Consumption of isoflavone-rich soy protein does not alter homocysteine or markers of inflammation in postmenopausal women

Greany, K A; Nettleton, J A; Wangen, K E; Thomas, W; Kurzer, M S

doi:10.1038/sj.ejcn.1602885

Cited by 51Phytoestrogen effects and researchFolate and B Vitamins ResearchNutritional Studies and Diet

Consumption of isoflavone-rich soy protein does not alter homocysteine or markers of inflammation in postmenopausal women

Greany, K A, Nettleton, J A, Wangen, K E, Thomas, W, Kurzer, M S·2008·European Journal of Clinical Nutrition

DOI 10.1038/sj.ejcn.1602885

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Abstract

Background/objective To investigate the effect of soy protein containing isoflavones on homocysteine (Hcy), C-reactive protein (CRP), soluble E-selectin (sE-selectin), soluble vascular adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1).Subject/methods In a randomized crossover design, 34 postmenopausal women consumed soy protein isolate (26+/-5 g protein containing 44+/-8 mg isoflavones per day) or milk protein isolate (26+/-5 g protein per day) for 6 weeks each. Fasting blood samples were collected at the end of each diet period and end points analyzed by enzyme-linked immunosorbent assay.Results Concentrations of Hcy, CRP, sE-selectin, sVCAM-1 and sICAM-1 were not different between soy and milk diet treatments. Results did not differ by equol production status or by baseline lipid concentration. Adjustment for intake of folate and methionine did not alter the Hcy results.Conclusions These data suggest that decreasing vascular inflammation and Hcy concentration are not likely mechanisms by which soy consumption reduces coronary heart disease risk.

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Authors: Greany, K. A., Nettleton, J. A., Wangen, K. E., Thomas, W., & Kurzer, M. S.
Affiliations: University of Minnesota (US)
Corresponding author: Kurzer, M S
ORCID: Thomas, W
Kurzer, M S
Venue: European Journal of Clinical Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2007-09-05
Volume: 62
Issue: 12
Pages: 1419-1425
ISSN: 0954-3007 (ISSN-L)
1476-5640
DOI: 10.1038/sj.ejcn.1602885
OpenAlex: W2009548637
Cited by: 51
References: 48
Citations by year: 2025: 4 · 2023: 1 · 2022: 4 · 2021: 7 · 2020: 6 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 4
FWCI: 1.42
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: European Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Defense
University of Minnesota
Jiangsu National Synergistic Innovation Center for Advanced Materials
U.S. Army
National Center for Research Resources (M01RR000400, M01-RR00400)
NIH Clinical Center
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: soy protein, isoflavones, homocysteine, inflammation, postmenopausal women, C-reactive protein, soluble adhesion molecules, soluble E-selectin, soluble VCAM-1, soluble ICAM-1, soy protein isolate, milk protein isolate, coronary heart disease risk, equol, folic acid, methionine
MeSH terms: Aged, C-Reactive Protein, Coronary Disease, Enzyme-Linked Immunosorbent Assay, Fasting, Female, Homocysteine, Humans, Inflammation, Isoflavones, Middle Aged, Milk Proteins, Biomarkers, Postmenopause, Cross-Over Studies, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, E-Selectin, Soybean Proteins

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Consumption of isoflavone-rich soy protein does not alter homocysteine or markers of inflammation in postmenopausal women

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