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Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation

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Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization

Chen, J., Laverty, D. J., Talele, S., Bale, A. A., Carlson, B. L., Porath, K. A., Bakken, K. K., Burgenske, D. M., Decker, P. A., Vaubel, R. A., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj5962 · Cited by 48 · see citing works

p53 and RAD9, the DNA Damage Response, and Regulation of Transcription Networks

Lieberman, H. B., Panigrahi, S. K., Hopkins, K. M., Wang, L., & Broustas, C. G. (2017) · Radiation Research · doi:10.1667/rr003cc.1 · Cited by 47 · see citing works

Emerging Roles of DDB2 in Cancer

Gilson, P., Drouot, G., Witz, A., Merlin, J., Bécuwe, P., & Harlé, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205168 · Cited by 43 · see citing works

Methylation-independent DNA Binding Modulates Specificity of Repressor of Silencing 1 (ROS1) and Facilitates Demethylation in Long Substrates

Ponferrada-Marín, M. I., Martínez-Macías, M. I., Morales‐Ruíz, T., Roldán‐Arjona, T., & Ariza, R. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.124578 · Cited by 43 · see citing works

Antimony Impairs Nucleotide Excision Repair: XPA and XPE as Potential Molecular Targets

Großkopf, C., Schwerdtle, T., Mullenders, L. H. F., & Hartwig, A. (2010) · Chemical Research in Toxicology · doi:10.1021/tx100106x · Cited by 43 · see citing works

p53 and ΔNp63α differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis

Schavolt, K. L., & Pietenpol, J. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210441 · Cited by 39 · see citing works

XPA-Mediated Regulation of Global Nucleotide Excision Repair by ATR Is p53-Dependent and Occurs Primarily in S-Phase

Li, Z., Musich, P. R., Serrano, M. A., Dong, Z., & Zou, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028326 · Cited by 38 · see citing works

Cellular Concentrations of DDB2 Regulate Dynamic Binding of DDB1 at UV-Induced DNA Damage

Alekseev, S., Luijsterburg, M. S., Pines, A., Geverts, B., Mari, P.-O., Giglia-Mari, G., Lans, H., Houtsmuller, A. B., Mullenders, L. H. F., Hoeijmakers, J. H. J., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01108-08 · Cited by 38 · see citing works

UV-B-induced DNA damage and repair in the mouse lens.

Mesa, R. A., & Bassnett, S. (2013) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.13-12644 · Cited by 38 · see citing works

Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells

Tsai, M.-H., Chen, X., Chandramouli, G., Chen, Y.-W., Yan, H., Zhao, S., Keng, P. C., Liber, H. L., Coleman, C. N., Mitchell, J. B., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1209082 · Cited by 38 · see citing works

E2F regulates DDB2: consequences for DNA repair in Rb-deficient cells

Prost, S., Lu, P., Caldwell, H., & Harrison, D. (2007) · Oncogene · doi:10.1038/sj.onc.1210151 · Cited by 36 · see citing works

The ubiquitin‐proteasome system in cancer, a major player in DNA repair. Part 1: post‐translational regulation

Vlachostergios, P. J., Patrikidou, A., Daliani, D., & Papandreou, C. N. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00824.x · Cited by 36 · see citing works

p21 Cooperates with DDB2 Protein in Suppression of Ultraviolet Ray-induced Skin Malignancies

Stoyanova, T. I., Roy, N., Bhattacharjee, S., Kopanja, D., Valli, T., Bagchi, S., & Raychaudhuri, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.295816 · Cited by 35 · see citing works

Cross-Resistance to Death Ligand-Induced Apoptosis in Cisplatin-Selected HeLa Cells Associated with Overexpression of DDB2 and Subsequent Induction of cFLIP

Sun, C., & Chao, C. C. ‐. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.008797 · Cited by 35 · see citing works

A novel response element confers p63- and p73-specific activation of the WNT4 promoter

Osada, M., Park, H. L., Nagakawa, Y., Begum, S., Yamashita, K., Wu, G., Kim, M. S., Trink, B., & Sidransky, D. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.118 · Cited by 34 · see citing works

Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage

Hsieh, W.-J., Hsieh, S., Chen, C.-C., & Wang, F.-F. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.047 · Cited by 34 · see citing works

Lack of p53 Ser389 Phosphorylation Predisposes Mice to Develop 2-Acetylaminofluorene–Induced Bladder Tumors but not Ionizing Radiation–Induced Lymphomas

Hoogervorst, E. M., Bruins, W., Zwart, E., van Oostrom, C. T. M., van den Aardweg, G. J., Beems, R. B., van den Berg, J., Jacks, T., STEEG, H. V., & de Vries, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4328 · Cited by 34 · see citing works

Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson

Menéndez, D., Inga, A., Jordan, J. J., & Resnick, M. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210277 · Cited by 31 · see citing works

Expanding molecular roles of UV-DDB: Shining light on genome stability and cancer

Beecher, M. L., Kumar, N., Jang, S., Rapić-Otrin, V., & Houten, B. V. (2020) · DNA repair · doi:10.1016/j.dnarep.2020.102860 · Cited by 31 · see citing works

DDB2 regulates Epithelial-to-Mesenchymal Transition (EMT) in Oral/Head and Neck Squamous Cell Carcinoma

Bommi, P. V., Ravindran, S., Raychaudhuri, P., & Bagchi, S. (2018) · Oncotarget · doi:10.18632/oncotarget.26168 · Cited by 28 · see citing works

Proficient Global Nucleotide Excision Repair in Human Keratinocytes but not in Fibroblasts Deficient in p53

Ferguson, B. E., & Oh, D. H. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1457 · Cited by 30 · see citing works

Variable structure motifs for transcription factor binding sites

Reid, J. E., Evans, K. J., Dyer, N. P., Wernisch, L., & Ott, S. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-30 · Cited by 28 · see citing works

Damaged DNA Binding Protein 2 in Reactive Oxygen Species (ROS) Regulation and Premature Senescence

Roy, N., Bagchi, S., & Raychaudhuri, P. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130911012 · Cited by 28 · see citing works

Inhibition of MDM2 by RG7388 confers hypersensitivity to X-radiation in xenograft models of childhood sarcoma

Phelps, D., Bondra, K., Seum, S., Chronowski, C., Leasure, J., Kurmasheva, R. T., Middleton, S., Wang, D., Mo, X., & Houghton, P. J. (2015) · Pediatric Blood &amp; Cancer · doi:10.1002/pbc.25465 · Cited by 27 · see citing works

Creating PWMs of transcription factors using 3D structure-based computation of protein-DNA free binding energies

Alamanova, D., Stegmaier, P., & Kel, A. E. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-225 · Cited by 27 · see citing works

Impaired repair of cyclobutane pyrimidine dimers in human keratinocytes deficient in p53 and p63

Ferguson, B. E., Li, H., Dong, T. K., Hsiao, J. L., & Oh, D. H. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm244 · Cited by 27 · see citing works

Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity

Kobaisi, F., Fayyad, N., Rezvani, H. R., Fayyad‐Kazan, M., Sulpice, E., Badran, B., Fayyad‐Kazan, H., Gidrol, X., & Rachidi, W. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4654206 · Cited by 27 · see citing works

The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair

Lin, P. S., McPherson, L. A., Chen, A. Y., Sage, J., & Ford, J. M. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.03.003 · Cited by 25 · see citing works

Influences of p53 deficiency on the apoptotic response, DNA damage removal and mutagenesis in UVB-exposed mouse skin

Ikehata, H., Okuyama, R., Ogawa, E., Nakamura, S., Usami, A., Mori, T., Tanaka, K., Aiba, S., & Ono, T. (2010) · Mutagenesis · doi:10.1093/mutage/geq019 · Cited by 26 · see citing works

Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts

Guillermo-Lagae, R., Deep, G., Ting, H., Agarwal, C., & Agarwal, R. (2015) · Oncotarget · doi:10.18632/oncotarget.5519 · Cited by 26 · see citing works

Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells

Schreck, I., Chudziak, D., Schneider, S., Seidel, A., Platt, K. L., Oesch, F., & Weiß, C. (2009) · Toxicology · doi:10.1016/j.tox.2009.02.006 · Cited by 26 · see citing works

Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: Impact on DNA repair and UV-induced skin cancer

Pines, A., Backendorf, C., Alekseev, S., Jansen, J. G., de Gruijl, F. R., Vrieling, H., & Mullenders, L. H. F. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.09.011 · Cited by 25 · see citing works

USF-1 Is Critical for Maintaining Genome Integrity in Response to UV-Induced DNA Photolesions

Baron, Y., Corre, S., Mouchet, N., Vaulont, S., Prince, S., & Galibert, M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002470 · Cited by 25 · see citing works

DDB2 is a novel AR interacting protein and mediates AR ubiquitination/degradation

Chang, S., Su, C.-H., Chen, H.-H., Huang, C.-W., Tsao, L.-P. B., Tsao, Y., & Chen, S. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.07.023 · Cited by 25 · see citing works

Post-Transcriptional Regulation of DNA Damage-Responsive Gene Expression

McKay, B. C. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5523 · Cited by 24 · see citing works

Macroenvironment-gene-microenvironment interactions in ultraviolet radiation-induced melanomagenesis

Mo, X., Preston, S., & Zaidi, M. R. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2019.03.008 · Cited by 25 · see citing works

Nucleotide Excision Repair and its Connection with Cancer and Ageing

Andressoo, J., Hoeijmakers, J. H. J., & de Waard, H. (2006) · Springer eBooks · doi:10.1007/1-4020-3764-3_3 · Cited by 24 · see citing works

Association of Transcription-Coupled Repair but Not Global Genome Repair with Ultraviolet-B-Induced Langerhans Cell Depletion and Local Immunosuppression

Kölgen, W., STEEG, H. V., van der Horst, G. T. J., Hoeijmakers, J. H. J., van Vloten, W. A., de Gruijl, F. R., & Garssen, J. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12476.x · Cited by 22 · see citing works

Deficient global genome repair of UV-induced cyclobutane pyrimidine dimers in terminally differentiated myocytes and proliferating fibroblasts from the rat heart

van der Wees, C. G. C., Vreeswijk, M. P. G., Persoon, M., van der Laarse, A., van Zeeland, A. A., & Mullenders, L. H. F. (2003) · DNA repair · doi:10.1016/j.dnarep.2003.06.001 · Cited by 21 · see citing works

Here Comes the Sun: Recognition of UV-Damaged DNA

Chu, G., & Yang, W. (2008) · Cell · doi:10.1016/j.cell.2008.12.015 · Cited by 20 · see citing works

The ubiquitin‐proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation

Vlachostergios, P. J., Patrikidou, A., Daliani, D., & Papandreou, C. N. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00825.x · Cited by 20 · see citing works

DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy

Dardare, J., Witz, A., Betz, M., François, A., Meras, M., Lamy, L., Lambert, A., Grandemange, S., Husson, M., Rouyer, M., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1052163 · Cited by 18 · see citing works

RAD9A promotes metastatic phenotypes through transcriptional regulation of anterior gradient 2 (AGR2)

Broustas, C. G., Hopkins, K. M., Panigrahi, S. K., Wang, L., Virk, R. K., & Lieberman, H. B. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy131 · Cited by 19 · see citing works

Tumor-prone phenotype of the DDB2-deficient mice

Yoon, T., Chakrabortty, A., Franks, R., Valli, T., Kiyokawa, H., & Raychaudhuri, P. (2005) · Oncogene · doi:10.1038/sj.onc.1208211 · Cited by 91 · see citing works

DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen

Itoh, T., Cado, D., Kamide, R., & Linn, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306551101 · Cited by 98 · see citing works

Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein

Tang, J. Y., & Chu, G. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00052-6 · Cited by 195 · see citing works

Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48 DDB2 and p53

Itoh, T., O’Shea, C. E., & Linn, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7540-7553.2003 · Cited by 73 · see citing works

Studies of the murine DDB1 and DDB2 genes

Zolezzi, F., & Linn, S. (2000) · Gene · doi:10.1016/s0378-1119(00)00022-6 · Cited by 29 · see citing works