Probiotic Bifidobacterium bifidum strains desialylate MUC13 and increase intestinal epithelial barrier function
Open accessAbstract
Probiotic bacteria including Bifidobacterial species have the capacity to improve intestinal health, but the underlying molecular mechanisms are often not understood. Bifidobacteria are considered keystone species but have a relatively low abundance in the adult intestinal tract. Bifidobacterium colonization depends on degradation of host-derived carbohydrates, including human milk oligosaccharides and mucin-associated oligosaccharides. Specific Bifidobacterium strains can enhance intestinal barrier integrity and improve symptoms of gastrointestinal disorders. We previously reported that the transmembrane mucin MUC13 localizes to the apical and lateral membrane and regulates epithelial tight junction strength. Here, we screened probiotic bacterial strains for their capacity to modulate MUC13 and enhance intestinal barrier function. Of these probiotic bacteria, a Bifidobacterium bifidum strain uniquely degraded the MUC13 O- glycosylated extracellular domain. Further characterization of two probiotic B. bifidum strains (W23 and W28) and the type strain 20456 demonstrated that the W23 and W28 strains adhered strongly to the apical surface, had high sialidase activity, penetrated the mucus layer, and enhanced epithelial barrier integrity. These results underscore the strain-specific properties of these specific B. bifidum strains that most likely contribute to their probiotic effects in the intestinal tract.
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In contrast to most HBS, which primarily metabolize plant-derived glycans, B. bifidum degrades host-derived complex carbohydrates, including mucin and intestinal epithelial glycans.
“In contrast to most HBS, which primarily metabolize plantderived glycans, B. bifidum degrades host-derived complex carbohydrates, including mucin and intestinal epithelial glycans [11,12] .”
From Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum (2026) · cites this paper as [12]
The Discussion (page not provided) states that B. bifidum degrades host-derived mucin glycans, and reports that strains W23 and W28 deglycosylate the intestinal epithelial glycocalyx, including MUC13. It names two other Bifidobacterium species that degrade plant-derived polysaccharides, but does not establish that most HBS primarily metabolize plant-derived glycans. (LLM, conf=0.86)
Experimental — accuracy not yet measuredBifidobacterium bifidum is an infant gut symbiont specialized in degrading host-derived glycans.
“Bifidobacterium bifidum ( B. bifidum ) is an infant gut symbiont specialized in degrading host-derived glycans.”
From Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum (2026) · cites this paper as [12]
B. bifidum exhibits highly specialized metabolic pathways adapted to the unique nutritional and ecological conditions of the neonatal gut environment.
“B. bifidum exhibits highly specialized metabolic pathways adapted to the unique nutritional and ecological conditions of the neonatal gut environment.”
From Genome-scale insights into the metabolic landscape and evolutionary development of Bifidobacterium bifidum (2026) · cites this paper as [12]
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Selleri, E., Longhi, G., Tarracchini, C., Carolis, E. D., Petraro, S., Mancabelli, L., Milani, C., Turroni, F., Ventura, M., & Lugli, G. A. (2026) · Microbiome Research Reports · doi:10.20517/mrr.2026.19
- Authors
- Segui-Perez, C., Huang, L. Z. X., Paganelli, F. L., Lievens, E., & Strijbis, K.
- Affiliations
- Utrecht University (NL)
- Winclove Probiotics (Netherlands) (NL)
- Corresponding author
- Strijbis, Karin
- Venue
- Scientific Reports
- Published
- 2025-03-13
- Volume
- 15
- Issue
- 1
- Pages
- 8778-8778
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC11906825
- OpenAlex
- W4408398805
- Cited by
- 45
- References
- 69
- Citations by year
- 2026: 29 · 2025: 16
- FWCI
- 21.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- Winclove Probiotics B.V. (UU-KS-CSP)
- European Research Council (ERC-2019-STG 852452)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- Bifidobacterium bifidum, probiotics, MUC13, sialidase activity, intestinal epithelial barrier, tight junctions, bacterial adhesion, mucin degradation, human milk oligosaccharides
- MeSH terms
- Bifidobacterium bifidum, Epithelial Cells, Glycosylation, Humans, Intestinal Mucosa, Mucins, Neuraminidase, Caco-2 Cells, Tight Junctions, Probiotics
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