A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
Open accessAbstract
The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target.
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PLCG2 polymorphisms are associated with both reduced and increased risk of Alzheimer's disease and with longevity.
“PLCG2 polymorphisms are associated with both reduced and increased risk of Alzheimer’s disease (AD) and with longevity.”
From Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain (2023) · cites this paper as [2]
The Conclusions (page unavailable) state that the PLCG2 rs72824905-G allele is associated with decreased Alzheimer’s disease risk and an increased chance of longevity. The paper does not establish the claim’s additional association between PLCG2 polymorphisms and increased Alzheimer’s disease risk. (LLM, conf=0.90)
Experimental — accuracy not yet measuredThe P522R variant in PLCG2 confers protection for Alzheimer's disease and results in a subtle increase in enzymatic activity.
“The P522R variant in PLCG2 has been shown to confer protection for AD and to result in a subtle increase in enzymatic activity.”
From PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages (2021) · cites this paper as [6]
The Discussion reports that this PLCG2 variant was associated with reduced Alzheimer’s disease risk and that the authors replicated the protective association. It also reports a slight increase in activity from earlier functional experiments, but says those findings need confirmation; describing the activity increase as a demonstrated result overstates the evidence. (LLM, conf=0.87)
Experimental — accuracy not yet measuredPLCG2 encodes PLCγ2, which upon activation by specific membrane receptors or Rac GTPases enables hydrolysis of PI(4,5)P2 into DAG and IP3.
“PLCG2 encodes Phospholipase C Gamma 2 (PLCγ2), which, upon activation by specific membrane receptors or Rac GTPases, enables hydrolysis of phosphatidylinositol (van der Lee et al. 2019; Kadamur and Ross 2013) bisphosphate (PI(4,5)P2) into diacylglycerol (DAG) and inositol 1,4,5 trisphosphate (IP3).”
From Alzheimer's Protection by <scp>PLCγ2</scp> Compacts Plaques, Redistributes Microglia, and Protects Synapses in <scp> <i>App</i> <sup> <i>NL</i> </sup> </scp> <sup> <i>‐G‐F</i> </sup> Mice (2026) · cites this paper as van der Lee et al. 2019
The Introduction identifies phospholipase Cγ2 as the protein product of PLCG2 and describes its role in transmembrane immune-signal transduction. Neither the Introduction nor the retrieved passages specify activation by membrane receptors or Rac GTPases, or hydrolysis of PI(4,5)P2 into DAG and IP3. No page number is available in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredThe PLCγ2 variant had no protective effect on the risk of progressive supranuclear palsy, amyotrophic lateral sclerosis, Parkinson's disease, or multiple sclerosis.
“In contrast, the PLCγ2 variant had no protective effect on the risk of progressive supranuclear palsy, amyotrophic lateral sclerosis, Parkinson's disease, or multiple sclerosis (163).”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [163]
The Discussion reports no protective association for ALS, Parkinson’s disease or multiple sclerosis. It says the progressive supranuclear palsy analysis was inconclusive because of insufficient power, so the source does not establish that the variant had no protective effect on that disease. (LLM, conf=0.92)
Experimental — accuracy not yet measuredA recent study on a centenarian cohort suggested this variant could exert a beneficial effect on the entire immune system and promote healthy ageing, thus indicating that protection might also be mediated via the peripheral immune system, and could span the entire organism.
“As a recent study on a centenarian cohort suggested, this variant could exert a beneficial effect on the entire immune system and promote healthy ageing [9], thus indicating that protection might also be mediated via the peripheral immune system, and could span the entire organism”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [9]
The Results (Association with longevity; page unavailable) report enrichment of rs72824905-G among cognitively healthy centenarians, and the Introduction (page unavailable) says PLCG2 functions in immune cells in both the brain and periphery. These passages support a possible link to healthy ageing, but the paper does not show that this variant benefits the entire immune system; its Discussion says the variant’s functional effects still need study. The statement about organism-wide protection follows the citation and is the citing authors’ inference. (LLM, conf=0.83)
Experimental — accuracy not yet measured
PLCG2P522R is associated with resilience to AD and other neurodegenerative disorders, including frontotemporal dementia and Lewy body dementia.
