Cited by 207Immune cells in cancerGenetics, Aging, and Longevity in Model OrganismsPhagocytosis and Immune Regulation

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

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van Beek, Adriaan A., Van den Bossche, Jan, Mastroberardino, Pier G., de Winther, Menno P.J., Leenen, Pieter J.M.·2019·Trends in Immunology

Abstract

Aging is a complex process with an impact on essentially all organs. Declined cellular repair causes increased damage at genomic and proteomic levels upon aging. This can lead to systemic changes in metabolism and pro-inflammatory cytokine production, resulting in low-grade inflammation, or 'inflammaging'. Tissue macrophages, gatekeepers of parenchymal homeostasis and integrity, are prime inflammatory cytokine producers, as well as initiators and regulators of inflammation. In this opinion piece, we summarize intrinsic alterations in macrophage phenotype and function with age. We propose that alternatively activated macrophages (M2-like), which are yet pro-inflammatory, can accumulate in tissues and promote inflammaging. Age-related increases in endoplasmic reticulum stress and mitochondrial dysfunction might be cell-intrinsic forces driving this unusual phenotype.

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Crossref · 10.1016/j.it.2018.12.007

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Authors
van Beek, A. A., Van den Bossche, J., Mastroberardino, P. G., de Winther, M. P. J., & Leenen, P. J. M.
Affiliations
Erasmus MC (NL)
Corresponding author
Leenen, Pieter J.M.
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2019-02
Volume
40
Issue
2
Pages
113-127
ISSN
1471-4906 (ISSN-L)
OpenAlex
W2906988593
Cited by
207
References
112
Citations by year
2026: 13 · 2025: 31 · 2024: 30 · 2023: 24 · 2022: 29 · 2021: 43 · 2020: 29 · 2019: 8
FWCI
2.35
Type
journal article
Language
en
Open access
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
Funders
  • TI Food and Nutrition
  • ZonMW
  • Netherlands Heart Foundation
  • Spark-Holding BV
  • European Union and Fondation Leducq
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords
inflammaging, low-grade inflammation, alternative activation, M2 macrophages, endoplasmic reticulum stress, mitochondrial dysfunction, inflammatory cytokines, tissue homeostasis, cellular senescence
MeSH terms
Animals, Humans, Inflammation, Macrophages, Mitochondria, Cytokines, Cellular Senescence, Endoplasmic Reticulum Stress

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