Extended gate field-effect-transistor for sensing cortisol stress hormone
Open accessAbstract
Cortisol is a hormone released in response to stress and is a major glucocorticoid produced by adrenal glands. Here, we report a wearable sensory electronic chip using label-free detection, based on a platinum/graphene aptamer extended gate field effect transistor (EG-FET) for the recognition of cortisol in biological buffers within the Debye screening length. The device shows promising experimental features for real-time monitoring of the circadian rhythm of cortisol in human sweat. We report a hysteresis-free EG-FET with a voltage sensitivity of the order of 14 mV/decade and current sensitivity up to 80% over the four decades of cortisol concentration. The detection limit is 0.2 nM over a wide range, between 1 nM and 10 µM, of cortisol concentrations in physiological fluid, with negligible drift over time and high selectivity. The dynamic range fully covers those in human sweat. We propose a comprehensive analysis and a unified, predictive analytical mapping of current sensitivity in all regimes of operation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
Nishita, M., Park, S.-Y., Nishio, T., Kamizaki, K., Wang, Z., Tamada, K., Takumi, T., Hashimoto, R., Otani, H., Pazour, G. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-016-0028-x · Cited by 15,947 · see citing works
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works
Stress and disorders of the stress system
Chrousos, G. P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.106 · Cited by 3,215 · see citing works
The Concepts of Stress and Stress System Disorders: Overview of Physical and Behavioral Homeostasis
Chrousos, G. P. (1992) · JAMA · doi:10.1001/jama.1992.03480090092034 · Cited by 2,689 · see citing works
Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
Gold, L., Ayers, D., Bertino, J., Bock, C., Bock, A., Brody, E. N., Carter, J., Dalby, A. B., Eaton, B. E., Fitzwater, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015004 · Cited by 1,754 · see citing works
Enz, C., Krummenacher, F., & Vittoz, E. A. (1995) · Analog Integrated Circuits and Signal Processing · doi:10.1007/bf01239381 · Cited by 1,234 · see citing works
Reproducibility crisis: Blame it on the antibodies
Baker, M. (2015) · Nature · doi:10.1038/521274a · Cited by 830 · see citing works
Aptamers and Their Biological Applications
Song, K.-M., Lee, S., & Ban, C. (2012) · Sensors · doi:10.3390/s120100612 · Cited by 830 · see citing works
Parlak, O., Keene, S. T., Marais, A., Curto, V. F., & Salleo, A. (2018) · Science Advances · doi:10.1126/sciadv.aar2904 · Cited by 603 · see citing works
Enamel peptides reveal the sex of the Late Antique ‘Lovers of Modena’
Lugli, F., Rocco, G. D., Vazzana, A., Genovese, F., Pinetti, D., Cilli, E., Carile, M. C., Silvestrini, S., Gabanini, G., Arrighi, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49562-7 · Cited by 332 · see citing works
Ikenoue, T., Terakado, Y., Nakagawa, H., Hikiba, Y., Fujii, T., Matsubara, D., Noguchi, R., Zhu, C., Yamamoto, K., Kudo, Y., et al. (2017) · Scientific Reports · doi:10.1038/srep39567 · Cited by 331 · see citing works
Recent advances in cortisol sensing technologies for point-of-care application
Kaushik, A., Vasudev, A., Arya, S. K., Pasha, S. K., & Bhansali, S. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.09.060 · Cited by 316 · see citing works
Intraindividual coupling of daily stress and cognition.
Sliwinski, M. J., Smyth, J. M., Hofer, S. M., & Stawski, R. S. (2006) · Psychology and Aging · doi:10.1037/0882-7974.21.3.545 · Cited by 306 · see citing works
Shinwari, M. W., Deen, M. J., & Landheer, D. (2006) · Microelectronics Reliability · doi:10.1016/j.microrel.2006.10.003 · Cited by 268 · see citing works
Aptamer-based lateral flow assay for point of care cortisol detection in sweat
Dalirirad, S., & Steckl, A. J. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.11.161 · Cited by 260 · see citing works
Chu, C.-H., Sarangadharan, I., Regmi, A., Chen, Y.-W., Hsu, C.-P., Chang, W.-H., Lee, G.-Y., Chyi, J., Chen, C.-C., Shiesh, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05426-6 · Cited by 248 · see citing works