“The mildly hypermorphic P522R variant (PLCG2P522R) is associated with resilience to AD as well as to other neurodegenerative disorders, including frontotemporal dementia and Lewy body dementia, 8 , 9”
From Alzheimer's disease–associated PLCG2 variants alter microglial state and function in human induced pluripotent stem cell–derived microglia‐like cells (2025) · cites this paper as [9]
Three under-expressed pathways were related to aging, consistent with the previously reported association between PLCG2 and longevity.
“On the other hand, three under-expressed pathways were related to aging, consistent with the previously reported association between PLCG2 and longevity(2).”
From Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brain (2023) · cites this paper as [2]
The PLCG2 P522R rare variant provides robust protection against AD (odds ratio ≈ 0.68).
“These include PLCG2 P522R rare variant (rs72824905) that provides robust protection against AD (odds ratio ≈ 0.68 [1, 4], comparable to having one APOE2 allele [5]”
From PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain (2026) · cites this paper as [4]
Human genetic studies have identified a nonsynonymous PLCG2 variant (rs72824905-G) that confers reduced risk of AD, dementia with Lewy bodies, and frontotemporal dementia while increasing the likelihood of longevity.
“Human genetic studies have identified a nonsynonymous PLCG2 variant (rs72824905-G) that confers reduced risk of AD, dementia with Lewy bodies, and frontotemporal dementia while increasing the likelihood of longevity, highlighting PLCG2 as a candidate therapeutic target [4].”
From PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain (2026) · cites this paper as [4]
The P522R variant in PLCG2 is protective not only in Alzheimer's disease but also in other neurodegenerative diseases such as frontotemporal dementia and dementia with Lewy bodies.
“The missense variant P522R in PLCG2 (rs72824905-G, P = 5.38 × 10−10, OR = 0.68) was shown to be protective, not only in the context of AD4,5, but also in other neurodegenerative diseases such as frontotemporal dementia and dementia with Lewy bodies6.”
From PLCγ2 regulates TREM2 signalling and integrin-mediated adhesion and migration of human iPSC-derived macrophages (2021) · cites this paper as [6]
The PLCG2-P522R variant decreases the risk of Alzheimer's disease and increases longevity.
“Genetic studies have identified a protective P522R variant in the PLCG2 gene (PLCG2-P522R; rs72824905 C > G), which decreases the risk of Alzheimer’s disease (AD) and increases longevity [1–4].”
From Protective PLCG2 variants associate with a delayed onset of Alzheimer’s disease among heterozygous APOE ε4 carriers (2026) · cites this paper as [4]
Human studies associated the R522 variant with increased longevity in centenarian cohorts.
“Human studies confirmed the relevance of the R522 variant with other dementias and associated it with increased longevity in centenarian cohorts (Bellenguez et al. 2022; Conway et al. 2018; van der Lee et al. 2019).”
From Alzheimer's Protection by <scp>PLCγ2</scp> Compacts Plaques, Redistributes Microglia, and Protects Synapses in <scp> <i>App</i> <sup> <i>NL</i> </sup> </scp> <sup> <i>‐G‐F</i> </sup> Mice (2026) · cites this paper as van der Lee et al. 2019
Human studies confirmed the relevance of the R522 variant with other dementias.
“Human studies confirmed the relevance of the R522 variant with other dementias and associated it with increased longevity in centenarian cohorts (Bellenguez et al. 2022; Conway et al. 2018; van der Lee et al. 2019).”
From Alzheimer's Protection by <scp>PLCγ2</scp> Compacts Plaques, Redistributes Microglia, and Protects Synapses in <scp> <i>App</i> <sup> <i>NL</i> </sup> </scp> <sup> <i>‐G‐F</i> </sup> Mice (2026) · cites this paper as van der Lee et al. 2019
PLCγ2 has a role in Alzheimer's disease.
“Given the role for PLCγ2 in AD, we investigated how Plcg2 R522 expressing microglia altered amyloid‐driven pathology (Sims et al. 2017; Bellenguez et al. 2022; van der Lee et al. 2019).”
