The long-term effect of dietary advice in men with coronary disease: follow-up of the Diet and Reinfarction trial (DART)
Abstract
Objective To assess the long-term effect of dietary advice on diet and mortality after a randomised trial of men with a recent history of myocardial infarction.Design Questionnaire survey and mortality follow-up after a trial of dietary advice.Setting Twenty-one hospitals in south Wales and south-west England.Subjects Former participants in the Diet and Reinfarction Trial.Main outcome measures Current fish intake and cereal fibre intake. All-cause mortality, stroke mortality and coronary mortality.Results By February 2000, after 21147 person years of follow-up, 1083 (53%) of the men had died. Completed questionnaires were obtained from 879 (85%) of the 1030 men alive at the beginning of 1999. Relative increases in fish and fibre intake were still present at 10 y but were much smaller. The early reduction in all-cause mortality observed in those given fish advice (unadjusted hazard 0.70 (95% CI 0.54, 0.92)) was followed by an increased risk over the next 3 y (unadjusted hazard 1.31 (95% CI 1.01, 1.70). Fat and fibre advice had no clear effect on coronary or all-cause mortality. The risk of stroke death was increased in the fat advice group-the overall unadjusted hazard was 2.03 (95% CI 1.14, 3.63).Conclusions In this follow-up of a trial of intensive dietary advice following myocardial infarction we did not observe any substantial long-term survival benefit. Further trials of fish and fibre advice are feasible and necessary to clarify the role of these foods in coronary disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Follow-up of DART-1 at 5 years showed increased rates of CVD in the fish/fish oil group that did not persist through 10 years.
“Follow-up of DART-1 at 5y also showed increased rates of CVD in the fish/fish oil group that did not persist through the 10y assessment (202).”
From Food Consumption and its Impact on Cardiovascular Disease: Importance of Solutions Focused on the Globalized Food System (2015) · cites this paper as [202]
Cites
Burr, M. L., Gilbert, J. F., Holliday, R. M., Elwood, P. C., Fehily, A. M., Rogers, S., Sweetnam, P. M., & Deadman, N. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90828-3 · Cited by 2,610 · see citing works
Lack of Effect of a High-Fiber Cereal Supplement on the Recurrence of Colorectal Adenomas
Alberts, D. S., Martı́nez, M. E., Roe, D. J., Guillen-Rodriguez, J., Marshall, J. R., van Leeuwen, J. B., Reid, M. E., Ritenbaugh, C., Vargas, P. A., Bhattacharyya, A., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200004203421602 · Cited by 823 · see citing works
Kinsella, J. E., Lokesh, B. R., & Stone, R. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.1.1 · Cited by 717 · see citing works
Bonithon‐Kopp, C., Kronborg, O., Giacosa, A., Räth, U., & Faivre, J. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02813-0 · Cited by 475 · see citing works
Dietary fat intake and prevention of cardiovascular disease: systematic review
Hooper, L., Summerbell, C., Higgins, J., Thompson, R. L., Capps, N., Smith, G., Riemersma, R., & Ebrahim, S. (2001) · British medical journal · doi:10.1136/bmj.322.7289.757 · Cited by 409 · see citing works
Marckmann, P., & Grønbæk, M. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600832 · Cited by 280 · see citing works
Inverse Association of Dietary Fat With Development of Ischemic Stroke in Men
Gillman, M. W. (1997) · JAMA · doi:10.1001/jama.1997.03550240035030 · Cited by 199 · see citing works
Prevention of ischemia‐induced cardiac Sudden death by n−3 polyunsaturated fatty acids in dogs
Billman, G. E., Kang, J. X., & Leaf, A. (1997) · Lipids · doi:10.1007/s11745-997-0149-2 · Cited by 199 · see citing works
The Relationship of Dietary Fat and Cholesterol to Mortality in 10 Years: The Honolulu Heart Program
McGee, D., REED, D. M., Stemmerman, G. N., Rhoads, G., Yano, K., & Feinleib, M. (1985) · International Journal of Epidemiology · doi:10.1093/ije/14.1.97 · Cited by 76 · see citing works
