The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population
Open accessAbstract
High-intensity focused ultrasound (HIFU) provides a potential noninvasive alternative to conventional therapies. We report our preliminary experience from clinical trials designed to evaluate the safety and feasibility of a novel, extracorporeal HIFU device for the treatment of liver and kidney tumours in a Western population. The extracorporeal, ultrasound-guided Model-JC Tumor Therapy System (HAIFU Technology Company, China) has been used to treat 30 patients according to four trial protocols. Patients with hepatic or renal tumours underwent a single therapeutic HIFU session under general anaesthesia. Magnetic resonance imaging 12 days after treatment provided assessment of response. The patients were subdivided into those followed up with further imaging alone or those undergoing surgical resection of their tumours, which enabled both radiological and histological assessment. HIFU exposure resulted in discrete zones of ablation in 25 of 27 evaluable patients (93%). Ablation of liver tumours was achieved more consistently than for kidney tumours (100 vs 67%, assessed radiologically). The adverse event profile was favourable when compared to more invasive techniques. HIFU treatment of liver and kidney tumours in a Western population is both safe and feasible. These findings have significant implications for future noninvasive image-guided tumour ablation.
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Cites
High-intensity focused ultrasound in the treatment of solid tumours
Kennedy, J. E. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1591 · Cited by 1,282
Self-citationLivraghi, T., Giorgio, A., Marin, G., Salmi, A., de Sio, I., Bolondi, L., Pompili, M., Brunello, F., Lazzaroni, S., & Torzilli, G. (1995) · Radiology · doi:10.1148/radiology.197.1.7568806 · Cited by 939
High intensity focused ultrasound: surgery of the future?
Kennedy, J. E., ter Haar, G. R., & Cranston, D. (2003) · The British Journal of Radiology · doi:10.1259/bjr/17150274 · Cited by 709
Self-citationA NEW METHOD FOR THE GENERATION AND USE OF FOCUSED ULTRASOUND IN EXPERIMENTAL BIOLOGY
Lynn, J. G., Zwemer, R. L., Chick, A. J., & Miller, A. E. (1942) · Journal of General Physiology · doi:10.1085/jgp.26.2.179 · Cited by 690
Shibata, T., Iimuro, Y., Yamamoto, Y., Maetani, Y., Ametani, F., Itoh, K., & Konishi, J. (2002) · Radiology · doi:10.1148/radiol.2232010775 · Cited by 575
High-intensity focused ultrasound for the treatment of liver tumours
Kennedy, J. E., Wu, F., ter Haar, G. R., Gleeson, F. V., Phillips, R. R., Middleton, M. R., & Cranston, D. (2004) · Ultrasonics · doi:10.1016/j.ultras.2004.01.089 · Cited by 435
Self-citationIn Situ Tumor Ablation Creates an Antigen Source for the Generation of Antitumor Immunity
den Brok, M. H. M. G. M., Sutmuller, R. P. M., van der Voort, R., Bennink, E. J., Figdor, C. G., Ruers, T. J. M., & Adema, G. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3949 · Cited by 426
Image-guided Tumor Ablation: Proposal for Standardization of Terms and Reporting Criteria
Goldberg, S. N., Charboneau, J. W., Dodd, G. D., Dupuy, D. E., Gervais, D. A., Gillams, A. R., Kane, R. A., Lee, F. T., Livraghi, T., McGahan, J. P., et al. (2003) · Radiology · doi:10.1148/radiol.2282021787 · Cited by 375
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Blana, A., Walter, B., Rogenhofer, S., & Wieland, W. F. (2004) · Urology · doi:10.1016/j.urology.2003.09.020 · Cited by 350
Vogl, T. J., Straub, R., Eichler, K., Söllner, O., & Mack, M. G. (2004) · Radiology · doi:10.1148/radiol.2302020646 · Cited by 286
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Self-citationIzadifar, Z., Izadifar, Z., Chapman, D., & Babyn, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020460 · Cited by 457
Heating technology for malignant tumors: a review
Kok, H. P., Cressman, E. N. K., Ceelen, W., Brace, C. L., Ivkov, R., Grüll, H., ter Haar, G., Wust, P., & Crezee, J. (2020) · International Journal of Hyperthermia · doi:10.1080/02656736.2020.1779357 · Cited by 422
Self-citationHistotripsy methods in mechanical disintegration of tissue: Towards clinical applications
Khokhlova, V. A., Fowlkes, J. B., Roberts, W. W., Schade, G. R., Xu, Z., Khokhlova, T. D., Hall, T. L., Maxwell, A. D., Wang, Y.-N., & Cain, C. A. (2015) · International Journal of Hyperthermia · doi:10.3109/02656736.2015.1007538 · Cited by 317
Emerging Nanomedicine‐Enabled/Enhanced Nanodynamic Therapies beyond Traditional Photodynamics
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Metadata
- Authors
- Illing, R. O., Kennedy, J. E., Wu, F., ter Haar, G. R., Protheroe, A. S., Friend, P. J., Gleeson, F. V., Cranston, D. W., Phillips, R. R., & Middleton, M. R.
- Venue
- British Journal of Cancer
- Published
- 2005-09-27
- Volume
- 93
- Issue
- 8
- Pages
- 890-895
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- OpenAlex
- W2085131028
- Cited by
- 584
- References
- 13
- FWCI
- 17.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Illing, R. O., Kennedy, J. E., Wu, F., ter Haar, G. R., Protheroe, A. S., Friend, P. J., Gleeson, F. V., Cranston, D. W., Phillips, R. R., & Middleton, M. R. (2005). The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population. British Journal of Cancer. https://doi.org/10.1038/sj.bjc.6602803
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