Campos, R., Borme, J., Guerreiro, J. R. L., Machado, G., Cerqueira, M. F., Petrovykh, D. Y., & Alpuim, P. (2019) · ACS Sensors · doi:10.1021/acssensors.8b00344 · Cited by 217 · see citing works
Chemical Sensors: An Introduction for Scientists and Engineers
Janata, J. (2010) · Cited by 198 · see citing works
Sanghavi, B. J., Moore, J. A., Chávez, J. L., Hagen, J. A., Kelley‐Loughnane, N., Chou, C., & Swami, N. S. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.11.044 · Cited by 188 · see citing works
Carbon fiber based electrochemical sensor for sweat cortisol measurement
Sekar, M. K., Pandiaraj, M., Bhansali, S., Ponpandian, N., & Viswanathan, C. (2019) · Scientific Reports · doi:10.1038/s41598-018-37243-w · Cited by 164 · see citing works
Vabbina, P. K., Kaushik, A. K., Pokhrel, N., Bhansali, S., & Pala, N. (2014) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.07.026 · Cited by 155 · see citing works
Carbon nanotubes and graphene nano field-effect transistor-based biosensors
Tran, T., & Mulchandani, A. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.12.002 · Cited by 150 · see citing works
Highly sensitive palladium oxide thin film extended gate FETs as pH sensor
Das, A., Ko, D. H., Chen, C.-H., Chang, L., Lai, C., Chu, F.-C., Chow, L., & Lin, R. (2014) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2014.08.057 · Cited by 142 · see citing works
Hansen, Å. M., Garde, A. H., Christensen, J., Eller, N. H., & Netterstrøm, B. (2003) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510310001942 · Cited by 120 · see citing works
Tuteja, S., Ormsby, C., & Neethirajan, S. (2018) · Nano-Micro Letters · doi:10.1007/s40820-018-0193-5 · Cited by 119 · see citing works
Label-free, chemiresistor immunosensor for stress biomarker cortisol in saliva
Tlili, C., Myung, N. V., Shetty, V., & Mulchandani, A. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.04.045 · Cited by 117 · see citing works
Jo, S., Lee, W., Park, J., Kim, W., Kim, W., Lee, G., Lee, H., Hong, J., & Park, J. (2019) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2019.127424 · Cited by 98 · see citing works
Field effect detection of biomolecular interactions
Estrela, P., Stewart, A., Yan, F., & Migliorato, P. (2005) · Electrochimica Acta · doi:10.1016/j.electacta.2005.02.075 · Cited by 92 · see citing works
Surface plasmon resonance immunosensor for cortisol and cortisone determination
Frasconi, M., Mazzarino, M., Botrè, F., & Mazzei, F. (2009) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-009-2914-6 · Cited by 81 · see citing works
Electrochemical Sensing of Cortisol: A Recent Update
Singh, A., Kaushik, A. K., Kumar, R., Nair, M. G., & Bhansali, S. (2014) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-014-0894-2 · Cited by 80 · see citing works
Jang, H.-J., Lee, T., Song, J., Russell, L., Li, H., Dailey, J., Searson, P. C., & Katz, H. E. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18855 · Cited by 80 · see citing works
Mitchell, J. S., Lowe, T. E., & Ingram, J. R. (2008) · The Analyst · doi:10.1039/b817083p · Cited by 79 · see citing works
Jayant, R. D., Yndart, A., Sagar, V., Bhansali, S., Nair, M. G., Kaushik, A. K., & Atluri, V. S. R. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s75514 · Cited by 77 · see citing works
Direct immune-detection of cortisol by chemiresistor graphene oxide sensor
Kim, Y., Lee, K., Jung, H., Kang, H. K., Jo, J., Park, I., & Lee, H. H. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.07.017 · Cited by 75 · see citing works
Flexible ISFET Biosensor Using IGZO Metal Oxide TFTs and an ITO Sensing Layer
Smith, J. T., Shah, S. S., Goryll, M., Stowell, J. R., & Allee, D. R. (2014) · IEEE Sensors Journal · doi:10.1109/jsen.2013.2295057 · Cited by 74 · see citing works
Fernandez, R. E., Umasankar, Y., Manickam, P., Nickel, J. C., Iwasaki, L. R., Kawamoto, B., Todoki, K. C., Scott, J. M., & Bhansali, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-17835-8 · Cited by 74 · see citing works
Reconfigurable Carbon Nanotube Multiplexed Sensing Devices
Xu, X., Clément, P., Eklӧf, J., Kelley‐Loughnane, N., Moth‐Poulsen, K., Chávez, J. L., & Palma, M. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00856 · Cited by 73 · see citing works
Adam, E. K. (2012) · Monographs of the Society for Research in Child Development · doi:10.1111/j.1540-5834.2012.00657.x · Cited by 68 · see citing works
