PKR, a cognitive decline biomarker, can regulate translation via two consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients
Open accessAbstract
In Alzheimer’s disease (AD), the control of translation is dysregulated, precisely, two opposite pathways: double‐stranded RNA‐dependent protein kinase (PKR) is up‐regulated and mammalian target of rapamycin (mTOR) is down‐regulated. These biochemical alterations were found at the periphery in lymphocytes of AD patients and were significantly correlated with cognitive and memory test scores. However, the molecular crosslink between these two opposite signalling pathways remains unknown. The tumour suppressor p53 and Redd1 (regulated in development and DNA damage response) could be two downstream targets of active PKR to explain the breakdown of translation in AD patients. In this study, the protein and gene levels of p53 and Redd1 were assayed in lymphocytes of AD patients and in age‐matched controls by Western blotting and RT‐PCR. Furthermore, correlations were analysed with both the level of active PKR and the Mini Mental State Examination score (MMSE). The results show that the gene and protein levels of p53 and Redd1 were significantly increased about 1.5‐fold for both gene and Redd1 protein and 2.3‐fold for active p53 in AD lymphocytes compared to age‐matched controls. Furthermore, statistical correlations between proteins and genes suggest that active PKR could phosphorylate p53 which could induce the transcription of Redd1 gene. No correlations were found between MMSE scores and levels of p53 or Redd1, contrary to active PKR levels. PKR represents a cognitive decline biomarker able to dysregulate translation via two consecutive targets p53 and Redd1 in AD lymphocytes.
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PKR and eIF2α levels were negatively correlated with cognitive and memory test scores in AD patients, with higher PKR expression associated with lower cognitive test scores.
“These modifications were significantly correlated with cognitive and memory test scores performed in AD patients.”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [102]
PKR represents an initiator of deregulated translation via two consecutive targets p53 and Redd1 in AD lymphocytes.
“In addition, we reported that PKR represents an initiator of deregulated translation via two consecutive targets p53 and Redd1 in AD lymphocytes [102].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [102]
p53 and Redd1 at transcriptional and translational levels were not correlated with the MMSE scores.
“However, p53 and Redd1 at transcriptional and translational levels were not correlated with the MMSE scores [102].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [102]
In Alzheimer's disease, eIF2a and p53 are targets of PKR.
“In AD, eIF2a and p53 are targets of PKR [28, 30, 97, 102, 129].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [102]
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Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384 · see citing works
The coordinate regulation of the p53 and mTOR pathways in cells
Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235 · see citing works
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
Ray, S., Britschgi, M., Herbert, C., Takeda-Uchimura, Y., Boxer, A., Blennow, K., Friedman, L. F., Galasko, D. R., Jutel, M., Karydas, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1653 · Cited by 1,048 · see citing works
PKR; a sentinel kinase for cellular stress
Williams, B. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203127 · Cited by 820 · see citing works
The complexity of p53 stabilization and activation
Lavin, M. F., & Gueven, N. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401925 · Cited by 701 · see citing works
Ribosomal S6 Kinase Signaling and the Control of Translation
Dufner, A., & Thomas, G. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4683 · Cited by 676 · cited 1× · see citing works
“1824 also another translation effector protein: p70S6K (p70 ribosomal S6 kinase) [13].”
