Cited by 205Neurogenesis and neuroplasticity mechanismsMesenchymal stem cell researchAcute Ischemic Stroke Management

Neural stem cell therapy for subacute and chronic ischemic stroke

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Boese, Austin C., Le, Quan-Son Eric, Pham, Dylan, Hamblin, Milton H., Lee, Jean-Pyo·2018·Stem Cell Research & Therapy

Abstract

Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading cause of death and disability. Clinically, extensive injury from ischemic stroke results from ischemia-reperfusion (IR), which is accompanied by inflammation, blood-brain barrier (BBB) damage, neural cell death, and extensive tissue loss. Tissue plasminogen activator (tPA) is still the only US Food and Drug Administration-approved clot-lysing agent. Whereas the thrombolytic role of tPA within the vasculature is beneficial, the effects of tPA (in a non-thrombolytic role) within the brain parenchyma have been reported as harmful. Thus, new therapies are needed to reduce the deleterious side effects of tPA and quickly facilitate vascular repair following stroke. The Stroke Treatment Academic Industry Roundtable (STAIR) recommends that stroke therapies "focus on drugs/devices/treatments with multiple mechanisms of action and that target multiple pathways". Thus, based on multifactorial ischemic cascades in various stroke stages, effective stroke therapies need to focus on targeting and ameliorating early IR injury as well as facilitating angiogenesis, neurogenesis, and neurorestorative mechanisms following stroke. This review will discuss the preclinical perspectives of NSC transplantation as a promising treatment for neurovascular injury and will emphasize both the subacute and chronic phase of ischemic stroke.

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  • Neural plasticity persists throughout life in humans.

    “Although until recently it was thought that the central nervous system (CNS) was fixed and incapable of regeneration, nowadays it is well-established that neural plasticity persists throughout life in humans [214], [215].”

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  1. [223]Kang SS Keasey MP Arnold SA Reid R Geralds J Hagg T Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice Neurobiol Dis 2012 49C 68 78 PMC3657597 22960105

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Authors
Boese, A. C., Le, Q.-S. E., Pham, D., Hamblin, M. H., & Lee, J.-P.
Affiliations
Tulane University (US)
Corresponding author
Lee, Jean-Pyo
Venue
Stem Cell Research & Therapy
Published
2018-06-13
Volume
9
Issue
1
Pages
154-154
ISSN
1757-6512 (ISSN-L)
OpenAlex
W2808420239
Cited by
205
References
247
Citations by year
2026: 4 · 2025: 28 · 2024: 19 · 2023: 46 · 2022: 38 · 2021: 30 · 2020: 19 · 2019: 15 · 2018: 5 · 2017: 1
FWCI
2.18
Type
journal article
Language
en
Open access
Locations
  • Stem Cell Research & Therapy (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Louisiana Clinical and Translational Science Center
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
neural stem cell transplantation, ischemic stroke, ischemia-reperfusion injury, subacute stroke, chronic stroke, tissue plasminogen activator, blood-brain barrier disruption, neuroinflammation, angiogenesis, neurogenesis, neurovascular injury, stroke treatment
MeSH terms
Brain Ischemia, Chronic Disease, Humans, Tissue Plasminogen Activator, Stroke, Stem Cell Transplantation

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