yin, R., Pang, J., Chen, Y., Li, Z., Su, S., & Wen, Y. (2024) · Food & Function · doi:10.1039/d4fo03948c · Cited by 19 · see citing works

Whole-genome sequencing and in vitro probiotic characterization of Pediococcus pentosaceus ELAB 60WB isolated from fermented cherry tomatoes

Megur, A., Ambrutaitytė, K., Šimoliūnas, E., Lastauskienė, E., & Burokas, A. (2025) · LWT · doi:10.1016/j.lwt.2025.117547 · Cited by 19 · see citing works

Nutrient acquisition of gut microbiota: Implications for tumor immunity

Wang, Y., Huang, J., Tong, H., Jiang, Y., Yu, J., & Ma, X. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.003 · Cited by 18 · see citing works

Mucosa-associated bacteria and metabolites in inflammatory bowel disease: from inside to insight

Wang, X., He, L., Dong, Y., Qin, X., Zhang, H., Wang, B., Wang, S., & Cao, H. (2026) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00887-4 · Cited by 21 · see citing works

Phage-encoded carbohydrate-interacting proteins in the human gut

Rothschild-Rodriguez, D., Hedges, M., Kaplan, M., Karav, S., & Nóbrega, F. L. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1083208 · Cited by 18 · see citing works

Microbial Metabolomes in Alzheimer’s Disease: From Pathogenesis to Therapeutic Potential

Borrego-Ruiz, A., & Borrego, J. J. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47090724 · Cited by 20 · see citing works

Genomic and functional diversity of the human-derived isolates of Faecalibacterium

Li, W., Lin, X., Liang, H., Wu, Z., Wang, M., Sun, J., Li, X., He, W., Gao, X., Hu, T., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1379500 · Cited by 17 · see citing works

A review on gut microbiota and miRNA crosstalk: implications for Alzheimer’s disease

Ayyanar, M. P., & Vijayan, M. (2024) · GeroScience · doi:10.1007/s11357-024-01432-5 · Cited by 23 · see citing works

Chronic Strongyloides stercoralis infection increases presence of the Ruminococcus torques group in the gut and alters the microbial proteome

Tran, N. T. D., Chaidee, A., Surapinit, A., Yingklang, M., Roytrakul, S., Charoenlappanit, S., Pinlaor, P., Hongsrichan, N., Anutrakulchai, S., Cha’on, U., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-31118-5 · Cited by 16 · see citing works

Causal relationship between gut Prevotellaceae and risk of sepsis: a two-sample Mendelian randomization and clinical retrospective study in the framework of predictive, preventive, and personalized medicine

Luo, Y., Zhou, Y., Huang, P., Zhang, Q., Luan, F., Peng, Y., Wei, J., Li, N., Wang, C., Wang, X., et al. (2023) · The EPMA Journal · doi:10.1007/s13167-023-00340-6 · Cited by 16 · see citing works

Comprehensive Safety Assessment of Lacticaseibacillus paracasei subsp. paracasei NTU 101 Through Integrated Genotypic and Phenotypic Analysis

Chen, C.-T., Chao, W.-Y., Lin, C., Shih, T., & Pan, T. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46110734 · Cited by 16 · see citing works

Dysbiosis and reduced small intestinal function are required to induce intestinal insufficiency in mice

Berlin, P., Barrantes, I., Reiner, J., Schröder, E., Vollmar, B., Bull, J., Kreikemeyer, B., Lamprecht, G., & Witte, M. (2023) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00201.2022 · Cited by 15 · see citing works

Large-scale computational analyses of gut microbial CAZyme repertoires enabled by CaymanPreprint

Ducarmon, Q. R., Karcher, N., Tytgat, H. L. P., Delannoy-Bruno, O., Pekel, S., Springer, F., Schudoma, C., & Zeller, G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.08.574624 · Cited by 15 · see citing works

Altered microbial biogeography in an innate model of colitis

Boger-May, A. M., Reed, T., LaTorre, D., Ruley-Haase, K., Hoffman, H., English, L., Roncagli, C., Overstreet, A.-M. C., & Boone, D. L. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2123677 · Cited by 14 · see citing works

Incorporating metabolic activity, taxonomy and community structure to improve microbiome-based predictive models for host phenotype prediction

Monshizadeh, M., & Ye, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2302076 · Cited by 13 · see citing works

Living on the edge: Mucus-associated microbes in the colon

Joja, M., Grant, E. T., & Desai, M. S. (2025) · Mucosal Immunology · doi:10.1016/j.mucimm.2025.04.003 · Cited by 14 · see citing works

Profiling Antibiotic Resistance in Acinetobacter calcoaceticus

Glover, J. S., Ticer, T. D., & Engevik, M. A. (2022) · Antibiotics · doi:10.3390/antibiotics11070978 · Cited by 14 · see citing works

Microbiota-Accessible Boron-Containing Compounds in Complex Regional Pain Syndrome

Biță, C. E., Scorei, I. R., Vreju, F. A., Mușetescu, A. E., Mogoşanu, G. D., Biţă, A., Dinescu, V. C., Dinescu, Ș. C., Criveanu, C., Bărbulescu, A. L., et al. (2023) · Medicina · doi:10.3390/medicina59111965 · Cited by 14 · see citing works

