Towards a future where Alzheimer’s disease pathology is stopped before the onset of dementia
Open accessAbstract
Alzheimer's disease (AD) is a major healthcare challenge with no curative treatment at present. To address this challenge, we need a paradigm shift, where we focus on pre-dementia stages of AD. In this Perspective, we outline a strategy to move towards a future with personalized medicine for AD by preparing for and investing in effective and patient-orchestrated diagnosis, prediction and prevention of the dementia stage. While focusing on AD, this Perspective also discusses studies that do not specify the cause of dementia. Future personalized prevention strategies encompass multiple components, including tailored combinations of disease-modifying interventions and lifestyle. By empowering the public and patients to be more actively engaged in the management of their health and disease and by developing improved strategies for diagnosis, prediction and prevention, we can pave the way for a future with personalized medicine, in which AD pathology is stopped to prevent or delay the onset of dementia.
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Integrating dementia risk reduction in a primary care setting has been proposed as a potentially advantageous and feasible approach.
“Integrating dementia risk reduction in a primary care setting has been proposed as a potentially advantageous and feasible approach [11–13].”
From Multidomain Dementia Risk Reduction in Primary Care is Feasible: A Proof-of-concept study (2024) · cites this paper as [12]
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- W.M.v.d.F. has performed contract research for Biogen MA and Boehringer Ingelheim. All funding is paid to her institution. W.M.v.d.F. has been an invited speaker at Biogen MA, Danone, Eisai, WebMD Neurology (Medscape), Springer Healthcare, the European Brain Council and Novo Nordisk. W.M.v.d.F. is a consultant to the Oxford Health Policy Forum, Roche and Biogen MA.
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- Authors
- van der Flier, W. M., de Vugt, M. E., Smets, E. M. A., Blom, M., & Teunissen, C. E.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Alzheimer Nederland (NL)
- Amsterdam Neuroscience (NL)
- Venue
- Nature Aging
- Published
- 2023-05-18
- Volume
- 3
- Issue
- 5
- Pages
- 494-505
- ISSN
- 2662-8465 (ISSN-L)
- OpenAlex
- W4377019940
- Cited by
- 220
- References
- 83
- Citations by year
- 2026: 32 · 2025: 84 · 2024: 93 · 2023: 11
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Aging (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (acceptedVersion, cc-by)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- ZonMw (#73305095007)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, pre-dementia, dementia prevention, personalized medicine, early diagnosis, disease-modifying interventions, lifestyle intervention, patient empowerment, patient engagement
- MeSH terms
- Alzheimer Disease, Humans, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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