Good cop, bad cop: the different faces of NF-κB

Signaling to NF-κB

Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842

Activators and target genes of Rel/NF-κB transcription factors

Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727

Activators and Target Genes of Rel/NF-кB Transcription Factors

Loop, T., & Pahl, H. L. (2003) · Springer eBooks · doi:10.1007/978-94-010-0163-2_1 · Cited by 3,179

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750

The two NF-κB activation pathways and their role in innate and adaptive immunity

Bonizzi, G., & Karin, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.03.008 · Cited by 2,535

IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

Greten, F. R., Eckmann, L., Greten, T. F., Park, J. M., Li, Z.-W., Egan, L. J., Kagnoff, M. F., & Karin, M. (2004) · Cell · doi:10.1016/j.cell.2004.07.013 · Cited by 2,433

The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation

Hoffmann, A., Levchenko, A., Scott, M. L., & Baltimore, D. (2002) · Science · doi:10.1126/science.1071914 · Cited by 1,890

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792

Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation

Viatour, P., Merville, M., Bours, V., & Chariot, A. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.11.009 · Cited by 1,516

The IKK NF-κB system: a treasure trove for drug development

Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364

Protein Kinase A-Induced Phosphorylation of the p65 Subunit of Nuclear Factor-κB Promotes Schwann Cell Differentiation into a Myelinating Phenotype

Yoon, C., Korade, Ž., & Carter, B. D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4439-07.2008 · Cited by 85

The Biphasic Role of NF-κB in Progression and Chemoresistance of Ovarian Cancer

Yang, G. S., Xiao, X., Rosen, D. G., Cheng, X., Wu, X., Chang, B., Liu, G., Xue, F., Mercado‐Uribe, I., Chiao, P. J., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-3265 · Cited by 85

Benzyl Isothiocyanate–Mediated Inhibition of Histone Deacetylase Leads to NF-κB Turnoff in Human Pancreatic Carcinoma Cells

Batra, S., Sahu, R. P., Kandala, P. K., & Srivastava, S. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-1146 · Cited by 87

Induction of a pro‐apoptotic ATM–NF‐κB pathway and its repression by ATR in response to replication stress

Wu, Z., & Miyamoto, S. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.127 · Cited by 82

Selective Inhibition of IκB Kinase Sensitizes Mantle Cell Lymphoma B Cells to TRAIL by Decreasing Cellular FLIP Level

Roué, G., Pérez‐Galán, P., López‐Guerra, M., Villamor, N., Campo, E., & Colomer, D. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1923 · Cited by 83

Platelet-Rich Plasma and Skeletal Muscle Healing: A Molecular Analysis of the Early Phases of the Regeneration Process in an Experimental Animal Model

Dimauro, I., Grasso, L., Fittipaldi, S., Fantini, C., Mercatelli, N., Racca, S., Geuna, S., Gianfrancesco, A. D., Caporossi, D., Pigozzi, F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102993 · Cited by 82

Biliverdin inhibits activation of NF‐κB: Reversal of inhibition by human biliverdin reductase

Gibbs, P., & Maines, M. D. (2007) · International Journal of Cancer · doi:10.1002/ijc.22978 · Cited by 84

Epigallocatechin-3-gallate Inhibits LPS-Induced NF-κB and MAPK Signaling Pathways in Bone Marrow-Derived Macrophages

Joo, S. Y., Song, Y.-A., Park, Y., Myung, E., Chung, C., Park, K.-J., Cho, S. B., Lee, W., Kim, H. S., Rew, J., et al. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.2.188 · Cited by 81

The role of αB-crystallin in skeletal and cardiac muscle tissues

Dimauro, I., Antonioni, A., Mercatelli, N., & Caporossi, D. (2017) · Cell Stress and Chaperones · doi:10.1007/s12192-017-0866-x · Cited by 88

Impact of Intravascular Hemolysis in Malaria on Liver Dysfunction

Dey, S., Bindu, S., Goyal, M., Pal, C., Alam, A., Iqbal, M. S., Kumar, R., Sarkar, S., & Bandyopadhyay, U. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.341255 · Cited by 82