Anderson, J. W., & Hanna, T. J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.307 · Cited by 72 · see citing works
Diet and reinfarction trial (DART): design, recruitment, and compliance
Burr, M. L., Fehily, M., Rogers, S., WELSBY, E., KING, S., & SANDHAM, S. (1989) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a059528 · Cited by 70 · see citing works
FEHILY, A. M., Vaughan‐Williams, E., Shiels, K. M., Williams, A. H., Horner, M., Bingham, G., Burr, M. L., & Holliday, R. M. (1989) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.1989.tb00026.x · Cited by 38 · see citing works
Changing patterns of coronary heart disease, stroke, and nutrient intake in Japan
Kimura, N. (1983) · Preventive Medicine · doi:10.1016/0091-7435(83)90198-6 · Cited by 36 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
Abdelhamid, A. S., Brown, T. J., Brainard, J. S., Biswas, P., Thorpe, G., Moore, H. J., Deane, K. H., AlAbdulghafoor, F. K., Summerbell, C. D., Worthington, H. V., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003177.pub3 · Cited by 631 · see citing works
Anand, S. S., Hawkes, C., de Souza, R. J., Mente, A., Dehghan, M., Nugent, R., Zulyniak, M. A., Weis, T., Bernstein, A. M., Krauss, R. M., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.07.050 · Cited by 507 · see citing works
“Follow-up of the DART-1 trial at 5 years also showed increased rates of CVD in the fish/fish oil group that did not persist through the 10-year assessment (202).”
BackgroundNutritional aspects of cereals
McKevith, B. (2004) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2004.00418.x · Cited by 491 · see citing works
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
Abdelhamid, A. S., Brown, T. J., Brainard, J. S., Biswas, P., Thorpe, G., Moore, H. J., Deane, K. H., AlAbdulghafoor, F. K., Summerbell, C. D., Worthington, H. V., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003177.pub4 · Cited by 409 · see citing works
Dietary lignans: physiology and potential for cardiovascular disease risk reduction
Peterson, J. J., Dwyer, J. T., Adlercreutz, H., Scalbert, A., Jacques, P. F., & McCullough, M. L. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00319.x · Cited by 376 · see citing works
The western diet and lifestyle and diseases of civilization
Carrera-Bastos, P., Fontes, O'Keefe, Lindeberg, & Cordain (2011) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s16919 · Cited by 342 · see citing works
“after adjustment for possible confounding factors (such as medication and health state).(260) Another class of antinutrients that may increase intestinal”
BackgroundCardiovascular benefits of omega-3 fatty acids
Vonschacky, C., & Harris, W. S. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.08.019 · Cited by 335 · see citing works
Flight, I. H. K., & Clifton, P. M. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602435 · Cited by 308 · see citing works
“Ness et al. (2002) followed up a secondary prevention, randomized controlled trial in South Wales, UK, conducted by Burr et al. (1989).”
Dietary fatty acids and cardiovascular disease: An epidemiological approach
Erkkilä, A. T., de Mello, V. D., Risérus, U., & Laaksonen, D. E. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.01.004 · Cited by 304 · see citing works
Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease
Abdelhamid, A. S., Brown, T. J., Brainard, J. S., Biswas, P., Thorpe, G. C., Moore, H. J., Deane, K. H., Summerbell, C. D., Worthington, H. V., Song, F., et al. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003177.pub5 · Cited by 295 · see citing works
Bartrina, J. A., & Pérez‐Rodrigo, C. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512001444 · Cited by 261 · see citing works
“The observational evidence that a strong inverse relationship is present between n-3 PUFAs or fish intake and risk of CHD is convincing; three well-designed randomized controlled trials (GISSI((69)), DART I((87)) and JELIS((88)) reported significant benefits for n-3 PUFAs inpatientswith establishedCHD.”
