The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane
Open accessAbstract
The air-blood barrier with its complex architecture and dynamic environment is difficult to mimic in vitro. Lung-on-a-chips enable mimicking the breathing movements using a thin, stretchable PDMS membrane. However, they fail to reproduce the characteristic alveoli network as well as the biochemical and physical properties of the alveolar basal membrane. Here, we present a lung-on-a-chip, based on a biological, stretchable and biodegradable membrane made of collagen and elastin, that emulates an array of tiny alveoli with in vivo-like dimensions. This membrane outperforms PDMS in many ways: it does not absorb rhodamine-B, is biodegradable, is created by a simple method, and can easily be tuned to modify its thickness, composition and stiffness. The air-blood barrier is reconstituted using primary lung alveolar epithelial cells from patients and primary lung endothelial cells. Typical alveolar epithelial cell markers are expressed, while the barrier properties are preserved for up to 3 weeks.
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Cited by
A guide to the organ-on-a-chip
Leung, C. M., de Haan, P., Ronaldson-Bouchard, K., Kim, G.-A., Ko, J., Rho, H. S., Chen, Z., Habibovic, P., Jeon, N. L., Takayama, S., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00118-6 · Cited by 1,116
Human disease models in drug development
Loewa, A., Feng, J. J., & Hedtrich, S. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00063-3 · Cited by 331
Roadblocks confronting widespread dissemination and deployment of Organs on Chips
Alver, C. G., Drabbe, E., Ishahak, M., & Agarwal, A. (2024) · Nature Communications · doi:10.1038/s41467-024-48864-3 · Cited by 74
Basement membrane properties and their recapitulation in organ-on-chip applications
Salimbeigi, G., Vrana, N. E., Ghaemmaghami, A. M., Huri, P. Y., & McGuinness, G. B. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100301 · Cited by 57
Skin models of cutaneous toxicity, transdermal transport and wound repair
Vilela de Sousa, I., Ferreira, M. J. S., Bebiano, L. B., Simões, S., Matos, A. F., Pereira, R. F., & Granja, P. L. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad014 · Cited by 17
Metadata
- Authors
- Zamprogno, P., Wüthrich, S., Achenbach, S., Thoma, G., Stucki, J. D., Hobi, N., Schneider-Daum, N., Lehr, C.-M., Huwer, H., Geiser, T., Schmid, R. A., & Guenat, O. T.
- Venue
- Communications Biology
- Published
- 2021-02-05
- Volume
- 4
- Issue
- 1
- Pages
- 168-168
- ISSN
- 2399-3642 (ISSN-L)
- OpenAlex
- W3127330876
- Cited by
- 348
- References
- 49
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane. https://app.cochat.ai/papers/10.1038/s42003-021-01695-0
- The paper
- Zamprogno, P., Wüthrich, S., Achenbach, S., Thoma, G., Stucki, J. D., Hobi, N., Schneider-Daum, N., Lehr, C.-M., Huwer, H., Geiser, T., Schmid, R. A., & Guenat, O. T. (2021). Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane. Communications Biology. https://doi.org/10.1038/s42003-021-01695-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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