BackgroundThe Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function
Clemens, M. J., & Elia, A. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.503 · Cited by 605 · see citing works
The target of rapamycin (TOR) proteins
Raught, B., Gingras, A., & Sonenberg, N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121145898 · Cited by 603 · see citing works
Shoshani, T., Faerman, A., Mett, I., Zelin, E., Tenne, T., Gorodin, S., Moshel, Y., Elbaz, S., Budanov, A., Chajut, A., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2283-2293.2002 · Cited by 546 · see citing works
Ellisen, L. W., Ramsayer, K. D., Johannessen, C. M., Yang, A., Beppu, H., Minda, K., Oliner, J. D., McKeon, F., & Haber, D. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00706-2 · Cited by 474 · see citing works
Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1
Sofer, A., Lei, K., Johannessen, C. M., & Ellisen, L. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.5834-5845.2005 · Cited by 449 · see citing works
Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): Mechanism of action
Gil, J., & Estéban, M. (2000) · APOPTOSIS · doi:10.1023/a:1009664109241 · Cited by 369 · see citing works
Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease
Rojo, L. E., Fernández, J. A., Maccioni, A. A., Jimenez, J. M., & Maccioni, R. B. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.10.001 · Cited by 351 · see citing works
Culmsee, C., Zhu, X., Yu, Q., Chan, S. L., Camandola, S., Guo, Z., Greig, N. H., & Mattson, M. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00220.x · Cited by 317 · see citing works
Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease
de la Monte, S. M., Sohn, Y. K., & Wands, J. R. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00131-7 · Cited by 307 · see citing works
Chang, R. C. C., Wong, A. K. Y., Ng, H.-K., & Hugon, J. (2002) · NeuroReport · doi:10.1097/00001756-200212200-00011 · Cited by 289 · see citing works
Self-citationIntracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease
Ohyagi, Y., Asahara, H., Chui, D.-H., Tsuruta, Y., Sakae, N., Miyoshi, K., Yamada, T., Kikuchi, H., Taniwaki, T., Murai, H., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2637fje · Cited by 281 · see citing works
Wang, H., Kubica, N., Ellisen, L. W., Jefferson, L. S., & Kimball, S. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610023200 · Cited by 262 · see citing works
Corradetti, M. N., Inoki, K., & Guan, K.-L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c400557200 · Cited by 237 · see citing works
Targets and mechanisms for the regulation of translation in malignant transformation
Clemens, M. J. (2004) · Oncogene · doi:10.1038/sj.onc.1207544 · Cited by 222 · see citing works
Lafay‐Chebassier, C., Paccalin, M., Page, G., Barc‐Pain, S., Perault‐Pochat, M. C., Gil, R., Pradier, L., & Hugon, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03187.x · Cited by 211 · see citing works
Self-citationCuddihy, A. R., Hoi-Tao Wong, A., Wai Ning Tam, N., Li, S., & Koromilas, A. E. (1999) · Oncogene · doi:10.1038/sj.onc.1202620 · Cited by 203 · see citing works
Changes of p53 in the Brains of Patients with Alzheimer's Disease
Kitamura, Y., Shimohama, S., Kamoshima, W., Matsuoka, Y., Nomura, Y., & Taniguchi, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6301 · Cited by 185 · see citing works
Lombardi, V., Garcı́a, M., Rey, L., & Cacabelos, R. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00046-6 · Cited by 182 · see citing works
Presenilin-Dependent -Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease
Alves da Costa, C., Sunyach, C., Pardossi-Piquard, R., Sevalle, J., Vincent, B., Boyer, N., Kawarai, T., Girardot, N., St. George-Hyslop, P., & Checler, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0651-06.2006 · Cited by 168 · see citing works
p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells
Hooper, C., Meimaridou, E., Tavassoli, M., Melino, G., Lovestone, S., & Killick, R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.026 · Cited by 165 · see citing works
An RNA‐dependent protein kinase is involved in tunicamycin‐induced apoptosis and Alzheimer's disease
Onuki, R., Bando, Y., Suyama, E., Katayama, T., Kawasaki, H., Baba, T., Tohyama, M., & Taira, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600049 · Cited by 163 · see citing works
Oxidative Stress and Transcriptional Regulation in Alzheimer Disease
Shi, Q., & Gibson, G. E. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815721c3 · Cited by 156 · see citing works
Platelet amyloid precursor protein processing: A bio-marker for Alzheimer's disease
Tang, K., Hynan, L. S., Baskin, F., & Rosenberg, R. N. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.09.002 · Cited by 150 · see citing works
Growth Control Under Stress: mTOR Regulation through the REDD1-TSC Pathway
Ellisen, L. W. (2005) · Cell Cycle · doi:10.4161/cc.4.11.2139 · Cited by 131 · see citing works
Page, G., Rioux Bilan, A., Ingrand, S., Lafay-Chebassier, C., Pain, S., Perault Pochat, M. C., Bouras, C., Bayer, T., & Hugon, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.047 · Cited by 116 · see citing works
Self-citationBaltzis, D., Pluquet, O., Papadakis, A. I., Kazemi, S., Qu, L.-K., & Koromilas, A. E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704491200 · Cited by 107 · see citing works
Kimball, S. R., Do, A. N. D., Kutzler, L., Cavener, D. R., & Jefferson, L. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706643200 · Cited by 106 · see citing works
Uberti, D. L., Belloni, M., Grilli, M., Spano, P., & Memo, M. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00042.x · Cited by 104 · see citing works
Nair, V. D., McNaught, K. S. P., González‐Maeso, J., Sealfon, S. C., & Olanow, C. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603950200 · Cited by 97 · see citing works
T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease.