BackgroundOmega-3 Fatty Acids for Cardioprotection
Lee, J. H., O’Keefe, J. H., Lavie, C. J., Marchioli, R., & Harris, W. S. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.3.324 · Cited by 249 · see citing works
Meta-Analysis of observational studies on fish intake and coronary heart disease
Whelton, S. P., He, J., Whelton, P. K., & Muntner, P. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.01.038 · Cited by 242 · see citing works
EFSA Dietetic Products, N. (2014) · EFSA Journal · doi:10.2903/j.efsa.2014.3761 · Cited by 217 · see citing works
“…particularly when conducted in patients which were not yet under pharmacological therapy for secondary prevention according to current guidelines (Chen et al., 2011); and with data from the only intervention study with fish as dietary intervention for secondary prevention (Ness et al., 2002).”
Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease
Abdelhamid, A. S., Martin, N., Bridges, C., Brainard, J. S., Wang, X., Brown, T. J., Hanson, S., Jimoh, F. O., Ajabnoor, S. M., Deane, K. H., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012345.pub2 · Cited by 187 · see citing works
Colussi, G., Catena, C., Novello, M., Bertin, N., & Sechi, L. A. (2017) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.07.011 · Cited by 182 · see citing works
Reynolds, A. N., Akerman, A. P., Kumar, S., Pham, H. T. D., Coffey, S., & Mann, J. I. (2022) · BMC Medicine · doi:10.1186/s12916-022-02328-x · Cited by 192 · see citing works
Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk
Estruch, R., Martínez‐González, M. Á., Corella, D., Basora, J., Ruíz-Gutiérrez, V., Covas, M., Fiol, M., Gómez‐Gracia, E., López‐Sabater, M. C., Escoda, R., et al. (2009) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2008.082214 · Cited by 175 · see citing works
Fats and fatty acid requirements for adults
Elmadfa, I., & Kornsteiner, M. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000228996 · Cited by 161 · see citing works
Usefulness of Omega-3 Fatty Acids and the Prevention of Coronary Heart Disease
Harper, C. R., & Jacobson, T. A. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.07.071 · Cited by 160 · see citing works
DeFilippis, A. P., & Sperling, L. S. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.03.051 · Cited by 147 · see citing works
“This lack of sustained benefit may be caused by the substantial reduction in the difference in fish and fish oil intake between the intervention and placebo groups observed during the trial.(27) The Indian Experiment of Infarct Survival 4 trial(28)”
BackgroundResultPolyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease
Abdelhamid, A. S., Martin, N., Bridges, C., Brainard, J. S., Wang, X., Brown, T. J., Hanson, S., Jimoh, F. O., Ajabnoor, S. M., Deane, K. H., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012345.pub3 · Cited by 147 · see citing works
Integrating Complementary Medicine Into Cardiovascular Medicine
Vogel, J. H. K., Bolling, S. F., Costello, R. B., Guarneri, E. M., Krucoff, M. W., Longhurst, J. C., Olshansky, B., Pelletier, K. R., Tracy, C. M., Vogel, R. A., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.05.031 · Cited by 138 · see citing works
Marine and farmed fish in the Polish market: Comparison of the nutritional value
Usydus, Z., Szlinder-Richert, J., Adamczyk, M., & Szatkowska, U. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.10.080 · Cited by 128 · see citing works
“In addition to reducing the risk of some cardiovascular diseases (Calo et al., 2005; Ness et al., 2002; Rice, 2004) and cancers (Norat et al.”
BackgroundYang, Y., Zhao, L.-G., Wu, Q.-J., Ma, X., & Xiang, Y.-B. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwu257 · Cited by 119 · see citing works
Tuttle, K. R., Shuler, L. A., Packard, D. P., Milton, J. E., Daratha, K. B., Bibus, D. M., & Short, R. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.01.038 · Cited by 126 · see citing works
Hamley, S. (2017) · Nutrix Journal · doi:10.1186/s12937-017-0254-5 · Cited by 121 · see citing works
“The experimental groups of the adequately controlled trials were instructed to avoid “fried foods, pastry and cakes (except plain sponge)” (RCOT) [21]; “other margarines, cooking fat, other oils and most biscuits and cakes” (MRCT) [23]; and to limit other sources of fat “(e.g. cakes, pastries, biscuits, meat pies and…”
BackgroundInfluentialAre dietary recommendations for the use of fish oils sustainable?