Degraded Carrageenan Causing Colitis in Rats Induces TNF Secretion and ICAM-1 Upregulation in Monocytes through NF-κB Activation

Benard, C., Cultrone, A., Michel, C., Rosales, C., Segain, J.-P., Lahaye, M., Galmiche, J.-P., Cherbut, C., & Blottière, H. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008666 · Cited by 76

Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways

Jeong, J.-J., Jang, S.-E., Hyam, S. R., Han, M. J., & Kim, D.-H. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.013 · Cited by 78

Human Airway Smooth Muscle Cells from Asthmatic Individuals Have CXCL8 Hypersecretion Due to Increased NF-κB p65, C/EBPβ, and RNA Polymerase II Binding to the CXCL8 Promoter

John, A. E., Zhu, Y. M., Brightling, C. E., Pang, L., & Knox, A. J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803832 · Cited by 74

Angiogenesis and remodelling in human thoracic aortic aneurysms

Kessler, K., Borges, L. D. F., Ho‐Tin‐Noé, B., Jondeau, G., Michel, J., & Vranckx, R. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu196 · Cited by 77

The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression

Rajendran, N. K., George, B. P. A., Chandran, R., Tynga, I. M., Houreld, N. N., & Abrahamse, H. (2019) · Antioxidants · doi:10.3390/antiox8120640 · Cited by 79

NF-κB as a key player in regulation of cellular radiation responses and identification of radiation countermeasures

Singh, V. K., Gupta, D., & Arora, R. (2015) · Discoveries · doi:10.15190/d.2015.27 · Cited by 79

Regulation of the RelA (p65) transactivation domain

O'shea, J. M., & Perkins, N. D. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360603 · Cited by 75

Activation of TWIST1 by COL11A1 promotes chemoresistance and inhibits apoptosis in ovarian cancer cells by modulating NF‐κB‐mediated IKKβ expression

Wu, Y., Huang, Y., Chang, T., & Chou, C. (2017) · International Journal of Cancer · doi:10.1002/ijc.30932 · Cited by 72

Transmembrane protein with unknown function 16A overexpression promotes glioma formation through the nuclear factor-κB signaling pathway

Liu, J., Liu, Y., Ren, Y., Kang, L., & ZHANG, L. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.1888 · Cited by 71

NFκB promotes oxidative stress-induced necrosis and ischemia/reperfusion injury by inhibiting Nrf2-ARE pathway

Guo, X., Hong, S., He, H., Zeng, Y., Chen, Y., Mo, X., Li, J., Li, L., Steinmetz, R. N., & Liu, Q. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.031 · Cited by 72

Nucleolar Targeting of RelA(p65) Is Regulated by COMMD1-Dependent Ubiquitination

Thoms, H. C., Loveridge, C. J., Simpson, J., Clipson, A., Reinhardt, K., Dunlop, M. G., & Stark, L. A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1397 · Cited by 70

Synergistic Anticancer Activity of Capsaicin and 3,3′-Diindolylmethane in Human Colorectal Cancer

Clark, R., Lee, J., & Lee, S. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf506098s · Cited by 69

X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-κB activation

Kairisalo, M., Korhonen, L., Blomgren, K., & Lindholm, D. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.09.115 · Cited by 69

αB-crystallin, a small heat shock protein, modulates NF-κB activity in a phosphorylation-dependent manner and protects muscle myoblasts from TNF-α induced cytotoxicity

Adhikari, A. S., Singh, B. N., Rao, K. S., & Rao, C. M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.04.009 · Cited by 69

Rutin Attenuates Carfilzomib-Induced Cardiotoxicity Through Inhibition of NF-κB, Hypertrophic Gene Expression and Oxidative Stress