Shalit, F., Sredni, B., Brodie, C., Kott, E., & Huberman, M. (1995) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1995.1078 · Cited by 97 · see citing works
Paccalin, M., Pain-Barc, S., Pluchon, C., Paul, C., Besson, M.-N., Carret-Rebillat, A.-S., Rioux-Bilan, A., Gil, R., & Hugon, J. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000095562 · Cited by 96 · see citing works
Self-citationHorton, L. E., Bushell, M., Baus, D., Tilleray, V. J., Clemens, M. J., & Hensold, J. O. (2002) · Oncogene · doi:10.1038/sj.onc.1205662 · Cited by 92 · see citing works
Jin, H.-O., An, S., Lee, H.-C., Woo, S.-H., Seo, S.-K., Choe, T.-B., Yoo, D.-H., Lee, S.-B., Um, H.-D., & Lee, S.-J. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2006.12.014 · Cited by 91 · see citing works
Pannaccione, A., Boscia, F., Scorziello, A., Adornetto, A., Castaldo, P., Sirabella, R., Taglialatela, M., Renzo, G. F. D., & Annunziato, L. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.034868 · Cited by 83 · see citing works
Hippocampal Myc and p53 expression following transient global ischemia
McGahan, L., Hakim, A. M., & Robertson, G. S. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00038-2 · Cited by 83 · see citing works
Conformationally altered p53: a novel Alzheimer's disease marker?
Lanni, C., Racchi, M., Mazzini, G., Ranzenigo, A., Polotti, R., Sinforiani, E., Olivari, L., Barcikowska, M., Styczyńska, M., Kuźnicki, J., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002060 · Cited by 81 · see citing works
Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson’s disease
Nair, V. D. (2006) · APOPTOSIS · doi:10.1007/s10495-006-6316-3 · Cited by 80 · see citing works
Kim, J.-R., Lee, S.-R., Chung, H. J., Kim, S., Baek, S.-H., Kim, J. H., & Kim, Y.-S. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.53 · Cited by 78 · see citing works
Gilman, C. P., Chan, S. L., Guo, Z., Zhu, X., Greig, N. H., & Mattson, M. P. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:3:159 · Cited by 77 · see citing works
Puma and p53 Play Required Roles in Death Evoked in a Cellular Model of Parkinson Disease
Biswas, S. C., Ryu, E. J., Park, C., Malagelada, C., & Greene, L. A. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6877-5 · Cited by 73 · see citing works
PKR Activation in Neurodegenerative Disease
Peel, A. L. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.2.97 · Cited by 67 · see citing works
Uberti, D. L., Lanni, C., Carsana, T., Francisconi, S., Missale, C., Racchi, M., Govoni, S. M., & Memo, M. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.013 · Cited by 65 · see citing works
Jozwiak, J., Jozwiak, S., Grzela, T., & Lazarczyk, M. (2005) · NeuroMolecular Medicine · doi:10.1385/nmm:7:4:287 · Cited by 63 · see citing works
Apoptotic Gene Expression in Alzheimer's Disease Hippocampal Tissue
Sajan, F. D., Martiniuk, F. T., Marcus, D. L., Frey, W. H., Hite, R., Bordayo, E. Z., & Freedman, M. L. (2007) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507302447 · Cited by 57 · see citing works
Unfolded p53: A Potential Biomarker for Alzheimer's Disease
Lanni, C., Uberti, D. L., Racchi, M., Govoni, S. M., & Memo, M. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12109 · Cited by 55 · see citing works
Alzheimer's Disease-like Alterations in Peripheral Cells from Presenilin-1 Transgenic Mice
Eckert, A., Schindowski, K., Leutner, S., Luckhaus, C., Touchet, N., Czech, C., & Müller, W. E. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0378 · Cited by 55 · see citing works
Distinct destructive signal pathways of neuronal death in Alzheimer's disease
Shen, Y., He, P., Zhong, Z., McAllister, C. E., & Lindholm, K. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.10.002 · Cited by 53 · see citing works
The γ /η-Secretase-Derived APP Intracellular Domain Fragments Regulate p53
Checler, F., Sunyach, C., Pardossi‐Piquard, R., Sévalle, J., Vincent, B., Kawarai, T., Girardot, N., George‐Hyslop, P. S., & da Costa, C. A. (2007) · Current Alzheimer Research · doi:10.2174/156720507781788945 · Cited by 44 · see citing works
van Leeuwen, F. W., Hol, E. M., & Fischer, D. F. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s336 · Cited by 39 · see citing works
Schindowski, K., Kratzsch, T., Peters, J., Steiner, B., Leutner, S., Touchet, N., Maurer, K., Czech, C., Pradier, L., Frölich, L., et al. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:4:3:161 · Cited by 37 · see citing works
Uberti, D. L., Cenini, G., Olivari, L., Ferrari‐Toninelli, G., Porrello, E., Cecchi, C., Pensafini, A., Liguri, G., Govoni, S. M., Racchi, M., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04757.x · Cited by 31 · see citing works
Translational research? Ribosome integrity and a new p53 tumor suppressor checkpoint
Opferman, J. T., & Zambetti, G. P. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401923 · Cited by 27 · see citing works