Stability and predictors of change in salivary cortisol measures over six years: MESA
Wang, X., Sánchez, B. N., Golden, S. H., Shrager, S., Kirschbaum, C., Karlamangla, A. S., Seeman, T. E., & Roux, A. V. D. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.024 · Cited by 66 · see citing works
Kim, K. S., Ryeol, L. S., Kim, S., Lee, J. Y., Chung, C., Choe, W., & Yoo, P. J. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.09.135 · Cited by 66 · see citing works
Dielectric-Modulated Field Effect Transistors for DNA Detection: Impact of DNA Orientation
Kalra, S., Kumar, M. J., & Dhawan, A. (2016) · IEEE Electron Device Letters · doi:10.1109/led.2016.2613110 · Cited by 65 · see citing works
Palit, S., Singh, K., Lou, B., Her, J.-L., Pang, S., & Pan, T.-M. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.127850 · Cited by 58 · see citing works
Graphene oxide surface blocking agents can increase the DNA biosensor sensitivity
Liu, B., Huang, P. J., Kelly, E. Y., & Liu, J. (2016) · Biotechnology Journal · doi:10.1002/biot.201500540 · Cited by 55 · see citing works
Iskierko, Z., Sosnowska, M., Sharma, P. S., Benincori, T., D'Souza, F. W., Kamińska, I., Fronc, K., & Noworyta, K. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.06.073 · Cited by 51 · see citing works
A fluorimetric assay for cortisol
Appel, D., Schmid, R. D., Drăgan, C.-A., Bureik, M., & Urlacher, V. B. (2005) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-005-0022-9 · Cited by 51 · see citing works
Selection of high affinity aptamer-ligand for dexamethasone and its electrochemical biosensor
Mehennaoui, S., Poorahong, S., Jiménez, G. C., & Siaj, M. (2019) · Scientific Reports · doi:10.1038/s41598-019-42671-3 · Cited by 51 · see citing works
Cortisol, Cushing's Syndrome, and a Shrinking Brain--New Evidence for Reversibility
McEwen, B. S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.9999 · Cited by 47 · see citing works
Fabrication of N-doped multidimensional carbon nanofibers for high-performance cortisol biosensors
Jeong, G., Oh, J., & Jang, J. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.01.061 · Cited by 43 · see citing works
Comparative Study of Field Effect Transistor Based Biosensors
Moon, D., Han, J., & Meyyappan, M. (2016) · IEEE Transactions on Nanotechnology · doi:10.1109/tnano.2016.2615855 · Cited by 41 · see citing works
Synthesis of MUC1 aptamer-stabilized gold nanoclusters for cell-specific imaging
Feng, B., Xing, Y., Lan, J., Su, Z., & Wang, F. (2020) · Talanta · doi:10.1016/j.talanta.2020.120796 · Cited by 41 · see citing works
Real-time aptamer quantum dot fluorescent flow sensor
Bogomolova, A., & Aldissi, M. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.04.001 · Cited by 37 · see citing works
Wang, Z., Xie, Z., Cui, G., Liu, L., Song, S., Kuang, H., & Xu, C. (2017) · Food and Agricultural Immunology · doi:10.1080/09540105.2017.1297779 · Cited by 35 · see citing works
Perceived stress and risk of colorectal cancer in men and women: a prospective cohort study
Nielsen, N. R., Kristensen, T. S., Strandberg‐Larsen, K., Zhang, Z., Schnohr, P., & Grønbæk, M. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01826.x · Cited by 26 · see citing works
Adaptation of DELFIATM Cortisol Kit for Determination of Salivary Cortisol Concentration
Höferl, M., Krist, S., & Buchbauer, G. (2005) · Archiv der Pharmazie · doi:10.1002/ardp.200500116 · Cited by 26 · see citing works
Special Focus on Nanoscale Regeneration
Dalby, M. J., & Biggs, M. J. P. (2015) · Nanomedicine · doi:10.2217/nnm.15.34 · Cited by 15 · see citing works
Bellando, F., Garcia-Cordero, E., Wildhaber, F., Longo, J., Guérin, H., & Ionescu, A. M. (2017) · Technical digest - International Electron Devices Meeting/Technical digest · doi:10.1109/iedm.2017.8268413 · Cited by 15 · see citing works
Self-citationDhull, N., Kaur, G., Gupta, V., & Tomar, M. (2018) · Vacuum · doi:10.1016/j.vacuum.2018.09.034 · Cited by 15 · see citing works
Khalifa, A., Abdulateef, S. A., Kabaa, E. A., Ahmed, N. M., & Sabah, F. A. (2020) · Materials Science in Semiconductor Processing · doi:10.1016/j.mssp.2019.104911 · Cited by 12 · see citing works