Imam, F., Al-Harbi, N. O., Al-Harbia, M. M., Korashy, H. M., Ansari, M. A., Sayed‐Ahmed, M. M., Nagi, M. N., Iqbal, M., Anwer, M. K., Kazmi, I. A., et al. (2015) · Cardiovascular Toxicology · doi:10.1007/s12012-015-9356-5 · Cited by 68

Nonsteroidal anti-inflammatory drug induces proinflammatory damage in gastric mucosa through NF-κB activation and neutrophil infiltration: Anti-inflammatory role of heme oxygenase-1 against nonsteroidal anti-inflammatory drug

Bindu, S., Mazumder, S., Dey, S., Pal, C., Goyal, M., Alam, A., Iqbal, M. S., Sarkar, S., Siddiqui, A. A., Banerjee, C., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.027 · Cited by 69

Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM+ B Cells in The Absence of Germinal Centers

Abós, B., Wang, T.-H., Castro, R., Granja, A. G., Leal, E., Havixbeck, J. J., Luque, A., Barreda, D. R., Secombes, C., & Tafalla, C. (2016) · Scientific Reports · doi:10.1038/srep30004 · Cited by 62

Genome editing in cardiovascular diseases

Mani, I. (2021) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2021.01.021 · Cited by 66

Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

Hošek, J., Bartoš, M., Chudík, S., Dall’Acqua, S., Innocenti, G., Kartal, M., Kokoška, L., Kollár, P., Kutil, Z., Landa, P., et al. (2011) · Journal of Natural Products · doi:10.1021/np100638h · Cited by 64

Tomato Lycopene Extract Prevents Lipopolysaccharide-Induced NF-κB Signaling but Worsens Dextran Sulfate Sodium-Induced Colitis in NF-κBEGFP Mice

Joo, Y., Karrasch, T., Mühlbauer, M., Allard, B., Narula, A. S., Herfarth, H. H., & Jobin, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004562 · Cited by 63

Identification of a novel pro‐apopotic function of NF‐κB in the DNA damage response

Karl, S., Pritschow, Y., Volčič, M., Häcker, S., Baumann, B., Wiesmüller, L., Debatin, K., & Fulda, S. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00888.x · Cited by 63

Identification of a Nuclear Localization Sequence in β-Arrestin-1 and Its Functional Implications

Hoeppner, C. Z., Cheng, N., & Ye, R. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294058 · Cited by 62

Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

Ankers, J., Awais, R., Jones, N. A., Boyd, J., Ryan, S., Adamson, A. D., Harper, C. V., Bridge, L., Spiller, D. G., Jackson, D. A., et al. (2016) · eLife · doi:10.7554/elife.10473 · Cited by 63

Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17/Treg imbalance

Kang, G., & Kim, D. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.05.044 · Cited by 62

The Fire Within: NF-κB Involvement in Non–Small Cell Lung Cancer

Dimitrakopoulos, F.-I. D., Kottorou, A. E., Kalofonou, M., & Kalofonos, H. P. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3578 · Cited by 61

NF-κB activation enhances cell death by antimitotic drugs in human prostate cancer cells

Parrondo, R. D., Pozas, A. D. L., Reiner, T., Rai, P., & Perez‐Stable, C. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-182 · Cited by 61

Differential mechanism of NF‐κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

Gossye, V., Elewaut, D. S., Bougarne, N., Bracke, D., Calenbergh, S. V., Haegeman, G., & Bosscher, K. D. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24963 · Cited by 60

Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity™ (PSP)

Hsieh, T., Wu, P., Park, S., & WU, J. M. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-30 · Cited by 60

Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines

Li, Z., Li, Q.-Z., Chen, L., Chen, B.-D., Wang, B., Zhang, X., & Li, W.-P. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2043-5 · Cited by 61

NF-κB signalling in cerebral ischaemia

Schwaninger, M., Inta, I. M., & Herrmann, O. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341291 · Cited by 59

Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium–Induced Colitis

Zhang, J., Cao, L., Wang, H., Cheng, X., Wang, L., Zhu, L., Yan, T., Xie, Y., Wu, Y. C., Zhao, M., et al. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.063800 · Cited by 59

Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity

Begalli, F., Bennett, J., Capece, D., Verzella, D., D’Andrea, D., Tornatore, L., & Franzoso, G. (2017) · Biomedicines · doi:10.3390/biomedicines5030050 · Cited by 62

IKK/Nuclear Factor-kappaB and Oncogenesis

Bradford, J. W., & Baldwin, A. S. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800249-0.00003-2 · Cited by 58

Synergistic effects of particulate matter (PM10) and SO2 on human non-small cell lung cancer A549 via ROS-mediated NF-κB activation

Yun, Y., Gao, R., Yue, H., Li, G., Zhu, N., & Sang, N. (2015) · Journal of Environmental Sciences · doi:10.1016/j.jes.2014.09.041 · Cited by 58

The TLR3 ligand polyI:C downregulates connexin 43 expression and function in astrocytes by a mechanism involving the NF‐κB and PI3 kinase pathways

Zhao, Y.-M., Rivieccio, M. A., Lutz, S. E., Scemes, E., & Brosnan, C. (2006) · Glia · doi:10.1002/glia.20418 · Cited by 61

A Distinctive Physiological Role for IκBβ in the Propagation of Mitochondrial Respiratory Stress Signaling

Biswas, G., Tang, W., Sondheimer, N., Guha, M., Bansal, S., & Avadhani, N. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710481200 · Cited by 57

Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer

Szymańska, E., Nowak, P., Kolmus, K., Cybulska, M., Goryca, K., Derezińska‐Wołek, E., Szumera‐Ciećkiewicz, A., Brewińska‐Olchowik, M., Grochowska, A., Piwocka, K., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201910812 · Cited by 56

Design, synthesis, and biological evaluation of benzofuran- and 2,3-dihydrobenzofuran-2-carboxylic acid N-(substituted)phenylamide derivatives as anticancer agents and inhibitors of NF-κB

Choi, M.-H., Jo, H., Park, H.-J., Kumar, A. S., Lee, J., Yun, J., Kim, Y., Han, S., Jung, J., Cho, J., et al. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.04.050 · Cited by 56

Influence of low oxygen tensions on expression of pluripotency genes in stem cells

Szabłowska‐Gadomska, I., Zayat, V., & Bużańska, L. (2011) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2011-1825 · Cited by 56

Progesterone and calcitriol attenuate inflammatory cytokines CXCL1 and CXCL2 in ovarian and endometrial cancer cells

Kavandi, L., Collier, M. A., Nguyen, H., & Syed, V. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24191 · Cited by 56

Nuclear Factor-κB: a Key Regulator in Health and Disease of Lungs

Batra, S., Balamayooran, G., & Sahoo, M. K. (2011) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-011-0136-z · Cited by 58

An RNAi screen identifies USP2 as a factor required for TNF‐α‐induced NF‐κB signaling

Metzig, M. O., Nickles, D., Falschlehner, C., Lehmann‐Koch, J., Straub, B. K., Roth, W., & Boutros, M. (2011) · International Journal of Cancer · doi:10.1002/ijc.26124 · Cited by 55

TfR1 interacts with the IKK complex and is involved in IKK–NF-κB signalling

Kenneth, N. S., Mudie, S., Naron, S., & Rocha, S. (2012) · Biochemical Journal · doi:10.1042/bj20120625 · Cited by 57

Theaflavin Inhibits LPS-Induced IL-6, MCP-1, and ICAM-1 Expression in Bone Marrow-Derived Macrophages Through the Blockade of NF-κB and MAPK Signaling Pathways

Kim, S., & Joo, Y. (2011) · Chonnam Medical Journal · doi:10.4068/cmj.2011.47.2.104 · Cited by 55

High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca 2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-κB Activity

Riquelme, D., Álvarez, Á., Leal, N. R., Adasme, T., Espinoza, I., Valdés, J. A., Troncoso, N., Härtel, S., Hidalgo, J., Hidalgo, C., et al. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3238 · Cited by 56

