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Cited by 173Phytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative StressExercise and Physiological Responses

Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers

Pedersen, CB, Kyle, J, Jenkinson, AMcE, Gardner, PT, McPhail, DB, Duthie, GG·2000·European Journal of Clinical Nutrition
DOI 10.1038/sj.ejcn.1600972
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Abstract

Objective To assess whether consumption of 500 ml of blueberry juice or cranberry juice by healthy female subjects increased plasma phenolic content and antioxidant capacity.Design Latin square arrangement to eliminate ordering effects. After an overnight fast, nine volunteers consumed 500 ml of blueberry juice, cranberry juice or a sucrose solution (control); each volunteer participated on three occasions one week apart, consuming one of the beverages each time. Blood samples were obtained by venipuncture at intervals up to four hours after consumption of the juices. Urine samples were also obtained four hours after consuming the juice.Results Consumption of cranberry juice resulted in a significant increase in the ability of plasma to reduce potassium nitrosodisulphonate and Fe(III)-2,4, 6-Tri(2-pyridyl)-s-triazine, these measures of antioxidant capacity attaining a maximum after 60-120 min. This corresponded to a 30% increase in vitamin C and a small but significant increase in total phenols in plasma. Consumption of blueberry juice had no such effects.Conclusion The increase in plasma antioxidant capacity following consumption of cranberry juice could mainly be accounted for by an increase in vitamin C rather than phenolics. This also accounted for the lack of an effect of the phenolic-rich but vitamin C-low blueberry juice.Sponsorship Funded by the Scottish Executive Rural Affairs Department and the Danish Government.

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Crossref · 10.1038/sj.ejcn.1600972

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25 of 25 references verified0 citation errors · 0 not checkable

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  • Benefits of berry intervention were seen in healthy subjects and in those with existing metabolic risk factors.

    “Benefits were seen in healthy subjects and in those with existing metabolic risk factors.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [35]

  • The most significant outcomes of clinical studies show an increase in plasma or urinary antioxidant capacity, a decrease in LDL oxidation and lipid peroxidation, a decrease in plasma glucose or total cholesterol, and an increase in HDL-cholesterol following berry intervention.

    “The most significant outcomes of these clinical studies show an increase in plasma or urinary antioxidant capacity, a decrease in LDL oxidation and lipid peroxidation, a decrease in plasma glucose or total cholesterol, and an increase in HDL-cholesterol following berry intervention.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [35]

  • Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (fresh, juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism.

    “Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (either fresh, or as juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [35]

  • Of 20 trials reviewed, nine involved measures of post-prandial status, in which berry consumption was shown to significantly decrease postprandial oxidative stress, especially lipid peroxidation.

    “Of 20 trials reviewed, nine involved measures of post-prandial status, in which berry consumption was shown to significantly decrease postprandial oxidative stress, especially lipid peroxidation.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [35]

  • Clinical studies in healthy humans, subjects with diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, or in smokers, show a significant decrease in CVD risk factors, especially glucose, lipids and lipid peroxidation, and systolic blood pressure, following berry intervention.

    “Clinical studies in healthy humans, subjects with diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, or in smokers, show a significant decrease in CVD risk factors, especially glucose, lipids and lipid peroxidation, and systolic blood pressure, following berry intervention.”

    From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [35]

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Authors
Pedersen, C., Kyle, J., Jenkinson, A., Gardner, P., McPhail, D., & Duthie, G.
Affiliations
  • Technical University of Denmark (DK)
  • University of Aberdeen (GB)
Corresponding author
Duthie, GG
ORCID
Kyle, J
Venue
European Journal of Clinical Nutrition
Publisher
Springer Science and Business Media LLC
Published
2000-05-01
Volume
54
Issue
5
Pages
405-408
ISSN
  • 0954-3007 (ISSN-L)
  • 1476-5640
DOI
10.1038/sj.ejcn.1600972
OpenAlex
W2149044585
Cited by
173
References
25
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 11 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 5 · 2014: 12 · 2013: 15 · 2012: 6
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
blueberry juice, cranberry juice, plasma antioxidant capacity, phenolic compounds, vitamin C, dietary antioxidants, fruit juice consumption, healthy women, urinary excretion
MeSH terms
Adult, Antioxidants, Ascorbic Acid, Beverages, Chelating Agents, Female, Ferric Compounds, Fruit, Humans, Kinetics, Nitroso Compounds, Oxidation-Reduction, Phenols, Triazines

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