From Alzheimer's Protection by <scp>PLCγ2</scp> Compacts Plaques, Redistributes Microglia, and Protects Synapses in <scp> <i>App</i> <sup> <i>NL</i> </sup> </scp> <sup> <i>‐G‐F</i> </sup> Mice (2026) · cites this paper as van der Lee et al. 2019
The R522 variant of PLCγ2 is in humans associated with longevity and protection of cognitive function in old age and protects against AD, as well as frontotemporal dementia and dementia with Lewy bodies.
“the R522 variant of PLCγ2 is in humans associated with longevity and protection of cognitive function in old age and protects against AD, as well as frontotemporal dementia and dementia with Lewy bodies (Sims et al. 2017; van der Lee et al. 2019; Strickland et al. 2020).”
From Alzheimer's Protection by <scp>PLCγ2</scp> Compacts Plaques, Redistributes Microglia, and Protects Synapses in <scp> <i>App</i> <sup> <i>NL</i> </sup> </scp> <sup> <i>‐G‐F</i> </sup> Mice (2026) · cites this paper as van der Lee et al. 2019
The rare PLCγ2 P522R variant is associated with protection against Alzheimer's disease and with a supporting role in healthy ageing.
“Importantly, it has also been found that a rare variant of PLCγ2 (P522R) has a protective role in Alzheimer's disease (AD).”
From Characterisation of molecular mechanisms for PLCγ2 disease-linked variants (2024) · cites this paper as van der Lee et al., 2019
The reduced risk of the P522R mutation for AD has been extended to other dementia subtypes including Lewy bodies and frontotemporal dementia.
“Recently, the reduced risk of the P522R mutation for AD has been extended to other dementia subtypes including Lewy bodies and frontotemporal dementia (163) (Fig. 4).”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [163]
The P522R variant was associated with an increased chance of reaching at least 90 years of age and then becoming a cognitively healthy centenarian.
“This variant was also associated with an increased chance of reaching at least 90 years of age and then becoming a cognitively healthy centenarian, that is, people in whom the absence of dementia and extreme longevity is combined (163).”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [163]
The PLCG2 p.Pro522Arg polymorphism is associated with promotion of healthy ageing.
“and finally promotion of healthy ageing [1, 8, 9]”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [9]
The protective PLCγ2 variant seems to counteract the harmful effect of the APOE ε4 allele, as shown for a cognitively healthy centenarian carrying both homozygous APOE ε4 and the PLCG2 protective polymorphism.
“Moreover, the protective PLCγ2 variant seems to counteract the harmful effect of the APOE ε4 allele, as shown for a cognitively healthy centenarian carrying both the homozygous APOE ε4 and the PLCG2 protective polymorphism [9].”
From TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation (2021) · cites this paper as [9]
The PLCG2 M28L variant confers a modest increased risk of AD (OR ≈ 1.16).
“other rare PLCG2 variants, such as M28L (rs61749044) that confers a modest increased risk of AD (OR ≈ 1.16) [1, 4, 7–13]”
From PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain (2026) · cites this paper as [4]
The Results (‘Association with brain diseases’; page unavailable) report reduced AD risk for a different PLCG2 variant, rs72824905-G (OR = 0.57). Searches for M28L, rs61749044, and Met28Leu found no passage in our copy addressing that variant or an AD odds ratio of approximately 1.16. The result for a different variant does not contradict the claim about M28L. (LLM, conf=0.76)
Experimental — accuracy not yet measuredA non-synonymous coding variant in PCLG2 is associated with lower Alzheimer disease risk.
“A non-synonymous coding variant in PCLG2, a gene with suspected immune function, has been associated with decreased risk of AD (van der Lee et al., 2019).”
