Mitochondrial dysfunction in Parkinson's disease

The protein kinase complement of the human genome

Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R. S., Sherer, T., MacKenzie, G. M., Garcia‐Osuna, M., Panov, A. V., & Greenamyre, J. T. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,770

Mitochondrial membrane permeabilization in cell death

Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,854

Signaling—2000 and Beyond

Hunter, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81688-8 · Cited by 2,586

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1769 · Cited by 1,570

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737556100 · Cited by 1,203

The origins of protein phosphorylation

Cohen, P. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e127 · Cited by 1,183

Abnormalities of the electron transport chain in idiopathic parkinson's disease

Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

Cui, L., Jeong, H., Borovecki, F., Parkhurst, C. N., Tanese, N., & Krainc, D. (2006) · Cell · doi:10.1016/j.cell.2006.09.015 · Cited by 1,012

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

Palacino, J. J., Sagi, D., Goldberg, M. S., Krauss, S., Motz, C., Wacker, M., Klose, J., & Shen, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401135200 · Cited by 995

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

Goldberg, M. S., Fleming, S. M., Palacino, J. J., Cepeda, C., Lam, H. A., Bhatnagar, A., Meloni, E. G., Wu, N., Ackerson, L. C., Klapstein, G. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308947200 · Cited by 913

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

Kraytsberg, Y., Kudryavtseva, E., McKee, A. C., Geula, C., Kowall, N. W., & Khrapko, K. (2006) · Nature Genetics · doi:10.1038/ng1778 · Cited by 896

Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease

Schapira, A. H. V., Mann, V. M., Cooper, J. A. D., Dexter, D. T., Daniel, S. E., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb05809.x · Cited by 673

Origin and functional consequences of the complex I defect in Parkinson's disease

Swerdlow, R. H., Parks, J. K., Miller, S. W., Davis, R. E., Tuttle, J. B., Trimmer, P. A., Sheehan, J. P., Bennett, J. P., & Parker, W. D. (1996) · Annals of Neurology · doi:10.1002/ana.410400417 · Cited by 638

Mitochondrial disease

Schapira, A. H. V. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68970-8 · Cited by 617

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

Strauss, K. M., Martins, L. M., Plun‐Favreau, H., Marx, F. P., Kautzmann, S., Berg, D., Gasser, T., Wszolek, Z., Müller, T. H., Bornemann, A., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi215 · Cited by 569

Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study

Luoma, P., Melberg, A., Rinne, J. O., Kaukonen, J. A., Nupponen, N. N., Chalmers, R. M., Oldfors, A., Rautakorpi, I., Peltonen, L., Majamaa, K., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16983-3 · Cited by 548

Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease

van der Walt, J. M., Nicodemus, K. K., Martin, E. R., Scott, W. K., NANCE, M. A., Watts, R. L., Hubble, J. P., Haines, J. L., Koller, W. C., Lyons, K. E., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/373937 · Cited by 537

Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons.

Levitt, P., Pintar, J. E., & Breakefield, X. O. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.20.6385 · Cited by 527

PINK1 mutations are associated with sporadic early‐onset parkinsonism

Valente, E. M., Salvi, S., Ialongo, T., Marongiu, R., Elia, A. E., Caputo, V., Romito, L. M., Albanese, A., Dallapiccola, B., & Bentivoglio, A. R. (2004) · Annals of Neurology · doi:10.1002/ana.20256 · Cited by 506

Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

Shoffner, J. M., Brown, M. D., Torroni, A., Lott, M. T., Cabell, M. F., Mirra, S. S., Beal, M. F., Yang, C.-C., Gearing, M., Salvo, R., et al. (1993) · Genomics · doi:10.1006/geno.1993.1299 · Cited by 450

Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease

Haas, R. H., Nasirian, F., Nakano, K., Ward, D., Pay, M., Hill, R., & Shults, C. W. (1995) · Annals of Neurology · doi:10.1002/ana.410370604 · Cited by 435

Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

Zhang, L., Shimoji, M., Thomas, B., Moore, D. J., Yu, S.-W., Marupudi, N. I., Torp, R., Torgner, I. A., Ottersen, O. P., Dawson, T. M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi211 · Cited by 425