Jenkins, D. J. A., Sievenpiper, J. L., Pauly, D., Sumaila, U. R., Kendall, C. W. C., & Mowat, F. M. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.081274 · Cited by 115 · see citing works
“Reinfarction Trial (DART), was reversed at 3 years in a posttrial follow-up.(19) The reversal may have been due to lower compliance with the dietary regimen over time.”
BackgroundMann, J. I. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602940 · Cited by 112 · see citing works
“However, the study was underpowered and the degree of compliance is uncertain (Ness et al., 2002).”
BackgroundOmega 3 fatty acids for prevention and treatment of cardiovascular disease
Hooper, L., Harrison, R. A., Summerbell, C. D., Moore, H., Worthington, H. V., Ness, A., Capps, N., Davey Smith, G., Riemersma, R., & Ebrahim, S. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003177.pub2 · Cited by 264 · see citing works
Marine n-3 polyunsaturated fatty acids and coronary heart disease
Schmidt, E. B., Arnesen, H., Caterina, R. D., Rasmussen, L. H., & Kristensen, S. D. (2004) · Thrombosis Research · doi:10.1016/j.thromres.2004.09.006 · Cited by 106 · see citing works
The role of omega-3 fatty acids in cardiovascular disease
von Schacky, C. (2003) · Current Atherosclerosis Reports · doi:10.1007/s11883-003-0086-y · Cited by 104 · see citing works
Effects of omega-3 fatty acids on cardiovascular disease.
Wang, C., Chung, M. C., Lichtenstein, A. H., Balk, E. M., Kupelnick, B., DeVine, D., Lawrence, A., & Lau, J. (2004) · PubMed Central · Cited by 96 · see citing works
Breakfast Cereals and Risk of Heart Failure in the Physicians' Health Study I
Djoussé, L., & Gaziano, J. M. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.19.2080 · Cited by 86 · see citing works
Fatty acids and cardiovascular disease
Lecerf, J. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00194.x · Cited by 86 · see citing works
Welch, A. A., Bingham, S. A., Ive, J., Friesen, M. D., Wareham, N. J., Ríboli, E., & Khaw, K. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.6.1330 · Cited by 83 · see citing works
Mechanick, J. I., Brett, E. M., Chausmer, A. B., Dickey, R. A., Wallach, S., Bergman, D. A., Garber, J. R., Hamilton, C. R., Handelsman, Y., Holdy, K. E., et al. (2003) · Endocrine Practice · doi:10.4158/ep.9.5.417 · Cited by 73 · see citing works
n−3 Fatty acids, cardiac arrhythmia and fatal coronary heart disease
Brouwer, I. A., Geelen, A., & Katan, M. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.02.004 · Cited by 69 · see citing works
The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype
Anil, E. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005307 · Cited by 65 · see citing works
“However, a 10-year follow-up study (Ness et al. 2002) has demonstrated that the effects of the initial dietary changes that were imposed did not result in continued survival benefit, although this follow up has been criticised for the lack of assessment of dietary habits during the follow-up period.”
Costabile, G., Vetrani, C., Bozzetto, L., Giacco, R., Bresciani, L., Rio, D. D., Vitale, M., Pepa, G. D., Brighenti, F., Riccardi, G., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab188 · Cited by 67 · see citing works
Food and Western Disease Health and Nutrition from an Evolutionary Perspective
Lindeberg, S. (2009) · Cited by 64 · see citing works
Woodside, J. V., & Kromhout, D. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005465 · Cited by 63 · see citing works
“However, after longer-term follow-up this protective effect was not found to persist (Ness et al. 2002), although this lack of effect may have been related to only small sustained increases in fish intake in the fish group.”
