Cited by 105Smoking Behavior and CessationMobile Health and mHealth ApplicationsSubstance Abuse Treatment and Outcomes

A randomized controlled trial of a smoking cessation smartphone application with a carbon monoxide checker

Open access
Masaki, Katsunori, Tateno, Hiroki, Nomura, Akihiro, Muto, Tomoyasu, Suzuki, Shin, Satake, Kohta, Hida, Eisuke, Fukunaga, Koichi·2020·npj Digital Medicine

Abstract

Abstract Evidence of the long-term efficacy of digital therapies for smoking cessation that include a smartphone application (app) is limited. In this multi-center randomized controlled trial, we tested the efficacy of a novel digital therapy for smoking cessation: the “CureApp Smoking Cessation (CASC)” system, including a CASC smartphone app, a web-based patient management PC software for primary physicians, and a mobile exhaled carbon monoxide (CO) checker. A total of 584 participants with nicotine dependence were recruited from October 2017 to January 2018, and allocated 1:1 to the CASC intervention group or the control group. Both groups received a standard smoking cessation treatment with pharmacotherapy and counseling for 12 weeks. Meanwhile, the intervention group used the CASC system, and the control group used a control-app without a mobile CO checker, each for 24 weeks. The primary outcome was the biochemically validated continuous abstinence rate (CAR) from weeks 9 to 24. The main secondary outcome was an extended CAR from weeks 9 to 52. Except for 12 participants who did not download or use the apps, 285 participants were assigned to the intervention group, and 287, to the control. CAR from weeks 9 to 24 in the intervention group was significantly higher than that in the control group (63.9% vs. 50.5%; odds ratio [OR], 1.73; 95% confidence interval [CI], 1.24 to 2.42; P = 0.001). The CAR from weeks 9 to 52 was also higher in the intervention group than that in the control group (52.3% vs. 41.5%; OR, 1.55; 95% CI, 1.11 to 2.16; P = 0.010). No specific adverse events caused by the CASC system were reported. Augmenting standard face-to-face counseling and pharmacotherapy with a novel smartphone app, the CASC system significantly improved long-term CARs compared to standard treatment and a minimally supportive control app.

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Authors
Masaki, K., Tateno, H., Nomura, A., Muto, T., Suzuki, S., Satake, K., Hida, E., & Fukunaga, K.
Affiliations
  • Keio University (JP)
  • Kanazawa University (JP)
  • The University of Osaka (JP)
Corresponding author
Tateno, Hiroki
Venue
npj Digital Medicine
Published
2020-03-12
Volume
3
Issue
1
Pages
35-35
ISSN
2398-6352 (ISSN-L)
OpenAlex
W3010960582
Cited by
102
References
29
Citations by year
2026: 10 · 2025: 22 · 2024: 19 · 2023: 24 · 2022: 13 · 2021: 8 · 2020: 6
FWCI
7.67
Type
journal article
Language
en
Open access
Locations
  • npj Digital Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Keio University
  • China Aerospace Science and Technology Corporation
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
smoking cessation, mobile application, digital therapy, exhaled carbon monoxide, nicotine dependence, continuous abstinence rate, long-term abstinence, pharmacotherapy, counseling

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