Ionescu, A. M., Cristoloveanu, S., Rusu, A., Chovet, A., & Hassein-Bey, A. (2002) · IEEE International SOI Conference (SOI) · doi:10.1109/soi.1993.344559 · Cited by 4 · see citing works
Self-citationEinstein’s Struggles with Quantum Theory: A Reappraisal
Sauer, T. (2008) · Physics Today · doi:10.1063/1.2930739 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 61 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
End-to-end design of wearable sensors
Ates, H. C., Nguyen, P. Q., Gonzalez-Macia, L., Morales-Narváez, E., Güder, F., Collins, J. J., & Dincer, C. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00460-x · Cited by 1,306 · see citing works
Skin-Interfaced Wearable Sweat Sensors for Precision Medicine
Min, J., Tu, J., Xu, C., Lukas, H., Shin, S., Yang, Y., Solomon, S. A., Mukasa, D., & Gao, W. F. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00823 · Cited by 728 · see citing works
A physicochemical-sensing electronic skin for stress response monitoring
Xu, C., Song, Y., Sempionatto, J. R., Solomon, S. A., Yu, Y., Nyein, H. Y. Y., Tay, R. Y., Li, J., Heng, W., Min, J., et al. (2024) · Nature Electronics · doi:10.1038/s41928-023-01116-6 · Cited by 420 · see citing works
Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization
Dai, C., Liu, Y., & Wei, D. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00924 · Cited by 310 · see citing works
Wearable Cortisol Aptasensor for Simple and Rapid Real-Time Monitoring
An, J. E., Kim, K. H., Park, S. J., Seo, S. E., Kim, J., Ha, S., Bae, J., & Kwon, O. S. (2022) · ACS Sensors · doi:10.1021/acssensors.1c01734 · Cited by 147 · see citing works
Field effect transistor based wearable biosensors for healthcare monitoring
Nguyen, T. T.-H., Nguyen, C. M., Huynh, M. A., Vu, H. H., Nguyen, T., & Nguyen, N. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02153-1 · Cited by 151 · see citing works
Krishnan, S. K., Nataraj, N., Meyyappan, M., & Pal, U. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c03399 · Cited by 141 · see citing works
Shkodra, B., Petrelli, M., Angeli, M. A. C., Garoli, D., Nakatsuka, N., Lugli, P., & Petti, L. (2021) · Applied Physics Reviews · doi:10.1063/5.0058591 · Cited by 107 · see citing works
2D Materials in Advanced Electronic Biosensors for Point‐of‐Care Devices
Nisar, S., Dastgeer, G., Shazad, Z. M., Zulfiqar, M., Rasheed, A., Iqbal, M. Z., Hussain, K., Rabani, I., Kim, D.-K., Irfan, A., et al. (2024) · Advancement of science · doi:10.1002/advs.202401386 · Cited by 92 · see citing works
Antibody-Coated Wearable Organic Electrochemical Transistors for Cortisol Detection in Human Sweat
Demuru, S., Kim, J., Chazli, M. E., Bruce, S., Dupertuis, M., Binz, P., Saubade, M., Lafaye, C., & Briand, D. (2022) · ACS Sensors · doi:10.1021/acssensors.2c01250 · Cited by 95 · see citing works
Gao, J., Wang, C., Chu, Y., Han, Y., Gao, Y., Wang, Y., Wang, C., Liu, H., Han, L. G., & Zhang, Y. (2021) · Talanta · doi:10.1016/j.talanta.2021.123197 · Cited by 87 · see citing works
Karuppaiah, G., Lee, M., Bhansali, S., & Manickam, P. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115600 · Cited by 82 · see citing works
Ultraprecise Antigen 10-in-1 Pool Testing by Multiantibodies Transistor Assay
Dai, C., Guo, M., Wu, Y., Cao, B., Wang, X., Wu, Y., Kang, H., Kong, D., Zhu, Z., Ying, T., et al. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c08598 · Cited by 75 · see citing works
Ultrasensitive dopamine detection with graphene aptasensor multitransistor arrays
Abrantes, M., Rodrigues, D., Domingues, T., Nemala, S. S., Monteiro, P., Borme, J., Alpuim, P., & Jacinto, L. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01695-0 · Cited by 74 · see citing works
Recent Advances in Graphene Field‐Effect Transistor Toward Biological Detection
Sun, M., Zhang, C., Lu, S., Mahmood, S., Wang, J., Sun, C., Pang, J., Han, L. G., & Liu, H. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202405471 · Cited by 70 · see citing works
An, J., Park, H., Kim, J., Park, H., Kim, T. P., Park, C., Kim, J., Lee, M., & Lee, T. (2023) · ACS Sensors · doi:10.1021/acssensors.3c00879 · Cited by 64 · see citing works
Cortisol Immunosensors: A Literature Review
Karachaliou, C., Koukouvinos, G., Goustouridis, D., Raptis, I., Kakabakos, S. E., Petrou, P. S., & Livaniou, E. (2023) · Biosensors · doi:10.3390/bios13020285 · Cited by 63 · see citing works
