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Hydrogel scaffolds for tissue engineering: Progress and challenges

Open access
El-Sherbiny, Ibrahim M., Yacoub, Magdi H.·2013·Global Cardiology Science and Practice

Abstract

Designing of biologically active scaffolds with optimal characteristics is one of the key factors for successful tissue engineering. Recently, hydrogels have received a considerable interest as leading candidates for engineered tissue scaffolds due to their unique compositional and structural similarities to the natural extracellular matrix, in addition to their desirable framework for cellular proliferation and survival. More recently, the ability to control the shape, porosity, surface morphology, and size of hydrogel scaffolds has created new opportunities to overcome various challenges in tissue engineering such as vascularization, tissue architecture and simultaneous seeding of multiple cells. This review provides an overview of the different types of hydrogels, the approaches that can be used to fabricate hydrogel matrices with specific features and the recent applications of hydrogels in tissue engineering. Special attention was given to the various design considerations for an efficient hydrogel scaffold in tissue engineering. Also, the challenges associated with the use of hydrogel scaffolds were described.

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Metadata

Authors
El-Sherbiny, I. M., & Yacoub, M. H.
Venue
Global Cardiology Science and Practice
Published
2013-09
Volume
2013
Issue
3
Pages
38
ISSN
2305-7823 (ISSN-L)
OpenAlex
W2126956733
Cited by
1,062
References
12
FWCI
7.75
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Hydrogel scaffolds for tissue engineering: Progress and challenges. https://app.cochat.ai/papers/10.5339/gcsp.2013.38
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El-Sherbiny, I. M., & Yacoub, M. H. (2013). Hydrogel scaffolds for tissue engineering: Progress and challenges. Global Cardiology Science and Practice. https://doi.org/10.5339/gcsp.2013.38

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.