BackgroundMyint, P., Welch, A., Bingham, S., Luben, R., Wareham, N., Day, N., & Khaw, K. (2006) · Public Health Nutrition · doi:10.1017/phn2006942 · Cited by 57 · see citing works
Secondary prevention of CHD in UK men: the Diet and Reinfarction Trial and its sequel
Burr, M. L. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005241 · Cited by 53 · see citing works
“No benefit could be attributed to advice to eat more cereal fibre despite good compliance; indeed, the fibre-advice group had higher mortality in the first 2 years, of borderline statistical significance (Ness et al. 2002).”
BackgroundLi, S., Flint, A., Pai, J. K., Forman, J. P., Hu, F. B., Willett, W. C., Rexrode, K. M., Mukamal, K. J., & Rimm, E. B. (2014) · BMJ · doi:10.1136/bmj.g2659 · Cited by 52 · see citing works
Antiarrhythmic effects of n-3 fatty acids: evidence from human studies
Geelen, A., Brouwer, I. A., Zock, P. L., & Katan, M. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200402000-00006 · Cited by 47 · see citing works
Crowe, F. L., Key, T. J. A., Appleby, P. N., Overvad, K., Schmidt, E. B., Egeberg, R., Tjønneland, A. M., Kaaks, R., Teucher, B., Boeing, H., et al. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.51 · Cited by 45 · see citing works
Do vegetarians have to eat fish for optimal cardiovascular protection?
Mangat, I. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.26736i · Cited by 44 · see citing works
Omega-3 fatty acids and cardiovascular disease risk: do we understand the relationship?
Vrablı́k, M., Prusíková, M., Šnejdrlová, M., & Zlatohlávek, L. (2009) · Physiological Research · doi:10.33549/physiolres.931860 · Cited by 43 · see citing works
Fish and cardiovascular health
Undeland, I., Ellegård, L., & Sandberg, A. (2004) · Scandinavian Journal of Nutrition · doi:10.1080/11026480410000427 · Cited by 43 · see citing works
“Based on eight prospective cohort studies, the risk for stroke was either reduced (53 /55, 57) or unaffected (41, 46, 55, 58) by increased fish intake.”
BackgroundMarine n−3 polyunsaturated fatty acids and coronary heart disease
Schmidt, E. B., Arnesen, H., Christensen, J., Rasmussen, L. H., Kristensen, S., & Caterina, R. D. (2004) · Thrombosis Research · doi:10.1016/j.thromres.2004.09.007 · Cited by 43 · see citing works
Diets and clinical coronary events: the truth is out there.
Yancy, W., Westman, E., French, P. A., & Califf, R. (2003) · Circulation · doi:10.1161/01.cir.0000049205.35749.00 · Cited by 47 · see citing works
Dietary Fibers and Cardiometabolic Diseases
Riccioni, G., Sblendorio, V., Gemello, E., Di Bello, B., Scotti, L., Cusenza, S., & D’Orazio, N. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13021524 · Cited by 41 · see citing works
“[65] followed up a secondary prevention, randomized controlled trial in South Wales, UK, conducted by Burr et al.”
BackgroundFunctional Properties of Fish and Fish Products: A Review
Usydus, Z., & Szlinder-Richert, J. (2011) · International Journal of Food Properties · doi:10.1080/10942912.2010.503356 · Cited by 41 · see citing works
“The survey showed a 29% reduction in all the causes of death.[33] The best benefits were observed in the prevention of lethal myocardial infarction.”
BackgroundOmega‐3 fatty acids in coronary heart disease: Recent updates and future perspectives
Ajith, T. A., & Jayakumar, T. G. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13034 · Cited by 41 · see citing works
The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway
Aquila, G., Marracino, L., Martino, V., Calabria, D., Campo, G. C., Caliceti, C., & Rizzo, P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5470470 · Cited by 41 · see citing works
“Several clinical trials have been conducted to assess the cardiovascular benefits of EPA and DHA treatments (i.e., diet and reinfarction trial (DART) [50], Japan EPA Liquid Intervention Study (JELIS) [51], and Gruppo Italiano per lo Studio della Sopravvivenza nell’infarto (GISSI) [52]).”