The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation

Rodriguez, M. S., Egaña, I., Lopitz‐Otsoa, F., Aillet, F., Lopez-Mato, M. P., Dorronsoro, A., Lobato-Gil, S., Sutherland, J. D., Barrio, R., Trigueros, C., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.366 · Cited by 54

C-Geranylated Flavanones from Paulownia tomentosa Fruits as Potential Anti-inflammatory Compounds Acting via Inhibition of TNF-α Production

Hanáková, Z., Hošek, J., Babula, P., Dall’Acqua, S., Václavík, J., & Šmejkal, K. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00005 · Cited by 54

Menthol in electronic cigarettes: A contributor to respiratory disease?

Nair, V., Tran, M., Behar, R. Z., Zhai, S., Cui, X., Phandthong, R., Wang, Y., Pan, S., Luo, W., Pankow, J. F., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115238 · Cited by 53

Anticancer Activity of Protocatechualdehyde in Human Breast Cancer Cells

Choi, J., Jiang, X., Jeong, J. B., & Lee, S. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.0159 · Cited by 53

EGF receptor uses SOS1 to drive constitutive activation of NFκB in cancer cells

De, S., Dermawan, J. K. T., & Stark, G. R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412390111 · Cited by 53

Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1α Have an Antagonistic Connection

Newton, I. P., Kenneth, N. S., Appleton, P. L., Näthke, I. S., & Rocha, S. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-04-0312 · Cited by 52

Effects of different hypoxia degrees on endothelial cell cultures—Time course study

Bâldea, I., Teacoe, I. D., Olteanu, D. E., Vaida-Voievod, C., Clichici, A., Sîrbu, A. C., Filip, G. A., & Clichici, S. V. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.11.003 · Cited by 52

The triple role of glutathione S-transferases in mammalian male fertility

Llavanera, M., Mateo‐Otero, Y., Bonet, S., Barranco, I., Fernández-Fuertes, B., & Yeste, M. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03405-w · Cited by 52

Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB

Aksenova, V., Turoverova, L. V., Георгиевич, Х. М., Magnusson, K., Tulchinsky, E. M., Melino, G., Pinaev, G. P., Barlev, N. A., & Tentler, D. (2013) · Oncotarget · doi:10.18632/oncotarget.901 · Cited by 51

Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status

Sandhu, R., Rein, J., D’Arcy, M. E., Herschkowitz, J. I., Hoadley, K. A., & Troester, M. A. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu175 · Cited by 51

Regulation of Signal Transduction by Glutathione Transferases

Pajaud, J., Kumar, S., Rauch, C., Morel, F., & Aninat, C. (2012) · International Journal of Hepatology · doi:10.1155/2012/137676 · Cited by 50

Ischemia–reperfusion injury in rat steatotic liver is dependent on NFκB P65 activation

Ramachandran, S., Liaw, J. M., Jia, J., Glasgow, S. C., Liu, W., Csontos, K. A., Upadhya, G. A., Mohanakumar, T., & Chapman, W. C. (2012) · Transplant Immunology · doi:10.1016/j.trim.2012.01.001 · Cited by 49

Role of lysine methylation of NF-κB in differential gene regulation

Lu, T., Yang, M., Huang, D.-B., Han, W., Ozer, G. H., Ghosh, G., & Stark, G. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311770110 · Cited by 49

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways

Li, B., Zheng, L., Ye, J., Zhang, C., Zhou, J. H. S., Huang, Q.-J., Guo, Y., Wang, L., Yu, P., Liu, S., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2108-x · Cited by 52

The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-κB inhibition

Müerköster, S. S., Rausch, A. V., Isberner, A., Minkenberg, J., Blaszczuk, E., Witt, M., Fölsch, U. R., Schmitz, F., Schäfer, H., & Arlt, A. (2007) · Oncogene · doi:10.1038/sj.onc.1210728 · Cited by 49

Redox Control of Protein–DNA Interactions: From Molecular Mechanisms to Significance in Signal Transduction, Gene Expression, and DNA Replication