Shajari, S., Salahandish, R., Zare, A., Hassani, M., Moossavi, S., Munro, E., Rashid, R., Rosenegger, D., Bains, J. S., & Sanati Nezhad, A. (2023) · Advanced Science · doi:10.1002/advs.202204171 · Cited by 55 · see citing works
Extended-gate field-effect transistor chemo- and biosensors: State of the art and perspectives
Janićijević, Ž., Nguyen‐Le, T., & Baraban, L. (2023) · Next Nanotechnology · doi:10.1016/j.nxnano.2023.100025 · Cited by 55 · see citing works
Barman, S. C., Ali, M., Hasan, E. A., Wehbe, N., Alshareef, H. N., & Sulaiman, D. A. (2024) · ACS Materials Letters · doi:10.1021/acsmaterialslett.3c01225 · Cited by 55 · see citing works
Chen, X., Liang, Y., Tang, N., Li, C., Zhang, Y., Xu, F., Shi, G., & Zhang, M. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116016 · Cited by 52 · see citing works
Sasaki, Y., Zhang, Y., Fan, H., Ohshiro, K., Zhou, Q., Tang, W., Lyu, X., & Minami, T. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.133458 · Cited by 47 · see citing works
Hosseini, S. N., Das, P. S., Lazarjan, V. K., Gagnon-Turcotte, G., Bouzid, K., & Gosselin, B. J. (2023) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2023.3252402 · Cited by 44 · see citing works
Graphene Transistors for In Vitro Detection of Health Biomarkers
Dai, C., Kong, D., Chen, C., Liu, Y., & Wei, D. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202301948 · Cited by 44 · see citing works
Ghasemi, F., & Salimi, A. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.108432 · Cited by 43 · see citing works
Zou, J., Bai, H., Zhang, L., Shen, Y., Yang, C., Zhuang, W., Hu, J., Yao, Y., & Hu, W. W. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00719k · Cited by 45 · see citing works
Dong, Y., Liu, T., Chen, S., Nithianandam, P., Matar, K., & Li, J. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202210136 · Cited by 38 · see citing works
Functionalization of an extended-gate field-effect transistor (EGFET) for bacteria detection
Könemund, L., Neumann, L., Hirschberg, F., Biedendieck, R., Jahn, D., Johannes, H., & Kowalsky, W. (2022) · Scientific Reports · doi:10.1038/s41598-022-08272-3 · Cited by 37 · see citing works
Janghorban, M., Aradanas, I., Kazemi, S., Ngaju, P., & Pandey, R. (2022) · Biosensors · doi:10.3390/bios12110986 · Cited by 35 · see citing works
Recent advances in aptamer-based platforms for cortisol hormone monitoring
Mohammadi, F., Zahraee, H., Kazemi, M., Habibi, Z. S., Taghdisi, S. M., Abnous, K., Khoshbin, Z., & Chen, C. (2023) · Talanta · doi:10.1016/j.talanta.2023.125010 · Cited by 35 · see citing works
Recent Advances in Silicon FET Devices for Gas and Volatile Organic Compound Sensing
Mukherjee, A., & Rosenwaks, Y. (2021) · Chemosensors · doi:10.3390/chemosensors9090260 · Cited by 36 · see citing works
Noninvasive On-Skin Biosensors for Monitoring Diabetes Mellitus
Sedighi, A., Kou, T., Huang, H., & Li, Y. (2025) · Nano-Micro Letters · doi:10.1007/s40820-025-01843-9 · Cited by 36 · see citing works
van Smeden, L., Saris, A., Sergelen, K., de Jong, A. M., Yan, J., & Prins, M. W. J. (2022) · ACS Sensors · doi:10.1021/acssensors.2c01358 · Cited by 34 · see citing works
Wang, S., Qi, X., Hao, D., Moro, R., Ma, Y., & Ma, L. (2022) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/ac4f24 · Cited by 33 · see citing works
Fan, J., Pico, A. A. F., & Gupta, M. (2021) · Materials Advances · doi:10.1039/d1ma00479d · Cited by 32 · see citing works
Mahmoodi, S. R., Xie, P., Zachs, D. P., Peterson, E. J., Graham, R. S., Kaiser, C. R. W., Lim, H. H., Allen, M. G., & Javanmard, M. (2021) · Science Advances · doi:10.1126/sciadv.abf4401 · Cited by 31 · see citing works
Applications of Transistor-Based Biochemical Sensors
Gao, Q., Fu, J., Li, S., & Ming, D. (2023) · Biosensors · doi:10.3390/bios13040469 · Cited by 30 · see citing works
Electrochemical Sensors for Cortisol: A Review
Naeem, A. N., Guldin, S., & Ghoreishizadeh, S. S. (2024) · IEEE Sensors Journal · doi:10.1109/jsen.2023.3349293 · Cited by 29 · see citing works
Halima, H. B., Bellagambi, F. G., Brunon, F., Alcácer, A., Pfeiffer, N., Heuberger, A., Hangouët, M., Zine, N., Bausells, J., & Errachid, A. (2022) · Talanta · doi:10.1016/j.talanta.2022.123802 · Cited by 29 · see citing works