Is Fish Oil Good or Bad for Heart Disease? Two Trials with Apparently Conflicting Results
Burr, M. L., Dunstan, F., & George, C. H. (2005) · The Journal of Membrane Biology · doi:10.1007/s00232-005-0784-1 · Cited by 34 · see citing works
“Long-term survival was not greatly improved in the group originally given fish advice, either because of a diminishing difference in fish intake between the two groups, or because the benefits occurred specifically during the immediate post-infarct period (Ness et al., 2002).”
BackgroundThe Puzzle of Dietary Fat Intake and Risk of Ischemic Stroke: A Brief Review of Epidemiologic Data
He, K., Xu, Y., & Horn, L. V. (2007) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2006.11.010 · Cited by 30 · see citing works
Fernandez-Jarne, E. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.2.474 · Cited by 107 · see citing works
Ness, A., Ashfield-Watt, P. A. L., WHITING, J. M., Smith, G. D., Hughes, J., & Burr, M. L. (2004) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2004.00506.x · Cited by 25 · see citing works
Exploring newer cardioprotective strategies: ω-3 fatty acids in perspective
Tremoli, E., Tufano, A., Russolillo, A., Lupoli, R., Minno, G. D., & Minno, M. N. D. D. (2010) · Thrombosis and Haemostasis · doi:10.1160/th10-01-0008 · Cited by 24 · see citing works
“GISSI HF trial (17, 18) Study description: Long-term administration (3.”
BackgroundRadakovich, K., Heilbrun, L. K., Venkatranamamoorthy, R., Lababidi, S., Klurfeld, D. M., & Djurić, Z. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5501_6 · Cited by 22 · see citing works
“Follow-up studies of cardiovascular disease in men have shown persistence of dietary changes as much as 10 yr after dietary intervention (4,5).”
BackgroundDietary advice for people with schizophrenia
Pearsall, R., Praveen, K. T., Pelosi, A. J., & Geddes, J. R. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009547.pub2 · Cited by 22 · see citing works
Randomized Trials of Secondary Prevention Programs in Coronary Artery Disease: A Systematic Review
Clark, A. M., McAlister, F. A., Hartling, L., & Vandermeer, B. (2005) · Cited by 18 · see citing works
Olstad, D. L., Beall, R. F., Spackman, E., Dunn, S., Lipscombe, L. L., Williams, K., Oster, R. T., Scott, S., Zimmermann, G. L., McBrien, K., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-050006 · Cited by 15 · see citing works
Noce, A., Marrone, G., Daniele, F. D., Lauro, M. D., Zaitseva, A. P., Jones, G. W., LORENZO, A. D., & Daniele, N. D. (2020) · Nutrients · doi:10.3390/nu12092519 · Cited by 15 · see citing works
“Successively, the Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto (GISSI) [50,51] and Diet And Reinfarction Trial (DART) [48] studies have demonstrated a reduction in CV risk following treatment with ω-3 PUFAs, representing the milestones of clinical recommendations forω-3 PUFA treatment in cardiopathi…”
BackgroundMarckmann, P. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.1.1 · Cited by 15 · see citing works
The Hot Air and Cold Facts of Dietary Fibre
Coffin, C. S., & Shaffer, E. A. (2006) · Canadian Journal of Gastroenterology · doi:10.1155/2006/390953 · Cited by 14 · see citing works
Cardioprotective role of omega-3 polyunsaturated fatty acids
Varga, Z. (2008) · Orvosi Hetilap · doi:10.1556/oh.2008.28296 · Cited by 11 · see citing works
Poisson, acides gras oméga 3 et risque cardiovasculaire : données épidémiologiques
Lecerf, J. (2004) · Cahiers de Nutrition et de Diététique · doi:10.1016/s0007-9960(04)94447-1 · Cited by 11 · see citing works
Dietary interventions in cardiac rehabilitation – The gap between guidelines and clinical practice
Kristensen, M. B., Dieperink, K. B., Rossau, H. K., Egholm, C. L., Viggers, L., Bertelsen, B. M., & Zwisler, A. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.05.007 · Cited by 10 · see citing works
Fish oils – adjuvant therapy in chronic heart failure?
