Cited by 496NF-κB Signaling PathwaysSignaling Pathways in DiseaseTGF-β signaling in diseases

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Good cop, bad cop: the different faces of NF-κB

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Perkins, N D, Gilmore, T D·2006·Cell Death & Differentiation

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Abstract

Complexes formed from the nuclear factor kappaB (NF-kappaB) family of transcription factors are ubiquitously expressed and are induced by a diverse array of stimuli. This results in their becoming activated in a wide variety of different settings. While the functions of NF-kappaB in many of these contexts have been the subject of intense research and are now well established, it is also clear that there is great diversity in the effects and consequences of NF-kappaB activation. NF-kappaB subunits do not necessarily regulate the same genes, in an identical manner, in all of the different circumstances in which they are induced. This review will discuss the different functions of NF-kappaB, the pathways that modulate NF-kappaB subunit activity and, in contrast to its more commonly thought of role as a promoter of cancer cell growth and survival, the ability of NF-kappaB, under some circumstances, to behave as a tumor suppressor.

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Authors: Perkins, N. D., & Gilmore, T. D.
Affiliations: University of Dundee (GB)
Boston University (US)
Corresponding author: Perkins, N D
ORCID: Perkins, N D
Gilmore, T D
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2006-01-13
Volume: 13
Issue: 5
Pages: 759-772
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/sj.cdd.4401838
OpenAlex: W1533671266
Cited by: 489
References: 103
Citations by year: 2026: 9 · 2025: 12 · 2024: 22 · 2023: 21 · 2022: 15 · 2021: 21 · 2020: 23 · 2019: 13 · 2018: 19 · 2017: 24 · 2016: 19 · 2015: 30 · 2014: 38 · 2013: 22 · 2012: 26
FWCI: 2.37
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed (publishedVersion)
Newcastle University ePrints (Newcastle Univesity)
Funders: Wellcome Trust
Cancer Research UK
Royal Society
National Institutes of Health
National Cancer Institute (CA 47763)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: NF-κB, transcription factors, tumor suppression, gene expression regulation, NF-κB subunits
MeSH terms: Carcinogens, Humans, Models, Biological, Neoplasms, Signal Transduction, NF-kappa B, Tumor Suppressor Proteins, I-kappa B Kinase

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Good cop, bad cop: the different faces of NF-κB

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