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Cited by 52Phytoestrogen effects and researchMenopause: Health Impacts and TreatmentsFolate and B Vitamins Research

The effect of the phytoestrogen genistein and hormone replacement therapy on homocysteine and C-reactive protein level in postmenopausal women

D'Anna, Rosario, Baviera, Giovanni, Corrado, Francesco, Cancellieri, Francesco, Crisafulli, Alessandra, Squadrito, Francesco·2005·Acta Obstetricia Et Gynecologica Scandinavica
DOI 10.1111/j.0001-6349.2005.00661.x
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Abstract

BACKGROUND: The aim of the study was to evaluate the effect, in postmenopausal women, of the phytoestrogen genistein and hormone replacement therapy (HRT) on circulating two independent factors of cardiovascular risk: homocysteine and C-reactive protein (CRP). METHODS: Ninety healthy postmenopausal women, from 50 to 60 years of age, were randomly assigned to receive genistein (n = 30; 54 mg/die) or continuous combined estrogen/progestin therapy (17-beta-estradiol 1 mg plus norethisterone acetate 0.5 mg) or placebo. Plasma homocysteine and serum CRP were measured at baseline and after 6 months of treatment. RESULTS: In the genistein group, plasma homocysteine and serum CRP showed no statistically significant difference from baseline (homocysteine: 11.36 +/- 0.39 micromol/l; CRP: 1.73 +/- 0.31 mg/l) to 6 months treatment (homocysteine: 10.72 +/- 0.46 micromol/l; CRP: 2.13 +/- 0.45 mg/l), without any significant difference versus the placebo group (homocysteine: 11.25 +/- 0.43 micromol/l; CRP: 1.74 +/- 0.22 mg/l). In the HRT group there was a slight, but not significant reduction, of plasma homocysteine mean value from baseline (11.21 +/- 0.44 micromol/l) to 6 months treatment (10.45 +/- 0.38 micromol/l); whereas CRP mean value at the end of treatment (3.30 +/- 0.55 mg/l) was significantly higher from baseline (1.61 +/- 0.25 mg/l) (P < 0.01). However, after 6 months, no significant difference existed with the other two groups. CONCLUSIONS: The phytoestrogen genistein, after 6 months treatment, does not modify the independent cardiovascular risk linked to circulating homocysteine or CRP level. Our experience confirms critical increase of CRP serum level after HRT treatment, but not plasma homocysteine significant variation.

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  • In obese non-diabetic or diabetic individuals, some studies observed improved insulin sensitivity after prolonged neutralizing TNF-a antibody treatment.

    “In obese non-diabetic or diabetic individuals, several studies have observed improvement of insulin sensitivity after prolonged treatment with neutralising TNF-a antibodies (150,151) , whereas other trials did not report such effects of TNF-a antibody injections, despite dampening of systemic inflammation (152) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [151]

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Authors
D'Anna, R., Baviera, G., Corrado, F., Cancellieri, F., Crisafulli, A., & Squadrito, F.
Affiliations
University of Messina (IT)
ORCID
Venue
Acta Obstetricia Et Gynecologica Scandinavica
Publisher
Wiley
Published
2005-04-12
Volume
84
Issue
5
Pages
474-477
ISSN
  • 0001-6349 (ISSN-L)
  • 1600-0412
DOI
10.1111/j.0001-6349.2005.00661.x
OpenAlex
W2039587555
Cited by
52
References
33
Citations by year
2025: 1 · 2023: 2 · 2021: 4 · 2020: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 4
FWCI
4.01
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Obstetricia Et Gynecologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Keywords
genistein, phytoestrogens, hormone replacement therapy, postmenopausal women, homocysteine, C-reactive protein, cardiovascular risk, estrogen-progestin therapy, norethisterone acetate, estradiol, inflammatory markers, hyperhomocysteinemia, menopausal symptoms, hot flashes, sleep disorders
MeSH terms
Norethindrone Acetate, C-Reactive Protein, Cardiovascular Diseases, Estradiol, Female, Homocysteine, Humans, Middle Aged, Norethindrone, Estrogen Replacement Therapy, Treatment Outcome, Postmenopause, Genistein, Phytoestrogens

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