Paccalin, M., Pain, S., Pluchon, C., Paul, C., Bazin, H., Gil, R., & Hugon, J. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.20.2428 · Cited by 22 · see citing works
Self-citationPeripheral p70S6k levels and emotional memory in patients with Alzheimer's disease
Paccalin, M., Khidir, F. A., Pain, S., Pluchon, C., Perrault-Pochat, M.-C., Gil, R., & Hugon, J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.07.053 · Cited by 16 · see citing works
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Flagged first, then by citations
1 of the 61 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Muvarak, N. E., Chowdhury, K., Xia, L., Robert, C., Choi, E. Y., Cai, Y., Bellani, M. A., Zou, Y. S., Singh, Z. N., Duong, V. H., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.09.002 · Cited by 201 · see citing works
Roles of AMP-activated Protein Kinase in Alzheimer’s Disease
Cai, Z., Yan, L., Li, K., Quazi, S. H., & Zhao, B. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8173-2 · Cited by 191 · see citing works
dsRNA-Dependent Protein Kinase PKR and its Role in Stress, Signaling and HCV Infection
Dabo, S., & MEURS, E. F. (2012) · Viruses · doi:10.3390/v4112598 · Cited by 171 · see citing works
Activation of mTOR: a culprit of Alzheimer’s disease?
Cai, Z., Zhou, Y., Xiao, M., Yan, L.-J., & He, W. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75717 · Cited by 161 · see citing works
Cai, Z.-Y., Zhao, B., Li, K.-S., Zhang, L.-Q., Li, C., Quazi, S. H., & Tan, Y. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23011 · Cited by 129 · see citing works
The impact of PKR activation: from neurodegeneration to cancer
Marchal, J. A., López, G., Perán, M., Comino, A., Delgado, J. R., Garcı́a-Garcı́a, J., Conde, V., Aranda, F. M., Rivas, C., Estéban, M., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-248294 · Cited by 104 · see citing works
Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory
Trinh, M. A., & Klann, E. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.04.013 · Cited by 95 · see citing works
PKR involvement in Alzheimer’s disease
Hugon, J., Mouton‐Liger, F., Dumurgier, J., & Paquet, C. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0308-0 · Cited by 86 · see citing works
Self-citationIs REDD1 a metabolic double agent? Lessons from physiology and pathology
Britto, F. A., Dumas, K., Giorgetti‐Peraldi, S., Ollendorff, V., & Favier, F. B. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00340.2020 · Cited by 70 · see citing works
The stress-responsive protein REDD1 and its pathophysiological functions
Kim, J., Kwon, Y., & Kim, Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01056-3 · Cited by 59 · see citing works
Canal, M., Romaní-Aumedes, J., Martín‐Flores, N., Pérez-Fernández, V., & Malagelada, C. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00313 · Cited by 57 · see citing works
Genome-wide analysis of H4K5 acetylation associated with fear memory in mice
Park, C., Rehrauer, H., & Mansuy, I. M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-539 · Cited by 56 · see citing works
Guan, L., Crasta, K., & Maier, A. B. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101634 · Cited by 54 · see citing works
PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
Morel, M., Couturier, J., Lafay‐Chebassier, C., Paccalin, M., & Page, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00849.x · Cited by 47 · see citing works
Self-citationJessica, P., Bongartz, H., Klepsch, O., Wundrack, N., Poli, V., Schaper, F., & Dittrich, A. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.04.004 · Cited by 46 · see citing works
RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer’s disease
Pérez‐Sisqués, L., Sancho‐Balsells, A., Solana‐Balaguer, J., Campoy‐Campos, G., Vives-Isern, M., Soler-Palazón, F., Anglada‐Huguet, M., López-Toledano, M. A., Mandelkow, E., Alberch, J., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03899-y · Cited by 44 · see citing works
Couturier, J., Morel, M., Pontcharraud, R., Gontier, V., Fauconneau, B., Paccalin, M., & Page, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041954 · Cited by 44 · see citing works
Self-citationRedd1 knockdown prevents doxorubicin-induced cardiac senescence
Huang, P., Bai, L., Liu, L., Fu, J. F., Wu, K., Liu, H., Liu, Y., Qi, B., & Qi, B. (2021) · Aging · doi:10.18632/aging.202972 · Cited by 42 · see citing works
Tan, M., Wang, S., Song, J., & Jia, J. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.093 · Cited by 37 · see citing works
RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death
Martín‐Flores, N., Romaní-Aumedes, J., Rué, L., Canal, M., Sanders, P., Straccia, M., Allen, N. D., Alberch, J., Canals, J. M., Pérez‐Navarro, E., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9166-6 · Cited by 26 · see citing works
Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?
