Hepatocellular Carcinoma: Regional Therapy with a Magnetic Targeted Carrier Bound to Doxorubicin in a Dual MR Imaging/ Conventional Angiography Suite—Initial Experience with Four Patients
Abstract
Four patients with inoperable hepatocellular carcinoma were treated with a magnetic targeted carrier bound to doxorubicin (MTC-DOX) by using a joint magnetic resonance (MR) imaging/conventional angiography system consisting of a 1.5-T short-bore magnet connected to a C-arm angiography unit by a sliding tabletop. Selective transcatheter delivery of the MTC-DOX to the hepatic artery was monitored by using intraprocedural MR imaging, and interim catheter manipulation was performed with fluoroscopic guidance to optimize agent delivery to the tumor and minimize delivery to normal tissue. The final fraction of treated tumor volume ranged from 0.64 to 0.91. The fraction of affected normal liver volume ranged from 0.07 to 0.30. The dual MR imaging/conventional angiography system shows promise for directing magnetically targeted tumor therapies.
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Only one magnetically targeted nanocarrier (MTC-DOX) has been evaluated in patients, and it did not produce convincing results, leading to termination of clinical development in phase II/III.
“From a translational point of view, only one magnetically targeted nanocarrier (which was loaded with doxorubicin; MTC-DOX) has been evaluated in patients, but it did not produce convincing results, leading to termination of clinical development in phase II/III [232, 233].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [232]
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- Authors
- Wilson, M. W., Kerlan, R. K., Fidelman, N. A., Venook, A. P., LaBerge, J. M., Koda, J., & Gordon, R. L.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Radiology
- Published
- 2004-01
- Volume
- 230
- Issue
- 1
- Pages
- 287-293
- ISSN
- 0033-8419 (ISSN-L)
- 1527-1315
- OpenAlex
- W2169532237
- Cited by
- 190
- References
- 15
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 13 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 9
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Radiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- hepatocellular carcinoma, doxorubicin, hepatic artery, fluoroscopic guidance, tumor targeting, inoperable liver cancer
- MeSH terms
- Adult, Aged, Angiography, Antibiotics, Antineoplastic, Doxorubicin, Drug Carriers, Equipment Design, Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Magnetic Resonance Imaging, Magnetics, Male, Middle Aged
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