The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Good cop, bad cop: the different faces of NF-κB
Open accessAbstract
Complexes formed from the nuclear factor kappaB (NF-kappaB) family of transcription factors are ubiquitously expressed and are induced by a diverse array of stimuli. This results in their becoming activated in a wide variety of different settings. While the functions of NF-kappaB in many of these contexts have been the subject of intense research and are now well established, it is also clear that there is great diversity in the effects and consequences of NF-kappaB activation. NF-kappaB subunits do not necessarily regulate the same genes, in an identical manner, in all of the different circumstances in which they are induced. This review will discuss the different functions of NF-kappaB, the pathways that modulate NF-kappaB subunit activity and, in contrast to its more commonly thought of role as a promoter of cancer cell growth and survival, the ability of NF-kappaB, under some circumstances, to behave as a tumor suppressor.
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“In the NF-κB system (e.g. [2020-2024]) (Fig 8), NF-κB is normally held inactive in the cytoplasm by binding to an inhibitor IκB (often IκBα). Pro-inflammatory cytokines such as TNF-α, LPS [2025-2030] and IL-1 [2031] act by binding to receptors at the cell surface and initiating signalling pathways that lead to the activation of a particular kinase, IκB kinase or IKK. This kinase phosphorylates the”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [2024]
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Cites
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Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
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The two NF-κB activation pathways and their role in innate and adaptive immunity
Bonizzi, G., & Karin, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.03.008 · Cited by 2,535
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
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The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
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Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation
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The IKK NF-κB system: a treasure trove for drug development
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Crosstalk of reactive oxygen species and NF-κB signaling
Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505
The complexity of NF-κB signaling in inflammation and cancer
Hoesel, B., & Schmid, J. A. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-86 · Cited by 3,277
Integrating cell-signalling pathways with NF-κB and IKK function
Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350
Self-citationTargeting cancer stem cell pathways for cancer therapy
Yang, L., Shi, P., Zhao, G., Xu, J., Peng, W., Zhang, J., Zhang, G., Wang, X., Dong, Z., Chen, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0110-5 · Cited by 1,957
Cellular Stress Responses: Cell Survival and Cell Death
Fulda, S., Gorman, A. M., Hori, O., & Samali, A. (2010) · International Journal of Cell Biology · doi:10.1155/2010/214074 · Cited by 1,590
Metadata
- Authors
- Perkins, N. D., & Gilmore, T. D.
- Affiliations
- University of Dundee (GB)
- Boston University (US)
- Corresponding author
- Perkins, N D
- Venue
- Cell Death & Differentiation
- Published
- 2006-01-13
- Volume
- 13
- Issue
- 5
- Pages
- 759-772
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- OpenAlex
- W1533671266
- Cited by
- 489
- References
- 103
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 22 · 2023: 21 · 2022: 15 · 2021: 21 · 2020: 23 · 2019: 13 · 2018: 19 · 2017: 24 · 2016: 19 · 2015: 30 · 2014: 38 · 2013: 22 · 2012: 26
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Death and Differentiation (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Wellcome Trust
- Cancer Research UK
- Royal Society
- National Institutes of Health
- National Cancer Institute (CA 47763)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- NF-κB, transcription factors, tumor suppression, gene expression regulation, NF-κB subunits
- MeSH terms
- Carcinogens, Humans, Models, Biological, Neoplasms, Signal Transduction, NF-kappa B, Tumor Suppressor Proteins, I-kappa B Kinase
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