Cited by 36Fatty Acid Research and HealthGestational Diabetes Research and ManagementLipid metabolism and biosynthesis

Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women

Thomas, B, Ghebremeskel, K, Lowy, C, Min, Y, Crawford, M A·2004·European Journal of Clinical Nutrition

Abstract

Objective The polyunsaturated fatty acids, arachidonic (AA) and docosahexaenoic (DHA), are vital structural and functional components of the neural, vascular and visual systems. There is increased demand for these fatty acids during pregnancy. Diabetes impairs the synthesis of both AA and DHA. We have investigated the possibility that pregnancy-induced diabetes compromises the levels of plasma AA and DHA in newly diagnosed expectant mothers. Design Cross-sectional study. Setting London, UK. Subjects and methods Venous blood was obtained from 44 women with gestational diabetes mellitus (GDM) and from the same number of nondiabetics, during the third trimester. Fatty acid composition of plasma choline phosphoglycerides (CPG), triglycerides (TG) and cholesterol esters (CE) was analysed. Results The GDM women had higher levels of AA (20:4n-6; P<0.0001) and AA/linoleic acid ratio (20:4n-6/18:2n-6; P<0.01) in the CPG, and linoleic acid (LA; P<0.0001), total n-6 (P<0.01), DHA (P<0.05) and n-3 metabolites (P<0.05) in TG compared to their nondiabetic counterparts. Similarly, AA (P<0.0001), osbond acid (22:5n-6; P<0.05), total n-6 metabolites (P<0.0001), AA/LA (P<0.0001) and n-6 metabolites/LA (P<0.01) were higher in the CE of the GDM women. There was no difference in the levels of DHA in CPG and CE between the two groups (P>0.05). Conclusions The results of this study do not provide evidence that the activity of delta-6 or delta-5 desaturases, which are vital for the synthesis of AA and DHA, is compromised by pregnancy-induced diabetes. However, since the samples were taken at diagnosis, it is conceivable that the duration of the diabetes was too short to have a discernable adverse effect on the levels of AA and DHA in plasma lipids.

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Crossref · 10.1038/sj.ejcn.1601996

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Authors
Thomas, B., Ghebremeskel, K., Lowy, C., Min, Y., & Crawford, M. A.
Affiliations
  • London Metropolitan University (GB)
  • St Thomas' Hospital (GB)
Corresponding author
Thomas, B
Venue
European Journal of Clinical Nutrition
Published
2004-05-19
Volume
58
Issue
11
Pages
1492-1497
ISSN
  • 0954-3007 (ISSN-L)
  • 1476-5640
OpenAlex
W1963687284
Cited by
36
References
34
Citations by year
2026: 1 · 2025: 1 · 2023: 3 · 2021: 2 · 2020: 5 · 2019: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
0.90
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • March of Dimes Foundation
  • Diabetes UK
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
gestational diabetes mellitus, arachidonic acid, docosahexaenoic acid, polyunsaturated fatty acids, plasma fatty acid composition, choline phospholipids, triglycerides, cholesterol esters, linoleic acid, n-6/n-3 ratio, delta-6 desaturase, delta-5 desaturase, fatty acid synthesis, pregnancy
MeSH terms
Adult, Age Factors, Cholesterol Esters, Cross-Sectional Studies, Docosahexaenoic Acids, Fasting, Female, Humans, Phosphatidylcholines, Pregnancy, Pregnancy Trimester, Third, Triglycerides, Body Mass Index, Case-Control Studies, Diabetes, Gestational, Arachidonic Acid

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