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death

Darios, F. D. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg044 · Cited by 407

Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

Martins, L. M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., Teismann, P., Abuin, A., Grau, E., Geppert, M., Livi, G. P., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9848-9862.2004 · Cited by 395

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

Unoki, M., & Nakamura, Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204608 · Cited by 382

Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Beilina, A. G., van der Brug, M., Ahmad, R., Kesavapany, S., Miller, D. W., Petsko, G. A., & Cookson, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500617102 · Cited by 382

Mitochondrial respiratory chain disorders I: mitochondrial DNA defects

Leonard, J., & Schapira, A. H. V. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05225-3 · Cited by 365

Platelet mitochondria function in Parkinson's disease

Krige, D., Carroll, M. T., Cooper, J. A. D., MARSDEN, C. D., & Schapira, A. H. V. (1992) · Annals of Neurology · doi:10.1002/ana.410320612 · Cited by 358

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

Yokota, T., Sugawara, K., Ito, K., Takahashi, R., Ariga, H., & Mizusawa, H. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.056 · Cited by 356

Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

Betarbet, R. S., Canet-Aviles, R., Sherer, T., Mastroberardino, P. G., McLendon, C., Kim, J.-H., Lund, S. A., Na, H. M., Taylor, G., Bence, N., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.003 · Cited by 344

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

Ikebe, S.-I., Tanaka, M., Ohno, K., Sato, W., Hattori, K., Kondo, T., Mizuno, Y., & Ozawa, T. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90497-b · Cited by 341

Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

Höglinger, G. U., Féger, J., Prigent, A., Michel, P. P., Parain, K., Champy, P., Ruberg, M., Oertel, W. H., & Hirsch, É. C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01533.x · Cited by 331

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP

Javitch, J. A., & Snyder, S. H. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90740-4 · Cited by 317

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

Gu, M., Cooper, J. A. D., Taanman, J., & Schapira, A. H. V. (1998) · Annals of Neurology · doi:10.1002/ana.410440207 · Cited by 313

Glutathione peroxidase activity in Parkinson's disease brain

Kish, S. J., Morito, C. L. H., & Hornykiewicz, O. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90078-3 · Cited by 303

Parkinsonism Induced By 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine (MPTP): Implications for Treatment and the Pathogenesis of Parkinson’s Disease

Langston, J. W., & Ballard, P. (1984) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100046333 · Cited by 281

Novel PINK1 mutations in early‐onset parkinsonism

Hatano, Y., Li, Y., Sato, K., Asakawa, S., Yamamura, Y., Tomiyama, H., Yoshino, H., Asahina, M., Kobayashi, S. S., Hassin‐Baer, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20251 · Cited by 280

Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes

Chiba, K., Trevor, A. J., & Castagnoli, N. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91071-x · Cited by 269

Parkin enhances mitochondrial biogenesis in proliferating cells

Kuroda, Y., Mitsui, T., Kunishige, M., Shono, M., Akaike, M., Azuma, H., & Matsumoto, T. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl006 · Cited by 268

Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe

Champy, P., Höglinger, G. U., Féger, J., Gleye, C., Hocquemiller, R., Laurens, A., Guérineau, V., Laprévôte, O., Medja, F., Lombès, A., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02138.x · Cited by 254

Complex I, iron, and ferritin in Parkinson's disease substantia nigra

Mann, V. M., Cooper, J. M., Daniel, S. E., Srai, K., Jenner, P., Marsden, C. D., & Schapira, A. H. V. (1994) · Annals of Neurology · doi:10.1002/ana.410360612 · Cited by 251

The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis

Xu, J., Zhong, N., Wang, H., Elias, J. E., Kim, C. Y., Woldman, I., Pifl, C., Gygi, S. P., Geula, C., & Yankner, B. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi134 · Cited by 250

L166P Mutant DJ-1, Causative for Recessive Parkinson's Disease, Is Degraded through the Ubiquitin-Proteasome System

