Dietary Fibers and Cardiometabolic Diseases

Riccioni, Graziano; Sblendorio, Valeriana; Gemello, Eugenio; Di Bello, Barbara; Scotti, Luca; Cusenza, Salvatore; D’Orazio, Nicolantonio

doi:10.3390/ijms13021524

Cited by 41Food composition and propertiesNutritional Studies and DietGut microbiota and health

Dietary Fibers and Cardiometabolic Diseases

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Riccioni, Graziano, Sblendorio, Valeriana, Gemello, Eugenio, Di Bello, Barbara, Scotti, Luca, Cusenza, Salvatore, D’Orazio, Nicolantonio·2012·International Journal of Molecular Sciences

DOI 10.3390/ijms13021524PMC PMC3291975

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Abstract

The high prevalence of cardiovascular disease (CVD) is largely attributable to the contemporary lifestyle that is often sedentary and includes a diet high in saturated fats and sugars and low ingestion of polyunsaturated fatty acids (PUFAs), fruit, vegetables, and fiber. Experimental data from both animals and humans suggest an association between increased dietary fiber (DF) intakes and improved plasma lipid profiles, including reduced low density lipoprotein cholesterol (LDL-C) concentrations. These observations underline that the intake of DF may protect against heart disease and stroke.

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Chia seeds include viscous and soluble fibers that reduce cholesterol levels by affecting lipid metabolism in the liver.
“Chia seeds include viscous and soluble fibers that have been shown to reduce cholesterol levels by affecting the metabolism of lipids in the liver [51].”
From Effects of chia seed (Salvia hispanica L.) supplementation on cardiometabolic health in overweight subjects: a systematic review and meta-analysis of RCTs (2024) · cites this paper as [51]
Section 3.5 states that soluble fiber lowers cholesterol, and Section 3.1 discusses possible liver-related mechanisms, including reduced hepatic cholesterol synthesis. The paper does not identify chia seeds as a source of these fibers or show that chia seeds produce this effect; it also presents the hepatic mechanisms as hypotheses rather than established explanations. (LLM, conf=0.86)
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[67]Jacobs D.R. Jr Pereira M.A. Meyer K.A. Kushi L.H. Fiber from whole grains, but not refined grains, is inversely associated with all-cause mortality in older women: The Iowa women’s health study J. Am. Coll. Nutr. 2000 19 326S 330S 10875605
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www.mdpi.com/journal/ijms Dietary Fibers and Cardiometabolic Diseases
Riccioni, G., Sblendorio, V., Gemello, E., Bello, B. D., Scotti, L., & Cusenza, S. (2012)
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Authors: Riccioni, G., Sblendorio, V., Gemello, E., Di Bello, B., Scotti, L., Cusenza, S., & D’Orazio, N.
Affiliations: University of Chieti-Pescara (IT)
University of Modena and Reggio Emilia (IT)
Human Nutrition, Department of Biochemical Sciences, University “G. D’Annunzio” Chieti, 66013, Italy
Corresponding author: Riccioni, Graziano
ORCID: Gemello, Eugenio
Scotti, Luca
D’Orazio, Nicolantonio
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2012-02-02
Volume: 13
Issue: 2
Pages: 1524-1540
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms13021524
PMC: PMC3291975
OpenAlex: W2073565044
Cited by: 41
References: 85
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
FWCI: 3.57
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: dietary fiber, cardiometabolic disease, cardiovascular disease, plasma lipid profile, LDL cholesterol, stroke, sedentary lifestyle, saturated fat, polyunsaturated fatty acids, fruit and vegetable intake
MeSH terms: Animals, Dietary Carbohydrates, Dietary Fats, Dietary Fiber, Heart Diseases, Humans, Cholesterol, LDL, Stroke

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