From Alzheimer Disease: An Update on Pathobiology and Treatment Strategies (2019) · cites this paper as van der Lee et al., 2019
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The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description
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Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases
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Bayesian association scan reveals loci associated with human lifespan and linked biomarkers
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Self-citationLongitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study
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Self-citationThe ApoE Gene Is Related with Exceptional Longevity: A Systematic Review and Meta-Analysis
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Self-citationAnalysis of neurodegenerative disease-causing genes in dementia with Lewy bodies
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Self-citationRh‐CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE
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Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease riskPreprint
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Self-citationGenome‐wide association study of neocortical Lewy‐related pathology
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Cool-temperature-mediated activation of phospholipase C-γ 2 in the human hereditary disease PLAID
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TREM2 p.R47H substitution is not associated with dementia with Lewy bodies
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Effects of the APOE ε4 allele and education on cognitive function in Japanese centenarians
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Successful Replication of GWAS Hits for Multiple Sclerosis in 10,000 Germans Using the Exome Array
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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
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Amyloid-β-independent regulators of tau pathology in Alzheimer disease
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The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration
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The Longitudinal Aging Study Amsterdam: cohort update 2019 and additional data collections
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The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration
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Phospholipase C families: Common themes and versatility in physiology and pathology
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The Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions
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“ated with a lower risk for other neurodegenerative diseases and increased the likelihood for longevity [2].”
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Self-citationLongitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study
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Single-cell peripheral immunoprofiling of Alzheimer’s and Parkinson’s diseases
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Cognitively healthy centenarians are genetically protected against Alzheimer's disease
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Self-citationGenetic architecture of common non-Alzheimer’s disease dementias
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Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies
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Rh‐CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE
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Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo
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Phospholipase Cγ2 regulates endocannabinoid and eicosanoid networks in innate immune cells
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Molecular biology of autoinflammatory diseases
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Epigenetic regulation in the pathophysiology of Lewy body dementia
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Alzheimer’s Disease Genetics: A Dampened Microglial Response?
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A unified model of dementias and age‐related neurodegeneration
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“The risks of dementia with Lewy bodies and frontotemporal dementia were shown to be reduced in individuals carrying the PLCγ2-P522R variant, and the protective variant has been found to be highly expressed among old (100 + years) individuals with well-preserved cognitive functions [11].”
Strickland, S. L., Morel, H., Prusinski, C., Allen, M., Patel, T. A., Carrasquillo, M. M., Conway, O. J., Lincoln, S. J., Reddy, J. S., Nguyen, T., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01050-0 · Cited by 15 · see citing works
Self-citationCarriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system
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Can Anti–β-amyloid Monoclonal Antibodies Work in Autosomal Dominant Alzheimer Disease?
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NFκB1: a common biomarker linking Alzheimer's and Parkinson's disease pathology