Miller, D. W., Ahmad, R., Hague, S., Baptista, M. J., Canet-Aviles, R., McLendon, C., Carter, D. M., Zhu, P., Stadler, J., Chandran, J. S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304272200 · Cited by 242

Analysis of Steady-state Protein Phosphorylation in Mitochondria Using a Novel Fluorescent Phosphosensor Dye

Schulenberg, B., Aggeler, R. J., Beechem, J., Capaldi, R., & Patton, W. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300189200 · Cited by 230

Novel PINK1 mutations in early-onset parkinsonism

波田野, 靖. (2005) · Medical Entomology and Zoology · Cited by 227

Proteome Analysis Reveals Phosphorylation of ATP Synthase β-Subunit in Human Skeletal Muscle and Proteins with Potential Roles in Type 2 Diabetes

Højlund, K., Wrzesinski, K., Larsen, P. M., Fey, S. J., Roepstorff, P., Handberg, A., Dela, F., Vinten, J., McCormack, J. G., Reynet, C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212881200 · Cited by 221

Evidence for mitochondrial dysfunction in Parkinson's disease—a critical appraisal

Schapira, A. H. V. (1994) · Movement Disorders · doi:10.1002/mds.870090202 · Cited by 218

Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects

Leonard, J. V., & Schapira, A. H. V. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05226-5 · Cited by 197

Progression after chronic manganese exposure

Huang, C., Lu, C.-S., Chu, N.-S., Hochberg, F., Lilienfeld, D. E., Olanow, W. C., & Calne, D. B. (1993) · Neurology · doi:10.1212/wnl.43.8.1479 · Cited by 197

Mitochondrial involvement in Parkinson's disease

Orth, M. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00124-3 · Cited by 188

Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

Pyle, A., Foltynie, T., Tiangyou, W., Lambert, C., Keers, S. M., Allcock, L. M., Davison, J., Lewis, S. J. G., Perry, R. H., Barker, R. A., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20417 · Cited by 176

The Phosphorylation of Subunits of Complex I from Bovine Heart Mitochondria

Chen, R., Fearnley, I. M., Peak‐Chew, S., & Walker, J. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402710200 · Cited by 168

Mitochondrial function and parental sex effect in Huntington's disease

Mann, V. M. (1990) · The Lancet · doi:10.1016/0140-6736(90)92242-a · Cited by 146

Characterization of dynamic and steady‐state protein phosphorylation using a fluorescent phosphoprotein gel stain and mass spectrometry

Schulenberg, B., Goodman, T., Aggeler, R. J., Capaldi, R., & Patton, W. F. (2004) · Electrophoresis · doi:10.1002/elps.200406007 · Cited by 146

Point mutations of mitochondrial genome in Parkinson's disease

Ikebe, S.-I., Tanaka, M., & Ozawa, T. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00209-w · Cited by 144

Identification of 14 new phosphoproteins involved in important plant mitochondrial processes

Bykova, N. V., Egsgaard, H., & Møller, I. M. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00250-3 · Cited by 127

Homozygous PINK1 C‐terminus mutation causing early‐onset parkinsonism

Rohé, C. F., Montagna, P., Breedveld, G. J., Cortelli, P., Oostra, B. A., & Bonifati, V. (2004) · Annals of Neurology · doi:10.1002/ana.20247 · Cited by 126

Distinct clustering of point mutations in mitochondrial DNA among patients with mitochondrial encephalomyopathies and with Parkinson's disease

Ozawa, T., Tanaka, M., Ino, H., Ohno, K., Sano, T., Wada, Y., Yoneda, M., Tanno, Y., Miyatake, T., Tanaka, T., et al. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80276-1 · Cited by 121

A Pure Parkinsonian Syndrome Following Acute Carbon Monoxide Intoxication

Klawans, H. L., Stein, R. W., Tanner, C. M., & Goetz, C. G. (1982) · Archives of Neurology · doi:10.1001/archneur.1982.00510170044012 · Cited by 114

Mitochondria and Dopamine

Shen, J., & Cookson, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.012 · Cited by 114