Janghorban, M., Aradanas, I., Malaeb, K., Abuelazm, H., Nittala, A. S., Hu, J., Murari, K., & Pandey, R. (2023) · ACS Sensors · doi:10.1021/acssensors.3c02110 · Cited by 26 · see citing works
Khoris, I. M., Nasrin, F., Chowdhury, A. D., & Park, E. Y. (2022) · Analytica Chimica Acta · doi:10.1016/j.aca.2022.339817 · Cited by 26 · see citing works
2D Materials‐Based Field‐Effect Transistor Biosensors for Healthcare
Li, J., Wijaya, L. N. A., Jang, D. W., Hu, Y., You, J., Cai, Y., Gao, Z., Mi, Y., & Luo, Z. (2024) · Small · doi:10.1002/smll.202408961 · Cited by 25 · see citing works
From new materials to advanced biomedical applications of solid-state biosensor: A review
Tabata, M., & Miyahara, Y. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.131033 · Cited by 25 · see citing works
Recent Advances toward Wearable Sweat Monitoring Systems
Shen, H., Xue, L., Ma, Y., Huang, H., & Chen, L. (2022) · Advanced Materials Technologies · doi:10.1002/admt.202200513 · Cited by 25 · see citing works
Matada, M. S. S., Kuppuswamy, G. P., Sasi, S., Jayaraman, S. V., Nutalapati, V., Kumar, S. S., & Sivalingam, Y. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c19431 · Cited by 25 · see citing works
Chakoma, S. M., Pei, X. M., Qin, H., Ghandehari, A., Najafikhoshnoo, S., Rajendran, J., & Esfandyarpour, R. (2024) · Nano Research · doi:10.1007/s12274-024-6738-7 · Cited by 24 · see citing works
Kim, K. H., Seo, S. E., Park, C. S., Kim, S., Lee, S., Ryu, C., Yong, D., Park, Y. M., & Kwon, O. S. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202209726 · Cited by 23 · see citing works
Multifunctional terahertz microscopy for biochemical and chemical imaging and sensing
Wang, J., Ando, M., Nagata, H., Yoshida, S., Sakai, K., & Kiwa, T. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114901 · Cited by 23 · see citing works
Sharma, S., Kar, D., Moudgil, A., Das, S., & Mishra, P. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.135486 · Cited by 23 · see citing works
Kim, K. H., Kim, J., Seo, S. E., Lee, H. G., & Kwon, O. S. (2025) · BioChip Journal · doi:10.1007/s13206-024-00176-w · Cited by 20 · see citing works
Yin, T., Song, J., Hao, X., Wen, Y., Yang, P., Gao, C., Cui, R., Li, D., Hu, Y., Xu, L., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c18891 · Cited by 21 · see citing works
Cortisol Monitoring Devices toward Implementation for Clinically Relevant Biosensing In Vivo
Kusov, P. A., Kotelevtsev, Y. V., & Drachev, V. P. (2023) · Molecules · doi:10.3390/molecules28052353 · Cited by 24 · see citing works
Hatada, M., Pavlidis, S., & Sode, K. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116118 · Cited by 20 · see citing works
Kim, K. H., Seo, S. E., Park, C. S., Kim, S., Lee, S., Ryu, C., Yong, D., Park, Y. M., & Kwon, O. S. (2022) · Angewandte Chemie · doi:10.1002/ange.202209726 · Cited by 19 · see citing works
Probst, D., Twiddy, J. S., Hatada, M., Pavlidis, S., Daniele, M. A.-A., & Sode, K. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c04599 · Cited by 19 · see citing works
Sweat, tears, and beyond: advanced wearable sensors for personalized health and athletic performance
Gülgösteren, E., Ermiş, S. A., Algin, A., Toros, T., Serin, E., Şekeroğlu, M. Ö., & KAYIŞOĞLU, N. B. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1684674 · Cited by 21 · see citing works
Fonseka, L. N., & Woo, B. K. (2021) · JMIR mHealth and uHealth · doi:10.2196/28664 · Cited by 16 · see citing works
A Low-Temperature-Processed, Soft-Fluidic OEGFET Saliva Aptasensor for Cortisol
Massey, R. S., & Prakash, R. (2022) · IEEE Journal on Flexible Electronics · doi:10.1109/jflex.2022.3152465 · Cited by 16 · see citing works
Dehghani, P., Salehirozveh, M., Tajabadi, A., Yeung, C. C., Lam, M., Leung, H. Y., & Roy, V. A. L. (2025) · ACS Sensors · doi:10.1021/acssensors.4c03250 · Cited by 15 · see citing works
Bian, L., Shao, W., Liu, Z., Zeng, Z., & Star, A. (2022) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/ac6e8d · Cited by 15 · see citing works
Perspective—Electrochemical Bio-wearables for Cortisol Monitoring
Pandey, R. (2024) · ECS Sensors Plus · doi:10.1149/2754-2726/ad408e · Cited by 15 · see citing works
Emerging trends in wearable and non-invasive cortisol sensing technologies – a review