Shlomai, J. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3029 · Cited by 48

Cytokines as genetic modifiers in K5���/���mice and in human epidermolysis bullosa simplex

Roth, W., Reuter, U., Wohlenberg, C., Bruckner‐Tuderman, L., & Magin, T. M. (2009) · Human Mutation · doi:10.1002/humu.20981 · Cited by 48

Regulation of Nrf2 and NF-κB during lead toxicity in bovine granulosa cells

Aglan, H. S., Gebremedhn, S., Salilew‐Wondim, D., Neuhof, C., Tholen, E., Hoelker, M., Schellander, K., & Tesfaye, D. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03177-x · Cited by 48

Biliverdin reductase: a target for cancer therapy?

Gibbs, P., Miralem, T., & Maines, M. D. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00119 · Cited by 47

Antioxidative effects of the spice cardamom against non-melanoma skin cancer by modulating nuclear factor erythroid-2-related factor 2 and NF-κB signalling pathways

Das, I., Acharya, A., Berry, D. L., Sen, S., Williams, E. M., Permaul, E., Sengupta, A., Bhattacharya, S., & Saha, T. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511006283 · Cited by 47

Small-molecule Inhibitors of IκB Kinase (IKK) and IKK-related Kinases

Llona‐Minguez, S., Baiget, J., & Mackay, S. P. (2013) · Pharmaceutical Patent Analyst · doi:10.4155/ppa.13.31 · Cited by 48

Selective repression of YKL‐40 by NF‐κB in glioma cell lines involves recruitment of histone deacetylase‐1 and ‐2

Bhat, K., Pelloski, C. E., Zhang, Y., Kim, S. H., Cruz, C. D. L., Rehli, M., & Aldape, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.08.010 · Cited by 46

Crosstalk between p53 and nuclear factor-κB systems: pro- and anti-apoptotic functions of NF-κB

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Sensitization of neuroblastoma cells for TRAIL‐induced apoptosis by NF‐κB inhibition

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SOCS2 Is Critical for the Balancing of Immune Response and Oxidate Stress Protecting Against Acetaminophen-Induced Acute Liver Injury

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Role of Sodium/Calcium Exchangers in Tumors

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To be an ally or an adversary in bladder cancer: the NF-κB story has not unfolded

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Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria population

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Anticancer Activity of a Novel High Phenolic Sorghum Bran in Human Colon Cancer Cells

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Insights into the Relationship between Nucleolar Stress and the NF-κB Pathway

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Probing the links: Long non-coding RNAs and NF-κB signalling in atherosclerosis

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LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation

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Elevated expression of tumor necrosis factor‐α signaling molecules in colonic tumors of Zucker obese (fa/fa) rats

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NFX1 Plays a Role in Human Papillomavirus Type 16 E6 Activation of NFκB Activity

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Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor

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FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer’s disease

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Mechanism of hypoxia-induced NFκB

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NF-κB signalling proteins p50/p105, p52/p100, RelA, and IKKε are over-expressed in oesophageal squamous cell carcinomas

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Chronic Activation of the Kinase IKKβ Impairs T Cell Function and Survival

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The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration

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Bone morphogenetic protein-7 antagonizes tumor necrosis factor-α–induced activation of nuclear factor κB and up-regulation of the ADAMTS, leading to decreased degradation of disc matrix macromolecules aggrecan and collagen II

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Regulation of cell death during infection by the severe acute respiratory syndrome coronavirus and other coronaviruses

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Use of flow cytometry in the phenotypic diagnosis of hodgkin's lymphoma

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Efficiency of photodynamic therapy on WM35 melanoma with synthetic porphyrins: Role of chemical structure, intracellular targeting and antioxidant defense

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Regulation of NF-κB function

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Tumor Promoting or Tumor Suppressing of NF-κ B, a Matter of Cell Context Dependency

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NF-κB: tumor promoter or suppressor?

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Regulation of NF-κB by Oncoproteins and Tumor Suppressor Proteins

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Reprogramming RelA.

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