Mitochondrial DNA analysis in Parkinson's disease

Schapira, A. H. V., Holt, I. J., Sweeney, M. G., Harding, A. E., Jenner, P. G., & MARSDEN, C. D. (1990) · Movement Disorders · doi:10.1002/mds.870050406 · Cited by 112

Mitochondrial ND5 mutations in idiopathic Parkinson’s disease

Parker, W. D., & Parks, J. K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.093 · Cited by 108

mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish

Ross, O. A. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00266-8 · Cited by 107

Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases

Singer, T. P., Salach, J. I., Castagnoli, N., & Trevor, A. (1986) · Biochemical Journal · doi:10.1042/bj2350785 · Cited by 92

A Novel Polymerase γ Mutation in a Family With Ophthalmoplegia, Neuropathy, and Parkinsonism

Mancuso, M., Filosto, M., Oh, S. J., & DiMauro, S. (2004) · Archives of Neurology · doi:10.1001/archneur.61.11.1777 · Cited by 92

Generalized mitochondrial dysfunction in Parkinson's disease detected by magnetic resonance spectroscopy of muscle

Penn, A. M. W., Roberts, T., Hodder, J., Allen, P. S., Zhu, G., & Martin, W. R. W. (1995) · Neurology · doi:10.1212/wnl.45.11.2097 · Cited by 80

Sequence Analysis of the Entire Mitochondrial Genome in Parkinson's Disease

Vives-Bauzá, C., Andreu, A. L., Manfredi, G., Beal, M. F., Janetzky, B., Gruenewald, T. H., & Lin, M. T. S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6388 · Cited by 73

Melanin Affinity of 1‐Methyl‐4‐phenyl‐1,2,5,6‐tetrahydropyridine, an Inducer of Chronic Parkinsonism in Humans

Lydén, A., Bondesson, U., LARSSON, B. S., & Lindquist, N. G. (1983) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1983.tb03446.x · Cited by 67

Mitochondrial respiratory chain function in multiple system atrophy

Gu, M., Gash, M. T., Cooper, J. A. D., Wenning, G. K., Daniel, S. E., Quinn, N. P., MARSDEN, C. D., & Schapira, A. H. V. (1997) · Movement Disorders · doi:10.1002/mds.870120323 · Cited by 66

A 31P magnetic resonance spectroscopy study of mitochondrial function in skeletal muscle of patients with Parkinson's disease

Taylor, D. J., Krige, D., Barnes, P. R. J., Kemp, G. J., Carroll, M. T., Mann, V. M., Cooper, J. A. D., MARSDEN, C. D., & Schapira, A. H. V. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90245-3 · Cited by 64

Mitochondrial DNA in Postmortem Brain from Patients with Parkinson's Disease

Lestienne, P. P., Nelson, I. P., Riederer, P. F., Reichmann, H., & Jellinger, K. A. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02087.x · Cited by 50

Characterization of the Binding of N‐Methyl‐4‐Phenylpyridine, the Toxic Metabolite of the Parkinsonian Neurotoxin N‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine, to Neuromelanin

D’Amato, R. J., Benham, D. F., & Snyder, S. H. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb04142.x · Cited by 50

Focused proteomics: Monoclonal antibody‐based isolation of the oxidative phosphorylation machinery and detection of phosphoproteins using a fluorescent phosphoprotein gel stain

Murray, J. M., Marusich, M. F., Capaldi, R., & Aggeler, R. J. (2004) · Electrophoresis · doi:10.1002/elps.200406006 · Cited by 45

Novel mitochondrial DNA mutations in Parkinson's disease

Richter, G., Sonnenschein, A., Grünewald, T. G. P., Reichmann, H., & Janetzky, B. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200060 · Cited by 42

Carbon-monoxide Encephalopathy

Gordon, E. B. (1965) · BMJ · doi:10.1136/bmj.1.5444.1232 · Cited by 42

Analysis of the trinucleotide CAG repeat from the DNA polymerase γ gene (POLG) in patients with Parkinson's disease

Taanman, J., & Schapira, A. H. V. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.023 · Cited by 41