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Dementia with Lewy Bodies: Genomics, Transcriptomics, and Its Future with Data Science
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The Effect of Alzheimer’s Disease-Associated Genetic Variants on Longevity
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Self-citationThe relationship of early- and late-onset Alzheimer’s disease genes with COVID-19
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Therapeutic targeting of neuroimmune mechanisms in neurodegeneration
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Systems biology of Alzheimer’s Disease: a scoping review of key pathways and mechanisms
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Genetic architecture of neurodegenerative dementias
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A novel approach to resilience and its links with education and Alzheimer's disease genetics
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Self-citationPLCG2 rs72824905 Variant Reduces the Risk of Alzheimer’s Disease and Multiple Sclerosis
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mosGraphFlow: a novel integrative graph AI model mining disease targets from multi-omic dataPreprint
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- Authors
- DESGESCO (Dementia Genetics Spanish Consortium), E. (. D. E. D. B., van der Lee, S. J., biobank), E. (. D. E. D., IFGC (International FTD-Genomics Consortium), I. (. I. P. D. G. C., IPDGC (The International Parkinson Disease Genomics Consortium), Dementia), R.-F. (. A. M. F. I. F.-T., (NBB), N. B. B., The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Conway, O. J., Jansen, I., Carrasquillo, M. M., Kleineidam, L., van den Akker, E., Hernández, I., van Eijk, K. R., Stringa, N., Chen, J. A., Zettergren, A., Andlauer, T. F. M., Diez-Fairen, M., Simon-Sanchez, J., Lleó, A., Zetterberg, H., Nygaard, M., Blauwendraat, C., Savage, J. E., Mengel-From, J., Moreno-Grau, S., Wagner, M., Fortea, J., Keogh, M. J., Blennow, K., Skoog, I., Friese, M. A., Pletnikova, O., Zulaica, M., Lage, C., de Rojas, I., Riedel-Heller, S., Illán-Gala, I., Wei, W., Jeune, B., Orellana, A., Then Bergh, F., Wang, X., Hulsman, M., Beker, N., Tesi, N., Morris, C. M., Indakoetxea, B., Collij, L. E., Scherer, M., Morenas-Rodríguez, E., Ironside, J. W., van Berckel, B. N. M., Alcolea, D., Wiendl, H., Strickland, S. L., Pastor, P., Rodríguez Rodríguez, E., Boeve, B. F., Petersen, R. C., Ferman, T. J., van Gerpen, J. A., Reinders, M. J. T., Uitti, R. J., Tárraga, L., Maier, W., Dols-Icardo, O., Kawalia, A., Dalmasso, M. C., Boada, M., Zettl, U. K., van Schoor, N. M., Beekman, M., Allen, M., Masliah, E., de Munain, A. L., Pantelyat, A., Wszolek, Z. K., Ross, O. A., Dickson, D. W., Graff-Radford, N. R., Knopman, D., Rademakers, R., Lemstra, A. W., Pijnenburg, Y. A. L., Scheltens, P., Gasser, T., Chinnery, P. F., Hemmer, B., Huisman, M. A., Troncoso, J., Moreno, F., Nohr, E. A., Sørensen, T. I. A., Heutink, P., Sánchez-Juan, P., Posthuma, D., Clarimón, J., Christensen, K., Ertekin-Taner, N., Scholz, S. W., Ramirez, A., Ruiz, A., Slagboom, E., van der Flier, W. M., & Holstege, H.
- Affiliations
- Mayo Clinic in Florida (US)
- Amsterdam Neuroscience (NL)
- University of Bonn (DE)
- Leiden University Medical Center (NL)
- Universitat Internacional de Catalunya (ES)
- University Medical Center Utrecht (NL)
- University Hospital Mútua de Terrassa (ES)
- University of California, Los Angeles (US)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Sahlgrenska University Hospital (SE)
- Universitat Autònoma de Barcelona (ES)
- University of Southern Denmark (DK)
- Johns Hopkins University (US)
- University of Cambridge (GB)
- Mayo Clinic (US)
- University of Cologne (DE)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- National Institutes of Health (US)
- Hertie Institute for Clinical Brain Research (DE)
- Amsterdam Public Health (NL)
- Corresponding author
- Holstege, Henne
- ORCID
- van der Lee, Sven J.
- Jansen, Iris
- Carrasquillo, Minerva M.
- Kleineidam, Luca
- Stringa, Najada
- Chen, Jason A.
- Zettergren, Anna
- Andlauer, Till F. M.
- Lleó, Alberto
- Zetterberg, Henrik
- Nygaard, Marianne
- Blauwendraat, Cornelis
- Savage, Jeanne E.
- Wagner, Michael
- Fortea, Juan
- Keogh, Michael J.
- Blennow, Kaj
- Skoog, Ingmar
- Friese, Manuel A.
- Zulaica, Miren
- Lage, Carmen
- Riedel-Heller, Steffi
- Wei, Wei
- Jeune, Bernard
- Orellana, Adelina
- Wang, Xue
- Hulsman, Marc
- Beker, Nina
- Tesi, Niccolo
- Morris, Christopher M.
- Collij, Lyduine E.
- Scherer, Martin
- Ironside, James W.
- Alcolea, Daniel
- Wiendl, Heinz
- Strickland, Samantha L.
- Boeve, Bradley F.
- Petersen, Ronald C.
- Ferman, Tanis J.
- Reinders, Marcel J. T.
- Uitti, Ryan J.
- Tárraga, Lluís
- Maier, Wolfgang
- Kawalia, Amit
- Zettl, Uwe K.
- Beekman, Marian
- Allen, Mariet
- Masliah, Eliezer
- Pantelyat, Alexander
- Ross, Owen A.
- Dickson, Dennis W.
- Knopman, David
- Rademakers, Rosa
- Lemstra, Afina W.
- Pijnenburg, Yolande A. L.
- Scheltens, Philip
- Gasser, Thomas
- Chinnery, Patrick F
- Hemmer, Bernhard
- Huisman, Martijn A.
- Troncoso, Juan
- Nohr, Ellen A.
- Sørensen, Thorkild I. A.
