Cited by 251Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismIron Metabolism and Disorders

Complex I, iron, and ferritin in Parkinson's disease substantia nigra

Mann, V. M., Cooper, J. M., Daniel, S. E., Srai, K., Jenner, P., Marsden, C. D., Schapira, A. H. V.·1994·Annals of Neurology

Abstract

Elevated iron levels, enhanced oxidative damage, and complex I deficiency have been identified in the substantia nigra of Parkinson's disease patients. To understand the interrelationship of these abnormalities, we analyzed iron levels, ferritin levels, and complex I activity in the substantia nigra of patients with Parkinson's disease. Total iron levels were increased significantly, ferritin levels were unchanged, and complex I activities were decreased significantly in the substantia nigra samples. The failure of ferritin levels to increase with elevated iron concentrations suggests that the amount of reactive iron may increase in the substantia nigra of Parkinson's disease patients. There was no correlation between the iron levels and complex I activity or the iron-ferritin ratio and complex I activity in the substantia nigra samples.

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Crossref · 10.1002/ana.410360612

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17 of 17 references verified0 citation errors · 0 not checkable

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  • Increases of iron and a decrease of ferritin in the substantia nigra are indicative of high iron loading of ferritin.

    “Increases of iron and a decrease of ferritin in the substantia nigra101,116–119 are indicative of high iron loading of ferritin.120”

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Authors
Mann, V. M., Cooper, J. M., Daniel, S. E., Srai, K., Jenner, P., Marsden, C. D., & Schapira, A. H. V.
Affiliations
  • The Royal Free Hospital (GB)
  • King's College London (GB)
Corresponding author
Schapira, A. H. V.
Venue
Annals of Neurology
Publisher
Wiley
Published
1994-12
Volume
36
Issue
6
Pages
876-881
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2090098521
Cited by
251
References
17
Citations by year
2026: 3 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 9 · 2018: 6 · 2017: 16 · 2016: 7 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 9
FWCI
7.09
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
Parkinson's disease, substantia nigra, complex I, iron, ferritin, oxidative damage, reactive iron, mitochondrial complex I deficiency
MeSH terms
Aged, Aged, 80 and over, Brain Chemistry, Ferritins, Humans, Iron, Parkinson Disease, Substantia Nigra, Zinc, NAD(P)H Dehydrogenase (Quinone)

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