L ‐Dihydroxyphenylalanine and complex I deficiency in Parkinson's disease brain

Cooper, J. A. D., Daniel, S. E., MARSDEN, C. D., & Schapira, A. H. V. (1995) · Movement Disorders · doi:10.1002/mds.870100311 · Cited by 37

Suppression of MPTP-induced dopaminergic neurotoxicity in mice by nomifensine andl-DOPA

Melamed, E., Rosenthal, J., Globus, M., Cohen, O. S., & Uzzan, A. (1985) · Brain Research · doi:10.1016/0006-8993(85)91146-1 · Cited by 32

PARKINSONISM FOLLOWING CARBON MONOXID POISONING

GRINKER, R. R. (1926) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-192607000-00003 · Cited by 32

Production and disposition of 1‐methyl‐4‐phenylpyridinium in primary cultures of mouse astrocytes

Monte, D. A. D., Wu, E. Y., Irwin, I., DeLanney, L. E., & Langston, J. W. (1992) · Glia · doi:10.1002/glia.440050108 · Cited by 28

Absence of the Mitochondrial A7237T Mutation in Parkinson′s Disease

Lucking, C. B., Kösel, S., Mehraein, P., & Graeber, M. B. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1868 · Cited by 21

Parkinson disease: analysis of mitochondrial DNA in monozygotic twins.

Kösel, S., Grasbon-Frodl, E. M., Hagenah, J., Graeber, M. B., & Vieregge, P. (2000) · PubMed · doi:10.1007/pl00022973 · Cited by 20

Parkinson disease: analysis of mitochondrial DNA in monozygotic twins

Kösel, S., Grasbon-Frodl, E. M., Hagenah, J. M., Graeber, M. B., & Vieregge, P. (2000) · Neurogenetics · doi:10.1007/s100489900085 · Cited by 17

Protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism by the catecholamine uptake inhibitor nomifensine: Behavioral analysis in monkeys with partial striatal dopamine depletions

Schultz, W., Scarnati, E., Sundström, E., & Romo, R. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90044-4 · Cited by 16

Airplane dynamics: Engine thrust, engine braking, and wing lift

Pizzo, J. (1988) · The Physics Teacher · doi:10.1119/1.2342452 · Cited by 2

Increased activity of surviving locus ceruleus neurons in Alzheimer's disease

Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1

Untitled work

(2000) · doi:10.1002/1531-8249(200011)48:5

Parkinson disease

Poewe, W., Seppi, K., Tanner, C. M., Halliday, G. M., Brundin, P., Volkmann, J., Schrag, A.-E., & Lang, A. E. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.13 · Cited by 5,415

Selective neuronal vulnerability in Parkinson disease

Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.178 · Cited by 1,116

The PINK1/Parkin pathway regulates mitochondrial morphology

Poole, A. C., Thomas, R. E., Andrews, L. A., McBride, H. M., Whitworth, A. J., & Pallanck, L. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709336105 · Cited by 885

Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells

Kuznetsov, A. V., Veksler, V., Gellerich, F. N., Saks, V. A., Margreiter, R., & Kunz, W. S. (2008) · Nature Protocols · doi:10.1038/nprot.2008.61 · Cited by 839

Etiology and pathogenesis of Parkinson's disease

Schapira, A. H. V., & Jenner, P. G. (2011) · Movement Disorders · doi:10.1002/mds.23732 · Cited by 703

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

Schapira, A. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70327-7 · Cited by 883

Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis

Banerjee, R., Starkov, A. A., Beal, M. F., & Thomas, B. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.11.007 · Cited by 262

Mitochondrial Contribution to Parkinson's Disease Pathogenesis

Schapira, A. H. V., & Gegg, M. E. (2011) · Parkinson s Disease · doi:10.4061/2011/159160 · Cited by 155

doi:10.4061/2011/159160 Review Article Mitochondrial Contribution to Parkinson’s Disease Pathogenesis

Schapira, A. H. V., & Gegg, M. E. (2013)

Current perspective of mitochondrial biology in Parkinson's disease

Kaidery, N. A., & Thomas, B. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.03.001 · Cited by 95