Balasamy, S., Atchudan, R., Arya, S. K., & Sundramoorthy, A. K. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb01519g · Cited by 16 · see citing works
Enhancing pH Sensing Capabilities Through Hydroxylated Surface Groups on RuOx Flexible EGFET Sensor
Singh, K., Chen, C.-H., Tai, L., Pang, S., & Pan, T.-M. (2024) · IEEE Sensors Journal · doi:10.1109/jsen.2024.3379144 · Cited by 14 · see citing works
Ultra-sensitive aptameric field-effect transistor for cortisol sensing
Nguyen, T. T. H., Nguyen, T. T. H., Huynh, M. A., Trịnh, Q. T., Tanner, P., Ingebrandt, S., Vu, X. T., Nguyen, T.-K., & Nguyen, T. (2025) · Sensors and Actuators Reports · doi:10.1016/j.snr.2025.100324 · Cited by 14 · see citing works
Janićijević, Ž., Nguyen‐Le, T., Alsadig, A., Çela, I., Žilėnaite, R., Tonmoy, T. H., Kubeil, M., Bachmann, M. P., & Baraban, L. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2023.115701 · Cited by 13 · see citing works
Addressing the challenge of solution gating in biosensors based on field-effect transistors
Garika, V., Babbar, S., Samanta, S., Harilal, S., Eisenberg‐Lerner, A., Rotfogel, Z., Pikhay, E., Shehter, I., Elkayam, A., Bashouti, M. Y., et al. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116689 · Cited by 13 · see citing works
Rao, T., Li, J., Cai, W., Wu, M., Jiang, J., Yang, P., Zhou, Y. Z., & Liao, W. (2021) · ACS Omega · doi:10.1021/acsomega.1c05469 · Cited by 13 · see citing works
Dong, Y., Chen, S., Liu, T., & Li, J. (2022) · Small · doi:10.1002/smll.202106866 · Cited by 13 · see citing works
Pushing Biomolecule Detection Limit With Graphene Field‐effect Transistor Biosensors
Pham, C. D., Trịnh, Q. T., Zhang, J., Nguyen, N., & Nguyen, T. (2025) · Advanced Electronic Materials · doi:10.1002/aelm.202500368 · Cited by 12 · see citing works
Self-citationSurface-modified CMOS biosensors
Dehghandehnavi, F., Sajal, M., & Dandin, M. P. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1441430 · Cited by 12 · see citing works
Si, H., Huang, G., Liao, J., Fisher, A. C., & Lin, S. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c22970 · Cited by 12 · see citing works
Karaman, C., Aydemir, M., & Karaman, O. (2026) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2026.118687 · Cited by 10 · see citing works
Li, Y., Wei, S., Xiong, E., Hu, J., Zhang, X., Wang, Y., Zhang, J., Jiang, Y. L., Zhang, Z., Yin, H., et al. (2024) · Biosensors · doi:10.3390/bios14030144 · Cited by 11 · see citing works
Self-citationImmunosensor for Assessing the Welfare of Trainee Guide Dogs
Perkins, H., Higgins, M., Marcato, M., Galvin, P., & Teixeira, S. R. (2021) · Biosensors · doi:10.3390/bios11090327 · Cited by 11 · see citing works
Xu, B., Chang, H., Yang, G., Xu, Z., Li, J., Gu, Z., & Li, J. (2024) · The Analyst · doi:10.1039/d3an02115g · Cited by 10 · see citing works
Ju, Y., Baek, D. H., Choi, G., & Jang, A. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167209 · Cited by 11 · see citing works
Asgharian, H., Kammarchedu, V., Khamsi, P. S., Brustoloni, C. J.-M., & Ebrahimi, A. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c11393 · Cited by 11 · see citing works
The development of GFETs for biometric applications
Yang, W., Feng, W., Hou, S., Hao, Z., Huang, C., & Pan, Y. (2024) · Sensors & Diagnostics · doi:10.1039/d4sd00317a · Cited by 10 · see citing works
Li, J., Qi, F., Li, C., Tang, L., Li, C., Liu, Y., Li, Y., & Zhang, G. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.162542 · Cited by 10 · see citing works
Zhang, M., He, J., Zheng, Y., Shi, G., & Zhang, M. (2022) · The Analyst · doi:10.1039/d2an01393b · Cited by 10 · see citing works
Advances in Graphene Field Effect Transistors (FETs) for Amine Neurotransmitter Sensing
Alimohammadzadeh, E., & Hedley, J. (2024) · Applied Sciences · doi:10.3390/app142210109 · Cited by 9 · see citing works
Wang, Q., Zhao, Z.-A., Yao, K.-Y., Cheng, Y., Wong, S. H. D., Wong, D. W.-C., & Cheung, J. C. (2025) · Biosensors · doi:10.3390/bios15030193 · Cited by 9 · see citing works
Emerging biotransduction strategies on soft interfaces for biosensing
Tian, Y., Xu, G., Cai, K., Zhao, X. Q., Zhang, B., Wang, L., & Wang, T. (2022) · Nanoscale · doi:10.1039/d2nr05444b · Cited by 9 · see citing works