Characterization of Bifidobacterium bifidum growth and metabolism on whey protein phospholipid concentrate

Kim, Y.-T., Huang, Y.-P., Öztürk, G., Hahn, J., Taha, A. Y., Wang, A., Barile, D., & Mills, D. A. (2025) · Journal of Dairy Science · doi:10.3168/jds.2024-25885 · Cited by 13 · see citing works

Mucin-degrading gut bacteria: context-dependent roles in intestinal homeostasis and disease

Tiffany, E., Kim, K. S., Sittipo, P., Lee, D.-W., & Lee, Y. K. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2614054 · Cited by 15 · see citing works

Changes in the microbiota in different intestinal segments of mice with sepsis

Peng, Y., Wei, J., Jia, X., Luan, F., Man, M., Ma, X., Luo, Y., Li, Y., Li, N., Wang, Q., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.954347 · Cited by 12 · see citing works

The role of the glycome in symbiotic host-microbe interactions

Aminov, R. I., & Aminova, L. (2023) · Glycobiology · doi:10.1093/glycob/cwad073 · Cited by 12 · see citing works

Effects of probiotic supplementation on chronic inflammatory process modulation in colorectal carcinogenesis

Reis, S. K., Socca, E. A. R., de Souza, B. R., Genaro, S. C., Durán, N., & Fávaro, W. J. (2024) · Tissue and Cell · doi:10.1016/j.tice.2023.102293 · Cited by 12 · see citing works

Differential effects of high-fat diet on salivary and gut microbiota

Bai, J., Tian, Y., Lu, Y., Chen, Y., Yu, M., & Gao, X. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1547555 · Cited by 14 · see citing works

Enabling technologies for in situ biomanufacturing using probiotic yeast

Parker, W., Taylor, A., Razdan, A., Escarce, J., & Crook, N. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115605 · Cited by 12 · see citing works

Characterization of the gut microbiome in an osteosarcoma mouse model

Le, D., Chambers, M. M., Mercado, K., & Gutowski, C. J. (2023) · Journal of Orthopaedic Research® · doi:10.1002/jor.25635 · Cited by 11 · see citing works

Associations between the gut microbiome and metabolic, inflammatory, and appetitive effects of sleeve gastrectomy

Brown, H. N., Barber, T. M., Renshaw, D. W., Farnaud, S., Oduro‐Donkor, D., & Turner, M. C. (2023) · Obesity Reviews · doi:10.1111/obr.13600 · Cited by 12 · see citing works

Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities

Sisk-Hackworth, L., Brown, J., Sau, L., Levine, A. A., Tam, L. Y. I., Ramesh, A., Shah, R. S., Kelley-Thackray, E. T., Wang, S., Nguyen, A., et al. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00564-1 · Cited by 13 · see citing works

Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation

Dekkers, K. F., Pertiwi, K., Baldanzi, G., Lundmark, P., Hammar, U., Moksnes, M. R., Coward, E., Nethander, M., Salih, G. A., Miari, M., et al. (2026) · Nature Genetics · doi:10.1038/s41588-026-02512-2 · Cited by 12 · see citing works

Ant may well destroy a whole dam: glycans of colonic mucus barrier disintegrated by gut bacteria.

Li, S., Chen, M.-F., Wang, Z., Abudourexiti, W., Zhang, L., Ding, C., Ding, L., & Gong, J.-F. (2024) · Microbiology Research · doi:10.1016/j.micres.2023.127599 · Cited by 10 · see citing works

Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors

Suda, Y., Nakamura, K., Matsuyama, F., Hamada, Y., Makabe, H., Narita, M., Nagumo, Y., Mori, T., Kuzumaki, N., & Narita, M. (2024) · Molecular Brain · doi:10.1186/s13041-024-01091-9 · Cited by 11 · see citing works

Identifying Mucus‐Degrading Microbes Within the Human Gut Microbiota

Glover, J. S., Ticer, T. D., & Engevik, M. A. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.r5626 · Cited by 1 · see citing works

Mucosal glycan degradation of the host by the gut microbiota

Bell, A., & Juge, N. (2020) · Glycobiology · doi:10.1093/glycob/cwaa097 · Cited by 111 · see citing works

Identification of mucin degraders of the human gut microbiota

Raimondi, S., Musmeci, E., Candeliere, F., Amaretti, A., & Rossi, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-90553-4 · Cited by 173 · see citing works

Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion

Bakshani, C. R., Ojuri, T. O., Pilgaard, B., Holck, J., McInnes, R. S., Kozak, R. P., Zakhour, M. I., Çakaj, S., Kerouedan, M., Newton, E., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-024-01911-7 · Cited by 97 · see citing works

The butyrate-producing Gram-positive human gut bacterium, Hoskinsella mucinilytica, selectively targets host mucin N-acetylhexosamines

Pudlo, N. A., Pereira, G. V., Schaus, S. R., Yang, Q., Fuentes, J. J., Jin, C., Hein, R., Zhang, L., Terrapon, N., Lyssiotis, C. A., et al. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111371