Taga, M. F., Minett, T., Classey, J. D., Matthews, F. E., Brayne, C., Ince, P. G., Nicoll, J. A. R., Hugon, J., Boche, D., & CFAS, M. (2016) · Brain Pathology · doi:10.1111/bpa.12388 · Cited by 27 · see citing works
Self-citationCouturier, J., Page, G., Morel, M., Gontier, C., Lecron, J., Pontcharraud, R., Fauconneau, B., & Paccalin, M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100258 · Cited by 25 · see citing works
Self-citationWei, C., Li, S., Zhu, Y., Chen, W., Li, C., & Xu, R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.902092 · Cited by 15 · see citing works
Julian, A., Dugast, E., Ragot, S., Krolak‐Salmon, P., Berrut, G., DANTOINE, T. F., Hommet, C., Hanon, O., Page, G., & Paccalin, M. (2015) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0332-5 · Cited by 15 · see citing works
Self-citationRTP801 mediates transneuronal toxicity in culture via extracellular vesicles
Solana‐Balaguer, J., Martín‐Flores, N., Garcia‐Segura, P., Campoy‐Campos, G., Pérez‐Sisqués, L., Chicote‐González, A., Fernández‐Irigoyen, J., Santamaría, E., Pérez‐Navarro, E., Alberch, J., et al. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12378 · Cited by 8 · see citing works
The mTOR Signaling Pathway in Neurodegenerative Diseases
Francois, A., Vérité, J., Bilan, A. R., Janet, T., Calon, F., Fauconneau, B., Paccalin, M., & Page, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00011-6 · Cited by 8 · see citing works
Self-citationMice with type I interferon signaling deficiency are prone to epilepsy upon HSV-1 infection
Yang, W., Tang, C., Fan, D., Wang, Y., Wang, P., An, J., & Luan, G. (2024) · Virologica Sinica · doi:10.1016/j.virs.2024.01.002 · Cited by 6 · see citing works
Chicote‐González, A., Solana‐Balaguer, J., Garcia‐Segura, P., Campoy‐Campos, G., Pérez, I. P., Pérez‐Navarro, E., Rodríguez, M. J., Alberch, J., Giralt, A., Sòria, G., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70051 · Cited by 7 · see citing works
Gao, P., Sun, T., Qian, X., Liu, A. J., Li, S., Xia, Y., Zhang, J., & Ma, H. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04476-x · Cited by 4 · see citing works
Grainger, D., Kutzler, L., Rannels, S. L., & Kimball, S. R. (2016) · F1000Research · doi:10.12688/f1000research.7691.1 · Cited by 4 · see citing works
Solana‐Balaguer, J., Martín‐Flores, N., Garcia‐Segura, P., Campoy‐Campos, G., Pérez‐Sisqués, L., Chicote‐González, A., Fernández‐Irigoyen, J., Santamaría, E., Pérez‐Navarro, E., Alberch, J., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2736462/v1
- Authors
- Damjanac, M., Page, G., Ragot, S., Laborie, G., Gil, R., Hugon, J., & Paccalin, M.
- Affiliations
- Université de Poitiers (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Université Paris Cité (FR)
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2009-02-04
- Volume
- 13
- Issue
- 8b
- Pages
- 1823-1832
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC6529964
- OpenAlex
- W2070069944
- Cited by
- 31
- References
- 61
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre Hospitalier Universitaire de Poitiers
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- Alzheimer's disease, PKR, p53, REDD1, translational regulation, lymphocytes, mTOR, cognitive decline biomarkers, protein phosphorylation, double-stranded RNA-dependent protein kinase, Mini-Mental State Examination
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Base Sequence, Cognition Disorders, Female, Humans, Lymphocytes, Male, Transcription Factors, Protein Biosynthesis, Blotting, Western, Signal Transduction, Biomarkers, Tumor Suppressor Protein p53, DNA Primers, eIF-2 Kinase, Reverse Transcriptase Polymerase Chain Reaction
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