Vitale, I. A., Fuochi, N., Martella, D., Parmeggiani, C., Marrazza, G., & Palchetti, I. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.117965 · Cited by 8 · see citing works
Lee, S.-J., & Cho, W.-J. (2025) · Biosensors · doi:10.3390/bios15030134 · Cited by 8 · see citing works
Toward Reagentless and Universal Biomolecular Sensing: Molecular Pendulum-Based Bioanalysis
Wu, Z., Isaacson, S. E., Flynn, C. D., Das, J., & Kelley, S. O. (2025) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5c00573 · Cited by 8 · see citing works
Electrochemical Affinity Sensors Using Field Effect Transducer Devices for Chemical Analysis
Halima, H. B., Errachid, A., & Jaffrezic-Renault, N. J. (2021) · Electroanalysis · doi:10.1002/elan.202100451 · Cited by 8 · see citing works
Massey, R. S., & Prakash, R. (2021) · Proceedings of IEEE Sensors/Proceedings of IEEE Sensors ... · doi:10.1109/sensors47087.2021.9639461 · Cited by 8 · see citing works
Teikari, P., & Pietrusz, A. (2021) · doi:10.31236/osf.io/w734a · Cited by 11 · see citing works
Asgharian, H., Kammarchedu, V., Gu, S. J., & Ebrahimi, A. (2025) · npj 2D Materials and Applications · doi:10.1038/s41699-025-00646-1 · Cited by 7 · see citing works
Jöhr, J., Martinez, T., Marquis, R., Bruce, S., Binz, P., Rey, S., Hafner, G., Attwell, C., & Diserens, K. (2023) · Cureus · doi:10.7759/cureus.44878 · Cited by 7 · see citing works
Kuznetsov, A. E., Sheshil, A., Smolin, E. S., Grudtsov, V. P., Ryazantsev, D. V., Shustinskiy, M., Tikhonova, T. B., Kitiashvili, I., Vechorko, V., & Komarova, N. V. (2024) · Sensors · doi:10.3390/s24113681 · Cited by 7 · see citing works
Transistor-Based Biomolecule Sensors: Recent Technological Advancements and Future Prospects
Murugasenapathi, N. K., Ghosh, R., Ramanathan, S., Ghosh, S., Chinnappan, A., Mohamed, S. J., Jebakumari, K. A. E., Gopinath, S. C. B., Ramakrishna, S., & Palanisamy, T. (2021) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2021.2002133 · Cited by 7 · see citing works
Multilayer Label-Free Non-Faradic Electrochemical Impedance Immunosensor for Cortisol Detection
Gupta, C., Pattanayek, S. K., Mukherjee, B., & Kumar, S. (2023) · IEEE Sensors Journal · doi:10.1109/jsen.2023.3344470 · Cited by 6 · see citing works
Lee, S., Kang, C., Song, J., Kwon, Y., & Kim, J. (2024) · Analytica Chimica Acta · doi:10.1016/j.aca.2024.343497 · Cited by 6 · see citing works
Wei, X., Tian, T., Ye, Z., Li, Q., Li, Z., & Mao, S. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.137384 · Cited by 6 · see citing works
Laser-Induced Graphene as Versatile Sensing Electrodes for Extended-Gate Field-Effect Transistors
Na, Y. J., Park, J., Park, S. C., Park, W. G., Kim, K.-W., Wang, B., & Ahn, J. (2024) · IEEE Sensors Journal · doi:10.1109/jsen.2024.3419076 · Cited by 6 · see citing works
Saha, C., Kumari, P., Hazarika, M., Waziri, I., & Mallick, K. (2025) · New Journal of Chemistry · doi:10.1039/d5nj02622a · Cited by 5 · see citing works
Casanova, A., Alimohammadzadeh, E., McCormirk, S., Thomas, Y. R. J., den Dulk, R., Baldi, A., Fernández‐Sánchez, C., Ghaemmaghami, A. M., & Mailley, P. (2026) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2026.118981 · Cited by 5 · see citing works
Bracamonte, A. G. (2023) · Recent Progress in Materials · doi:10.21926/rpm.2301008 · Cited by 5 · see citing works
- Authors
- Sheibani, S., Capua, L., Kamaei, S., Akbari, S. S. A., Zhang, J., Guerin, H., & Ionescu, A. M.
- Affiliations
- University of Tehran (IR)
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Ionescu, Adrian M.
- Venue
- Communications Materials
- Published
- 2021-01-19
- Volume
- 2
- Issue
- 1
- Pages
- 10-10
- ISSN
- 2662-4443 (ISSN-L)
- PMC
- PMC7815575
- OpenAlex
- W3123066175
- Cited by
- 158
- References
- 61
- Citations by year
- 2026: 17 · 2025: 30 · 2024: 40 · 2023: 28 · 2022: 28 · 2021: 15
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Communications Materials (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- H2020 European Research Council (695459)
- Topics
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- extended-gate field-effect transistor, wearable biosensors, label-free detection, human sweat, circadian rhythm, Debye screening, current sensitivity, detection limit
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