Witte, K. K., & Clark, A. L. (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000136728.27524.f5 · Cited by 10 · see citing works
Jenkins, D. J. A., Sievenpiper, J. L., Chiavaroli, L., Mirrahimi, A., & Kendall, C. W. C. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720002 · Cited by 9 · see citing works
“The initial promise at 2 years of the earlier Diet and Reinfarction Trial (DART) study was reversed at 5 years (3 years postintervention) and neutral at 10-year follow-up [12,13].”
BackgroundComparison in nutritional quality between wild and cultured cuttlefish Sepia pharaonis
Wen, J., Chen, D., & Zeng, L. (2014) · Chinese Journal of Oceanology and Limnology · doi:10.1007/s00343-014-3083-9 · Cited by 9 · see citing works
Nutritional Quality and Safety of the Important Commercial CuttlefishSepia lycidas
Wen, J., Chen, D., Zeng, L., Wang, Y., Li, T., & Lai, J. (2013) · Journal of Aquatic Food Product Technology · doi:10.1080/10498850.2012.760025 · Cited by 8 · see citing works
“In addition to reducing the risk of some cardiovascular diseases (Ness et al., 2002) and cancers (Norat et al.”
BackgroundThe Use of Fish Oil Supplements in Clinical Practice: A Review
Guilliams, T. G. (2005) · Cited by 7 · see citing works
Effects of Omega‐3 Fatty Acids on Cardiovascular Disease: Summary
Wang, C., Chung, M. K., Lichtenstein, A. H., Balk, E. M., Kupelnick, B., DeVine, D., Lawrence, A., & Lau, J. T. F. (2004) · Cited by 7 · see citing works
The nutritional value of selected species of fish from lake and fish farm of north-eastern Poland
Woźniak, M., Poczyczyński, P., & Kozłowski, K. (2013) · Polish Journal of Natural Science · Cited by 6 · see citing works
Kohansal, E., Askarinejad, A., MozafaryBazargany, M., Sabahizadeh, A., Pakmehr, S., & Haghjoo, M. (2024) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2024.101397 · Cited by 5 · see citing works
“In DART-1989, fish oil reduced mortality in men recovering from myocardial infarction (MI) [33], while in DART-2002, fish oil capsules were associated with an increased risk of cardiac and sudden death in men with stable angina [34].”
BackgroundResultGielen, S., Mezzani, A., Hambrecht, R., & Saner, H. E. (2009) · doi:10.1093/med/9780199566990.003.025 · Cited by 5 · see citing works
Awulachew, M. T. (2024) · Food science and nutrition · doi:10.5772/intechopen.114157 · Cited by 5 · see citing works
Lifestyle management: preventing Type 2 diabetes and cardiovascular complications
Stiegler, R. S., Zimmet, P., Cameron, A. J., & Shaw, J. E. (2009) · Therapy · doi:10.2217/thy.09.37 · Cited by 4 · see citing works
Fish, omega-3 fatty acids and heart disease
Brouwer, I. A. (2008) · Elsevier eBooks · doi:10.1533/9781845694586.2.165 · Cited by 4 · see citing works
Acides gras et maladies cardiovasculaires
Lecerf, J.-M. (2008) · Sciences des Aliments · doi:10.3166/sda.28.53-67 · Cited by 3 · see citing works
EVIDENCIAS SOBRE LAS GRASAS EN LA DIETA Y ENFERMEDAD CORONARIA
Gallegos, N. A. G., Ruiz, C. J., & Nájar, M. E. M. (2009) · RESPYN Revista Salud Pública y Nutrición · Cited by 2 · see citing works
Commentary: Is olive oil a key ingredient in the Mediterranean recipe for health?