- Heutink, Peter
- Clarimón, Jordi
- Christensen, Kaare
- Scholz, Sonja W.
- Holstege, Henne
- Venue
- Acta Neuropathologica
- Published
- 2019-05-26
- Volume
- 138
- Issue
- 2
- Pages
- 237-250
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC6660501
- OpenAlex
- W2944923405
- Cited by
- 120
- References
- 67
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 18 · 2023: 13 · 2022: 10 · 2021: 23 · 2020: 29 · 2019: 6 · 2018: 1
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-01-18)
- Open access
- hybrid
- doi.org
- Locations
- Acta Neuropathologica (publishedVersion, cc-by)
- SSRN Electronic Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, cc-by)
- Pure Amsterdam UMC (publishedVersion, cc-by)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Explore Bristol Research (publishedVersion, cc-by)
- VU Research Portal (publishedVersion, other-oa)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, cc-by)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- DZNE Pub (submittedVersion, cc-by)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- UCrea (University of Cantabria) (submittedVersion, cc-by)
- Bristol Research (University of Bristol) (submittedVersion, cc-by)
- CONICET Digital (CONICET) (submittedVersion, cc-by)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by)
- Research Repository (Delft University of Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Apollo (cc-by)
- Funders
- Mayo Clinic (P50 NS072187, U01 AG046139, R01 NS080820)
- Alzheimer's Association (ZEN‐01‐3151)
- Alexander von Humboldt-Stiftung
- American Parkinson Disease Association (R01 NS078086, P50 NS072187)
- University of Miami
- Johns Hopkins University (P50-AG005146, AG005146)
- Georgetown University
- CurePSP
- Virginia Commonwealth University
- Wellcome Trust (084762, 212219/Z/18/Z, WT084762)
- Little Family Foundation (P50 NS072187, R01 NS078086)
- Demensförbundet
- European Federation of Pharmaceutical Industries and Associations (115975)
- Sol Goldman Charitable Trust
- Lewy Body Dementia Association
- Motor Neurone Disease Association
- University College London
- ZonMw (733051061, 733050814)
- Bundesministerium für Bildung und Forschung (01GI0916, 01GI0917, 01ZX1614J)
- Generalitat de Catalunya (2017-SGR)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (050.060.810, 480- 05-003, 453-13-005, 453-14-005)
- Vetenskapsrådet (2013-2300, 2013‐2496, 2015-02830)
- Banco Bilbao Vizcaya Argentaria
- Sahlgrenska Universitetssjukhuset
- Stichting ALS Nederland
- Centre for Medical Systems Biology
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (PI13/02434, Program1, PI16/01861)
- Grifols
- National Institutes of Health (U19-AG03365, NIH P50, NS38377, AG046139, NS100693, NS072187, Z01-AG000949, P50 NS38377)
- Center for Individualized Medicine, Mayo Clinic
- Tau Consortium
- Medical Research Council (MC_UU_00015/7)
- Instituto de Salud Carlos III (PI16/, PI13/02434, PI15/00878, PI14/01126, PI11/, PI16/01861, PI14/, PI12/02288, PI08/0139, PI17/01019, PI16/01652, PI17/01895, PI11/02526)
- European Regional Development Fund (PI16/01861, PI13/02434, 01126)
- National Institute on Aging (RF1AG051504, AG046139, K23AG059891, RF AG051504, AG051504, P01AG008761, AG-005146, U19‐AG03365, NIH P50, P50AG005146, U01AG046139, R01AG061796, ZIA-NS003154, P30AG062422)
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke (NS 38377, NINDS R01 NS078086, NS078086, P50NS38377, R01NS080820, R01NS078086, NS080820, P50NS038377, U54NS100693, NS072187, P50NS072187, R35NS097261, NS100693, ZIANS003154)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- PLCγ2, non-synonymous mutations, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, longevity, neurodegenerative diseases, genetic risk, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, etiology
- MeSH terms
- Alleles, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Brain, Dementia, Humans, Longevity, Multiple Sclerosis, Mutation, Parkinson Disease, Risk, Microglia, Genetic Predisposition to Disease, Lewy Body Disease, Phospholipase C gamma, Genome-Wide Association Study, Frontotemporal Dementia, Neuroimaging
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