Ness, A. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.2.481 · Cited by 2 · see citing works
Wood, N. (2011) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v1i10.116 · Cited by 1 · see citing works
Friedman, E. (2014) · Foreign Affairs · Cited by 1 · see citing works
Postgenomic Properties of Natural Micronutrients
Sharanova, N. É., & Vasil'ev, A. V. (2018) · Bulletin of experimental biology and medicine · doi:10.1007/s10517-018-4298-0
Externalities from grain consumption: a survey
Metzgar, M. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.634789 · Cited by 1 · see citing works
“For example, one large random controlled trial showed no change in cardiovascular mortality from increased grain consumption (Ness et al. 2002).”
BackgroundDietary advice for schizophrenia
Pearsall, R., Pelosi, A. J., & Geddes, J. R. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009547 · Cited by 1 · see citing works
Saller, R., Römer-Lüthi, C., Müller, M., Brignoli, R., Noll, G., & Meier, R. F. (2006) · Schweizerische Zeitschrift für Ganzheitsmedizin / Swiss Journal of Integrative Medicine · doi:10.1159/000282057 · Cited by 1 · see citing works
Omega-3 Fatty Acids and Cardiovascular Disease
Lee, J. H. (2013) · Journal of Marine Science Research & Development · doi:10.4172/2155-9910.s1-001 · Cited by 1 · see citing works
Lipfert, F. W., Doe - Office Of Science, & Sullivan, T. M. (2006) · doi:10.2172/899613 · Cited by 1 · see citing works
“(1989) was based on a difference of only 36 deaths, while 8 years later, the mortality increment in this cohort had decreased to 23 deaths and become non-significant (Ness et al., 2002).”
BackgroundInfluentialHamazaki, T. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602009 · Cited by 1 · see citing works
Olstad, D. L., Beall, R. F., Spackman, E., Dunn, S., Lipscombe, L. L., Williams, K., Oster, R. T., Scott, S., Zimmermann, G. L., McBrien, K., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-180761/v1 · Cited by 1 · see citing works
Fish and cardiovascular health
Undeland, I., Ellegård, L., & Sandberg, A. (2004) · Food & Nutrition Research · doi:10.3402/fnr.v48i3.1638 · Cited by 1 · see citing works
N-3 fatty acids from fish and markers of cardiac arrhythmia
Geelen, A. (2004) · doi:10.18174/121589
[Epidemiology without moderation].
Lindeberg, S. (2008) · PubMed
Versari, D., Daghini, E., Salvetti, G., & Salvetti, A. (2008) · High Blood Pressure & Cardiovascular Prevention · doi:10.2165/0151642-200815040-00002
- Authors
- Ness, A., Hughes, J., Elwood, P., Whitley, E., Smith, G., & Burr, M.
- Affiliations
- University Hospital Llandough (GB)
- University of Bristol (GB)
- ORCID
- Whitley, E
- Venue
- European Journal of Clinical Nutrition
- Published
- 2002-05-24
- Volume
- 56
- Issue
- 6
- Pages
- 512-518
- ISSN
- 0954-3007 (ISSN-L)
- 1476-5640
- OpenAlex
- W2101683206
- Cited by
- 111
- References
- 14
- Citations by year
- 2026: 1 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 7 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 6
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- dietary recommendations, myocardial infarction, coronary disease, fish consumption, all-cause mortality, stroke mortality, coronary heart disease mortality, long-term follow-up, men
- MeSH terms
- Animals, Edible Grain, Coronary Disease, Diet Surveys, Dietary Fats, Dietary Fiber, Fishes, Follow-Up Studies, Humans, Male, Myocardial Infarction, Patient Compliance, Surveys and Questionnaires, Recurrence, Risk Factors, Survival Analysis, Seafood, Stroke
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
